N Sidell

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Regulation and modulation of abnormal immune responses in endometriosis
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory Center for Advanced Research on Women s Health, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 955:159-73; discussion 199-200, 396-406. 2002
  2. ncbi request reprint Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression
    ShouWei Han
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 111:322-31. 2004
  3. ncbi request reprint Growth-related oncogene produced in human breast cancer cells and regulated by Syk protein-tyrosine kinase
    Jing Li
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 117:14-20. 2005
  4. ncbi request reprint Pharmacokinetics of chronically administered all-trans-retinoyl-beta-glucuronide in mice
    N Sidell
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1502:264-72. 2000
  5. pmc Retinoic acid is a cofactor for translational regulation of vascular endothelial growth factor in human endometrial stromal cells
    Neil Sidell
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Endocrinol 24:148-60. 2010
  6. pmc Carcinogenic effects in a phenylketonuria mouse model
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e4292. 2009
  7. pmc Inhibition of estrogen-induced mammary tumor formation in MMTV-aromatase transgenic mice by 4-chlorophenylacetate
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA
    Cancer Lett 251:302-10. 2007
  8. ncbi request reprint Transcriptional inhibition of the estrogen response element by antiestrogenic piperidinediones correlates with intercalation into DNA measured by energy calculations
    Neil Sidell
    Department of Gynceology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Steroid Biochem Mol Biol 96:335-45. 2005
  9. pmc Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, United States
    J Steroid Biochem Mol Biol 124:121-7. 2011
  10. pmc In vitro and in vivo effects of easily administered, low-toxic retinoid and phenylacetate compounds on human neuroblastoma cells
    N Sidell
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Br J Cancer 89:412-9. 2003

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Regulation and modulation of abnormal immune responses in endometriosis
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory Center for Advanced Research on Women s Health, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 955:159-73; discussion 199-200, 396-406. 2002
    ....
  2. ncbi request reprint Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression
    ShouWei Han
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 111:322-31. 2004
    ..This work demonstrates that signaling through specific matrix-binding beta1 integrins (i.e., alpha5beta1) resulting from exaggerated deposition in lung of the matrix glycoprotein fibronectin might promote lung carcinoma cell growth...
  3. ncbi request reprint Growth-related oncogene produced in human breast cancer cells and regulated by Syk protein-tyrosine kinase
    Jing Li
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 117:14-20. 2005
    ..In summary, our findings provide evidence that human breast cancer cells express and secrete GRO and implicate this cytokine as an essential mediator of the antiinvasive properties of Syk tyrosine kinase...
  4. ncbi request reprint Pharmacokinetics of chronically administered all-trans-retinoyl-beta-glucuronide in mice
    N Sidell
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1502:264-72. 2000
    ....
  5. pmc Retinoic acid is a cofactor for translational regulation of vascular endothelial growth factor in human endometrial stromal cells
    Neil Sidell
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Endocrinol 24:148-60. 2010
    ..These findings suggest a link between the spatiotemporal changes of retinoid synthesis in the periimplantation stroma and the capacity to quickly up-regulate focal VEGF secretion needed to induce early angiogenic events of pregnancy...
  6. pmc Carcinogenic effects in a phenylketonuria mouse model
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e4292. 2009
    ..Together, these studies support the use of PAH(enu2) mice as a model for studying human PKU. Chronically elevated levels of PA in the PAH(enu2) mice were not protective against cancer...
  7. pmc Inhibition of estrogen-induced mammary tumor formation in MMTV-aromatase transgenic mice by 4-chlorophenylacetate
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA
    Cancer Lett 251:302-10. 2007
    ..The data suggest that 4-CPA is a novel therapeutic agent that could be used in the prevention or treatment of estrogen-sensitive breast cancer...
  8. ncbi request reprint Transcriptional inhibition of the estrogen response element by antiestrogenic piperidinediones correlates with intercalation into DNA measured by energy calculations
    Neil Sidell
    Department of Gynceology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Steroid Biochem Mol Biol 96:335-45. 2005
    ....
  9. pmc Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, United States
    J Steroid Biochem Mol Biol 124:121-7. 2011
    ....
