Research Topics
Genomes and Genes
Species | Yoland SmithSummaryAffiliation: Emory University Country: USA Publications
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Publications
Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brainsYoland Smith
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia, USA
Mov Disord 23:S534-47. 2008..In this review, the role of basal ganglia dopamine and its functional relevance in normal and pathological conditions will be discussed...
Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopaYoland Smith
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Neuropsychopharmacology 37:213-46. 2012....- Thalamic contributions to Basal Ganglia-related behavioral switching and reinforcementYoland Smith
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30329, USA
J Neurosci 31:16102-6. 2011..We will also address the possibility that degeneration of the thalamostriatal system could underlie some of the deficits in redirection of attention in response to salient stimuli seen in Parkinson's disease... - Striatal spine plasticity in Parkinson's disease: pathological or not?Y Smith
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA
Parkinsonism Relat Disord 15:S156-61. 2009..Future studies are needed to further characterize the mechanisms underlying striatal spine plasticity, and determine if it represents a pathological feature or compensatory process of PD... - The thalamostriatal systems: anatomical and functional organization in normal and parkinsonian statesYoland Smith
Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
Brain Res Bull 78:60-8. 2009..Although the available clinical evidence is encouraging, these procedures remain empirical at this stage because of the limited understanding of the thalamostriatal systems... 
Localization and function of pre- and postsynaptic kainate receptors in the rat globus pallidusXiao Tao Jin
Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
Eur J Neurosci 23:374-86. 2006....- Effects of stimulation of the centromedian nucleus of the thalamus on the activity of striatal cells in awake rhesus monkeysBijli Nanda
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Eur J Neurosci 29:588-98. 2009..Through these indirect effects, local CM stimulation may engage large portions of the striatum. These effects may be relevant in the interpretation of the therapeutic effects of CM stimulation for the treatment of neurological disorders... - Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampusKaren Newell-Litwa
Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 30:820-31. 2010..We propose that anatomically restricted mechanisms within the brain diversify the biogenesis and composition of synaptic vesicles... - Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic dietKristopher J Bough
Department of Pharmacology, Emory University, Atlanta, GA, USA
Epilepsy Res 74:232-6. 2007..These multiple studies suggest that the anticonvulsant nature of the KD does not stem from enhanced glutamate re-uptake... - The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapseJennifer Larimore
Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 22:4854-67. 2011..Our findings indicate a novel vesicle transport mechanism requiring BLOC-1 and AP-3 complexes for cargo sorting from neuronal cell bodies to neurites and nerve terminals... - Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeysGunasingh J Masilamoni
Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
Brain 134:2057-73. 2011..This suggests that the use of metabotropic glutamate receptor 5 antagonists may be a useful strategy to reduce degeneration of catecholaminergic neurons in Parkinson's disease... - Astrocytic and neuronal localization of the scaffold protein Na+/H+ exchanger regulatory factor 2 (NHERF-2) in mouse brainMaryse Paquet
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Comp Neurol 494:752-62. 2006.... - D1- and D2-like dopamine receptors regulate signaling properties of group I metabotropic glutamate receptors in the rat globus pallidusOlga V Poisik
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
Eur J Neurosci 26:852-62. 2007.... - GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidusXiao Tao Jin
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
Eur J Neurosci 36:2482-92. 2012.... - Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: localization to and within dendritic spinesE Chris Muly
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329, USA
J Comp Neurol 469:185-97. 2004.... - The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activityMaryse Paquet
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 281:29949-61. 2006..These observations reveal that NHERF-2 can selectively modulate mGluR5 signaling, which may contribute to cell-specific regulation of mGluR5 activity... - An electron microscope immunocytochemical study of GABA(B) R2 receptors in the monkey basal ganglia: a comparative analysis with GABA(B) R1 receptor distributionAli Charara
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 476:65-79. 2004.... - Ultrastructural evidence for pre- and postsynaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampusAlyssa L Tippens
Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 506:569-83. 2008..These findings provide the first detailed ultrastructural analysis of Ca(v)1.2 localization in the brain and support functionally diverse roles of these channels in the hippocampal formation... - Localization and pharmacological modulation of GABA-B receptors in the globus pallidus of parkinsonian monkeysAdriana Galvan
Yerkes National Primate Research Center, 954 Gatewood Road NE, Emory University Atlanta, GA 30329, USA
Exp Neurol 229:429-39. 2011..These changes in GABA-B receptor function may contribute to bursting activities in the parkinsonian state... - Differential synaptic plasticity of the corticostriatal and thalamostriatal systems in an MPTP-treated monkey model of parkinsonismDinesh V Raju
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
Eur J Neurosci 27:1647-58. 2008..These findings provide striking evidence that suggests a differential degree of plasticity of the corticostriatal and thalamostriatal system in PD... - Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatumJames W Bogenpohl
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
J Comp Neurol 520:570-89. 2012..Together, these data foster a deeper understanding of the substrates through which A(2A) R could regulate primate basal ganglia function and potentially mediate its therapeutic effects in parkinsonism... - Localization and function of GABA transporters in the globus pallidus of parkinsonian monkeysAdriana Galvan
Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, GA, USA
Exp Neurol 223:505-15. 2010..These results suggest that, after dopaminergic depletion, the functions of GABA transporters are altered in GPi; without major changes in their subcellular localization... - Activation of nigral and pallidal dopamine D1-like receptors modulates basal ganglia outflow in monkeysMichele A Kliem
Yerkes National Primate Center, Emory University, School of Medicine, 954 Gatewood Road, Atlanta, GA 30322, USA
J Neurophysiol 98:1489-500. 2007..Our results support the finding that D1LR activation may have powerful effects on GPi and SNr neurons and may mediate some of the effects of dopamine replacement therapies in Parkinson's disease... - Differential localization of protein phosphatase-1alpha, beta and gamma1 isoforms in primate prefrontal cortexJill R Bordelon
Division of Neuroscience, Yerkes National Primate Research Center, and Department of Neurology, Emory University, Atlanta, GA 30322, USA
Cereb Cortex 15:1928-37. 2005.... - Differential structural plasticity of corticostriatal and thalamostriatal axo-spinous synapses in MPTP-treated Parkinsonian monkeysRosa M Villalba
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
J Comp Neurol 519:989-1005. 2011.... - GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transportersAdriana Galvan
Department of Neurology, Emory University, Atlanta, GA 30322, USA
J Neurophysiol 94:990-1000. 2005.... - Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidusOlga Poisik
Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
Neuropharmacology 49:57-69. 2005..Therefore, our findings do not only shed light on the functions of group II mGluRs in the GP, they also illustrate the therapeutic potential of mGluR-targeting allosteric modulators in neurological disorders such as Parkinson's disease... - Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1Avanti Gokhale
Department of Cell Biology, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 32:3697-711. 2012..Thus, our quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility... - Extrastriatal D2-like receptors modulate basal ganglia pathways in normal and Parkinsonian monkeysArash Hadipour-Niktarash
Yerkes National Primate Research Center, Atlanta, GA, USA
J Neurophysiol 107:1500-12. 2012.... - Ultrastructural localization and function of dopamine D1-like receptors in the substantia nigra pars reticulata and the internal segment of the globus pallidus of parkinsonian monkeysMichele A Kliem
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
Eur J Neurosci 31:836-51. 2010.... - GABA(B) receptors in the centromedian/parafascicular thalamic nuclear complex: an ultrastructural analysis of GABA(B)R1 and GABA(B)R2 in the monkey thalamusRosa M Villalba
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 496:269-87. 2006..Overall, these findings provide evidence for multiple sites where GABA(B) receptors could modulate GABAergic and glutamatergic transmission in the primate CM/PF complex... - Group I metabotropic glutamate receptors in the monkey striatum: subsynaptic association with glutamatergic and dopaminergic afferentsMaryse Paquet
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 23:7659-69. 2003.... - Differential synaptology of vGluT2-containing thalamostriatal afferents between the patch and matrix compartments in ratsDinesh V Raju
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 499:231-43. 2006..These observations pave the way for understanding differential regulatory mechanisms of striatal outflow from the patch and matrix compartments by thalamostriatal afferents... - Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeysRosa M Villalba
Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE Atlanta, GA 30322, USA
Exp Neurol 215:220-7. 2009.... - Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidusXiao Tao Jin
