Research Topics
| Leslee J ShawSummaryAffiliation: Emory University Country: USA Publications
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Publications
Coronary artery calcium to predict all-cause mortality in elderly men and womenPaolo Raggi
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
J Am Coll Cardiol 52:17-23. 2008..We sought to study the prognostic utility of coronary artery calcium (CAC) in the elderly...- Cost-effectiveness and future implications for cardiovascular imagingLeslee J Shaw
Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia 30324, USA
Can J Cardiol 29:350-7. 2013..Ongoing multicentre registries and clinical trials will further enrich this evidence base with regard to value-based imaging strategies that provide enhanced effectiveness and efficiency resulting in improved patient outcomes... 
Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientistsVirginia M Miller
Departments of Surgery, Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
Biol Sex Differ 2:14. 2011..abstract:..- Impact of left ventricular function and the extent of ischemia and scar by stress myocardial perfusion imaging on prognosis and therapeutic risk reduction in diabetic patients with coronary artery disease: results from the Bypass Angioplasty RevascularizaLeslee J Shaw
Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, 1462 Clifton Rd NE, Room 529, Atlanta, GA 30306, USA
J Nucl Cardiol 19:658-69. 2012..Comparisons of post-intervention ischemic burden have not been explored but are relevant to treatment decisions. This study examined differences in 1-year stress myocardial perfusion SPECT (MPS) abnormalities by randomized treatment... - Imaging for preventionLeslee J Shaw
Emory University School of Medicine, Atlanta, GA 30324, USA
Med Clin North Am 96:103-12. 2012.... - Comparative effectiveness of exercise electrocardiography with or without myocardial perfusion single photon emission computed tomography in women with suspected coronary artery disease: results from the What Is the Optimal Method for Ischemia Evaluation Leslee J Shaw
Emory University, Atlanta, GA 30324, USA
Circulation 124:1239-49. 2011..It remains unclear whether the addition of myocardial perfusion imaging (MPI) to the standard ECG exercise treadmill test (ETT) provides incremental information to improve clinical decision making in women with suspected CAD... - Sex differences in mortality associated with computed tomographic angiographic measurements of obstructive and nonobstructive coronary artery disease: an exploratory analysisLeslee J Shaw
Emory University, 1256 Briarcliff Road NE, Atlanta, GA 30306, USA
Circ Cardiovasc Imaging 3:473-81. 2010..Limited data are available to explore sex differences in prognosis with coronary computed tomographic angiographic (CCTA) measurements of CAD including novel nonobstructive plaque extent... - Risk assessment and predictive value of coronary artery disease testingLeslee J Shaw
School of Medicine, Emory University, Atlanta, Georgia 30306, USA
J Nucl Med 50:1296-306. 2009..Despite a high level of evidence, comparative research is not available across modalities that could definitively drive utilization of cardiac imaging modalities... - Prognostic accuracy of B-natriuretic peptide measurements and coronary artery calcium in asymptomatic subjects (from the Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research [EISNER] study)Leslee J Shaw
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Cardiol 104:1245-50. 2009..4% and 35.7% of CV events in patients with hypertension and in elderly patients beyond the Framingham risk score. In conclusion, BNP and CAC are independently predictive of CV events... - Prognosis by coronary computed tomographic angiography: matched comparison with myocardial perfusion single-photon emission computed tomographyLeslee J Shaw
Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30306, USA
J Cardiovasc Comput Tomogr 2:93-101. 2008..The aim of this report was to compare all-cause death rates for 7 CTA subsets, using the Duke prognostic index, compared with percentage of ischemic myocardium by MPS... 
