Donald Stein

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Progesterone exerts neuroprotective effects after brain injury
    Donald G Stein
    Brain Research Laboratory, Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Brain Res Rev 57:386-97. 2008
  2. doi request reprint A clinical/translational perspective: can a developmental hormone play a role in the treatment of traumatic brain injury?
    Donald G Stein
    Department of Emergency Medicine, Emory University, USA
    Horm Behav 63:291-300. 2013
  3. pmc Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, 1365B Clifton Rd, Atlanta, GA 30322, USA
    J Neuroinflammation 8:42. 2011
  4. ncbi request reprint Sex differences in brain damage and recovery of function: experimental and clinical findings
    Donald G Stein
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Prog Brain Res 161:339-51. 2007
  5. ncbi request reprint The case for progesterone
    Donald G Stein
    Department of Emergency Medicine, Emory University School of Medicine, 1648 Pierce Dr, NE, Evans Bldg Rm 261, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1052:152-69. 2005
  6. doi request reprint Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update
    D G Stein
    Brain Research Laboratory, Department of Emergency Medicine, Emory University, 1365 B Clifton Road NE, Suite 5100, Atlanta, GA 30322, USA
    Neuroscience 191:101-6. 2011
  7. doi request reprint Progesterone in the clinical treatment of acute traumatic brain injury
    Donald G Stein
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA
    Expert Opin Investig Drugs 19:847-57. 2010
  8. pmc Is progesterone a worthy candidate as a novel therapy for traumatic brain injury?
    Donald G Stein
    Department of Emergency Medicine, Emory University, Atlanta, Georgia 30822, USA
    Dialogues Clin Neurosci 13:352-9. 2011
  9. pmc Progesterone and vitamin d hormone as a biologic treatment of traumatic brain injury in the aged
    Donald G Stein
    Department of Emergency Medicine, Emory University School of Medicine, 1365 B Clifton Road NE, Suite 5100, Atlanta, GA 30322, USA
    PM R 3:S100-10. 2011
  10. ncbi request reprint Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries
    Donald G Stein
    Department of Emergency Medicine, Emory University, 1648 Pierce Drive, Room 261, Atlanta, GA 30322, USA
    Pediatr Rehabil 6:13-22. 2003

