Samuel H Speck

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Maintenance of gammaherpesvirus latency requires viral cyclin in the absence of B lymphocytes
    Linda F van Dyk
    Department of Microbiology and Immunology, University of Colorado Health Science Center, Denver 80262, USA
    J Virol 77:5118-26. 2003
  2. pmc NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency
    Laurie T Krug
    Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, 1462 Clifton Road, Suite 429, Atlanta, GA 30322, USA
    J Virol 83:4732-48. 2009
  3. pmc Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen
    Xiaozhen Liang
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS Pathog 7:e1002220. 2011
  4. pmc Identification of spliced gammaherpesvirus 68 LANA and v-cyclin transcripts and analysis of their expression in vivo during latent infection
    Robert D Allen
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, 954 Gatewood Rd, NE, Atlanta, GA 30329, USA
    J Virol 80:2055-62. 2006
  5. pmc Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome
    Clinton R Paden
    Emory Vaccine Center, Emory University School of Medicine, 1452 Clifton Road, Suite 429, Atlanta, GA 30322, USA
    J Virol 84:7214-24. 2010
  6. pmc A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology
    Andrew G Evans
    Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:669-84. 2008
  7. pmc Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice
    Ana L Mora
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University, 615 Michael Street, Suite 205K, Atlanta, GA 30322, USA
    Am J Respir Crit Care Med 175:1139-50. 2007
  8. pmc Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection
    Jeremy H Herskowitz
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Virol 82:3295-310. 2008
  9. pmc Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latency
    Kathleen S Gray
    Emory Vaccine Center, 1462 Clifton Road, Suite 429, Atlanta, GA 30322, USA
    J Virol 83:314-28. 2009
  10. pmc Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis
    Laurie T Krug
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA
    Am J Pathol 177:608-21. 2010

Research Grants

  1. MOLECULAR MECHANISMS OF MICROBIAL PATHOGENESIS
    SAMUEL SPECK; Fiscal Year: 2007

Collaborators

  • Scott A Tibbetts
  • Leslie S Kean
  • Laurie T Krug
  • Lisa M Gargano
  • Herbert W Virgin
  • Mauricio Rojas
  • Christian P Larsen
  • Jesse Roman
  • Ana L Mora
  • Allan D Kirk
  • Rafi Ahmed
  • Ellen N Kersh
  • Linda F van Dyk
  • David R Fitzpatrick
  • Jianguo Xu
  • DON E GANEM
  • J M Boss
  • Christopher Wilson
  • J Craig Forrest
  • Kathleen S Gray
  • Christopher M Collins
  • Clinton R Paden
  • Robert D Allen
  • Nathaniel J Moorman
  • Janice M Moser
  • Jason W Upton
  • Andrea M Siegel
  • Andrew G Evans
  • David O Willer
  • Jeremy H Herskowitz
  • Shivaprakash Gangappa
  • Xiaozhen Liang
  • Meagan A Jacoby
  • Sharookh B Kapadia
  • Jonathan M Beus
  • Douglas C Braaten
  • Rebecca L Sparks-Thissen
  • Saranya A Selvaraj
  • Victor Van Berkel
  • Mark DeZalia
  • Dale Stapler
  • Michael L Farrell
  • Kelly B McClellan
  • Iglika Pavlova
  • Vera L Tarakanova
  • Scott Kreher
  • Chie Yu Lin
  • Jennifer Elliott
  • Pingfan Liu
  • Iglika V Pavlova
  • Emily J Paulson
  • Lina I Yoo
  • Jennifer M Alexander
  • Beth Levine
  • Eric T Clambey
  • Salila S Hashmi
  • Linda L Stempora
  • Stephanie A Monday
  • Kelly M Hamby
  • Jennifer A Cheeseman
  • Danxia Duan
  • Joshy Jacob
  • Francine M Morales
  • Ryan P Powers
  • Ruth J Napier
  • Udaya Shankari Rangaswamy
  • Neal N Iwakoshi
  • Justin B Mendel
  • Eun D Lee
  • Veranika Pozharskaya
  • Mark N Dezalia
  • Julie Collins
  • Shelley Dickerson
  • Jeremy Herskowitz
  • Jay L Hess
  • Felipe Suarez
  • Karen E Weck
  • Natalie Shakhnovsky
  • Lina Yoo
  • E Brook Goodhew
  • Christopher A Nelson
  • Joyce D Fingeroth
  • Steven Templeton
  • Tracy M Handel
  • Tom J Brett
  • Josh Woloszynek
  • Travis J Jewett
  • Daved H Fremont
  • John L Yates
  • James E Goldman