Myocardial perfusion imaging in the evaluation of chest pain in the acute care setting: Clinical and economic outcomesLeslee J Shaw
Department of Imaging, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
J Nucl Cardiol 14:S133-8. 2007- Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health--National Heart, Lung, and Blood Institute sponsored WLeslee J Shaw
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Clin Endocrinol Metab 93:1276-84. 2008..Women with polycystic ovary syndrome (PCOS) have a greater clustering of cardiac risk factors. However, the link between PCOS and cardiovascular (CV) disease is incompletely described... - Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology-National Cardiovascular Data RegistryLeslee J Shaw
Emory Program in Cardiovascular Outcomes Research and Epidemiology, 1256 Briarcliff Rd NE, Suite 1 N, Emory University School of Medicine, Atlanta, GA 30306, USA
Circulation 117:1787-801. 2008..Although populations referred for coronary angiography are increasingly diverse, there is limited information on coronary artery disease (CAD) prevalence and in-hospital mortality other than for predominately white male patients... - Cardiovascular imaging research at the crossroadsLeslee J Shaw
Emory University School of Medicine, Atlanta, Georgia 30306, USA
JACC Cardiovasc Imaging 3:316-24. 2010..In this review, we will discuss current health policy of CV imaging as well as the future of CV imaging-based comparative effectiveness research... - Induced cardiovascular procedural costs and resource consumption patterns after coronary artery calcium screening: results from the EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) studyLeslee J Shaw
Emory University School of Medicine, Atlanta, Georgia, USA
J Am Coll Cardiol 54:1258-67. 2009..We prospectively evaluated procedural costs and resource consumption patterns in the EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) study after coronary calcium (CAC) measurements... - Importance of socioeconomic status as a predictor of cardiovascular outcome and costs of care in women with suspected myocardial ischemia. Results from the National Institutes of Health, National Heart, Lung and Blood Institute-sponsored Women's Ischemia Leslee J Shaw
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30306, USA
J Womens Health (Larchmt) 17:1081-92. 2008..For women, who are more likely to live in poverty, defining the clinical and economic impact of socioeconomic factors may aid in defining redistributive policies to improve healthcare quality... - Ethnic differences in the prognostic value of stress technetium-99m tetrofosmin gated single-photon emission computed tomography myocardial perfusion imagingLeslee J Shaw
Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Am Coll Cardiol 45:1494-504. 2005..This study was designed to evaluate the differential prognostic value of gated single-photon emission computed tomographic imaging (SPECT) imaging in an ethnically diverse multicenter registry... - Cardiovascular disease risk stratification with stress single-photon emission computed tomography technetium-99m tetrofosmin imaging in patients with the metabolic syndrome and diabetes mellitusLeslee J Shaw
Cedars Sinai Medical Center, Los Angeles, California, USA
Am J Cardiol 97:1538-44. 2006..In conclusion, cardiovascular prognosis is affected by the degree of metabolic dysfunction, and stress-induced reductions in myocardial perfusion provide an accurate means for near-term risk stratification... - Adenosine myocardial perfusion single-photon emission computed tomography in women compared with men. Impact of diabetes mellitus on incremental prognostic value and effect on patient managementDaniel S Berman
Department of Imaging, Division of Nuclear Medicine, and CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California Los Angeles, School of Medicine, Los Angeles, California 90048, USA
J Am Coll Cardiol 41:1125-33. 2003..This study was designed to assess the incremental prognostic value of adenosine stress myocardial perfusion single-photon emission computed tomography (MPS) in women versus men, and to explore the prognostic impact of diabetes mellitus... - Weight change modulates epicardial fat burden: a 4-year serial study with non-contrast computed tomographyRyo Nakazato
Departments of Imaging Division of Nuclear Medicine, Medicine Division of Cardiology, and the Cedars Sinai Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Atherosclerosis 220:139-44. 2012..Epicardial fat volume (EFV) is linked to cardiovascular event risk. We aimed to investigate the relationships between EFV and weight change... - Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface areaArik Wolak
Departments of Imaging, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California at Los Angeles, USA
JACC Cardiovasc Imaging 1:200-9. 2008..To determine normal limits for ascending and descending thoracic aorta diameters in a large population of asymptomatic, low-risk adult subjects... - Prognostic value of global MR myocardial perfusion imaging in women with suspected myocardial ischemia and no obstructive coronary disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) studyMark Doyle
