Yoland Smith

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Ultrastructural localization of CART (cocaine- and amphetamine-regulated transcript) peptides in the nucleus accumbens of monkeys
    Y Smith
    Yerkes Regional Primate Research Center, Division of Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    Synapse 27:90-4. 1997
  2. ncbi request reprint The thalamostriatal system: a highly specific network of the basal ganglia circuitry
    Yoland Smith
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Trends Neurosci 27:520-7. 2004
  3. ncbi request reprint Ionotropic and metabotropic GABA and glutamate receptors in primate basal ganglia
    Y Smith
    Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, 954, Gatewood Rd NE, Atlanta, GA 30322, USA
    J Chem Neuroanat 22:13-42. 2001
  4. pmc GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates
    Y Smith
    Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Anat 196:555-76. 2000
  5. ncbi request reprint Localization and function of pre- and postsynaptic kainate receptors in the rat globus pallidus
    Xiao Tao Jin
    Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Eur J Neurosci 23:374-86. 2006
  6. doi request reprint Effects of stimulation of the centromedian nucleus of the thalamus on the activity of striatal cells in awake rhesus monkeys
    Bijli Nanda
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Eur J Neurosci 29:588-98. 2009
  7. pmc Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus
    Karen Newell-Litwa
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 30:820-31. 2010
  8. ncbi request reprint An electron microscope immunocytochemical study of GABA(B) R2 receptors in the monkey basal ganglia: a comparative analysis with GABA(B) R1 receptor distribution
    Ali Charara
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 476:65-79. 2004
  9. ncbi request reprint Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: localization to and within dendritic spines
    E Chris Muly
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 469:185-97. 2004
  10. ncbi request reprint Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Epilepsy Res 74:232-6. 2007

Research Grants

  1. GABA RECEPTORS IN THE THALAMUS
    Yoland Smith; Fiscal Year: 2005
  2. GABA-B RECEPTORS AND PARKINSON'S DISEASE
    Yoland Smith; Fiscal Year: 2005
  3. METABOTROPIC GLUTAMATE RECEPTORS IN THE BASAL GANGLIA
    Yoland Smith; Fiscal Year: 2006
  4. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2007
  5. Training in Systems and Integrative Biology: Neuroscience
    Yoland Smith; Fiscal Year: 2007
  6. The Thalamostriatal System in Primate
    Yoland Smith; Fiscal Year: 2007
  7. The Thalamostriatal System in Primate
    Yoland Smith; Fiscal Year: 2009
  8. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2009
  9. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2010
  10. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2009

Detail Information

Publications70

  1. ncbi request reprint Ultrastructural localization of CART (cocaine- and amphetamine-regulated transcript) peptides in the nucleus accumbens of monkeys
    Y Smith
    Yerkes Regional Primate Research Center, Division of Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    Synapse 27:90-4. 1997
    ..These findings suggest that CART peptides may be a cotransmitter with gamma aminobutyric acid (GABA) in intrinsic axon collaterals of striatal projection neurons or interneurons in the primate nucleus accumbens...
  2. ncbi request reprint The thalamostriatal system: a highly specific network of the basal ganglia circuitry
    Yoland Smith
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Trends Neurosci 27:520-7. 2004
    ..A major task of future studies is to characterize the role(s) of corticostriatal and thalamostriatal pathways in regulating basal ganglia activity in normal and pathological conditions...
  3. ncbi request reprint Ionotropic and metabotropic GABA and glutamate receptors in primate basal ganglia
    Y Smith
    Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, 954, Gatewood Rd NE, Atlanta, GA 30322, USA
    J Chem Neuroanat 22:13-42. 2001
    ..In this review, we will provide a detailed account of the current knowledge of the localization of these receptors in the basal ganglia of humans and monkeys...
  4. pmc GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates
    Y Smith
    Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Anat 196:555-76. 2000
    ..Because of their 'modulatory' functions, these receptors are ideal targets for chronic drug therapies in neurodegenerative diseases such as Parkinson's disease...
  5. ncbi request reprint Localization and function of pre- and postsynaptic kainate receptors in the rat globus pallidus
    Xiao Tao Jin
    Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Eur J Neurosci 23:374-86. 2006
    ....