Detail Information

Publications64

  1. pmc Maintenance of gammaherpesvirus latency requires viral cyclin in the absence of B lymphocytes
    Linda F van Dyk
    Department of Microbiology and Immunology, University of Colorado Health Science Center, Denver 80262, USA
    J Virol 77:5118-26. 2003
    ....
  2. pmc NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency
    Laurie T Krug
    Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, 1462 Clifton Road, Suite 429, Atlanta, GA 30322, USA
    J Virol 83:4732-48. 2009
    ..Taken together, these data demonstrate that p50 is required for immune control by the host and has distinct tissue-dependent roles in the regulation of murine gammaherpesvirus latency during chronic infection...
  3. pmc Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen
    Xiaozhen Liang
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS Pathog 7:e1002220. 2011
    ....
  4. pmc Identification of spliced gammaherpesvirus 68 LANA and v-cyclin transcripts and analysis of their expression in vivo during latent infection
    Robert D Allen
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, 954 Gatewood Rd, NE, Atlanta, GA 30329, USA
    J Virol 80:2055-62. 2006
    ....
  5. pmc Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome
    Clinton R Paden
    Emory Vaccine Center, Emory University School of Medicine, 1452 Clifton Road, Suite 429, Atlanta, GA 30322, USA
    J Virol 84:7214-24. 2010
    ..Thus, these data provide the first evidence that a LANA homolog is directly involved in the formation and/or maintenance of an extrachromosomal viral episome in vivo, which is likely required for the reactivation of MHV68...
  6. pmc A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology
    Andrew G Evans
    Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:669-84. 2008
    ....
  7. pmc Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice
    Ana L Mora
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University, 615 Michael Street, Suite 205K, Atlanta, GA 30322, USA
    Am J Respir Crit Care Med 175:1139-50. 2007
    ..Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disorder of unknown cause. Several studies suggest an association between Epstein-Barr virus pulmonary infection and the development of IPF...
  8. pmc Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection
    Jeremy H Herskowitz
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Virol 82:3295-310. 2008
    ..Taken together, these analyses will aide future studies for identifying M2 interacting partners and B-cell signaling pathways that are manipulated by the M2 protein...
  9. pmc Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latency
    Kathleen S Gray
    Emory Vaccine Center, 1462 Clifton Road, Suite 429, Atlanta, GA 30322, USA
    J Virol 83:314-28. 2009
    ....
  10. pmc Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis
    Laurie T Krug
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA
    Am J Pathol 177:608-21. 2010
    ..Host determinants of latency might therefore represent new therapeutic targets for gammaherpesvirus-associated pulmonary fibrosis...
  11. ncbi request reprint The M4 gene of gammaHV68 encodes a secreted glycoprotein and is required for the efficient establishment of splenic latency
    Andrew G Evans
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    Virology 344:520-31. 2006
    ..These results suggest that M4 mediates an extracellular host-pathogen interaction that impacts the establishment of latent infection in the spleen, but not the peritoneum...
  12. pmc Role for MyD88 signaling in murine gammaherpesvirus 68 latency
    Lisa M Gargano
    Department of Microbiology and Immunology, Emory University School of Medicine, 1462 Clifton Road, Suite 429, Atlanta, GA 30329, USA
    J Virol 82:3853-63. 2008
    ..These data provide evidence for a unique role for MyD88 in the establishment of MHV68 latency...
  13. pmc The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells
    Jeremy H Herskowitz
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, GA 30329, USA
    J Virol 79:2261-73. 2005
    ....
  14. pmc Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication
    Robert D Allen
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 365:250-9. 2007
    ....
  15. pmc Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency
    Laurie T Krug
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Pathog 3:e11. 2007
    ....
  16. pmc Role of B-cell proliferation in the establishment of gammaherpesvirus latency
    Janice M Moser
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA
    J Virol 79:9480-91. 2005
    ..Thus, the studies provide direct evidence that the proliferation of latently infected B cells is critical for the establishment of chronic gammaHV68 infection...
  17. pmc ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication
    J Craig Forrest
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, 1462 Clifton Rd, Atlanta, GA 30322, USA
    J Virol 81:11957-71. 2007
    ..Overall, these data demonstrate the importance of mLANA in MHV68 replication and suggest that LANA proteins limit the induction of cellular stress responses to regulate the viral gene expression cascade and limit host cell injury...