Division of Cardiology, CV MRI Center, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 4772, USA
JACC Cardiovasc Imaging 3:1030-6. 2010.... - Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: Noninvasive risk stratification and a conceptual framework for the selection of noninvasive imaging tests in patients with known or suspected coronary artery diseaseDaniel S Berman
Department of Imaging and Medicine, Cedars Sinai Medical Center, Burns and Allen Research Institute, Los Angeles, California 90048, USA
J Nucl Med 47:1107-18. 2006..We consider it likely that, with an increased emphasis on prevention and a concomitant aging of the population, many forms of noninvasive cardiac imaging will continue to grow, with nuclear cardiology continuing to grow... - What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiographyYuka Otaki
Department of Imaging and Medicine, Cedars Sinai Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Nucl Cardiol 19:787-95. 2012..This article summarizes the current status of several studies from CONFIRM registry... - Performance of the traditional age, sex, and angina typicality-based approach for estimating pretest probability of angiographically significant coronary artery disease in patients undergoing coronary computed tomographic angiography: results from the mulVictor Y Cheng
Heart Institute and Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA
Circulation 124:2423-32, 1-8. 2011..Reliability of guideline probabilities has not been investigated in patients referred to noninvasive CAD testing... - Comparative use of radionuclide stress testing, coronary artery calcium scanning, and noninvasive coronary angiography for diagnostic and prognostic cardiac assessmentDaniel S Berman
Department of Imaging and Medicine, Cedars Sinai Medical Center, CSMC Burns and Allen Research Institute, Los Angeles, CA 90048, USA
Semin Nucl Med 37:2-16. 2007.... - Age- and sex-related differences in all-cause mortality risk based on coronary computed tomography angiography findings results from the International Multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International MulticenJames K Min
Department of Medicine, Cedars Sinai Heart Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
J Am Coll Cardiol 58:849-60. 2011..We examined mortality in relation to coronary artery disease (CAD) as assessed by ≥64-detector row coronary computed tomography angiography (CCTA)... - Determinants of risk and its temporal variation in patients with normal stress myocardial perfusion scans: what is the warranty period of a normal scan?Rory Hachamovitch
Division of Cardiovascular Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
J Am Coll Cardiol 41:1329-40. 2003..The aim of this study was to determine the predictors of risk and the temporal characteristics of risk associated with normal myocardial perfusion single photon emission computed tomography (MPS)... - Pericardial fat burden on ECG-gated noncontrast CT in asymptomatic patients who subsequently experience adverse cardiovascular eventsVictor Y Cheng
Department of Imaging, Cedars Sinai Medical Center, Los Angeles, California, USA
JACC Cardiovasc Imaging 3:352-60. 2010..We aimed to evaluate whether pericardial fat has value in predicting the risk of future adverse cardiovascular outcomes... - Prognostic value of automated vs visual analysis for adenosine stress myocardial perfusion SPECT in patients without prior coronary artery disease: a case-control studyYuan Xu
Departments of Imaging and Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd, Taper A047, Los Angeles, CA 90048, USA
J Nucl Cardiol 18:1003-9; quiz 1010-4. 2011.... - Incremental cost-effectiveness of exercise echocardiography vs. SPECT imaging for the evaluation of stable chest painLeslee J Shaw
Cedars Sinai Medical Center, David Geffen UCLA School of Medicine, Taper Building, Los Angeles, CA 90048, USA
Eur Heart J 27:2448-58. 2006..The opportunity costs of strategies favouring exercise echocardiography or SPECT imaging have been incompletely evaluated... - The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health--National Heart, Lung, and Blood Institute--sponsored Women's Ischemia Syndrome EvaluationLeslee J Shaw
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, Calif, USA
Circulation 114:894-904. 2006..Few data exist regarding the type and intensity of resource consumption in women with chest pain after coronary angiography... - Prognostic value of poststress left ventricular volume and ejection fraction by gated myocardial perfusion SPECT in women and men: gender-related differences in normal limits and outcomesTali Sharir
Department of Imaging, Division of Nuclear Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif. 90048, USA
J Nucl Cardiol 13:495-506. 2006..After separate criteria for abnormal EF and ESV index in women are used, the combination of severe ischemia and abnormal EF or ESV index identifies women at very high risk of cardiac events... - Quantitative assessment of myocardial perfusion abnormality on SPECT myocardial perfusion imaging is more reproducible than expert visual analysisDaniel S Berman
Department of Imaging Division of Nuclear Medicine, Cedars Sinai Heart Institute, 8700 Beverly Boulevard, Room 1258, Los Angeles, CA 90048, USA
