Research Topics
| David StephensSummaryAffiliation: Emory University Country: USA Publications
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Publications
Epidemic meningitis, meningococcaemia, and Neisseria meningitidisDavid S Stephens
Emory University School of Medicine, Atlanta, GA 30322, USA
Lancet 369:2196-210. 2007..The crucial challenge will be effective introduction of new meningococcal vaccines into developing countries, especially in sub-Saharan Africa, where they are urgently needed...
Protecting the herd: the remarkable effectiveness of the bacterial meningitis polysaccharide-protein conjugate vaccines in altering transmission dynamicsDavid S Stephens
Robert W Woodruff Health Sciences Center, 1440 Clifton Road NE, Suite 420, Emory University, Atlanta, Georgia 30322, USA
Trans Am Clin Climatol Assoc 122:115-23. 2011....- Conquering the meningococcusDavid S Stephens
Emory University School of Medicine, Atlanta, GA, USA
FEMS Microbiol Rev 31:3-14. 2007..This report reviews new discoveries impacting prevention and future prospects for conquering the meningococcus as a human pathogen... - Incidence of macrolide resistance in Streptococcus pneumoniae after introduction of the pneumococcal conjugate vaccine: population-based assessmentDavid S Stephens
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Lancet 365:855-63. 2005..We assessed emergence of macrolide-resistant invasive S pneumoniae disease in Atlanta, GA, USA, before and after the licensing, in February 2000, of the heptavalent pneumococcal conjugate vaccine for young children... - Biology and pathogenesis of the evolutionarily successful, obligate human bacterium Neisseria meningitidisDavid S Stephens
Emory University, Robert W Woodruff Health Sciences Center, 1440 Clifton Road, NE, Atlanta, GA 30322, USA
Vaccine 27:B71-7. 2009..We review the general status of our knowledge of pathogenesis of meningococcal carriage, transmission and virulence behavior with particular emphasis on the relevance of research on this topic to vaccine development... - Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducibleKarita D Ambrose
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Antimicrob Agents Chemother 49:4203-9. 2005..These data indicate a requirement for both Mef and Mel in the novel efflux-mediated macrolide resistance system in S. pneumoniae and other gram-positive bacteria and that the system is inducible by macrolides... - Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathwaySusu M Zughaier
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Infect Immun 72:371-80. 2004..KDO2 linked to meningococcal lipid A was structurally required for maximal activation of the human macrophage TLR4 pathway and indicates an important role for KDO-lipid A in endotoxin biologic activity... - Paclitaxel binding to human and murine MD-2Shanta M Zimmer
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 283:27916-26. 2008..In particular, Phe(126) appears to operate as a bridge for TLR4.MD-2 dimerization in the mouse but not the human protein... - TLR4-dependent adjuvant activity of Neisseria meningitidis lipid ASusu Zughaier
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, 1440 Clifton Road NE, Atlanta, GA 30322, USA
Vaccine 25:4401-9. 2007.... - KpsF is the arabinose-5-phosphate isomerase required for 3-deoxy-D-manno-octulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression in Neisseria meningitidisYih-Ling Tzeng
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, The Department of Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
J Biol Chem 277:24103-13. 2002..Furthermore, N. meningitidis, unlike enteric Gram-negative bacteria, can survive and synthesize only unglycosylated lipid A... - Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serumLisa A Lewis
Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts, USA
Infect Immun 77:1112-20. 2009..Our results support a role for lipid A phosphoethanolamine substitutions in resistance of this strict human pathogen to innate host defenses... - Genotype-specific carriage of Neisseria meningitidis in Georgia counties with hyper- and hyposporadic rates of meningococcal diseaseScott E Kellerman
Division of Public Health, Georgia Public Health Laboratory, Georgia Department of Human Resources, Emory University School of Medicine, Atlanta, USA
J Infect Dis 186:40-8. 2002..Shifts in carriage and transmission of meningococcal strains with different pathogenic potential are important determinants of meningococcal disease incidence... - Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniaeDorothea Zahner