  18. pmc Identification of closely spaced but distinct transcription initiation sites for the murine gammaherpesvirus 68 latency-associated M2 gene
    Mark DeZalia
    Emory Vaccine Center, Emory University School of Medicine, 1462 Clifton Road, Atlanta, GA 30322, USA
    J Virol 82:7411-21. 2008
    ..This initial detailed analysis of M2 gene transcription in vivo will aid future studies on regulation of M2 gene expression...
  19. pmc The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation
    Andrea M Siegel
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000039. 2008
    ..Thus, while the M2 protein is unique to MHV68, analysis of M2 function has revealed an important role for IL-10 in MHV68 pathogenesis-identifying a strategy that appears to be conserved between at least EBV and MHV68...
  20. pmc Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes
    Xiaozhen Liang
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Pathog 5:e1000677. 2009
    ....
  21. pmc The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latency
    Nathaniel J Moorman
    Division of Microbiology and Immunology and The Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Virol 77:10295-303. 2003
    ..Thus, consistent with its proposed role in replication of the latent viral episome, LANA appears to be a critical determinant in the establishment of gammaHV68 latency in the spleen post-intranasal infection...
  22. pmc A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge
    Janice M Moser
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    J Virol 80:1592-8. 2006
    ..These data indicate gammaherpesviruses that are unable to undergo lytic replication in vivo may not be viable vaccine candidates despite the detection of cells harboring viral genome at late times postinfection...
  23. pmc The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency
    Kathleen S Gray
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 84:4946-59. 2010
    ....
  24. pmc Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and antiviral antibody responses
    Andrea M Siegel
    Emory Vaccine Center and Department of Microbiology, 1462 Clifton Road, Suite 429, Atlanta, GA 30329, USA
    J Virol 84:674-85. 2010
    ....
  25. pmc Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo
    Lisa M Gargano
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 83:1474-82. 2009
    ....
  26. pmc Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo
    Clinton R Paden
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002906. 2012
    ..Interestingly, each of these mLANA-mutant viruses exhibited phenotypes similar to the mLANA-null mutant virus, indicating that DNA-binding is critical for mLANA function...
  27. pmc Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency
    Eric T Clambey
    Division of Microbiology and Immunology, Yerkes Regional Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    J Virol 76:6532-44. 2002
    ..These studies highlight the importance of loss-of-function mutations in defining the genetic requirements for the establishment and maintenance of herpesvirus latency...
  28. pmc Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication
    Iglika V Pavlova
    Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Virol 77:5731-9. 2003
    ..This work lays the foundation for characterizing the role of Rta in gamma HV68 chronic infection of mice...
  29. pmc Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein
    Christopher M Collins
    Emory Vaccine Center, Atlanta, Georgia 30322, USA
    J Virol 83:6484-93. 2009
    ....
  30. pmc The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cells
    Laurie T Krug
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA
    J Virol 87:3597-604. 2013
    ..This suggests a novel role for M1 in influencing long-term maintenance in a major latency reservoir irrespective of the degree of Vβ4(+) CD8(+) T cell expansion...
  31. pmc Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40
    David O Willer
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, 954 Gatewood Rd N E, Atlanta, GA 30329, USA
    J Virol 79:2891-9. 2005
    ..Taken together, these findings are consistent with a model in which chronic virus infection of CD40(-/-) mice is maintained through virus reactivation in the lungs and reseeding of latency reservoirs...
  32. pmc Evidence for CDK-dependent and CDK-independent functions of the murine gammaherpesvirus 68 v-cyclin
    Jason W Upton
    Department of Microbiology and Immunology, Emory University School of Medicine, 1462 Clifton Road, Suite 429, Atlanta, GA 30322, USA
    J Virol 80:11946-59. 2006
    ..Taken together, these data suggest that lytic replication and reactivation in vivo are differentially regulated by CDK-dependent and CDK-independent functions of v-cyclin, respectively...
  33. pmc Identification of candidate gammaherpesvirus 68 genes required for virus replication by signature-tagged transposon mutagenesis
    Nathaniel J Moorman
    Center for Emerging Infectious Diseases, Division of Microbiology and Immunology, Yerkes National Primate Center, Emory University, Atlanta, GA, USA
    J Virol 78:10282-90. 2004