Collaborators

Detail Information

Publications52

  1. pmc Progesterone exerts neuroprotective effects after brain injury
    Donald G Stein
    Brain Research Laboratory, Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Brain Res Rev 57:386-97. 2008
    ..Although many of its specific actions on neuroplasticity remain to be discovered, there is growing evidence that this hormone may be a safe and effective treatment for traumatic brain injury and other neural disorders in humans...
  2. doi request reprint A clinical/translational perspective: can a developmental hormone play a role in the treatment of traumatic brain injury?
    Donald G Stein
    Department of Emergency Medicine, Emory University, USA
    Horm Behav 63:291-300. 2013
    ..I discuss evidence that PROG is pleiotropically neuroprotective and may be a useful therapeutic and neuroprotective agent for central nervous system injury and some neurodegenerative diseases...
  3. pmc Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, 1365B Clifton Rd, Atlanta, GA 30322, USA
    J Neuroinflammation 8:42. 2011
    ..Therefore, in the present study, we examined the genomic profiles of TLR-mediated pathways in traumatically injured brain and PROG's effects on these genes...
  4. ncbi request reprint Sex differences in brain damage and recovery of function: experimental and clinical findings
    Donald G Stein
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Prog Brain Res 161:339-51. 2007
    ....
  5. ncbi request reprint The case for progesterone
    Donald G Stein
    Department of Emergency Medicine, Emory University School of Medicine, 1648 Pierce Dr, NE, Evans Bldg Rm 261, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1052:152-69. 2005
    ....
  6. doi request reprint Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update
    D G Stein
    Brain Research Laboratory, Department of Emergency Medicine, Emory University, 1365 B Clifton Road NE, Suite 5100, Atlanta, GA 30322, USA
    Neuroscience 191:101-6. 2011
    ..This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain...
  7. doi request reprint Progesterone in the clinical treatment of acute traumatic brain injury
    Donald G Stein
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA
    Expert Opin Investig Drugs 19:847-57. 2010
    ..Traumatic brain injury (TBI) has yet to find a safe and effective acute-stage neuroprotective treatment. Experimental drugs targeting a single receptor mechanism, gene, or brain locus have failed...
  8. pmc Is progesterone a worthy candidate as a novel therapy for traumatic brain injury?
    Donald G Stein
    Department of Emergency Medicine, Emory University, Atlanta, Georgia 30822, USA
    Dialogues Clin Neurosci 13:352-9. 2011
    ..Preclinical data suggest that progesterone may also be effective in stroke and some neurodegenerative disorders...
  9. pmc Progesterone and vitamin d hormone as a biologic treatment of traumatic brain injury in the aged
    Donald G Stein
    Department of Emergency Medicine, Emory University School of Medicine, 1365 B Clifton Road NE, Suite 5100, Atlanta, GA 30322, USA
    PM R 3:S100-10. 2011
    ....
  10. ncbi request reprint Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries
    Donald G Stein
    Department of Emergency Medicine, Emory University, 1648 Pierce Drive, Room 261, Atlanta, GA 30322, USA
    Pediatr Rehabil 6:13-22. 2003
    ..This review compares and evaluates estrogen and progesterone as neuroactive agents in the acute treatment of brain damage caused by stroke and trauma...
  11. ncbi request reprint Progesterone improves acute recovery after traumatic brain injury in the aged rat
    Sarah M Cutler
    Department of Emergency Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurotrauma 24:1475-86. 2007
    ..Thus, in aged male rats, treatment with 16 mg/kg progesterone improves short-term motor recovery and attenuates edema, secondary inflammation, and cell death after TBI...
  12. ncbi request reprint Tapered progesterone withdrawal enhances behavioral and molecular recovery after traumatic brain injury
    Sarah M Cutler
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30322, USA
    Exp Neurol 195:423-9. 2005
    ..A tapered withdrawal of the hormone further enhances short-term recovery after TBI...
  13. ncbi request reprint Allopregnanolone, a progesterone metabolite, enhances behavioral recovery and decreases neuronal loss after traumatic brain injury
    Jun He
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Restor Neurol Neurosci 22:19-31. 2004
    ..Thus, epiallopregnanolone was chosen as a control substance to examine further the role of GABA transmission in post-trauma neuroprotection...
  14. pmc Neurosteroids reduce inflammation after TBI through CD55 induction
    Jacob W VanLandingham
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Neurosci Lett 425:94-8. 2007
    ..The increased expression of CD55 could be an important mechanism by which steroids help to reduce the cerebral damage caused by inflammation...
  15. ncbi request reprint Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury
    Edward H Pettus
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Brain Res 1049:112-9. 2005
    ..The therapeutic benefit of post-TBI progesterone administration may be due to its salutary effect on inflammatory proteins known to increase immune cell invasion and cerebral edema...
  16. ncbi request reprint Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats
    Qingmin Guo
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 198:469-78. 2006
    ..Our results can be taken to show that the expression of AQP4 protein after TBI is time-dependent, region-specific, and possibly implicated in the formation and resolution of TBI-induced cerebral edema...
  17. ncbi request reprint Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury
    Jun He
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 189:404-12. 2004
    ....
  18. ncbi request reprint Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury
    Deborah A Shear
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Brain Res 1026:11-22. 2004
    ..In conclusion, transplanted NPCs survive in the host brain up to 14 months, migrate to the site of injury, enhance motor and cognitive recovery, and may play a role in trophic support following TBI...