J Nucl Cardiol 16:45-53. 2009..Few studies have addressed whether quantitative SPECT MPI assessment would be more reproducible for this application... - Impact of body mass index on cardiac mortality in patients with known or suspected coronary artery disease undergoing myocardial perfusion single-photon emission computed tomographyXingping Kang
Department of Imaging, Division of Nuclear Medicine, and CSMC Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
J Am Coll Cardiol 47:1418-26. 2006..In patients with known CAD undergoing MPS, obese and overweight patients were at lower risk of CD over three years than normal weight patients... - Diagnostic accuracy of gated Tc-99m sestamibi stress myocardial perfusion SPECT with combined supine and prone acquisitions to detect coronary artery disease in obese and nonobese patientsDaniel S Berman
Department of Imaging, Division of Nuclear Medicine, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, Calif 90048, USA
J Nucl Cardiol 13:191-201. 2006..The diagnostic value of gated myocardial perfusion single-photon emission computed tomography (MPS) with combined supine and prone acquisitions to detect coronary artery disease (CAD) in obese and nonobese patients has not been defined... - Statins use and coronary artery plaque composition: results from the International Multicenter CONFIRM RegistryRyo Nakazato
Cedars Sinai Heart Institute and Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA
Atherosclerosis 225:148-53. 2012..We evaluated the association of statin use to coronary plaque composition type in patients without known coronary artery disease (CAD) undergoing CCTA... - Coronary computed tomographic angiography as a gatekeeper to invasive diagnostic and surgical procedures: results from the multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: an International Multicenter) registryLeslee J Shaw
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
J Am Coll Cardiol 60:2103-14. 2012..This study sought to examine patterns of follow-up invasive coronary angiography (ICA) and revascularization (REV) after coronary computed tomography angiography (CCTA)... - Value of stress myocardial perfusion single photon emission computed tomography in patients with normal resting electrocardiograms: an evaluation of incremental prognostic value and cost-effectivenessRory Hachamovitch
Department of Imaging (Division of Nuclear Medicine, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, Calif 90048, USA
Circulation 105:823-9. 2002..These findings are opposite those of previous studies examining anatomic end points in this same population and thus, if confirmed, have significant implications for patient management... - Improved near-term coronary artery disease risk classification with gated stress myocardial perfusion SPECTLeslee J Shaw
Emory University School of Medicine, Atlanta, Georgia, USA
JACC Cardiovasc Imaging 3:1139-48. 2010..We compared analytical approaches to estimate the added value of myocardial perfusion single-photon emission computed tomography (MPS) variables in estimating coronary artery disease (CAD) outcomes... - Baseline stress myocardial perfusion imaging results and outcomes in patients with stable ischemic heart disease randomized to optimal medical therapy with or without percutaneous coronary interventionLeslee J Shaw
Emory University School of Medicine, Atlanta, GA 30306, USA
Am Heart J 164:243-50. 2012..The current post hoc substudy analysis examined the relationship between baseline stress myocardial ischemia and clinical outcomes based on randomized treatment assignment... - Impact of metabolic syndrome and diabetes on prognosis and outcomes with early percutaneous coronary intervention in the COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) trialDavid J Maron
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Am Coll Cardiol 58:131-7. 2011..Our purpose was to clarify the clinical utility of identifying metabolic syndrome (MetS) in patients with coronary artery disease (CAD)... - Clinical outcomes after both coronary calcium scanning and exercise myocardial perfusion scintigraphyAlan Rozanski
Department of Medicine, St Luke s Roosevelt Hospital, New York, New York, USA
J Am Coll Cardiol 49:1352-61. 2007..The purpose of this work was to assess the prognosis in patients undergoing both coronary artery calcium (CAC) scanning and exercise myocardial perfusion scintigraphy (MPS)... - Depression, inflammation, and incident cardiovascular disease in women with suspected coronary ischemia: the National Heart, Lung, and Blood Institute-sponsored WISE studyViola Vaccarino
Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30306, USA
J Am Coll Cardiol 50:2044-50. 2007..The purpose of this study was to examine prospectively whether inflammation explains the relationship between depression and cardiovascular disease (CVD)... - Comparison of atherosclerotic calcification burden in persons with the cardiometabolic syndrome and diabetesNathan D Wong
Department of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
J Cardiometab Syndr 1:90-4. 2006..52-2.90) for CAC and 1.14 (0.91-1.42), 1.03 (0.77-1.37), 1.03 (0.68-1.54), and 1.41 (1.03-1.92) for TAC. Multiple CMS risk factors are associated with increased CAC, but not TAC; DM with CMS has the highest prevalence of CAC and TAC... - Threshold for the upper normal limit of indexed epicardial fat volume: derivation in a healthy population and validation in an outcome-based studyHaim Shmilovich