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Antimicrob Agents Chemother 54:3516-9. 2010..Such induction may impact the efficacy of host defenses and of macrolide-based treatment of pneumococcal disease... - The Neisseria meningitidis serogroup A capsular polysaccharide O-3 and O-4 acetyltransferaseSeshu K Gudlavalleti
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 279:42765-73. 2004..MynC represents a new subclass of O-acetyltransferases that utilize acetyl-CoA to decorate the D-mannosamine capsule of N. meningitidis serogroup A... - Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogsSusu Zughaier
Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America
PLoS ONE 5:e9165. 2010..This study is the first report to identify brominated noscapines as innate immune pathway anti-inflammatory molecules... - Serogroup B meningococcal vaccinesShanta M Zimmer
Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases, Atlanta, GA 30033, USA
Curr Opin Investig Drugs 7:733-9. 2006..The epidemiology and pathogenesis of meningococcal disease are detailed, along with discussion of the challenges faced in the development of efficacious serogroup B vaccines... - Autoregulation of the MisR/MisS two-component signal transduction system in Neisseria meningitidisYih Ling Tzeng
Woodruff Memorial Research Building, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Bacteriol 188:5055-65. 2006..Thus, these results indicate that the meningococcal MisRS system constitutes a functional signal transduction circuit and that both components are critical in the autoregulation of their expression... - Hexa-acylation and KDO(2)-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid A for human monocyte derived dendritic cellsSusu Zughaier
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, VAMC 151 I, 1670 Clairmont Road, Atlanta, GA 30033, USA
Vaccine 24:1291-7. 2006.... - Preventing influenza: vaccine systems and practices in the SoutheastJulie A Gazmararian
Emory Center on Health Outcomes and Quality, Dept of Health Policy and Management, Rollins School of Public Health, Emory Univ, 1518 Clifton Rd NE, Atlanta, GA 30322, USA
Public Health Rep 121:684-94. 2006.... - Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4Shanta M Zimmer
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
Glycobiology 17:847-56. 2007..05). The hierarchy in the binding affinity of different lipid A structures for human rMD-2 was directly correlated with differences in TLR4 pathway activation and cytokine production by human macrophages... - Herd immunity and pneumococcal conjugate vaccine: a quantitative modelMichael Haber
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Vaccine 25:5390-8. 2007..Because the model was based on incidence rates and PCV7 coverage in Atlanta, our findings should be validated in other geographic areas... - MisR/MisS two-component regulon in Neisseria meningitidisYih Ling Tzeng
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Infect Immun 76:704-16. 2008..These data indicate that the MisR/S system influences a wide range of biological functions in N. meningitidis either directly or via intermediate regulators... 
Economics of an adolescent meningococcal conjugate vaccination catch-up campaign in the United StatesIsmael R Ortega-Sanchez
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 46:1-13. 2008..The objective of our study was to analyze the cost-effectiveness of a catch-up vaccination campaign with quadrivalent meningococcal conjugate vaccine for children and adolescents aged 11-17 years...- Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidisSusu M Zughaier
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30033, USA
J Endotoxin Res 13:343-57. 2007.... - Development and evaluation of an improved mouse model of meningococcal colonizationKyungcheol Yi
Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road NE, Atlanta, GA 30322, USA
Infect Immun 71:1849-55. 2003..In addition, this model allows investigation of the role of active immune response against meningococci... - Increase in pilus islet 2-encoded pili among Streptococcus pneumoniae isolates, Atlanta, Georgia, USADorothea Zahner
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Emerg Infect Dis 16:955-62. 2010..The increase in PI-2-containing isolates and the finding that isolates of all identified serotypes expressed highly conserved PI-2 pili supports their potential as a vaccine candidate... - The human host defense peptide LL-37 interacts with Neisseria meningitidis capsular polysaccharides and inhibits inflammatory mediators releaseSusu M Zughaier
