MARIALOURDES G TANSEYSummaryAffiliation: Emory University Country: USA Publications
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Publications
Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neuronsTerina N Martinez
Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, TX 75390, USA
Mol Neurodegener 7:45. 2012..Here we investigated the contribution of ceramide sphingolipid signaling in TNF-dependent toxicity...- Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challengeChristopher J Barnum
Department of Physiology, School of Medicine, Emory University, 615 Michael Street, Atlanta, GA 30324, USA
J Neuroinflammation 9:9. 2012..However, long-term outcomes of chronic psychological stressors that elicit a neuroinflammatory response remain unknown... - Does neuroinflammation fan the flame in neurodegenerative diseases?Tamy C Frank-Cannon
Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Neurodegener 4:47. 2009.... - Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic interventionMALU G TANSEY
Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30324, USA
Neurobiol Dis 37:510-8. 2010.... 
The TNF superfamily in 2009: new pathways, new indications, and new drugsMALU G TANSEY
Department of Physiology, Emory University, Atlanta, GA 30322, USA
Drug Discov Today 14:1082-8. 2009..This report summarizes recent developments in this highly druggable superfamily, including highlights of the latest international TNF conference...
Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?MALU G TANSEY
Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
Front Biosci 13:709-17. 2008..The rationale for current and future use of anti-inflammatory approaches to protect vulnerable neuronal populations in PD is also reviewed...- Parkin deficiency increases vulnerability to inflammation-related nigral degenerationTamy C Frank-Cannon
Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
J Neurosci 28:10825-34. 2008.... - TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative diseaseMelissa K McCoy
Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
J Neuroinflammation 5:45. 2008.... - Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory responseJae Kyung Lee
Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
J Neurosci 28:8517-28. 2008..RGS10 emerges as a novel drug target for prevention of nigrostriatal pathway degeneration, the neuropathological hallmark of PD... - Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian ratsMelissa K McCoy
Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Ther 16:1572-9. 2008..This strategy holds the potential for therapeutic application in the treatment of PD... - Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic interventionMALU G TANSEY
Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Exp Neurol 208:1-25. 2007.... - Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathologyFiona E McAlpine
Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
Neurobiol Dis 34:163-77. 2009..Targeted inhibition of solTNF in the CNS may slow the appearance of amyloid-associated pathology, cognitive deficits, and potentially the progressive loss of neurons in AD... - Neuroinflammation in Parkinson's diseaseJae Kyung Lee
Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
J Neuroimmune Pharmacol 4:419-29. 2009.... - The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotectionThi A Tran
Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Neuroinflammation 5:14. 2008..Therefore, the aims of our study were to identify specific microglial activities modulated by CDDO-Me in vitro, and to determine the extent to which this modulation affords neuroprotection against inflammatory stimuli... - Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's diseaseMelissa K McCoy
Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Exp Neurol 210:14-29. 2008..ADAS cells may be ideal for ex vivo gene transfer therapies in Parkinson's disease treatment... - Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's diseaseMelissa K McCoy
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 26:9365-75. 2006....
Research Grants
- TNF Signaling in NeurodegenerationMARIALOURDES G TANSEY; Fiscal Year: 2010....
- TNF Signaling in NeurodegenerationMALU TANSEY; Fiscal Year: 2006....
- RGS10 in microglia activation and dopaminergic neuron survivalMARIALOURDES G TANSEY; Fiscal Year: 2010..Completion of the proposed experiments may reveal new targets for therapies to prevent or delay development of PD in humans. ..