Department of Medicine, Heart Institute, Cardiac Imaging, Cedars Sinai Medical Center, Los Angeles, California, USA
Am J Cardiol 108:1680-5. 2011..In conclusion, in a healthy population we determined 68.1 cm(3)/m(2) as the 95th percentile threshold for abnormally high EFVi. EFVi exceeding this value independently predicted MACE and trended to add to CCS and FRS in this prediction... - Role of noninvasive imaging in asymptomatic high-risk patientsLeslee J Shaw
Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, Calif 90048, USA
J Nucl Cardiol 13:156-62. 2006 - Differences in prevalence, extent, severity, and prognosis of coronary artery disease among patients with and without diabetes undergoing coronary computed tomography angiography: results from 10,110 individuals from the CONFIRM (COronary CT Angiography EJamal S Rana
Heart Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
Diabetes Care 35:1787-94. 2012..We examined the prevalence, extent, severity, and prognosis of coronary artery disease (CAD) in individuals with and without diabetes (DM) who are similar in CAD risk factors... - Ischemia change in stable coronary artery disease is an independent predictor of death and myocardial infarctionAfshin Farzaneh-Far
Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
JACC Cardiovasc Imaging 5:715-24. 2012..The aim of this study was to evaluate the independent prognostic significance of ischemia change in stable coronary artery disease (CAD)... - Sex comparison of diagnostic accuracy of 64-multidetector row coronary computed tomographic angiography: results from the multicenter ACCURACY trialJanet C Tsang
Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 West Carson Street, Torrance, CA 90502, USA
J Cardiovasc Comput Tomogr 6:246-51. 2012..Coronary computed tomographic angiography (CTA) is a validated method for detection and exclusion of obstructive coronary artery stenosis... - The value of estimated functional capacity in estimating outcome: results from the NHBLI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) StudyLeslee J Shaw
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Am Coll Cardiol 47:S36-43. 2006..Our objective was to determine the prognostic value of estimated metabolic equivalents (METs) based on self-reported functional capacity by the Duke Activity Status Index (DASI) in symptomatic women... - Prognostic value of number and site of calcified coronary lesions compared with the total scoreMarcus Williams
Emory University School of Medicine, Atlanta, Georgia 30306, USA
JACC Cardiovasc Imaging 1:61-9. 2008..This study sought to evaluate the long-term prognostic value of the number and sites of calcified coronary lesions and to compare the accuracy of number of calcified lesions with the extent of total calcium score... - Electrocardiographic predictors of cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) studyBrian Triola
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Coll Cardiol 46:51-6. 2005..02). CONCLUSIONS: Several 12-lead ECG parameters, such as the QRS-T angle and the QRS and QTrr duration, are predictive of future cardiovascular events in women with suspected myocardial ischemia... - Incremental prognostic value of left ventricular function by myocardial ECG-gated FDG PET imaging in patients with ischemic cardiomyopathyCesar A Santana
Department of Radiology, Emory University of School of Medicine, Atlanta, GA 30322, USA
J Nucl Cardiol 11:542-50. 2004.... - Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery diseasePuja K Mehta
Women s Heart Center, Cedars Sinai Heart Institute, Los Angeles, California, USA
JACC Cardiovasc Imaging 4:514-22. 2011..We conducted a pilot study for a large definitive clinical trial evaluating the impact of ranolazine in women with angina, evidence of myocardial ischemia, and no obstructive coronary artery disease (CAD)... - Coronary artery calcium as a measure of biologic ageLeslee J Shaw
Cedars Sinai Medical Center, Los Angeles, CA, USA
Atherosclerosis 188:112-9. 2006..Age is assigned a heavy weight in the calculation of the total cardiovascular risk score but often the atherosclerotic disease burden varies from a patient's chronological age... - Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategiesLeslee J Shaw
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
J Am Coll Cardiol 47:S4-S20. 2006.... - Combined impact of age and estimated glomerular filtration rate on in-hospital mortality after percutaneous coronary intervention for acute myocardial infarction (from the American College of Cardiology National Cardiovascular Data Registry)Francesca Cardarelli
Division of Cardiology, Emory University, Atlanta, GA, USA
Am J Cardiol 103:766-71. 2009.... - Coronary CT angiography versus myocardial perfusion imaging for near-term quality of life, cost and radiation exposure: a prospective multicenter randomized pilot trialJames K Min
Heart Institute, Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, CA, USA
J Cardiovasc Comput Tomogr 6:274-83. 2012.... - Nomograms for estimating coronary artery disease prognosis with gated stress myocardial perfusion SPECTLeslee J Shaw
Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, 1462 Clifton Rd NE, Room 530, Atlanta, GA 30306, USA
J Nucl Cardiol 19:43-52. 2012..Nomograms can be useful tools for estimating coronary artery disease (CAD) risk. We sought to devise risk-based nomograms for stress myocardial perfusion SPECT to include measures of % ischemic myocardium and left ventricular function... - Depression, the metabolic syndrome and cardiovascular riskViola Vaccarino
Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1256 Briarcliff Road NE, Suite 1 North, Atlanta, GA 30306, USA
Psychosom Med 70:40-8. 2008..The relationship between depression and the metabolic syndrome is unclear, and whether metabolic syndrome explains the association between depression and cardiovascular disease (CVD) risk is unknown... - Cost-effective applications of cardiac computed tomography in coronary artery diseaseJames K Min
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, 520 E 70th Street, K415, New York, NY 10021, USA
Expert Rev Cardiovasc Ther 6:43-55. 2008..In this review, we discuss basic principles underlying economic efficiency analyses of medical products, using computed tomography in coronary artery disease as a case in point... - Mortality risk in symptomatic patients with nonobstructive coronary artery disease: a prospective 2-center study of 2,583 patients undergoing 64-detector row coronary computed tomographic angiographyFay Y Lin
Department of Medicine, Division of Cardiology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA
J Am Coll Cardiol 58:510-9. 2011..We examined mortality risk in relation to extent and composition of nonobstructive plaques by 64-detector row coronary computed tomographic angiography (CCTA)... - Prognostic estimation of coronary artery disease risk with resting perfusion abnormalities and stress ischemia on myocardial perfusion SPECTLeslee J Shaw
Emory University School of Medicine, Atlanta, GA 30306, USA
J Nucl Cardiol 15:762-73. 2008..Prognosis associated with myocardial perfusion single photon emission computed tomography (MPS) abnormalities on the resting scan as it relates to stress ischemia has been incompletely described... - Rationale and design of the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) RegistryJames K Min
Department of Medicine, Weill Cornell Medical College and the New York Presbyterian Hospital, 520 E 70th Street, Starr Pavilion, K415, New York, NY 10021, USA
J Cardiovasc Comput Tomogr 5:84-92. 2011..The primary aim of CONFIRM is to determine the prognostic value of CCTA findings for the prediction of future adverse CAD events... - Gated myocardial perfusion single photon emission computed tomography in the clinical outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial, Veterans Administration Cooperative study no. 424Leslee J Shaw
Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, Calif. 90048, USA
J Nucl Cardiol 13:685-98. 2006..We hope the evidence that emerges from the COURAGE trial will further establish the role of nuclear imaging in the evidence-based management of patients with stable coronary disease... - Calculation of coronary age using calcium scores in multiple ethnicitiesGopi K R Sirineni
Department of Radiology, Emory University School of Medicine, 1365 Clifton Road NE, AT 504, Atlanta, GA 30322, USA
Int J Cardiovasc Imaging 24:107-11. 2008..This method should allow patients to better understand the prognostic significance of their test results and may ensure a better compliance with preventive regimens... - The role of myocardial perfusion imaging in special populations: women, diabetics, and heart failureJennifer H Mieres
Division of Cardiology, North Shore University Hospital, Manhasset, NY 11030, USA
Semin Nucl Med 35:52-61. 2005.... - Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part II: gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular corC Noel Bairey Merz
Division of Cardiology, Department of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
J Am Coll Cardiol 47:S21-9. 2006..Additionally, innovative cardiovascular imaging techniques will be discussed. Finally, we identify critical areas of further inquiry needed to advance this new gender-specific IHD understanding into improved outcomes for women... - Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: assessment of patients with suspected coronary artery diseaseDaniel S Berman
Department of Imaging and Medicine, Cedars Sinai Medical Center, Burns and Allen Research Institute, Los Angeles, California 90048, USA
J Nucl Med 47:74-82. 2006..While CT and CMR are likely to grow considerably in diagnostic evaluation over the next several years, MPS and PET will continue to be very valuable techniques for this purpose... - Rationale and design of the DeFACTO (Determination of Fractional Flow Reserve by Anatomic Computed Tomographic AngiOgraphy) studyJames K Min
Department of Medicine, Imaging, and Biomedical Sciences, Cedars Sinai Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Cardiovasc Comput Tomogr 5:301-9. 2011.... - Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudyLeslee J Shaw
Emory University School of Medicine, Atlanta, GA 30306, USA