  6. doi request reprint Effects of stimulation of the centromedian nucleus of the thalamus on the activity of striatal cells in awake rhesus monkeys
    Bijli Nanda
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Eur J Neurosci 29:588-98. 2009
    ..Through these indirect effects, local CM stimulation may engage large portions of the striatum. These effects may be relevant in the interpretation of the therapeutic effects of CM stimulation for the treatment of neurological disorders...
  7. pmc Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus
    Karen Newell-Litwa
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 30:820-31. 2010
    ..We propose that anatomically restricted mechanisms within the brain diversify the biogenesis and composition of synaptic vesicles...
  8. ncbi request reprint An electron microscope immunocytochemical study of GABA(B) R2 receptors in the monkey basal ganglia: a comparative analysis with GABA(B) R1 receptor distribution
    Ali Charara
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 476:65-79. 2004
    ....
  9. ncbi request reprint Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: localization to and within dendritic spines
    E Chris Muly
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 469:185-97. 2004
    ....
  10. ncbi request reprint Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Epilepsy Res 74:232-6. 2007
    ..These multiple studies suggest that the anticonvulsant nature of the KD does not stem from enhanced glutamate re-uptake...
  11. pmc The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse
    Jennifer Larimore
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 22:4854-67. 2011
    ..Our findings indicate a novel vesicle transport mechanism requiring BLOC-1 and AP-3 complexes for cargo sorting from neuronal cell bodies to neurites and nerve terminals...
  12. pmc Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys
    Gunasingh J Masilamoni
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    Brain 134:2057-73. 2011
    ..This suggests that the use of metabotropic glutamate receptor 5 antagonists may be a useful strategy to reduce degeneration of catecholaminergic neurons in Parkinson's disease...
  13. pmc Metabotropic glutamate receptor 4 in the basal ganglia of parkinsonian monkeys: ultrastructural localization and electrophysiological effects of activation in the striatopallidal complex
    James Bogenpohl
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Neuropharmacology 66:242-52. 2013
    ..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  14. pmc GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus
    Xiao Tao Jin
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Eur J Neurosci 36:2482-92. 2012
    ....
  15. pmc Astrocytic and neuronal localization of the scaffold protein Na+/H+ exchanger regulatory factor 2 (NHERF-2) in mouse brain
    Maryse Paquet
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 494:752-62. 2006
    ....
  16. pmc The thalamostriatal systems: anatomical and functional organization in normal and parkinsonian states
    Yoland Smith
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Brain Res Bull 78:60-8. 2009
    ..Although the available clinical evidence is encouraging, these procedures remain empirical at this stage because of the limited understanding of the thalamostriatal systems...
  17. ncbi request reprint The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity
    Maryse Paquet
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:29949-61. 2006
    ..These observations reveal that NHERF-2 can selectively modulate mGluR5 signaling, which may contribute to cell-specific regulation of mGluR5 activity...
  18. doi request reprint Differential synaptic plasticity of the corticostriatal and thalamostriatal systems in an MPTP-treated monkey model of parkinsonism
    Dinesh V Raju
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Eur J Neurosci 27:1647-58. 2008
    ..These findings provide striking evidence that suggests a differential degree of plasticity of the corticostriatal and thalamostriatal system in PD...
  19. ncbi request reprint D1- and D2-like dopamine receptors regulate signaling properties of group I metabotropic glutamate receptors in the rat globus pallidus
    Olga V Poisik
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Eur J Neurosci 26:852-62. 2007
    ....
  20. ncbi request reprint GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters
    Adriana Galvan
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    J Neurophysiol 94:990-1000. 2005
    ....
  21. ncbi request reprint Ultrastructural evidence for pre- and postsynaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampus
    Alyssa L Tippens
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 506:569-83. 2008
    ..These findings provide the first detailed ultrastructural analysis of Ca(v)1.2 localization in the brain and support functionally diverse roles of these channels in the hippocampal formation...
  22. pmc Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum
    James W Bogenpohl
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 520:570-89. 2012
    ..Together, these data foster a deeper understanding of the substrates through which A(2A) R could regulate primate basal ganglia function and potentially mediate its therapeutic effects in parkinsonism...
  23. ncbi request reprint Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus
    Olga Poisik
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
    Neuropharmacology 49:57-69. 2005
    ..Therefore, our findings do not only shed light on the functions of group II mGluRs in the GP, they also illustrate the therapeutic potential of mGluR-targeting allosteric modulators in neurological disorders such as Parkinson's disease...