  19. pmc Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases
    Tauheed Ishrat
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 226:183-90. 2010
    ..We conclude that PROG and ALLO can help to protect BBB disruption following pMCAO...
  20. ncbi request reprint Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury
    Deborah A Shear
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 178:59-67. 2002
    ..These benefits of progesterone, in the absence of any known side effects, provide further support for clinical testing of this neurosteroid...
  21. ncbi request reprint The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats
    Myriam Djebaili
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurotrauma 22:106-18. 2005
    ....
  22. ncbi request reprint Does progesterone have neuroprotective properties?
    Donald G Stein
    Brain Research Laboratory, Department of Emergency Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Ann Emerg Med 51:164-72. 2008
    ..All are plausible mechanisms of neuroprotection...
  23. pmc The TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 390:678-83. 2009
    ..Our results demonstrate that the TRIF-dependent signaling pathway is not required for the activation of NF-kappaB signaling and brain injury after acute cerebral I/R...
  24. doi request reprint Progesterone and its metabolite allopregnanolone differentially regulate hemostatic proteins after traumatic brain injury
    Jacob W VanLandingham
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Cereb Blood Flow Metab 28:1786-94. 2008
    ....
  25. pmc Traumatic brain injury causes long-term reduction in serum growth hormone and persistent astrocytosis in the cortico-hypothalamo-pituitary axis of adult male rats
    Badrinarayanan S Kasturi
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurotrauma 26:1315-24. 2009
    ..We also tested the hypothesis that TBI to the medial frontal cortex (MFC) would induce inflammatory changes in the HT and AP...
  26. doi request reprint Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesterone
    Iqbal Sayeed
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res 1263:165-73. 2009
    ..Our results demonstrate that AP inhibits the mtPTP current. This may help to explain its more potent anti-apoptotic and neuroprotective effects compared to PROG...
  27. doi request reprint Progesterone as a neuroprotective factor in traumatic and ischemic brain injury
    Iqbal Sayeed
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Prog Brain Res 175:219-37. 2009
    ..These properties make progesterone a unique and compelling natural agent to consider for testing in clinical trial for CNS injuries including TBI and stroke...
  28. ncbi request reprint Effects of progesterone on the inflammatory response to brain injury in the rat
    Kimberly J Grossman
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Brain Res 1008:29-39. 2004
    ..Our results confirm the possibility that one way progesterone mediates its neuroprotective effects following injury is through its actions on the inflammatory response...
  29. pmc Progesterone decreases cortical and sub-cortical edema in young and aged ovariectomized rats with brain injury
    Badrinarayanan S Kasturi
    Brain Research Laboratory, Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Restor Neurol Neurosci 27:265-75. 2009
    ..2. TBI will induce edema in sub-cortical structures (SCS): the thalamus (TH), hypothalamus (HT), brain stem (BS) and anterior pituitary (AP). 3. Acute, systemic PROG treatment post-TBI will reduce edema in SCS...
  30. ncbi request reprint Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion
    Iqbal Sayeed
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA
    Restor Neurol Neurosci 25:151-9. 2007
    ..Since most cases of human stroke are caused by permanent occlusion of cerebral arteries, we assessed the neuroprotective effects of PROG on cerebral infarction and behavioral deficits in a permanent MCAO (pMCAO) model...
  31. ncbi request reprint The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats
    Stuart W Hoffman
    Brain Research Laboratory, Department of Emergency Medicine, Emory University, 1648 Pierce Drive, Atlanta, GA 30322, USA
    J Neurotrauma 20:859-70. 2003
    ..These results can be interpreted to demonstrate that after a 7-day delay, the chronic administration of DHEAS to injured rats significantly improves behavioral recovery on both sensorimotor and cognitive tasks...
  32. ncbi request reprint Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study
    Cynthia W Goss
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 76:231-42. 2003
    ..Progesterone did not affect lesion size, but a strong negative correlation was observed between thalamic GABA-A receptor density and water maze performance. Future studies could explore causes for this relationship...
  33. ncbi request reprint Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion
    Iqbal Sayeed
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Ann Emerg Med 47:381-9. 2006
    ..We compare the effects of postinjury administration of allopregnanolone, a metabolite of progesterone, to progesterone in an animal model of transient middle cerebral artery occlusion...
  34. ncbi request reprint Tapered progesterone withdrawal promotes long-term recovery following brain trauma
    Sarah M Cutler
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Exp Neurol 200:378-85. 2006
    ..Glial fibrillary acidic protein (GFAP) immunofluorescent staining followed this pattern as well. In conclusion, after TBI, AW affects select behaviors and molecular markers in the chronic recovery period...
  35. ncbi request reprint The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury
    Jacob W VanLandingham
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Neuropharmacology 51:1078-85. 2006
    ..These findings suggest that the progestin-mediated pro-survival response seen with TBI is regulated either independently of the classical PR or via nongenomic PR-regulated actions...
  36. ncbi request reprint ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury
    David W Wright
    Department of Emergency Medicine, School of Medicine of Emory University, Atlanta, GA, USA
    Ann Emerg Med 49:391-402, 402.e1-2. 2007
