MARIALOURDES G TANSEY

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity
    Vanesa Sanchez-Guajardo
    CNS Disease Modeling Group, Department of Biomedicine, Ole Worms Allé 3, Aarhus University, DK 8000 Aarhus C, Denmark
    ASN Neuro 5:113-39. 2013
  2. pmc Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B
    Thi A Tran
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e23660. 2011
  3. pmc Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
    Terina N Martinez
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, TX 75390, USA
    Mol Neurodegener 7:45. 2012
  4. pmc Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge
    Christopher J Barnum
    Department of Physiology, School of Medicine, Emory University, 615 Michael Street, Atlanta, GA 30324, USA
    J Neuroinflammation 9:9. 2012
  5. ncbi request reprint The TNF superfamily in 2009: new pathways, new indications, and new drugs
    MALU G TANSEY
    Department of Physiology, Emory University, Atlanta, GA 30322, USA
    Drug Discov Today 14:1082-8. 2009
  6. pmc Does neuroinflammation fan the flame in neurodegenerative diseases?
    Tamy C Frank-Cannon
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Neurodegener 4:47. 2009
  7. pmc Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention
    MALU G TANSEY
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30324, USA
    Neurobiol Dis 37:510-8. 2010
  8. ncbi request reprint Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Front Biosci 13:709-17. 2008
  9. pmc TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    J Neuroinflammation 5:45. 2008
  10. pmc Parkin deficiency increases vulnerability to inflammation-related nigral degeneration
    Tamy C Frank-Cannon
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    J Neurosci 28:10825-34. 2008

Research Grants

  1. TNF Signaling in Neurodegeneration
    MARIALOURDES G TANSEY; Fiscal Year: 2010
  2. TNF Signaling in Neurodegeneration
    MALU TANSEY; Fiscal Year: 2006
  3. TNF Signaling in Neurodegeneration
    MARIALOURDES G TANSEY; Fiscal Year: 2009
  4. RGS10 in microglia activation and dopaminergic neuron survival
    MARIALOURDES G TANSEY; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. pmc Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity
    Vanesa Sanchez-Guajardo
    CNS Disease Modeling Group, Department of Biomedicine, Ole Worms Allé 3, Aarhus University, DK 8000 Aarhus C, Denmark
    ASN Neuro 5:113-39. 2013
    ..Lastly, we discuss the immune-modulatory strategies currently under investigation in animal models of parkinsonism and the degree to which one might expect their outcomes to translate faithfully to a clinical setting...
  2. pmc Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B
    Thi A Tran
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e23660. 2011
    ....
  3. pmc Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
    Terina N Martinez
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, TX 75390, USA
    Mol Neurodegener 7:45. 2012
    ..Here we investigated the contribution of ceramide sphingolipid signaling in TNF-dependent toxicity...
  4. pmc Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge
    Christopher J Barnum
    Department of Physiology, School of Medicine, Emory University, 615 Michael Street, Atlanta, GA 30324, USA
    J Neuroinflammation 9:9. 2012
    ..However, long-term outcomes of chronic psychological stressors that elicit a neuroinflammatory response remain unknown...
  5. ncbi request reprint The TNF superfamily in 2009: new pathways, new indications, and new drugs
    MALU G TANSEY
    Department of Physiology, Emory University, Atlanta, GA 30322, USA
    Drug Discov Today 14:1082-8. 2009
    ..This report summarizes recent developments in this highly druggable superfamily, including highlights of the latest international TNF conference...
  6. pmc Does neuroinflammation fan the flame in neurodegenerative diseases?
    Tamy C Frank-Cannon
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Neurodegener 4:47. 2009
    ....
  7. pmc Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention
    MALU G TANSEY
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30324, USA
    Neurobiol Dis 37:510-8. 2010
    ....
  8. ncbi request reprint Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Front Biosci 13:709-17. 2008
    ..The rationale for current and future use of anti-inflammatory approaches to protect vulnerable neuronal populations in PD is also reviewed...
  9. pmc TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    J Neuroinflammation 5:45. 2008
    ....
  10. pmc Parkin deficiency increases vulnerability to inflammation-related nigral degeneration
    Tamy C Frank-Cannon
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    J Neurosci 28:10825-34. 2008
    ....
  11. pmc Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Ther 16:1572-9. 2008
    ..This strategy holds the potential for therapeutic application in the treatment of PD...
  12. pmc Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Exp Neurol 208:1-25. 2007
    ....
  13. pmc Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response
    Jae Kyung Lee
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    J Neurosci 28:8517-28. 2008
    ..RGS10 emerges as a novel drug target for prevention of nigrostriatal pathway degeneration, the neuropathological hallmark of PD...
  14. pmc Neuroinflammation in Parkinson's disease
    Jae Kyung Lee
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Neuroimmune Pharmacol 4:419-29. 2009
    ....
  15. pmc Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
    Fiona E McAlpine
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Neurobiol Dis 34:163-77. 2009
    ..Targeted inhibition of solTNF in the CNS may slow the appearance of amyloid-associated pathology, cognitive deficits, and potentially the progressive loss of neurons in AD...
  16. pmc The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
    Thi A Tran
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Neuroinflammation 5:14. 2008
    ..Therefore, the aims of our study were to identify specific microglial activities modulated by CDDO-Me in vitro, and to determine the extent to which this modulation affords neuroprotection against inflammatory stimuli...
  17. pmc Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Exp Neurol 210:14-29. 2008
    ..ADAS cells may be ideal for ex vivo gene transfer therapies in Parkinson's disease treatment...
  18. pmc Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:9365-75. 2006
    ....

Research Grants4

  1. TNF Signaling in Neurodegeneration
    MARIALOURDES G TANSEY; Fiscal Year: 2010
    ....
  2. TNF Signaling in Neurodegeneration
    MALU TANSEY; Fiscal Year: 2006
    ....
  3. TNF Signaling in Neurodegeneration
    MARIALOURDES G TANSEY; Fiscal Year: 2009
    ....
  4. RGS10 in microglia activation and dopaminergic neuron survival
    MARIALOURDES G TANSEY; Fiscal Year: 2010
    ..Completion of the proposed experiments may reveal new targets for therapies to prevent or delay development of PD in humans. ..