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Eur J Neurosci 33:1504-18. 2011..In conclusion, these data indicate that GAT-1 and GAT-3 represent different target sites through which GABA reuptake may subserve complementary regulation of GABAergic transmission in the rat GP... - α-1 Adrenergic receptors are localized on presynaptic elements in the nucleus accumbens and regulate mesolimbic dopamine transmissionDarlene A Mitrano
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 37:2161-72. 2012..These data indicate that local α1ARs control DA transmission in the medial NAc shell and behavioral responses to drugs of abuse... - The thalamostriatal system: a highly specific network of the basal ganglia circuitryYoland Smith
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA
Trends Neurosci 27:520-7. 2004..A major task of future studies is to characterize the role(s) of corticostriatal and thalamostriatal pathways in regulating basal ganglia activity in normal and pathological conditions... - Localization and expression of group I metabotropic glutamate receptors in the mouse striatum, globus pallidus, and subthalamic nucleus: regulatory effects of MPTP treatment and constitutive Homer deletionMasaaki Kuwajima
Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 27:6249-60. 2007..Thus, nigrostriatal dopaminergic lesion and Homer deletion lead to changes in the trafficking of group I mGluRs in vivo that are specific to receptor subtypes and brain areas... - Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkeyDarlene A Mitrano
Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Comp Neurol 500:788-806. 2007.... - Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesiclesKaren Newell-Litwa
Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 20:1441-53. 2009..Our results demonstrate that lysosomal and lysosome-related organelle biogenesis mechanisms regulate steady-state synaptic vesicle protein composition from shared early endosomes... - P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2Sami R Fam
Department of Pharmacology, Yerkes National Primate Research Center, and Division of Digestive Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 102:8042-7. 2005..These findings reveal that NHERF-2 is a key regulator of the cellular activity of P2Y(1)R and may therefore determine cell-specific differences in P2Y(1)R-mediated signaling... - Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleusMasaaki Kuwajima
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 474:589-602. 2004..These findings demonstrate that mGluR1a and mGluR5 exhibit a similar pattern of subsynaptic localization in monkey STN neurons, with both receptor subtypes exhibiting substantial extrasynaptic and perisynaptic localization... - Synaptic microcircuitry of tyrosine hydroxylase-containing neurons and terminals in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeysManey Mazloom
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 495:453-69. 2006..Finally, the coexpression of GABA in TH-positive terminals in the striatum of dopamine-depleted monkeys suggests dramatic neurochemical changes in the catecholaminergic modulation of striatal activity in Parkinson's disease... - Sodium channels and dendritic spike initiation at excitatory synapses in globus pallidus neuronsJesse E Hanson
Department of Biology, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 24:329-40. 2004..The ability of small amounts of excitation to trigger spikes in GP dendrites supports the prominent role of subthalamic input in the control of GP activity... - Anterograde axonal tract tracingDinesh V Raju
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Curr Protoc Neurosci . 2006..Combined with immunocytochemistry for neurotransmitters, neuropeptides, and receptors, tract tracing methods may be used to elucidate the phenotype of synapses that form the microcircuitry of specific neural systems... - Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neuronsStephanie Dallvechia-Adams
Division of Neuroscience, Yerkes Regional Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30322, USA
J Comp Neurol 448:360-72. 2002..Results of these studies suggest that the most significant behavioral states influenced by CART peptides, feeding and locomotion, may be mediated by direct and/or indirect modulation of VTA dopaminergic neuronal activity... - Continuous monitoring of intracerebral glutamate levels in awake monkeys using microdialysis and enzyme fluorometric detectionAdriana Galvan
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
J Neurosci Methods 126:175-85. 2003..This technique effectively detects short-term changes in glutamate levels evoked by physiologic or pharmacologic manipulations in the primate brain... - Age-related changes in the expression of axonal and glial group I metabotropic glutamate receptor in the rat substantia nigra pars reticulataGeorge Walton Hubert
Yerkes National Primate Research Center, Division of Neuroscience and Department of Neurology, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
J Comp Neurol 475:95-106. 2004.... - Localization and functions of kainate receptors in the basal gangliaXiao Tao Jin
Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University, 954, Catewood Road Northeast, Atlanta, Georgia 30322, USA
Adv Exp Med Biol 717:27-37. 2011..Because of their more subtle effects on neurotransmisison regulation than other ionotropic glutamate receptors, KARs represent interesting targets for the future development of pharmacotherapy for basal ganglia diseases... - Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortexE Chris Muly
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329, USA
J Comp Neurol 467:521-35. 2003..They further suggest differences in the cortical distribution of group I mGluRs between primates and rodents... - CART peptide and the mesolimbic dopamine systemKelly Philpot
Yerkes National Primate Research Center, Division of Neuroscience, Emory University, Atlanta, GA 30322, USA
Peptides 27:1987-92. 2006.... - Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticusKarin Borges
Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
Exp Neurol 201:416-27. 2006..These findings demonstrate astrocyte degeneration in the mouse dentate hilus specifically in the mouse pilocarpine epilepsy model, followed by astrogenesis leading to hilar repopulation... - (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonismGunasingh Masilamoni
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Exp Neurol 226:265-73. 2010..These findings demonstrate that (18)F-FECNT is a highly sensitive PET imaging ligand to quantify both striatal dopamine denervation and midbrain dopaminergic cell loss associated with parkinsonism... - Subcellular distribution of high-voltage-activated calcium channel subtypes in rat globus pallidus neuronsJesse E Hanson
Yerkes Regional Primate Research Center, Division of Neuroscience and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 442:89-98. 2002..Furthermore, the finding of a greater density of plasma membrane-bound L-type channels in distal dendrites expands the view that L-type channels are important only in somatic and proximal locations... - Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic dietKristopher J Bough
Department of Pharmacology, Emory University, Atlanta, GA, USA
Ann Neurol 60:223-35. 2006..The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies in adolescent rats to understand its anticonvulsant effect... - Metabotropic glutamate receptor 4 in the basal ganglia of parkinsonian monkeys: ultrastructural localization and electrophysiological effects of activation in the striatopallidal complexJames Bogenpohl
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Neuropharmacology 66:242-52. 2013..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'... - In vivo optogenetic control of striatal and thalamic neurons in non-human primatesAdriana Galvan
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
PLoS ONE 7:e50808. 2012..Experimental conditions such as the vector used, the number and rate of injections, or the light stimulation conditions have to be optimized for each structure studied... - Nigral and pallidal inputs to functionally segregated thalamostriatal neurons in the centromedian/parafascicular intralaminar nuclear complex in monkeyMamadou Sidibe
Yerkes Regional Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 447:286-99. 2002.... - Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidusOlga V Poisik
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 23:122-30. 2003..Together, these data illustrate a novel mechanism by which mGluR1 and mGluR5, members of the same family of G-protein-coupled receptors, can interact to modulate neuronal activity in the rat GP... - RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memorySarah Emerson Lee
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 107:16994-8. 2010..These results demonstrate that RGS14 is a key regulator of signaling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory but distinct from the canonical DG-CA3-CA1 circuit... - Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal GangliaXiao Tao Jin
Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University Atlanta, GA, USA
Front Syst Neurosci 5:63. 2011.... - Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patientsHua She
Department of Pharmacology, Rollins School of Public Health, Atlanta, Georgia, USA
J Clin Invest 121:930-40. 2011..Thus, direct regulation of complex I by mitochondrial MEF2D underlies its neuroprotective effects, and dysregulation of this pathway may contribute to PD... - Towards a transgenic model of Huntington's disease in a non-human primateShang Hsun Yang
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
Nature 453:921-4. 2008..Moreover, our data suggest that it will be feasible to generate valuable non-human primate models of HD and possibly other human genetic diseases... - Neuroglial plasticity at striatal glutamatergic synapses in Parkinson's diseaseRosa M Villalba
Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University Atlanta, GA, USA
Front Syst Neurosci 5:68. 2011.... - Striatal spine plasticity in Parkinson's diseaseRosa M Villalba
Yerkes National Primate Research Center, Emory University Atlanta, GA, USA
Front Neuroanat 4:133. 2010..Future studies to determine how alterations in striatal spine plasticity contribute to the symptomatology of parkinsonism are warranted...