    ..Notably, all but one of the candidate essential replication genes identified in this screen have been shown to be essential for the replication of at least one other herpesvirus...
  34. pmc Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection
    Kathleen S Gray
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 7:e43196. 2012
    ..These data provide the first evidence that the omentum is a site of chronic MHV68 infection that may contribute to the maintenance of chronic infection...
  35. pmc Tracking murine gammaherpesvirus 68 infection of germinal center B cells in vivo
    Christopher M Collins
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 7:e33230. 2012
    ..Finally, we have shown that marking of infected cells with MHV68-H2bYFP is extended long after the onset of latency - which should facilitate studies to track MHV68 latently infected cells at late times post-infection...
  36. ncbi request reprint Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance
    Dale Stapler
    Emory Transplant Center, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 180:3190-200. 2008
    ..These results define the viral gene and immune cell types involved in latent infection-mediated resistance to allograft tolerance and underscore the influence of latent herpesviruses on allograft survival...
  37. pmc Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B-lymphoblastoid cell lines
    Jennifer Elliott
    Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Virol 78:14062-5. 2004
    ..Taken together, these data argue that other factors, perhaps in conjunction with Wp methylation, play a role in suppressing Wp activity in LCLs...
  38. ncbi request reprint Disruption of the gene encoding the gammaHV68 v-GPCR leads to decreased efficiency of reactivation from latency
    Nathaniel J Moorman
    Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Virology 307:179-90. 2003
    ..From these experiments we conclude that the gammaHV68 v-GPCR is dispensable for acute virus replication in vivo, but does play a role in reactivation from latency...
  39. ncbi request reprint Murine gammaherpesvirus 68 Rta-dependent activation of the gene 57 promoter
    Iglika Pavlova
    Division for Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
    Virology 333:169-79. 2005
    ..Overall, analysis of the gammaHV68 gene 57 promoter suggests that mechanisms of Rta activation are conserved among gamma2-herpesviruses...
  40. pmc Viral latency and its regulation: lessons from the gamma-herpesviruses
    Samuel H Speck
    Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA
    Cell Host Microbe 8:100-15. 2010
    ..Here, we review the molecular basis of latency, with special attention to the gamma-herpesviruses, in which the understanding of this process is most advanced...
  41. pmc Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivo
    David O Willer
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Virol 77:8310-21. 2003
    ..Furthermore, at late times postinfection latent gammaHV68 is largely confined to the surface immunoglobulin D-negative subset of B cells...
  42. pmc Ex vivo stimulation of B cells latently infected with gammaherpesvirus 68 triggers reactivation from latency
    Janice M Moser
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, 954 Gatewood Rd, NE, Atlanta, GA 30329, USA
    J Virol 79:5227-31. 2005
    ....
  43. pmc Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade
    J Craig Forrest
    The Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 82:7688-99. 2008
    ..In addition, such cell lines may be of value in evaluating targeted therapies to gammaherpesvirus-related tumors...
  44. ncbi request reprint Characterization of murine gammaherpesvirus 68 v-cyclin interactions with cellular cdks
    Jason W Upton
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, NE Atlanta, GA 30329, USA
    Virology 341:271-83. 2005
    ..The latter suggests that, at least in vitro, the gammaHV68 v-cyclin exhibits functional characteristics of both cyclin E and cyclin A...
  45. ncbi request reprint Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice
    Ana L Mora
    Center for Translational Research of the Lung, Division of Pulmonary, Allergy, and Critical Care, Dept of Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 289:L711-21. 2005
    ..In summary, chronic herpesvirus pulmonary infection in IFN-gammaR-/- mice causes progressive pulmonary fibrosis and many of the pathological features seen in IPF...
  46. ncbi request reprint Synergistic autoactivation of the Epstein-Barr virus immediate-early BRLF1 promoter by Rta and Zta
    Pingfan Liu
    Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
    Virology 310:199-206. 2003
    ..Decreasing the amount of transfected Rta expression vector reduced background Rta activation, while retaining specific activation of Rp...
  47. pmc Deletion of Epstein-Barr virus regulatory sequences upstream of the EBNA gene promoter Wp1 is unfavorable for B-Cell immortalization
    Lina I Yoo
    Division of Microbiology and Immunology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Virol 76:11763-9. 2002