  24. pmc Differential structural plasticity of corticostriatal and thalamostriatal axo-spinous synapses in MPTP-treated Parkinsonian monkeys
    Rosa M Villalba
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 519:989-1005. 2011
    ....
  25. pmc Localization and function of GABA transporters in the globus pallidus of parkinsonian monkeys
    Adriana Galvan
    Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, GA, USA
    Exp Neurol 223:505-15. 2010
    ..These results suggest that, after dopaminergic depletion, the functions of GABA transporters are altered in GPi; without major changes in their subcellular localization...
  26. pmc Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1
    Avanti Gokhale
    Department of Cell Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 32:3697-711. 2012
    ..Thus, our quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility...
  27. pmc Extrastriatal D2-like receptors modulate basal ganglia pathways in normal and Parkinsonian monkeys
    Arash Hadipour-Niktarash
    Yerkes National Primate Research Center, Atlanta, GA, USA
    J Neurophysiol 107:1500-12. 2012
    ....
  28. ncbi request reprint Nigral and pallidal inputs to functionally segregated thalamostriatal neurons in the centromedian/parafascicular intralaminar nuclear complex in monkey
    Mamadou Sidibe
    Yerkes Regional Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 447:286-99. 2002
    ....
  29. doi request reprint Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brains
    Yoland Smith
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia, USA
    Mov Disord 23:S534-47. 2008
    ..In this review, the role of basal ganglia dopamine and its functional relevance in normal and pathological conditions will be discussed...
  30. doi request reprint Ultrastructural localization and function of dopamine D1-like receptors in the substantia nigra pars reticulata and the internal segment of the globus pallidus of parkinsonian monkeys
    Michele A Kliem
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Eur J Neurosci 31:836-51. 2010
    ....
  31. ncbi request reprint Activation of nigral and pallidal dopamine D1-like receptors modulates basal ganglia outflow in monkeys
    Michele A Kliem
    Yerkes National Primate Center, Emory University, School of Medicine, 954 Gatewood Road, Atlanta, GA 30322, USA
    J Neurophysiol 98:1489-500. 2007
    ..Our results support the finding that D1LR activation may have powerful effects on GPi and SNr neurons and may mediate some of the effects of dopamine replacement therapies in Parkinson's disease...
  32. pmc Differential localization of protein phosphatase-1alpha, beta and gamma1 isoforms in primate prefrontal cortex
    Jill R Bordelon
    Division of Neuroscience, Yerkes National Primate Research Center, and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Cereb Cortex 15:1928-37. 2005
    ....
  33. doi request reprint GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen
    Kalynda Kari Gonzales
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 521:2502-22. 2013
    ..These findings show that ChIs receive prominent GABAergic inputs from multiple origins, including a significant contingent from axon collaterals of direct and indirect pathway projection neurons...
  34. pmc In vivo optogenetic control of striatal and thalamic neurons in non-human primates
    Adriana Galvan
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e50808. 2012
    ..Experimental conditions such as the vector used, the number and rate of injections, or the light stimulation conditions have to be optimized for each structure studied...
  35. doi request reprint Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus
    Xiao Tao Jin
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Eur J Neurosci 33:1504-18. 2011
    ..In conclusion, these data indicate that GAT-1 and GAT-3 represent different target sites through which GABA reuptake may subserve complementary regulation of GABAergic transmission in the rat GP...
  36. pmc Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeys
    Rosa M Villalba
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE Atlanta, GA 30322, USA
    Exp Neurol 215:220-7. 2009
    ....
  37. ncbi request reprint Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey
    Darlene A Mitrano
    Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 500:788-806. 2007
    ....
  38. ncbi request reprint Group I metabotropic glutamate receptors in the monkey striatum: subsynaptic association with glutamatergic and dopaminergic afferents
    Maryse Paquet
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:7659-69. 2003
    ....
  39. pmc Differential synaptology of vGluT2-containing thalamostriatal afferents between the patch and matrix compartments in rats
    Dinesh V Raju
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 499:231-43. 2006
    ..These observations pave the way for understanding differential regulatory mechanisms of striatal outflow from the patch and matrix compartments by thalamostriatal afferents...
