Iqbal Sayeed

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Glibenclamide Administration Attenuates Infarct Volume, Hemispheric Swelling, and Functional Impairments following Permanent Focal Cerebral Ischemia in Rats
    Bushra Wali
    Department of Emergency Medicine, School of Medicine Emory University, Atlanta, GA 30322, USA
    Stroke Res Treat 2012:460909. 2012
  2. doi request reprint Progesterone as a neuroprotective factor in traumatic and ischemic brain injury
    Iqbal Sayeed
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Prog Brain Res 175:219-37. 2009
  3. doi request reprint Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesterone
    Iqbal Sayeed
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res 1263:165-73. 2009
  4. pmc Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats
    Huiling Tang
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Horm Behav 64:527-38. 2013
  5. pmc Progesterone and low-dose vitamin D hormone treatment enhances sparing of memory following traumatic brain injury
    Fang Hua
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Horm Behav 61:642-51. 2012
  6. pmc Progesterone in experimental permanent stroke: a dose-response and therapeutic time-window study
    Bushra Wali
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA, USA
    Brain 137:486-502. 2014
  7. pmc Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection
    Fahim Atif
    Department of Emergency Medicine, Brain Research Laboratory, 1365B Clifton Road NE, Suite 5100, Emory University, Atlanta, GA 30322, USA
    Neuropharmacology 67:78-87. 2013
  8. pmc Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases
    Tauheed Ishrat
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 226:183-90. 2010
  9. pmc Delayed progesterone treatment reduces brain infarction and improves functional outcomes after ischemic stroke: a time-window study in middle-aged rats
    Seema Yousuf
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
    J Cereb Blood Flow Metab 34:297-306. 2014
  10. ncbi request reprint Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion
    Iqbal Sayeed
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Ann Emerg Med 47:381-9. 2006