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine and Laboratories of Microbial Pathogenesis, Atlanta, Georgia, United States of America
PLoS ONE 5:e13627. 2010..We conclude that the capacity of meningococcal CPS to activate macrophages via TLR2 and TLR4-MD-2 can be inhibited by the human cationic host defense peptide LL-37 and propose that this impacts CPS-based vaccine responses... - Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophagesSusu M Zughaier
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, and Laboratories of Microbial Pathogenesis, Atlanta, GA, USA
Cell Microbiol 7:1251-62. 2005.... - Biofilm formation by Neisseria meningitidisKyungcheol Yi
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Infect Immun 72:6132-8. 2004..Some strains of meningococci form biofilms, and this process is likely important in menigococcal colonization... - Genetic basis for biosynthesis of the (alpha 1-->4)-linked N-acetyl-D-glucosamine 1-phosphate capsule of Neisseria meningitidis serogroup XYih Ling Tzeng
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Infect Immun 71:6712-20. 2003..An IS1016 element was found within the intergenic region separating ctrA and xcbA in multiple strains, and this element did not interfere with capsule expression... - Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxinsSusu M Zughaier
Division of Infectious Diseases, Emory University School of Medicine, VAMC I 151, 1670 Clairmont Rd, Atlanta, GA 30033, USA
Infect Immun 73:2940-50. 2005..E. coli 55:B5 and Vibrio cholerae LPS, at the same picomolar lipid A concentrations, selectively induced the MyD88-dependent pathway, while Salmonella LPS activated the MyD88-independent pathway... - Genetic basis for nongroupable Neisseria meningitidisJennifer M Dolan-Livengood
Department of Veterans Affairs Medical Center, Decatur, Georgia, USA
J Infect Dis 187:1616-28. 2003.... - Phase variable changes in genes lgtA and lgtC within the lgtABCDE operon of Neisseria gonorrhoeae can modulate gonococcal susceptibility to normal human serumWilliam M Shafer
Laboratories of Bacterial Pathogenesis, Veterans Affairs Medical Center Atlanta, Decatur, Georgia 30333, USA
J Endotoxin Res 8:47-58. 2002..Hence, phase variation within the lgtABCDE operon can significantly impact the ability of gonococci to subvert this important host defense system... - Endotoxin of Neisseria meningitidis composed only of intact lipid A: inactivation of the meningococcal 3-deoxy-D-manno-octulosonic acid transferaseYih-Ling Tzeng
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
J Bacteriol 184:2379-88. 2002..The expression of a fully acylated, unglycosylated lipid A indicates that lipid A biosynthesis in N. meningitidis can proceed without the addition of Kdo and that KdtA is not essential for survival of the meningococcus... - The MisR/MisS two-component regulatory system influences inner core structure and immunotype of lipooligosaccharide in Neisseria meningitidisYih Ling Tzeng
Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
J Biol Chem 279:35053-62. 2004..meningitidis through an environmental sensing two-component regulatory system, named misR(NMB0595)/misS(NMB0594) for regulator and sensor of the meningococcal inner core structure... - Pathogenesis and diagnosis of human meningococcal disease using immunohistochemical and PCR assaysJeannette Guarner
Infectious Disease Pathology Activity, Division of Viral Rickettsial Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Clin Pathol 122:754-64. 2004..Immunohistochemical analysis determined the distribution of meningococci and meningococcal antigens in tissue samples, allowing better insights into N meningitidis pathogenesis... - Requirement of NMB0065 for connecting assembly and export of sialic acid capsular polysaccharides in Neisseria meningitidisRhonda I Hobb
Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States
Microbes Infect 12:476-87. 2010.... - Translocation and surface expression of lipidated serogroup B capsular Polysaccharide in Neisseria meningitidisYih-Ling Tzeng
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30033, USA
Infect Immun 73:1491-505. 2005.... - Neisseria meningitidis serogroup W-135 carriage among US travelers to the 2001 HajjPeter M Dull
Epidemic Intelligence Service, Epidemiology Program Office, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 191:33-9. 2005..meningitidis serogroup W-135 increased significantly in pilgrims returning from the Hajj. Although the risk of disease to pilgrims appears to be low, the risk of spread to others of this pathogenic strain remains a concern... - Meningococcal conjugate vaccinesShanta M Zimmer