  40. ncbi request reprint GABA(B) receptors in the centromedian/parafascicular thalamic nuclear complex: an ultrastructural analysis of GABA(B)R1 and GABA(B)R2 in the monkey thalamus
    Rosa M Villalba
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 496:269-87. 2006
    ..Overall, these findings provide evidence for multiple sites where GABA(B) receptors could modulate GABAergic and glutamatergic transmission in the primate CM/PF complex...
  41. pmc α-1 Adrenergic receptors are localized on presynaptic elements in the nucleus accumbens and regulate mesolimbic dopamine transmission
    Darlene A Mitrano
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 37:2161-72. 2012
    ..These data indicate that local α1ARs control DA transmission in the medial NAc shell and behavioral responses to drugs of abuse...
  42. ncbi request reprint Localization and expression of group I metabotropic glutamate receptors in the mouse striatum, globus pallidus, and subthalamic nucleus: regulatory effects of MPTP treatment and constitutive Homer deletion
    Masaaki Kuwajima
    Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 27:6249-60. 2007
    ..Thus, nigrostriatal dopaminergic lesion and Homer deletion lead to changes in the trafficking of group I mGluRs in vivo that are specific to receptor subtypes and brain areas...
  43. ncbi request reprint Sodium channels and dendritic spike initiation at excitatory synapses in globus pallidus neurons
    Jesse E Hanson
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 24:329-40. 2004
    ..The ability of small amounts of excitation to trigger spikes in GP dendrites supports the prominent role of subthalamic input in the control of GP activity...
  44. pmc PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO(3) cotransport
    Soojung Lee
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Physiol Biochem 30:1444-55. 2012
    ..We previously reported that NBCn1 interacts with the postsynaptic density protein PSD-95 in the brain. Here, we elucidated the structural determinant and functional consequence of NBCn1/PSD-95 interaction...
  45. ncbi request reprint Age-related changes in the expression of axonal and glial group I metabotropic glutamate receptor in the rat substantia nigra pars reticulata
    George Walton Hubert
    Yerkes National Primate Research Center, Division of Neuroscience and Department of Neurology, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    J Comp Neurol 475:95-106. 2004
    ....
  46. ncbi request reprint Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleus
    Masaaki Kuwajima
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 474:589-602. 2004
    ..These findings demonstrate that mGluR1a and mGluR5 exhibit a similar pattern of subsynaptic localization in monkey STN neurons, with both receptor subtypes exhibiting substantial extrasynaptic and perisynaptic localization...
  47. ncbi request reprint Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex
    E Chris Muly
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 467:521-35. 2003
    ..They further suggest differences in the cortical distribution of group I mGluRs between primates and rodents...
  48. pmc P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2
    Sami R Fam
    Department of Pharmacology, Yerkes National Primate Research Center, and Division of Digestive Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:8042-7. 2005
    ..These findings reveal that NHERF-2 is a key regulator of the cellular activity of P2Y(1)R and may therefore determine cell-specific differences in P2Y(1)R-mediated signaling...
  49. pmc Synaptic microcircuitry of tyrosine hydroxylase-containing neurons and terminals in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys
    Maney Mazloom
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 495:453-69. 2006
    ..Finally, the coexpression of GABA in TH-positive terminals in the striatum of dopamine-depleted monkeys suggests dramatic neurochemical changes in the catecholaminergic modulation of striatal activity in Parkinson's disease...
  50. doi request reprint Anterograde axonal tract tracing
    Dinesh V Raju
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Curr Protoc Neurosci . 2006
    ..Combined with immunocytochemistry for neurotransmitters, neuropeptides, and receptors, tract tracing methods may be used to elucidate the phenotype of synapses that form the microcircuitry of specific neural systems...
  51. pmc Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
    Karen Newell-Litwa
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 20:1441-53. 2009
    ..Our results demonstrate that lysosomal and lysosome-related organelle biogenesis mechanisms regulate steady-state synaptic vesicle protein composition from shared early endosomes...
  52. ncbi request reprint Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons
    Stephanie Dallvechia-Adams
    Division of Neuroscience, Yerkes Regional Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    J Comp Neurol 448:360-72. 2002
    ..Results of these studies suggest that the most significant behavioral states influenced by CART peptides, feeding and locomotion, may be mediated by direct and/or indirect modulation of VTA dopaminergic neuronal activity...