Collaborators

Detail Information

Publications35

  1. pmc Glibenclamide Administration Attenuates Infarct Volume, Hemispheric Swelling, and Functional Impairments following Permanent Focal Cerebral Ischemia in Rats
    Bushra Wali
    Department of Emergency Medicine, School of Medicine Emory University, Atlanta, GA 30322, USA
    Stroke Res Treat 2012:460909. 2012
    ..Taken together, these data indicate that Glib has strong neuroprotective effects following ischemic stroke and may warrant further testing in future clinical trials for human stroke...
  2. doi request reprint Progesterone as a neuroprotective factor in traumatic and ischemic brain injury
    Iqbal Sayeed
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Prog Brain Res 175:219-37. 2009
    ..These properties make progesterone a unique and compelling natural agent to consider for testing in clinical trial for CNS injuries including TBI and stroke...
  3. doi request reprint Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesterone
    Iqbal Sayeed
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res 1263:165-73. 2009
    ..Our results demonstrate that AP inhibits the mtPTP current. This may help to explain its more potent anti-apoptotic and neuroprotective effects compared to PROG...
  4. pmc Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats
    Huiling Tang
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Horm Behav 64:527-38. 2013
    ..VDH+PROG combination therapy may attenuate some of the potential long-term, subtle, pathophysiological consequences of brain injury in older subjects...
  5. pmc Progesterone and low-dose vitamin D hormone treatment enhances sparing of memory following traumatic brain injury
    Fang Hua
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Horm Behav 61:642-51. 2012
    ..This effect may be one of the mechanisms underlying PROG's neuroprotective effects in combination with VDH...
  6. pmc Progesterone in experimental permanent stroke: a dose-response and therapeutic time-window study
    Bushra Wali
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA, USA
    Brain 137:486-502. 2014
    ..Progesterone shows promise as a potential therapeutic agent and should be examined for safety and efficacy in a clinical trial for ischaemic stroke. ..
  7. pmc Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection
    Fahim Atif
    Department of Emergency Medicine, Brain Research Laboratory, 1365B Clifton Road NE, Suite 5100, Emory University, Atlanta, GA 30322, USA
    Neuropharmacology 67:78-87. 2013
    ..Under specific conditions VDH potentiates P4's neuroprotective efficacy and should be considered as a potential partner of P4 in a low-cost, safe and effective combinatorial treatment for stroke...
  8. pmc Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases
    Tauheed Ishrat
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 226:183-90. 2010
    ..We conclude that PROG and ALLO can help to protect BBB disruption following pMCAO...
  9. pmc Delayed progesterone treatment reduces brain infarction and improves functional outcomes after ischemic stroke: a time-window study in middle-aged rats
    Seema Yousuf
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
    J Cereb Blood Flow Metab 34:297-306. 2014
    ..We conclude that, under the right treatment conditions, PROG treatment delayed up to 6 hours can improve functional deficits and reduce brain infarction, possibly by modulating GFAP, VEGF, and MMP-9 expression. ..
  10. ncbi request reprint Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion
    Iqbal Sayeed
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Ann Emerg Med 47:381-9. 2006
    ..We compare the effects of postinjury administration of allopregnanolone, a metabolite of progesterone, to progesterone in an animal model of transient middle cerebral artery occlusion...
  11. pmc Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone
    Fahim Atif
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
    Mol Med 15:328-36. 2009
    ..In conclusion, the findings of the present study can be taken to suggest that VDH warrants study as a potential partner for combination therapy with PROG...
  12. pmc Progesterone inhibits the growth of human neuroblastoma: in vitro and in vivo evidence
    Fahim Atif
    Departments of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
    Mol Med 17:1084-94. 2011
    ....
  13. pmc Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, 1365B Clifton Rd, Atlanta, GA 30322, USA
    J Neuroinflammation 8:42. 2011
    ..Therefore, in the present study, we examined the genomic profiles of TLR-mediated pathways in traumatically injured brain and PROG's effects on these genes...
  14. pmc Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats
    Tauheed Ishrat
    Department of Emergency Medicine, Brain Research Laboratory, 1365B Clifton Road NE, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res 1257:94-101. 2009
    ..Taken together, these data indicate that PROG is beneficial in one of the best-characterized models of stroke, and may warrant further testing in future clinical trials for human stroke...
  15. pmc Progesterone treatment in two rat models of ocular ischemia
    Rachael S Allen
    Emergency Medicine Emory University, Atlanta, Georgia, United States 2Department of Ophthalmology, Emory University, Atlanta, Georgia, United States 3Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Decatur, Georgia, United States
    Invest Ophthalmol Vis Sci 56:2880-91. 2015
    ..To determine whether the neurosteroid progesterone, shown to have protective effects in animal models of traumatic brain injury, stroke, and spinal cord injury, is also protective in ocular ischemia animal models...
  16. ncbi request reprint Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury
    Huiling Tang
    Department of Emergency Medicine, Emory University, Atlanta, GA, USA
    Brain Inj . 2015
    ..This study tested the hypothesis that PROG and VDH would exert additive and synergistic neuroprotective effects compared with individual treatment by modulating TLR4/NF-κB-mediated inflammation pathways after TBI in rats...
  17. pmc The TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 390:678-83. 2009
    ..Our results demonstrate that the TRIF-dependent signaling pathway is not required for the activation of NF-kappaB signaling and brain injury after acute cerebral I/R...
  18. doi request reprint Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury
    Christopher J MacNevin
    Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 52:6012-23. 2009
    ..The new derivatives demonstrated greatly improved solubility and select compounds have shown equivalent effectiveness to progesterone in reducing cerebral edema after TBI...
  19. ncbi request reprint Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion
    Iqbal Sayeed
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA
    Restor Neurol Neurosci 25:151-9. 2007
    ..Since most cases of human stroke are caused by permanent occlusion of cerebral arteries, we assessed the neuroprotective effects of PROG on cerebral infarction and behavioral deficits in a permanent MCAO (pMCAO) model...
  20. pmc Progesterone attenuates hemorrhagic transformation after delayed tPA treatment in an experimental model of stroke in rats: involvement of the VEGF-MMP pathway
    Soonmi Won
    Department of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
    J Cereb Blood Flow Metab 34:72-80. 2014
    ..The study concluded that PROG may extend the time window for tPA administration in ischemic stroke and reduce hemorrhagic conversion. ..
  21. doi request reprint Improved behavioral outcomes after progesterone administration in aged male rats with traumatic brain injury
    Bushra Wali
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Restor Neurol Neurosci 29:61-71. 2011
    ..The progesterone-treated rats had better functional outcomes than vehicle-treated rats with similar cortical injuries. The neurosteroid treatment did not affect the size of the necrotic cavity...
  22. pmc Deoxygedunin, a natural product with potent neurotrophic activity in mice
    Sung Wuk Jang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS ONE 5:e11528. 2010
    ..Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases...
  23. pmc Progesterone in transient ischemic stroke: a dose-response study
    Seema Yousuf
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, 1365B Clifton Road NE, Suite 5100, Atlanta, GA, 30322, USA
    Psychopharmacology (Berl) 231:3313-23. 2014
    ..Previous studies demonstrate the neuroprotective effects of progesterone in numerous animal injury models, but a systematic dose-response study in a transient ischemic stroke model is lacking...
  24. pmc TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice
    Fang Hua
    1 Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China 2 Institute of Neurological Diseases of Xuzhou Medical College, Xuzhou, China 3 Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Cereb Blood Flow Metab 35:536-42. 2015
    ..We conclude that TAK-242 is able to cross blood-brain barrier, blocks TLR4 signaling, mediates the expression of inflammatory cytokines, and protects the brain from acute damage induced by I/R...
  25. doi request reprint Sex-related differences in effects of progesterone following neonatal hypoxic brain injury
    Bethany L Peterson
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Behav Brain Res 286:152-65. 2015
    ..Progesterone-treated animals showed modest beneficial effects in both sexes compared to vehicle-treated injured animals. Sham animals given progesterone did not behave differently from vehicle-treated sham animals on any measures...
  26. pmc Severity of middle cerebral artery occlusion determines retinal deficits in rats
    Rachael S Allen
    Emergency Medicine, Emory University, Atlanta, GA 30322, USA Ophthalmology, Emory University, Atlanta, GA 30322, USA Electronic address
    Exp Neurol 254:206-15. 2014
    ..Temporary retinal deficits caused by MCAO are likely due to ischemia-induced increases in extracellular glutamate that impair signal conduction, but resolve by 9days after MCAO. ..
  27. pmc Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease
    Milos Cekic
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Front Neuroendocrinol 30:158-72. 2009
    ..The combination of PROG and VDH in pre-clinical and clinical studies is a novel and compelling approach to TBI treatment...
  28. pmc Progesterone Treatment Shows Benefit in Female Rats in a Pediatric Model of Controlled Cortical Impact Injury
    RASTAFA I GEDDES
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322 United States of America
    PLoS ONE 11:e0146419. 2016
    ..Here we investigated progesterone's effects in the same model of brain injury but with pre-pubescent females...
  29. doi request reprint Progesterone improves long-term functional and histological outcomes after permanent stroke in older rats
    Bushra Wali
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA, USA Electronic address
    Behav Brain Res 305:46-56. 2016
    ....
  30. pmc Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via vitamin D receptor-mediated NF-kB signaling pathways
    Soonmi Won
    Department of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 10:e0122821. 2015
    ..Our findings show a direct, VDR-mediated, protective effect of 1,25(OH) )2D3 against ischemic injury-induced blood-brain barrier dysfunction in cerebral endothelial cells. ..
  31. pmc Progesterone protects endothelial cells after cerebrovascular occlusion by decreasing MCP-1- and CXCL1-mediated macrophage infiltration
    Ebony Washington Remus
    Department of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, GA, USA
    Exp Neurol 271:401-8. 2015
    ..The treatment protects ischemic endothelial cells from macrophage infiltration and thus preserves vascularization after ischemic injury...
  32. pmc Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection
    Yu Yo Sun
    From the Department of Pediatrics and Center for Neurodegenerative Diseases, Emory University School of Medicine and Children s Healthcare of Atlanta, Atlanta, GA Y Y S, Y L, J L, C Y K Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA B W, D G S, I S Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA Y L, H M VisualSonics Inc Toronto, ON, Canada A H and Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan K A
    Stroke 46:1947-55. 2015
    ....
  33. ncbi request reprint Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats
    Qingmin Guo
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 198:469-78. 2006
    ..Our results can be taken to show that the expression of AQP4 protein after TBI is time-dependent, region-specific, and possibly implicated in the formation and resolution of TBI-induced cerebral edema...
  34. pmc Progesterone treatment shows benefit in a pediatric model of moderate to severe bilateral brain injury
    RASTAFA I GEDDES
    Department of Emergency Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 9:e87252. 2014
    ..In the present proof-of-concept study we investigated whether progesterone had neuroprotective effects in a pediatric model of moderate to severe bilateral brain injury...
  35. pmc Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death
    Sung Wuk Jang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:16329-34. 2007
    ..Thus, gambogic amide might not only establish a powerful platform for dissection of the physiological roles of NGF and TrkA receptor but also provide effective treatments for neurodegenerative diseases and stroke...