    ..This is the first report of an LCL in which transcription initiation from a Wp downstream of Wp1 has been documented...
  48. ncbi request reprint Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells
    Ellen N Kersh
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 176:4083-93. 2006
    ....
  49. pmc Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation
    Meagan A Jacoby
    Division of Microbiology and Immunology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Virol 76:1790-801. 2002
    ..These results indicate that the requirements for the establishment of latency are affected by the route of infection...
  50. pmc Heterologous Immunity Triggered by a Single, Latent Virus in Mus musculus: Combined Costimulation- and Adhesion- Blockade Decrease Rejection
    Jonathan M Beus
    Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 8:e71221. 2013
    ....
  51. pmc Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus
    Scott A Tibbetts
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:7125-32. 2002
    ..The immune system therefore controls chronic gammaherpesvirus infection by site-specific mechanisms that regulate both the number and reactivation phenotype of latently infected cells...
  52. pmc Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis
    Victor Van Berkel
    Departments of Pathology and Immunology and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:905-14. 2002
    ....
  53. ncbi request reprint Methylation of the EBV genome and establishment of restricted latency in low-passage EBV-infected 293 epithelial cells
    Emily J Paulson
    Immunology Graduate Program, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Virology 299:109-21. 2002
    ..Furthermore, these results are consistent with the hypothesis that methylation of Cp and Wp is required for entry into the type I or II latency programs...
  54. ncbi request reprint Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection
    Sharookh B Kapadia
    Department of Immunology and Pathology, Department of Molecular Microbiology, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Immunity 17:143-55. 2002
    ....
  55. pmc Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice
    Shivaprakash Gangappa
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Virol 76:11460-8. 2002
    ..We confirmed this model by the treatment of latently infected B-cell(-/-) mice with the antiviral drug cidofovir...
  56. pmc Identification of the in vivo role of a viral bcl-2
    Shivaprakash Gangappa
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 195:931-40. 2002
    ..As gamma-herpesviruses primarily cause human disease during chronic infection, these chronic disease genes may be important targets for therapeutic intervention...
  57. pmc Effective vaccination against long-term gammaherpesvirus latency
    Scott A Tibbetts
    Department of Pathology and Immunology and Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 77:2522-9. 2003
    ..These results demonstrate the potential of a memory immune response against gammaherpesviruses to alter long-term latency and suggest that limiting long-term latent infection in a clinically relevant situation is an attainable goal...
  58. pmc Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection
    Scott A Tibbetts
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 77:7696-701. 2003
    ..These results demonstrate that the equilibrium level of establishment of gammaherpesvirus latency is independent of the infectious dose and route of infection...
  59. pmc An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection
    Rebecca L Sparks-Thissen
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 78:6827-35. 2004
    ....
  60. pmc An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection
    Douglas C Braaten
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, St Louis, MO 63110, USA
    J Virol 79:2573-83. 2005
    ..The data also demonstrate for the first time that a strong CD8(+) T-cell response can limit long-term latent infection...
  61. pmc Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice
    Vera L Tarakanova
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 79:14668-79. 2005
    ..Our findings suggest that gammaHV68 induces lymphomas via hit-and-run oncogenesis, paracrine effects, or stimulation of chronic inflammation...
  62. pmc Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses
    Kelly B McClellan
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA
    PLoS Pathog 2:e58. 2006
    ..Exploitation of this property of B cells may allow enhanced vaccine responses to chronic virus infection...
  63. ncbi request reprint Structural basis of chemokine sequestration by a herpesvirus decoy receptor
    Jennifer M Alexander
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cell 111:343-56. 2002
    ..M3 also employs structural mimicry to promiscuously sequester chemokines, engaging conservative structural elements associated with both chemokine homodimerization and binding to G protein-coupled receptors...
  64. ncbi request reprint EBV framed in Burkitt lymphoma
    Samuel H Speck
    Nat Med 8:1086-7. 2002

Research Grants3

  1. MOLECULAR MECHANISMS OF MICROBIAL PATHOGENESIS
    SAMUEL SPECK; Fiscal Year: 2007
    ....