  53. pmc Thalamic contributions to Basal Ganglia-related behavioral switching and reinforcement
    Yoland Smith
    Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30329, USA
    J Neurosci 31:16102-6. 2011
    ..We will also address the possibility that degeneration of the thalamostriatal system could underlie some of the deficits in redirection of attention in response to salient stimuli seen in Parkinson's disease...
  54. doi request reprint Localization and functions of kainate receptors in the basal ganglia
    Xiao Tao Jin
    Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University, 954, Catewood Road Northeast, Atlanta, Georgia 30322, USA
    Adv Exp Med Biol 717:27-37. 2011
    ..Because of their more subtle effects on neurotransmisison regulation than other ionotropic glutamate receptors, KARs represent interesting targets for the future development of pharmacotherapy for basal ganglia diseases...
  55. ncbi request reprint CART peptide and the mesolimbic dopamine system
    Kelly Philpot
    Yerkes National Primate Research Center, Division of Neuroscience, Emory University, Atlanta, GA 30322, USA
    Peptides 27:1987-92. 2006
    ....
  56. pmc (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism
    Gunasingh Masilamoni
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Exp Neurol 226:265-73. 2010
    ..These findings demonstrate that (18)F-FECNT is a highly sensitive PET imaging ligand to quantify both striatal dopamine denervation and midbrain dopaminergic cell loss associated with parkinsonism...
  57. ncbi request reprint Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus
    Karin Borges
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 201:416-27. 2006
    ..These findings demonstrate astrocyte degeneration in the mouse dentate hilus specifically in the mouse pilocarpine epilepsy model, followed by astrogenesis leading to hilar repopulation...
  58. ncbi request reprint Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus
    Olga V Poisik
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:122-30. 2003
    ..Together, these data illustrate a novel mechanism by which mGluR1 and mGluR5, members of the same family of G-protein-coupled receptors, can interact to modulate neuronal activity in the rat GP...
  59. ncbi request reprint Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Ann Neurol 60:223-35. 2006
    ..The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies in adolescent rats to understand its anticonvulsant effect...
  60. pmc Localization and pharmacological modulation of GABA-B receptors in the globus pallidus of parkinsonian monkeys
    Adriana Galvan
    Yerkes National Primate Research Center, 954 Gatewood Road NE, Emory University Atlanta, GA 30329, USA
    Exp Neurol 229:429-39. 2011
    ..These changes in GABA-B receptor function may contribute to bursting activities in the parkinsonian state...
  61. pmc RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory
    Sarah Emerson Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:16994-8. 2010
    ..These results demonstrate that RGS14 is a key regulator of signaling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory but distinct from the canonical DG-CA3-CA1 circuit...
  62. ncbi request reprint Continuous monitoring of intracerebral glutamate levels in awake monkeys using microdialysis and enzyme fluorometric detection
    Adriana Galvan
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Neurosci Methods 126:175-85. 2003
    ..This technique effectively detects short-term changes in glutamate levels evoked by physiologic or pharmacologic manipulations in the primate brain...
  63. pmc Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia
    Xiao Tao Jin
    Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University Atlanta, GA, USA
    Front Syst Neurosci 5:63. 2011
    ....
  64. pmc Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients
    Hua She
    Department of Pharmacology, Rollins School of Public Health, Atlanta, Georgia, USA
    J Clin Invest 121:930-40. 2011
    ..Thus, direct regulation of complex I by mitochondrial MEF2D underlies its neuroprotective effects, and dysregulation of this pathway may contribute to PD...
  65. pmc Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa
    Yoland Smith
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Neuropsychopharmacology 37:213-46. 2012
    ....
  66. pmc Towards a transgenic model of Huntington's disease in a non-human primate
    Shang Hsun Yang
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 453:921-4. 2008
    ..Moreover, our data suggest that it will be feasible to generate valuable non-human primate models of HD and possibly other human genetic diseases...
  67. ncbi request reprint Subcellular distribution of high-voltage-activated calcium channel subtypes in rat globus pallidus neurons
    Jesse E Hanson
    Yerkes Regional Primate Research Center, Division of Neuroscience and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 442:89-98. 2002
    ..Furthermore, the finding of a greater density of plasma membrane-bound L-type channels in distal dendrites expands the view that L-type channels are important only in somatic and proximal locations...
