James Tumlin

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins
    J A Tumlin
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 99:1217-23. 1997
  2. ncbi request reprint Idiopathic IgA nephropathy: pathogenesis, histopathology, and therapeutic options
    James A Tumlin
    Clinical Research Division, Southeast Renal Associates, 2301 W Morehead Street, Charlotte, NC 28208, USA
    Clin J Am Soc Nephrol 2:1054-61. 2007
  3. ncbi request reprint A prospective, open-label trial of sirolimus in the treatment of focal segmental glomerulosclerosis
    James A Tumlin
    Department of Medicine, Division of Nephrology, Emory University School Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Clin J Am Soc Nephrol 1:109-16. 2006
  4. ncbi request reprint Pathophysiology of contrast-induced nephropathy
    James Tumlin
    Southeast Renal Research Institute SERRI, Charlotte, North Carolina 28028, USA
    Am J Cardiol 98:14K-20K. 2006
  5. ncbi request reprint Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial
    James A Tumlin
    Emory University School of Medicine, Renal Division, Atlanta, GA 30322, USA
    Am J Kidney Dis 46:26-34. 2005
  6. ncbi request reprint Clinical presentation, natural history, and treatment of crescentic proliferative IgA nephropathy
    James A Tumlin
    Division Nephrology and the Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Semin Nephrol 24:256-68. 2004
  7. ncbi request reprint Crescentic, proliferative IgA nephropathy: clinical and histological response to methylprednisolone and intravenous cyclophosphamide
    James A Tumlin
    Division of Nephrology, Emory University, Atlanta, GA 30322, USA
    Nephrol Dial Transplant 18:1321-9. 2003
  8. ncbi request reprint Expression and function of calcineurin in the mammalian nephron: physiological roles, receptor signaling, and ion transport
    J A Tumlin
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Kidney Dis 30:884-95. 1997
  9. ncbi request reprint Fenoldopam mesylate blocks reductions in renal plasma flow after radiocontrast dye infusion: a pilot trial in the prevention of contrast nephropathy
    J A Tumlin
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Am Heart J 143:894-903. 2002
  10. ncbi request reprint Fenoldopam, a dopamine agonist, for hypertensive emergency: a multicenter randomized trial. Fenoldopam Study Group
    J A Tumlin
    Emory University Hospital, Atlanta, GA, USA
    Acad Emerg Med 7:653-62. 2000