  10. pmc In vitro and in vivo effects of easily administered, low-toxic retinoid and phenylacetate compounds on human neuroblastoma cells
    N Sidell
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Br J Cancer 89:412-9. 2003
    ..Taken together, these findings demonstrate the possibility that RAG and/or 4-CPA may serve as effective, less-toxic alternatives to 13-cis RA, which is presently being utilised for nb therapy...
  11. ncbi request reprint Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells
    Thitikorn Wanichkul
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Fertil Steril 79:763-9. 2003
    ..To determine whether peroxisome proliferator-activated receptor (PPAR)-gamma ligands can affect the expression of interleukin-6 (IL-6) and cytokines related to the pathogenesis of endometriosis...
  12. ncbi request reprint Differentiation of human neuroblastoma by phenylacetate is mediated by peroxisome proliferator-activated receptor gamma
    S Han
    Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Cancer Res 61:3998-4002. 2001
    ..Taken together, these studies have confirmed a role for PPARgamma in neuroblastoma cell biology and indicated that the PPARgamma signaling pathway plays a direct role in the PA-induced differentiation response of this cell type...
  13. ncbi request reprint Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells
    ShouWei Han
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:4627-35. 2003
    ..In this study we explored the possible mechanism(s) of control of COX-2 gene expression through PPARgamma signaling in human cervical cancer...
  14. ncbi request reprint Novel expression and function of peroxisome proliferator-activated receptor gamma (PPARgamma) in human neuroblastoma cells
    S W Han
    Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 7:98-104. 2001
    ..Taken together, these studies have implicated a role for PPARgamma in peripheral nerve cell biology and suggest that the PPARgamma signaling pathway is involved in the regulation of nb cell growth and differentiation...
  15. ncbi request reprint Modulation by phenylacetate of early estrogen-mediated events in MCF-7 breast cancer cells
    Jingbo Liu
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Chemother Pharmacol 59:217-25. 2007
    ..We now shed additional light on the antiestrogenic action of PA by determining its effects on early events in the estrogen-signaling pathway...
  16. pmc Peroxisome-proliferator-activated-receptor gamma (PPARgamma) independent induction of CD36 in THP-1 monocytes by retinoic acid
    ShouWei Han
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA
    Immunology 106:53-9. 2002
    ..This study suggests a possible role for RA in physiological processes involving the scavenger receptor function in cells of the monocyte/macrophage lineage...
  17. ncbi request reprint Inhibition of estrogen-dependent breast cell responses with phenylacetate
    S Sawatsri
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 93:687-92. 2001
    ..The data suggests a novel mechanism of action that might bypass some of the limitations of conventional antiestrogen therapy...
  18. ncbi request reprint Conjugated linoleic acid blocks estrogen signaling in human breast cancer cells
    Prasong Tanmahasamut
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 134:674-80. 2004
    ..Taken together, these findings demonstrate that CLA compounds possess potent antiestrogenic properties that may at least partly account for their antitumor activity on breast cancer cells...
  19. pmc Mechanistic and therapeutic implications of angiogenesis in endometriosis
    Robert N Taylor
    Department of Gynecology and Obstetrics, Human Uterine Biology Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Reprod Sci 16:140-6. 2009
    ..Finally, we review the clinical implications of angiogenesis in this condition and propose potential antiangiogenic therapies that may become useful in the control or eradication of endometriotic lesions...
  20. ncbi request reprint Anti-estrogenic effects of conjugated linoleic acid through modulation of estrogen receptor phosphorylation
    Jingbo Liu
    Department of Gynecology and Obstetrics, Division of Research, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Breast Cancer Res Treat 94:161-9. 2005
    ..These results provide evidence that the anti-estrogenic activity of CLA is caused by inducing the dephosphorylation of ER alpha through stimulation of PP2A activity...
  21. ncbi request reprint RU486-induced growth inhibition of human endometrial cells involves the nuclear factor-kappa B signaling pathway
    ShouWei Han
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 88:713-9. 2003
    ..This study demonstrates that the inhibition of growth and apoptosis of human endometrial cells by RU486 involves stimulation of NF-kappa B binding with subsequent modulation of apoptosis regulatory genes bax and bcl-2...
  22. ncbi request reprint Up-regulation of gap junctional intercellular communication and connexin43 expression by retinoic acid in human endometrial stromal cells
    Prasong Tanmahasamut
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 90:4151-6. 2005
    ..Cx43 is the most widely expressed Cx in the endometrium and is known to be important in a variety of physiological and pathological processes in this tissue...