Department of Medicine, Emory University School of Medicine, Emory University Hospital, Atlanta, GA 30322, USA
Expert Opin Pharmacother 5:855-63. 2004..The search for an effective serogroup B meningococcal vaccine remains elusive. This manuscript reviews the conjugate meningococcal vaccines and their potential for meningococcal disease prevention... - Specific, sensitive, and quantitative enzyme-linked immunosorbent assay for human immunoglobulin G antibodies to anthrax toxin protective antigenConrad P Quinn
Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 8:1103-10. 2002..The anti-PA ELISAs proved valuable for the confirmation of cases of cutaneous and inhalational anthrax and evaluation of patients in whom the diagnosis of anthrax was being considered... - Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthraxConrad P Quinn
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
J Infect Dis 190:1228-36. 2004..Anti-PA IgG is an important diagnostic marker of anthrax, a predictor of serum anti-toxin activity, and a marker of immunological memory against anthrax... - Assessing the risk of laboratory-acquired meningococcal diseaseJames J Sejvar
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 43:4811-4. 2005..meningitidis. Prevention should focus on the implementation of class II biological safety cabinets or additional respiratory protection during manipulation of suspected meningococcal isolates... - Laboratory-acquired serogroup A meningococcal meningitisAlexander Tkeshelashvili Kessler
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, USA
J Occup Health 49:399-401. 2007 - Adjuvant therapy for meningococcal sepsisMarc Fischer
Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 24:177-8. 2005 - In vivo determination of Neisseria meningitidis serogroup A capsular polysaccharide by whole cell high-resolution magic angle spinning NMR spectroscopySeshu K Gudlavalleti
Laboratory of Microbial Pathogenesis, VA Medical Center and Division of Infectious Diseases, Atlanta, GA, USA
Carbohydr Res 341:557-62. 2006..HRMAS NMR can distinguish detailed complex carbohydrate structures expressed on bacteria. NMA express both O-3 and O-4 acetylated polymers but not in equimolar ratio amounts in vivo... - Induction of efflux-mediated macrolide resistance in Streptococcus pneumoniaeScott T Chancey
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Antimicrob Agents Chemother 55:3413-22. 2011..The induction of mef(E)-mel expression by inducing macrolides appears to be based on specific interactions of the macrolide C-5 saccharide with the ribosome that alleviate transcriptional attenuation of mef(E)-mel... - Management of anthrax meningitisJames J Sejvar
Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet Infect Dis 5:287-95. 2005..Such other agents include penicillin, ampicillin, meropenem, vancomycin, and rifampicin... - Cationic antimicrobial peptide resistance in Neisseria meningitidisYih Ling Tzeng
Department of Veterans Affairs Medical Center, Research 151, Room 5A188, 1670 Clairmont Road, Decatur, GA 30033, USA
J Bacteriol 187:5387-96. 2005..The modification of meningococcal lipid A head groups with PEA also prevents neutralization of the biological effects of endotoxin by CAMP... - Lipooligosaccharide structure contributes to multiple steps in the virulence of Neisseria meningitidisLaura Plant
Department of Medical Biochemistry and Microbiology, Biomedical Centrum, Uppsala University, PO Box 582, Uppsala, Sweden
Infect Immun 74:1360-7. 2006..Taken together, the results of this study further define the importance of the LOS structure as a virulence component involved in multiple steps in the pathogenesis of N. meningitidis... - O-Acetylation of the terminal N-acetylglucosamine of the lipooligosaccharide inner core in Neisseria meningitidis. Influence on inner core structure and assemblyCharlene M Kahler
Department of Microbiology, Monash University, Wellington Road, Victoria 3800, Australia
J Biol Chem 281:19939-48. 2006..O-Acetylation also likely influences resistance to complement-mediated lysis and may be important in LOS conjugate vaccine design... - Inner core assembly and structure of the lipooligosaccharide of Neisseria meningitidis: capacity of strain NMB to express all known immunotype epitopesCharlene M Kahler
Department of Microbiology, Monash University, Clayton 3800, Australia
Glycobiology 15:409-19. 2005..In conclusion, strain NMB has the capability to express all known inner core structures, but in in vitro culture L2 and L4 immunotype structures are predominantly expressed... - Vaccines for the unvaccinated: protecting the herdDavid S Stephens