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins
    J A Tumlin
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 99:1217-23. 1997
    ..We conclude that HSPs released from transformed steroid receptors can stimulate calcineurin activity through a transcription-independent pathway...
  2. ncbi request reprint Idiopathic IgA nephropathy: pathogenesis, histopathology, and therapeutic options
    James A Tumlin
    Clinical Research Division, Southeast Renal Associates, 2301 W Morehead Street, Charlotte, NC 28208, USA
    Clin J Am Soc Nephrol 2:1054-61. 2007
    ..The use of known clinical risk factors for disease progression in conjunction with specific histologic features can be a guide to both induction and consolidation therapies for individual patients with IgA nephropathy...
  3. ncbi request reprint A prospective, open-label trial of sirolimus in the treatment of focal segmental glomerulosclerosis
    James A Tumlin
    Department of Medicine, Division of Nephrology, Emory University School Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Clin J Am Soc Nephrol 1:109-16. 2006
    ..73 m2) at the end of 6 mo compared with nonresponders. In patients with steroid-resistant FSGS, sirolimus reduced proteinuria and glomerular pore size and increased K(f) in patients with steroid-resistant FSGS...
  4. ncbi request reprint Pathophysiology of contrast-induced nephropathy
    James Tumlin
    Southeast Renal Research Institute SERRI, Charlotte, North Carolina 28028, USA
    Am J Cardiol 98:14K-20K. 2006
    ..These effects, coupled with direct tubular toxicity of contrast media, lead to overt acute tubular necrosis and the syndrome of CIN...
  5. ncbi request reprint Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial
    James A Tumlin
    Emory University School of Medicine, Renal Division, Atlanta, GA 30322, USA
    Am J Kidney Dis 46:26-34. 2005
    ..We hypothesized that administration of low-dose fenoldopam during early ATN would decrease the need for dialysis therapy and/or incidence of death at 21 days...
  6. ncbi request reprint Clinical presentation, natural history, and treatment of crescentic proliferative IgA nephropathy
    James A Tumlin
    Division Nephrology and the Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Semin Nephrol 24:256-68. 2004
    ..Pulse solumedrol and intravenous cyclophosphamide effectively reduced peak serum creatinine, degree of proteinuria, the rate of decline in renal function, and the incidence of end-stage renal disease at 36 months...
  7. ncbi request reprint Crescentic, proliferative IgA nephropathy: clinical and histological response to methylprednisolone and intravenous cyclophosphamide
    James A Tumlin
    Division of Nephrology, Emory University, Atlanta, GA 30322, USA
    Nephrol Dial Transplant 18:1321-9. 2003
    ..Previous attempts to correlate specific histological findings including cellular crescents or endocapillary proliferation, with clinical outcomes, have produced conflicting results...
  8. ncbi request reprint Expression and function of calcineurin in the mammalian nephron: physiological roles, receptor signaling, and ion transport
    J A Tumlin
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Kidney Dis 30:884-95. 1997
    ..The mechanism is independent of transcription and appears to involve mechanisms involving heat shock proteins associated with the steroid receptor complex...
  9. ncbi request reprint Fenoldopam mesylate blocks reductions in renal plasma flow after radiocontrast dye infusion: a pilot trial in the prevention of contrast nephropathy
    J A Tumlin
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Am Heart J 143:894-903. 2002
    ..To determine whether fenoldopam mesylate attenuates reductions in RPF after contrast infusion, we conducted a double-blind, randomized, placebo-controlled pilot trial of fenoldopam mesylate in patients who underwent contrast angiography...
  10. ncbi request reprint Fenoldopam, a dopamine agonist, for hypertensive emergency: a multicenter randomized trial. Fenoldopam Study Group
    J A Tumlin
    Emory University Hospital, Atlanta, GA, USA
    Acad Emerg Med 7:653-62. 2000
    ..Despite successful therapies for chronic hypertension, hospital admissions for hypertensive emergency more than tripled between 1983 and 1992...
  11. pmc A phase III, randomized, double-blind, placebo-controlled study of tenecteplase for improvement of hemodialysis catheter function: TROPICS 3
    James Tumlin
    Department of Internal Medicine, Division of Nephrology, University of Tennessee College of Medicine in Chattanooga, Director, Southeast Renal Research Institute, 2300 East Third Street, Suite 100, Chattanooga, TN 37404, USA
    Clin J Am Soc Nephrol 5:631-6. 2010
    ..To address this problem, this study investigated whether the thrombolytic agent tenecteplase can restore blood flow rates (BFRs) in dysfunctional HD catheters...
  12. pmc Efficacy and safety of renal tubule cell therapy for acute renal failure
    James Tumlin
    Southeast Renal Associates Presbyterian Hospital, Charlotte, North Carolina, USA
    J Am Soc Nephrol 19:1034-40. 2008
    ..RAD therapy was also associated with more rapid recovery of kidney function, was well tolerated, and had the expected adverse event profile for critically ill patients with ARF...
  13. doi request reprint Fenoldopam reduces the need for renal replacement therapy and in-hospital death in cardiovascular surgery: a meta-analysis
    Giovanni Landoni
    Department of Cardiothoracic Anesthesia and Intensive Care, Universita Vita Salute San Raffaele, Milano, Italia e Istituto Scientifico San Raffaele, Milan, Italy
    J Cardiothorac Vasc Anesth 22:27-33. 2008
    ..To determine the efficacy of fenoldopam in the prevention of acute renal failure, the authors performed a systematic review of randomized, controlled trials and propensity-matched studies in patients undergoing cardiovascular surgery...
  14. ncbi request reprint Loss of the alpha-isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of transforming growth factor-beta
    Jennifer L Gooch
    Department of Medicine, Division of Nephrology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Transplantation 83:439-47. 2007
    ..However, mechanisms of extracellular matrix expansion and TGFbeta regulation following calcineurin inhibition are unknown. Mice lacking specific calcineurin catalytic subunit isoforms may offer important insight into this pathway...
  15. ncbi request reprint Angiotensin II stimulates calcineurin activity in proximal tubule epithelia through AT-1 receptor-mediated tyrosine phosphorylation of the PLC-gamma1 isoform
    Janice P Lea
    Renal Division, Emory University School of Medicine, 1639 Pierce Drive NE, Atlanta, GA 30322, USA
    J Am Soc Nephrol 13:1750-6. 2002
    ..It is therefore concluded that AngII stimulates calcineurin phosphatase activity in proximal tubule epithelial cells through a mechanism involving AT-1 receptor-mediated tyrosine phosphorylation of the PLC isoform...
  16. ncbi request reprint LJP 394 for the prevention of renal flare in patients with systemic lupus erythematosus: results from a randomized, double-blind, placebo-controlled study
    Donato Alarcon-Segovia
    Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Arthritis Rheum 48:442-54. 2003
    ..To determine whether LJP 394 delays or prevents renal flare in patients with systemic lupus erythematosus (SLE) and a history of renal disease...
  17. ncbi request reprint Calcineurin phosphatase activity: activation by glucocorticoids and role of intracellular calcium
    David C Tong
    Renal Division, Emory University School of Medicine, 1364 Clifton Road, N E, Atlanta, GA 30322, USA
    Transplantation 77:259-67. 2004
    ..Glucocorticoids stimulate release of intracellular calcium in peripheral lymphocytes, but their effects on calcineurin phosphatase activity are unknown...
  18. ncbi request reprint Fenoldopam mesylate for the prevention of contrast-induced nephropathy: a randomized controlled trial
    Gregg W Stone
    Department of Cardiology, Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY 10022, USA
    JAMA 290:2284-91. 2003
    ....
  19. ncbi request reprint Contrast-Induced Nephropathy (CIN) Consensus Working Panel: executive summary
    Peter A McCullough
    William Beaumont Hospital, Royal Oak, Michigan, USA
    Rev Cardiovasc Med 7:177-97. 2006
    ..In this executive summary, consensus statements and an algorithm for the risk stratification and management of CIN are presented...
  20. ncbi request reprint Beneficial impact of fenoldopam in critically ill patients with or at risk for acute renal failure: a meta-analysis of randomized clinical trials
    Giovanni Landoni
    Department of Cardiothoracic Anesthesia and Intensive Care, Universita Vita Salute San Raffaele, Milano, Italia
    Am J Kidney Dis 49:56-68. 2007
    ..Because there is uncertainty about the benefits of fenoldopam in such a setting, we performed a systematic review of randomized controlled trials of intensive care unit patients or those undergoing major surgery...
  21. doi request reprint Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trial
    Mario H Cardiel
    Hospital General Dr Miguel Silva, Morelia, Michoacan, Mexico
    Arthritis Rheum 58:2470-80. 2008
    ....

Research Grants4

  1. PREVENTION OF GRAFT FAILURE TO DIETARY N-3 FATTY ACIDS
    James Tumlin; Fiscal Year: 2002
    ..Secondary outcomes to be compared are molecular markers for thrombosis, inflammation, and vascular risk factors. ..