  23. ncbi request reprint Up-regulation of p21 gene expression by peroxisome proliferator-activated receptor gamma in human lung carcinoma cells
    ShouWei Han
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 10:1911-9. 2004
    ..In this study, we explored the role of PPARgamma signaling on the control of gene expression of the cycle-dependent kinase inhibitor p21 in human lung carcinoma cells...
  24. ncbi request reprint Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression
    ShouWei Han
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Chest 125:134S. 2004
  25. ncbi request reprint Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Lett 219:71-81. 2005
    ..These observations unveil a novel mechanism for p21 gene regulation by fibronectin in lung carcinoma cell growth that represents a potential target for therapy...
  26. pmc The tri-nucleotide spacer sequence between estrogen response element half-sites is conserved and modulates ERalpha-mediated transcriptional responses
    Feng jue Shu
    Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, WMB 4217, Atlanta, GA 30322, USA
    J Steroid Biochem Mol Biol 120:172-9. 2010
    ....
  27. pmc Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species
    Juanjuan Wu
    Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Physiol 589:863-75. 2011
    ..Together, these findings predict a redox-mediated mechanism for retinoid regulation of localized VEGF secretion in the human endometrium that may be necessary for the successful establishment of pregnancy...
  28. ncbi request reprint XR5944: A potent inhibitor of estrogen receptors
    Chandanamali Punchihewa
    College of Pharmacy, University of Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA
    Mol Cancer Ther 6:213-9. 2007
    ..This represents a novel mechanism of ER inhibition, which may allow the development of agents capable of overcoming resistance to current antiestrogens...
  29. ncbi request reprint Retinoic acid induced downregulation of MYCN is not mediated through changes in Sp1/Sp3
    Kelli K Kanemaru
    Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, Honolulu, Hawaii, USA
    Pediatr Blood Cancer 50:806-11. 2008
    ..Here, post-translational modifications of Sp proteins were examined as an alternate mechanism of RA-mediated promoter regulation...
  30. ncbi request reprint Retinoyl beta-glucuronide: a biologically active interesting retinoid
    Arun B Barua
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, USA
    J Nutr 134:286S-289S. 2004
    ....
  31. ncbi request reprint N-myc oncogene expression in neuroblastoma is driven by Sp1 and Sp3
    Matthew C Tuthill
    Molecular Carcinogenesis Section, Cancer Etiology Program, Cancer Research Center of Hawaii, The University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, HI 96813 2424, USA
    Mol Genet Metab 80:272-80. 2003
    ..Moreover when mutated, the CT-box may still function as a binding motif for alternate transcription factors such as NF-1 that can allow persistent N-myc expression...
  32. pmc Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival
    Mary J Laws
    Department of Veterinary Biosciences, and University of Illinois Urbana Champaign, Urbana, IL 61802, USA
    Development 135:2659-68. 2008
    ....

Research Grants14

  1. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2010
    ..The information gained from our studies will provide the basic framework for the therapeutic use of retinoid compounds to impede the genesis and growth of endometriotic lesions. ..
  2. Development and Testing of ERE-Targeting Molecules for Breast Cancer Therapy
    Neil Sidell; Fiscal Year: 2010
    ..In addition to providing a basic framework for the development of new antiestrogen compounds, these studies will establish a new concept of inhibiting DNA/transcription factor interactions with small molecule DNA binders. ..
  3. Development and Testing of ERE-Targeting Molecules for Breast Cancer Therapy
    Neil Sidell; Fiscal Year: 2009
    ..In addition to providing a basic framework for the development of new antiestrogen compounds, these studies will establish a new concept of inhibiting DNA/transcription factor interactions with small molecule DNA binders. ..
  4. PHENYLACETATE--NOVEL THERAPEUTIC USES IN BREAST CANCER
    Neil Sidell; Fiscal Year: 2005
    ..Taken together, the information gained from these studies will provide a basic framework for the rationale use of PA analogs or similar acting compounds in the clinic. ..
  5. DOES PKU PROTECT AGAINST CANCER?
    Neil Sidell; Fiscal Year: 2003
    ....
  6. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2010
    ..The information gained from our studies will provide the basic framework for the therapeutic use of retinoid compounds to impede the genesis and growth of endometriotic lesions. ..