Circulation 117:1283-91. 2008.... - DHEA-S levels and cardiovascular disease mortality in postmenopausal women: results from the National Institutes of Health--National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE)Chrisandra Shufelt
Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Clin Endocrinol Metab 95:4985-92. 2010..Low levels have been associated with increased cardiovascular disease (CVD) risk and all-cause mortality, although these results have not been consistently replicated, particularly in women... - Risk stratification in patients with remote prior myocardial infarction using rest-stress myocardial perfusion SPECT: prognostic value and impact on referral to early catheterizationMichael J Zellweger
Department of Imaging (Division of Nuclear Medicine, Cedars-Sinai Medical Center, The CSMC Burns and Allen Research Institute, Los Angeles, Calif. 90048, USA
J Nucl Cardiol 9:23-32. 2002..Patients with normal or mildly abnormal scan results or small MI in combination with absent or mild ischemia have a low risk for CD... - Myocardial ischemia in the absence of obstructive coronary artery disease in systemic lupus erythematosusMariko L Ishimori
Division of Rheumatology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
JACC Cardiovasc Imaging 4:27-33. 2011.... - Importance of residual myocardial ischemia after intervention in the genesis of cardiovascular events among patients with chronic coronary artery diseaseLeslee J Shaw
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Curr Cardiol Rep 13:280-6. 2011..This review provides a synopsis of available evidence on serial testing and meaningful thresholds for application of paired rest/stress myocardial perfusion single photon emission computed tomography imaging... - Prognostic value of coronary artery calcium screening in asymptomatic smokers and non-smokersLeslee J Shaw
Cedars Sinai Medical Center, Room 125 4, Taper Building, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Eur Heart J 27:968-75. 2006..Limited data are available on the impact of cigarette smoking on the prognostic value of coronary calcium... - Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging: results from the multicenter registry of 4,728 patientsLeslee J Shaw
Atlanta Cardiovascular Research Institute, Atlanta, Georgia 30342, USA
J Nucl Med 44:134-9. 2003..A total of 4,728 consecutively tested patients who underwent stress (99m)Tc-tetrofosmin SPECT at 5 U.S. hospitals were included in this series... - Adenosine sestamibi SPECT post-infarction evaluation (INSPIRE) trial: A randomized, prospective multicenter trial evaluating the role of adenosine Tc-99m sestamibi SPECT for assessing risk and therapeutic outcomes in survivors of acute myocardial infarctiJohn J Mahmarian
The Methodist DeBakey Heart Center and Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030 2717, USA
J Nucl Cardiol 11:458-69. 2004..Preliminary studies indicate that adenosine myocardial perfusion single photon tomography (SPECT) can safely and accurately stratify patients into low and high risk groups early after acute myocardial infarction (AMI)... - Diagnostic strategies for heart disease in women: an update on imaging techniques for optimal managementAmgad N Makaryus
Department of Medicine, Division of Cardiology, North Shore University Hospital, Manhasset, New York, USA
Cardiol Rev 15:279-87. 2007..In this article we review the literature regarding the diagnostic and prognostic evaluation of coronary artery disease in women with respect to imaging... - The right sided great vessels by cardiac multidetector computed tomography: normative reference values among healthy adults free of cardiopulmonary disease, hypertension, and obesityFay Y Lin
Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital, 520 E 70th Street, New York, NY 10021, USA
Acad Radiol 16:981-7. 2009..We sought to derive normative reference values for the thoracic great vessels using multidetector computed tomography (MDCT) in a healthy normotensive non-obese population free of cardiovascular disease... - Automated quantitation of pericardiac fat from noncontrast CTDamini Dey
Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Invest Radiol 43:145-53. 2008..We aimed to develop new software (QFAT) for automatic quantitation of PF from noncontrast cardiac CT and compare PF measures to other cardiovascular risk factors... - The clinical role of stress myocardial perfusion imaging in women with suspected coronary artery diseaseJennifer H Mieres
North Shore University Hospital, Division of Cardiology, 300 Community Drive, Manhasset, NY 11030, USA
Curr Cardiol Rep 6:27-31. 2004..This review discusses the clinical role of stress MPI in the management of women with suspected CAD... - Sequential single-photon emission computed tomography myocardial perfusion imagingLeslee J Shaw
Department of Medicine and Imaging, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Am J Cardiol 96:28J-39J. 2005.... - Comparison of prognostic usefulness of coronary artery calcium in men versus women (results from a meta- and pooled analysis estimating all-cause mortality and coronary heart disease death or myocardial infarction)Antonio Bellasi
Emory University School of Medicine, Atlanta, Georgia, USA
