Zachary Stowe

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi request reprint Zolpidem (Ambien) in pregnancy: placental passage and outcome
    Sandra Juric
    Dept of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Arch Womens Ment Health 12:441-6. 2009
  2. ncbi request reprint The onset of postpartum depression: Implications for clinical screening in obstetrical and primary care
    Zachary N Stowe
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am J Obstet Gynecol 192:522-6. 2005
  3. ncbi request reprint The use of mood stabilizers during breastfeeding
    Zachary N Stowe
    Women s Mental Health Program, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 68:22-8. 2007
  4. ncbi request reprint The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations
    Zachary N Stowe
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta GA, USA
    J Clin Psychiatry 64:73-80. 2003
  5. ncbi request reprint Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 162:2162-70. 2005
  6. ncbi request reprint Antidepressants in amniotic fluid: another route of fetal exposure
    Ada M Loughhead
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 163:145-7. 2006
  7. ncbi request reprint Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 164:1214-20. 2007
  8. ncbi request reprint The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient
    Jun Sheng Wang
    Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Rev 39:723-46. 2007
  9. doi request reprint Lamotrigine in bipolar disorder: efficacy during pregnancy
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bipolar Disord 10:432-6. 2008
  10. doi request reprint Lamotrigine in breast milk and nursing infants: determination of exposure
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Rd NE, Suite B6100, Atlanta, GA 30322
    Pediatrics 122:e223-31. 2008

Research Grants

  1. Risk and Predictors of Postpartum Depression
    Zachary Stowe; Fiscal Year: 2007
  2. Medications in Pregnancy: Defining Exposure
    Zachary Stowe; Fiscal Year: 2006
  3. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Zachary Stowe; Fiscal Year: 2003