J Infect Dis 197:643-5. 2008 - Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genesJulie C Dunning Hotopp
The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
Microbiology 152:3733-49. 2006..The N. meningitidis genome is characterized by the horizontal acquisition of multiple genetic islands; the study of these islands reveals important sets of genes varying between isolates and likely to be related to pathogenicity... - Workshop on vaccine pressure and Neisseria meningitidis, Annecy, France, 9-11 March 2005Jean Michel Alonso
Institut Pasteur, Paris, France
Vaccine 25:4125-9. 2007..The workshop concluded that there is no current evidence to suggest that serogroup C conjugate vaccine pressure has resulted in meningococcal serogroup switching or replacement... - A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factorJames J Walsh
Section of Pulmonary and Critical Care Medicine, Guthrie Clinic, Sayre, PA, USA
Clin Infect Dis 44:968-71. 2007..Clinical correlation of serologic assays for the lethal factor component of lethal toxin and anti-protective antigen immunoglobulin G are also presented... - Clinical issues in the prophylaxis, diagnosis, and treatment of anthraxDavid M Bell
Emerg Infect Dis 8:222-5. 2002 - Fatal inhalational anthrax in a 94-year-old Connecticut womanLydia A Barakat
Department of Infectious Diseases, Griffin Hospital, 130 Division St, Derby, CT 06418, USA
JAMA 287:863-8. 2002..The source of exposure to B anthracis in this patient is not known. Exposure to mail that was cross-contaminated as it passed through postal facilities contaminated with B anthracis spores is one hypothesis under investigation... - Impact of bioterrorism preparedness on the public health response to the 2003-2004 influenza vaccine crisisJulie A Gazmararian
Public Health Rep 120:589. 2005 - Industry-related outbreak of human anthraxJohn A Jernigan
Emerg Infect Dis 9:1657; author reply 1657-8; discussion 1658-9. 2003 - West Nile virus southeast conferenceDavid Rimland
Emerg Infect Dis 9:897-8. 2003
Research Grants
- MENINGOCOCCAL LIPOOLIGOSACCHARIDE & MUCOSAL PATHOGENESISDavid Stephens; Fiscal Year: 2006..The studies will also continue to define differences between enteric endotoxin and the unique structure and biology of meningococcal endotoxin. ..
- Regulation of Capsule Biosynthesis in N. meningitidisDavid Stephens; Fiscal Year: 2006....
- MENINGOCOCCAL LIPOOLIGOSACCHARIDE & MUCOSAL PATHOGENESISDavid Stephens; Fiscal Year: 2007..The studies will also continue to define differences between enteric endotoxin and the unique structure and biology of meningococcal endotoxin. ..
- Center for Clinical and Translational Science Advancement at EmoryDavid Stephens; Fiscal Year: 2006..At the end of this planning process, Emory University will have developed full plans for transforming the translational research efforts and will be applying for support for implementation of a CTSA in 2007. ..
- Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniaeDavid Stephens; Fiscal Year: 2007..pneumoniae. ..
- Atlanta Clinical and Translational Science Institute (KL2)David Stephens; Fiscal Year: 2007..The Atlanta- CTSI utilizes the complementary strengths of Emory, MSM, and GA Tech and other GA institutions to promote the discipline of clinical and translational science and to improve the healthcare of our community. ..
- Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniaeDavid Stephens; Fiscal Year: 2009..pneumoniae. ..
- CLINICAL RESEARCH CURRICULUM AWARDDavid Stephens; Fiscal Year: 2004..abstract_text> ..
- MENINGOCOCCAL LIPOOLIGOSACCARIDE & MUCOSAL PATHOGENESISDavid Stephens; Fiscal Year: 1993....
- REGULATION OF CAPSULE BIOSYNTHESIS IN N MENINGITIDISDavid Stephens; Fiscal Year: 2000..These studies have direct application to the development of new meningococcal vaccine strategies and should provide important information about the regulation of sialic acid in other important bacterial and biologic systems. ..
- MENINGOCOCCAL LIPOOLIGOSACCHARIDE & MUCOSAL PATHOGENESISDavid Stephens; Fiscal Year: 2001..g. inclusion of truncated LOS molecules in outer membrane vesicle vaccines), and should provide insights into the unique features of meningococcal endotoxin. ..
- MENINGOCOCCAL LIPOOLIGOSACCHARIDE & MUCOSAL PATHOGENESISDavid Stephens; Fiscal Year: 2003..The studies will also continue to define differences between enteric endotoxin and the unique structure and biology of meningococcal endotoxin. ..
- Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniaeDavid S Stephens; Fiscal Year: 2010..pneumoniae. ..