Am J Cardiol 100:409-14. 2007..66), suggesting an equivalent ability to risk stratify by gender. In conclusion, this meta- and pooled analysis revealed that CAC screening is equally accurate in stratifying risk in women and men... - Epidemiologic guidance with coronary artery calcium scoringPaolo Raggi
Division of Cardiology, Emory University School of Medicine, 1365 Clifton Road NE, AT 504, Atlanta, GA 30322, USA
Curr Cardiol Rep 10:60-6. 2008..Coronary artery calcium screening has become a widely used tool to estimate risk in a variety of categories in the general population and is discussed in this review... - A review of electron beam computed tomography: implications for coronary artery disease screeningRita F Redberg
Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143 0124, USA
Prev Cardiol 5:71-8. 2002..Widespread clinical use of EBCT is not recommended, pending data to establish its efficacy in the role of risk factor reduction and prevention of cardiovascular disease... - Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery diseaseSatyendra Giri
Nuclear Cardiology Laboratory, Division of Cardiology, Hartford Hospital, and the Department of Medicine and Nuclear Medicine, University of Connecticut School of Medicine, Farmington, CT 06102-5037, USA
Circulation 105:32-40. 2002..Using stress MPI in conjunction with clinical information can provide risk stratification of diabetic patients... - Early menopause predicts angina after myocardial infarctionSusmita Parashar
Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30306, USA
Menopause 17:938-45. 2010..It is unknown, however, whether early menopause predicts post-myocardial infarction (MI) angina. We examined whether younger AAM increases risk of post-MI angina... - The role of noninvasive testing in the diagnosis and prognosis of women with suspected CADLeslee J Shaw
Cedars-Sinai Medical Center, Los Angeles, CA, USA
J Fam Pract . 2005 - Impact of gender on risk stratification by exercise and dobutamine stress echocardiography: long-term mortality in 4234 women and 6898 menLeslee J Shaw
Cardiovascular Research Institute, 5665 Peachtree Dunwoody Road, Atlanta, GA, USA
Eur Heart J 26:447-56. 2005..The aim of this study was to examine 5-year mortality in 4234 women and 6898 men undergoing exercise or dobutamine stress echocardiography at three hospitals... - Diagnosis of coronary artery disease in womenRita F Redberg
Women's Cardiovascular Services, UCSF National Center for Excellence and School of Medicine, Division of Cardiology, University of California, San Francisco, 94143-0124, USA
Prog Cardiovasc Dis 46:239-58. 2003 - Women and ischemic heart disease: evolving knowledgeLeslee J Shaw
Emory Program in Cardiovascular Outcomes Research and Epidemiology, Emory University School of Medicine, Atlanta, Georgia, USA
J Am Coll Cardiol 54:1561-75. 2009..Continued research is indicated to devise therapeutic regimens to improve symptom burden and reduce risk in women with ischemic heart disease... - Functional versus anatomic imaging in patients with suspected coronary artery diseaseLeslee J Shaw
Emory University School of Medicine, Atlanta, GA 30306, USA
Cardiol Clin 27:597-604. 2009..This article reviews the relative value of anatomical versus functional imaging and their complementary role in different clinical scenarios... - Prognostic value of gated myocardial perfusion SPECTLeslee J Shaw
Atlanta Cardiovascular Research Institute, Atlanta, GA 30342, USA
J Nucl Cardiol 11:171-85. 2004 - Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: Consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, CounJennifer H Mieres
Circulation 111:682-96. 2005.... - Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)B Delia Johnson
Graduate School of Public Health, University of Pittsburgh, Parran 127, 130 DeSoto St, Pittsburgh, PA 15261, USA
Circulation 109:726-32. 2004..However, prior studies have yielded inconsistent results, and the independent predictive value of SAA for coronary artery disease (CAD) severity and cardiovascular events remains unclear... - Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women's Ischemia Syndrome EvaluationOscar C Marroquin
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
Circulation 109:714-21. 2004..Specifically, the metabolic syndrome was found to be a predictor of 4-year cardiovascular risk only when associated with significant angiographic CAD... - Technetium 99m sestamibi myocardial perfusion imaging predicts clinical outcome in the community outpatient setting. The Nuclear Utility in the Community (NUC) StudyGregory S Thomas
Mission Internal Medical Group, Mission Viejo, California 92691, USA
J Am Coll Cardiol 43:213-23. 2004.... - Assessing mature technology: what is the effect of high-quality risk stratification evidence with exercise echocardiography and single-photon emission computed tomography imaging?Leslee J Shaw
J Am Coll Cardiol 49:238-9. 2007 - Value of electrocardiographically gated single-photon emission computed tomographic myocardial perfusion scintigraphy in a cohort of symptomatic postmenopausal womenJennifer H Mieres
New York University School of Medicine, New York, USA
Am J Cardiol 99:1096-9. 2007..001). In conclusion, results of this study indicate high diagnostic and prognostic accuracy for MPS in symptomatic postmenopausal women...