Collaborators

Detail Information

Publications33

  1. doi request reprint Zolpidem (Ambien) in pregnancy: placental passage and outcome
    Sandra Juric
    Dept of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Arch Womens Ment Health 12:441-6. 2009
    ..Pregnant women with psychiatric illness treated with zolpidem may have less optimal obstetrical outcome, though it is unclear if this was related to the medication...
  2. ncbi request reprint The onset of postpartum depression: Implications for clinical screening in obstetrical and primary care
    Zachary N Stowe
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am J Obstet Gynecol 192:522-6. 2005
    ..Inconsistent diagnostic criteria fail to delineate guidelines for postpartum depression surveillance. This study evaluates the validity of commonly accepted postpartum onset criteria...
  3. ncbi request reprint The use of mood stabilizers during breastfeeding
    Zachary N Stowe
    Women s Mental Health Program, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 68:22-8. 2007
    ..Familiarity with the extant literature and its limitations and practical considerations will enable optimizing treatment plans that maintain maternal mental health, minimize nursing infant exposures, and provide infant monitoring...
  4. ncbi request reprint The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations
    Zachary N Stowe
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta GA, USA
    J Clin Psychiatry 64:73-80. 2003
    ....
  5. ncbi request reprint Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 162:2162-70. 2005
    ....
  6. ncbi request reprint Antidepressants in amniotic fluid: another route of fetal exposure
    Ada M Loughhead
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 163:145-7. 2006
    ..The authors' goal was to determine the concentration of antidepressants in amniotic fluid during maternal treatment of depression...
  7. ncbi request reprint Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 164:1214-20. 2007
    ..The objectives of the current study were to quantify placental permeability to antipsychotic medications and to document obstetrical outcomes for women taking these agents proximate to delivery...
  8. ncbi request reprint The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient
    Jun Sheng Wang
    Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Rev 39:723-46. 2007
    ..This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology...
  9. doi request reprint Lamotrigine in bipolar disorder: efficacy during pregnancy
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bipolar Disord 10:432-6. 2008
    ..The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG). We therefore compared recurrence risks among pregnant women with BPD treated with LTG to those discontinuing mood stabilizer therapies...
  10. doi request reprint Lamotrigine in breast milk and nursing infants: determination of exposure
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Rd NE, Suite B6100, Atlanta, GA 30322
    Pediatrics 122:e223-31. 2008
    ..We sought to characterize the determinants of lamotrigine concentrations in breast milk and nursing-infant plasma...
  11. doi request reprint Venlafaxine in human breast milk and nursing infant plasma: determination of exposure
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road, N E, Suite B6100, Atlanta, GA 30322, USA
    J Clin Psychiatry 70:1304-10. 2009
    ..The current study characterizes the level and determinants of venlafaxine and desvenlafaxine concentrations in breast milk and in nursing infant plasma...
  12. pmc The impact of maternal childhood abuse on maternal and infant HPA axis function in the postpartum period
    Sarah R Brand
    Department of Psychology, Emory University, United States
    Psychoneuroendocrinology 35:686-93. 2010
    ..The majority of previous studies in this area focus on adult offspring, and the degree to which the effects of parental child abuse can be detected earlier in the development of the offspring remains obscure...
  13. ncbi request reprint Maternal depression: a child's first adverse life event
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Clin Neuropsychiatry 7:113-9. 2002
    ..Paralleling the preclinical literature are human studies indicating similar acute effects. The clinical implications for the psychiatric treatment of depressed women who have children will be discussed...
  14. ncbi request reprint Parental depression: animal models of an adverse life event
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 159:1265-83. 2002
    ..This article reviews findings in preclinical research on the adverse impact of parental depression on the development of offspring, with emphasis on the relevance of this research for the psychiatric care of depressed parents...
  15. ncbi request reprint The treatment of postpartum depression: minimizing infant exposures
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 63:31-44. 2002
    ..Infant exposure and limitations to monitoring infant sera are reviewed. Lastly, a model and guide for reducing fetal and infant exposures is presented...
  16. ncbi request reprint A novel system for the determination of antidepressant concentrations in human breast milk
    Amy L Hostetter
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ther Drug Monit 26:47-52. 2004
    ..The method is shown to be a highly accurate and precise technique for measuring 12 different antidepressants in human breast milk and to be free of the matrix effects often encountered in breast milk drug analyses...
  17. ncbi request reprint Placental passage of tricyclic antidepressants
    Ada M Loughhead
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 59:287-90. 2006
    ..The use of antidepressants during pregnancy continues to garner considerable attention, though there are limited investigations that have sought to quantify fetal exposure...
  18. ncbi request reprint Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    J Psychopharmacol 20:54-9. 2006
    ....
  19. ncbi request reprint Clinical management of perinatal depression: focus on paroxetine
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacol Bull 37:148-66. 2003
    ..In contrast, the amniotic fluid, umbilical cord, and nursing infant sera literature demonstrated significantly different exposures to individual medications...
  20. pmc Maternal depression and infant cortisol: influences of timing, comorbidity and treatment
    Patricia A Brennan
    Psychology Department, Emory University, Atlanta, GA 30322, USA
    J Child Psychol Psychiatry 49:1099-107. 2008
    ..The potential roles of comorbid maternal anxiety disorders, timing of maternal depression, and maternal treatment with psychotropic medications during pregnancy are addressed...
  21. pmc Postpartum depression in women with epilepsy: influence of antiepileptic drugs in a prospective study
    Melanie Galanti
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Epilepsy Behav 16:426-30. 2009
    ..In conclusion, PPD rates are higher among women with epilepsy than the general population, particularly those who are multiparous or receiving AED polytherapy, and there is no evidence that AED selection modifies this risk...
  22. ncbi request reprint Psychiatric disorders in pregnancy
    Lori Levey
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Neurol Clin 22:863-93. 2004
    ..These basic guidelines can help decrease the number of exposures and aid in conducting clinical care with at least some reproductive safety data...
  23. pmc A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort
    Elisabeth B Binder
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA
    J Psychiatr Res 44:640-6. 2010
    ..The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population...
  24. ncbi request reprint Venlafaxine in the treatment of depressive and vasomotor symptoms in women with perimenopausal depression
    Charlotte O Ladd
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Depress Anxiety 22:94-7. 2005
    ..Further studies are warranted to investigate the utility of venlafaxine in perimenopausal depression...
  25. ncbi request reprint The fetus and maternal depression: implications for antenatal treatment guidelines
    Autumn L Henry
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Obstet Gynecol 47:535-46. 2004
  26. doi request reprint Platelet thromboxane A2 secretion in patients with major depression responsive to electroconvulsive therapy
    Erica C Bruce
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychosom Med 70:319-27. 2008
    ..Increased platelet activation may underlie the increased risk of coronary artery disease (CAD) in patients with MDD...
  27. ncbi request reprint Alterations in platelet serotonin transporter binding in women with postpartum onset major depression
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road NE, Suite B6100, Atlanta, GA 30322, USA
    J Psychiatr Res 38:467-73. 2004
    ..These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium...
  28. ncbi request reprint Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    JAMA 295:499-507. 2006
    ..However, systematic delineation of risk of relapse in women who maintain or discontinue pharmacological treatment during pregnancy is necessary...
  29. ncbi request reprint Estimates of nursing infant daily dose of fluoxetine through breast milk
    Rita Suri
    UCLA Neuropsychiatric Institute and Hospital, Los Angeles, California 90095, USA
    Biol Psychiatry 52:446-51. 2002
    ..This study compared three methods of estimating the daily dose of fluoxetine to nursing infants and the relationship between these estimates and infant serum concentrations...
  30. ncbi request reprint Placental passage of antidepressant medications
    Victoria Hendrick
    Mood Disorders Research Program, UCLA Neuropsychiatric Institute and Hospital, University of California Los Angeles, 300 Medical Plaza, Suite 2345, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:993-6. 2003
    ..This study determined the placental transfer of antidepressants and their metabolites...
  31. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
    ..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...
  32. ncbi request reprint Pancytopenia associated with the introduction of oxcarbazepine
    Martha R Calamaras
    J Clin Psychopharmacol 27:217-8. 2007
  33. ncbi request reprint Reintroduction of antidepressant therapy across pregnancy in women who previously discontinued treatment. A preliminary retrospective study
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychother Psychosom 73:255-8. 2004
    ..Pregnancy has frequently been described as a time of emotional well-being conferring 'protection' against psychiatric disorders. However, data to support this impression are sparse...

Research Grants12

  1. Risk and Predictors of Postpartum Depression
    Zachary Stowe; Fiscal Year: 2007
    ..Cohen, Nonacs and Otto), the Women's Life Center and Mood Disorders Research Program at UCLA (Dr. AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). ..
  2. Medications in Pregnancy: Defining Exposure
    Zachary Stowe; Fiscal Year: 2006
    ..The achievement of the objectives address several research priority areas noted in ORWH Agenda for Research on Women's Health for the 21st century. ..
  3. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Zachary Stowe; Fiscal Year: 2003
    ..Delineating of these subgroups provides an opportunity to screen for women "at risk" for relapse and allows for thoughtful treatment plan. ..