    ..Laboratory evidence indicates that progesterone has potent neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential benefit of administering progesterone to patients with acute traumatic brain injury...
  37. ncbi request reprint Slow-release and injected progesterone treatments enhance acute recovery after traumatic brain injury
    Sarah M Cutler
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Pharmacol Biochem Behav 84:420-8. 2006
    ..A continuous mode of pharmacological administration may prove to be more beneficial in translational and clinical testing than bolus injections over the same period of time...
  38. pmc Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone
    Fahim Atif
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
    Mol Med 15:328-36. 2009
    ..In conclusion, the findings of the present study can be taken to suggest that VDH warrants study as a potential partner for combination therapy with PROG...
  39. pmc Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats
    Tauheed Ishrat
    Department of Emergency Medicine, Brain Research Laboratory, 1365B Clifton Road NE, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res 1257:94-101. 2009
    ..Taken together, these data indicate that PROG is beneficial in one of the best-characterized models of stroke, and may warrant further testing in future clinical trials for human stroke...
  40. doi request reprint Effects of medroxyprogesterone acetate on cerebral oedema and spatial learning performance after traumatic brain injury in rats
    David W Wright
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Inj 22:107-13. 2008
    ....
  41. doi request reprint Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury
    Christopher J MacNevin
    Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 52:6012-23. 2009
    ..The new derivatives demonstrated greatly improved solubility and select compounds have shown equivalent effectiveness to progesterone in reducing cerebral edema after TBI...
  42. pmc Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease
    Milos Cekic
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Front Neuroendocrinol 30:158-72. 2009
    ..The combination of PROG and VDH in pre-clinical and clinical studies is a novel and compelling approach to TBI treatment...
  43. ncbi request reprint Concepts of CNS plasticity in the context of brain damage and repair
    Donald G Stein
    Department of Emergency Medicine and Neurology, Emory University, 1648 Pierce Drive, 261 Evans Building, Atlanta, GA 30322, USA
    J Head Trauma Rehabil 18:317-41. 2003
    ....
  44. pmc Traumatic brain injury and aging: is a combination of progesterone and vitamin D hormone a simple solution to a complex problem?
    Milos Cekic
    Emory University School of Medicine, Department of Emergency Medicine, Atlanta, Georgia 30322, USA
    Neurotherapeutics 7:81-90. 2010
    ..We also discuss some of the potential mechanisms and pathways through which the combination of hormones may work, singly and in synergy, to enhance survival and recovery after TBI...
  45. doi request reprint Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain
    Ciara C Tate
    Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA 30332 0535, USA
    J Tissue Eng Regen Med 3:208-17. 2009
    ..Together these results suggest that the use of appropriate extracellular matrix-based scaffolds can be exploited to improve cell transplantation therapy...
  46. ncbi request reprint 3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury
    Delphine Meffre
    UMR788 INSERM and University Paris 11 Steroids, Neuroprotection, Neuroregeneration, Kremlin Bicetre, France
    J Steroid Biochem Mol Biol 104:293-300. 2007
    ..This decrease has less impact in pseudopregnant females since they have high plasmatic and brain levels of PROG compared to males...
  47. ncbi request reprint The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury
    Delphine Meffre
    INSERM U488, Stéroïdes et Système Nerveux, Kremlin Bicetre, France
    J Neurochem 93:1314-26. 2005
    ....
  48. ncbi request reprint Fibronectin promotes survival and migration of primary neural stem cells transplanted into the traumatically injured mouse brain
    Matthew C Tate
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta 30332, USA
    Cell Transplant 11:283-95. 2002
    ..These results suggest that FGF2-responsive NSCs present a promising approach for cellular therapy following trauma and that the transplant location and environment may play an important role in graft survival and integration...
  49. ncbi request reprint Unilateral frontal lobe contusion and forelimb function: chronic quantitative and qualitative impairments in reflexive and skilled forelimb movements in rats
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    J Neurotrauma 21:1584-600. 2004
    ....
  50. ncbi request reprint Progesterone: therapeutic opportunities for neuroprotection and myelin repair
    Michael Schumacher
    UMR 788 Inserm and University Paris Sud 11, Kremlin Bicetre, France
    Pharmacol Ther 116:77-106. 2007
    ..A concept is emerging that progesterone may exert different actions and use different signaling mechanisms in normal and injured neural tissue...
  51. ncbi request reprint Stem cells and neurological disorders
    Donald G Stein
    Science 297:1807. 2002
  52. ncbi request reprint Developmental neurorehabilitation
    David A Johnson
    Pediatr Rehabil 9:173. 2006

Research Grants16

  1. Combination of progesterone and vitamin D in the treatment of Traumatic Brain Inj
    Donald Stein; Fiscal Year: 2009
    ....
  2. PROGESTERONE, TBI AND CNS REPAIR IN MATURE & AGED RATS.
    Donald Stein; Fiscal Year: 2007
    ..abstract_text> ..
  3. PROGESTERONE, TBI AND CNS REPAIR IN MATURE & AGED RATS.
    Donald Stein; Fiscal Year: 2007
    ....
  4. PROGESTERONE AFTER TRAUMATIC BRAIN INJURY
    Donald Stein; Fiscal Year: 2005
    ..Furthermore, the detailed assessment of progesterone's mechanisms of action will provide a foundation for the intelligent design of artificial therapeutic pharmaceuticals. ..
  5. The effects of progesterone and its metabolites on TBI
    Donald Stein; Fiscal Year: 2004
    ..abstract_text> ..
  6. Combination of progesterone and vitamin D in the treatment of Traumatic Brain Inj
    Donald G Stein; Fiscal Year: 2010
    ....