  68. ncbi request reprint Functional and ultrastructural analysis of group I mGluR in striatal fast-spiking interneurons
    Paola Bonsi
    Fondazione Santa Lucia I R C C S, Department of Neuroscience, Clinica Neurologica, University Tor Vergata, Via Montpellier, 00133 Rome, Italy
    Eur J Neurosci 25:1319-31. 2007
    ..Together, these results suggest that despite a common pattern of distribution, mGluR1 and mGluR5 exert distinct functions in the modulation of FS interneuron activity...
  69. ncbi request reprint Contextual inhibitory gating of impulse traffic in the intra-amygdaloid network
    DENIS PARE
    Center for Molecular Behavioral Neuroscience, Rutgers State University, Newark, New Jersey 07102, USA
    Ann N Y Acad Sci 985:78-91. 2003
    ..Thus, inhibitory mechanisms of the amygdala allow for flexible, context-dependent gating of BL impulses to the CE nucleus...
  70. ncbi request reprint NMDA-induced phosphorylation and regulation of mGluR5
    Sudar Alagarsamy
    Ferring Research Institute Inc, 3550 General Atomics Court, Building 2, Room 443, San Diego, CA 92121, USA
    Pharmacol Biochem Behav 73:299-306. 2002
    ....

Research Grants38

  1. GABA RECEPTORS IN THE THALAMUS
    Yoland Smith; Fiscal Year: 2005
    ..Such information is critical for the interpretation of functional studies and a better understanding of the pathophysiological changes generated at pallidothalamic and nigrothalamic synapses in Parkinson's disease. ..
  2. GABA-B RECEPTORS AND PARKINSON'S DISEASE
    Yoland Smith; Fiscal Year: 2005
    ..abstract_text> ..
  3. METABOTROPIC GLUTAMATE RECEPTORS IN THE BASAL GANGLIA
    Yoland Smith; Fiscal Year: 2006
    ..Together, findings obtained in these studies will serve as a basic framework to understand Homer/mGluRs interactions in normal and pathological basal ganglia functions. ..
  4. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2007
    ..Studies proposed in this application will lay the foundation for a deeper understanding of the functions of GABA-BRs in the basal ganglia, and their role in the alteration of basal ganglia function in PD. ..
  5. Training in Systems and Integrative Biology: Neuroscience
    Yoland Smith; Fiscal Year: 2007
    ....
  6. The Thalamostriatal System in Primate
    Yoland Smith; Fiscal Year: 2007
    ....
  7. The Thalamostriatal System in Primate
    Yoland Smith; Fiscal Year: 2009
    ..abstract_text> ..
  8. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2009
    ..Studies proposed in this application will lay the foundation for a deeper understanding of the functions of GABA-BRs in the basal ganglia, and their role in the alteration of basal ganglia function in PD. ..
  9. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2010
    ..Studies proposed in this application will lay the foundation for a deeper understanding of the functions of GABA-BRs in the basal ganglia, and their role in the alteration of basal ganglia function in PD. ..
  10. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2009
    ..Studies proposed in this application will lay the foundation for a deeper understanding of the functions of GABA-BRs in the basal ganglia, and their role in the alteration of basal ganglia function in PD. ..
  11. Plasticity of Striatal Glutamatergic Synapses in Parkinson's Disease
    Yoland Smith; Fiscal Year: 2010
    ..The results of these studies should further our current understanding of the neural plasticity that underlies functional changes in the basal ganglia circuitry in the parkinsonian state. ..
  12. SYNAPTIC INPUTS TO THALAMOSTRIATAL NEURONS
    Yoland Smith; Fiscal Year: 2001
    ..The results of the project, combined with previous data, are prerequisite to future functional studies of the thalamostriatal projection in normal and pathological conditions. ..
  13. GLUTAMATE AND GABA A RECEPTORS IN THE BASAL GANGLIA
    Yoland Smith; Fiscal Year: 2002
    ....
  14. GABAB Receptors and Parkinson's Disease
    Yoland Smith; Fiscal Year: 2010
    ..Studies proposed in this application will lay the foundation for a deeper understanding of the functions of GABA-BRs in the basal ganglia, and their role in the alteration of basal ganglia function in PD. ..