Gloria Salazar

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity
    Gloria Salazar
    Divison of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS ONE 4:e5896. 2009
  2. pmc Peroxisome proliferator-activated receptor γ coactivator-1α is a central negative regulator of vascular senescence
    Shiqin Xiong
    Division of Cardiology, Emory University Hospital, Emory University School of Medicine, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 33:988-98. 2013
  3. ncbi request reprint Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells
    Gloria Salazar
    Department of Cell Biology, Center for Neurodegenerative Disease, and Department of Pathology and Laboratory Medicine, Emory University, 615 Michael Street, Room 446, Atlanta, GA 30322, USA
    J Cell Sci 118:1911-21. 2005
  4. pmc Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
    Karen Newell-Litwa
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 20:1441-53. 2009
  5. pmc Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes
    Rafal Robert Nazarewicz
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:2886-95. 2011
  6. pmc Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic
    Branch Craige
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 19:1415-26. 2008
  7. pmc Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells
    Gloria Salazar
    Department of Cell Biology and Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 284:1790-802. 2009
  8. ncbi request reprint Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: an optical analysis in cultured hippocampal neurons
    Rachal Love
    Department of Cell Biology and The Center for Neurodegenerative Disease, Emory University, 615 Michael Street, Room 446, Atlanta, GA 30322, USA
    Brain Res 1061:1-12. 2005
  9. ncbi request reprint AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells
    Gloria Salazar
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    J Biol Chem 279:25430-9. 2004
  10. ncbi request reprint The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3
    Adam C Berger
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Sci 120:3640-52. 2007

Collaborators

  • Alexa L Mattheyses
  • Jun Guo
  • Marla Gearing
  • Yoland Smith
  • Masuko Ushio-Fukai
  • Juan M Falcon-Perez
  • Shiqin Xiong
  • Nikolay Patrushev
  • Victor Faundez
  • R Wayne Alexander
  • Lula Hilenski
  • Branch Craige
  • Rafal Robert Nazarewicz
  • Stephanie A Zlatic
  • Melanie L Styers
  • Rachal Love
  • Minhui Ma
  • Alejandra San Martin
  • Karen Newell-Litwa
  • Andrew A Peden
  • Adam C Berger
  • Emily J Grossniklaus
  • Pearl V Ryder
  • Farshad Forouzandeh
  • Bonnie Seidel-Rogol
  • Mushtaq Ahmad
  • Anita H Corbett
  • Karen A Newell-Litwa
  • Robert A Maue
  • Erica Werner
  • Andrew P Kowalczyk

Detail Information

Publications18

  1. pmc SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity
    Gloria Salazar
    Divison of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS ONE 4:e5896. 2009
    ..We propose that dityrosine-dependent membrane protein oligomerization may regulate the function of diverse membrane protein in normal and disease states...
  2. pmc Peroxisome proliferator-activated receptor γ coactivator-1α is a central negative regulator of vascular senescence
    Shiqin Xiong
    Division of Cardiology, Emory University Hospital, Emory University School of Medicine, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 33:988-98. 2013
    ..Senescence is associated with telomere and mitochondrial dysfunction and oxidative stress, implying a potential causal role of PGC-1α in senescence pathogenesis...
  3. ncbi request reprint Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells
    Gloria Salazar
    Department of Cell Biology, Center for Neurodegenerative Disease, and Department of Pathology and Laboratory Medicine, Emory University, 615 Michael Street, Room 446, Atlanta, GA 30322, USA
    J Cell Sci 118:1911-21. 2005
    ..Our results suggest that the coupling of zinc transporter 3 and Vglut1 transport mechanisms regulates neurotransmitter content in secretory vesicles...
  4. pmc Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
    Karen Newell-Litwa
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 20:1441-53. 2009
    ..Our results demonstrate that lysosomal and lysosome-related organelle biogenesis mechanisms regulate steady-state synaptic vesicle protein composition from shared early endosomes...
  5. pmc Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes
    Rafal Robert Nazarewicz
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:2886-95. 2011
    ..Thus, EEA1 serves a novel function as an obligate scaffold for Ang II-induced Akt activation in early endosomes...
  6. pmc Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic
    Branch Craige
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 19:1415-26. 2008
    ..We propose a mechanism whereby adaptors use canonical sorting motifs to selectively recruit a regulatory enzymatic activity to restricted membrane domains...
  7. pmc Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells
    Gloria Salazar
    Department of Cell Biology and Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 284:1790-802. 2009
    ..These results suggest that AP-3 and BLOC-1 act, either in concert or sequentially, to specify sorting of PI4KIIalpha along the endocytic route...
  8. ncbi request reprint Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: an optical analysis in cultured hippocampal neurons
    Rachal Love
    Department of Cell Biology and The Center for Neurodegenerative Disease, Emory University, 615 Michael Street, Room 446, Atlanta, GA 30322, USA
    Brain Res 1061:1-12. 2005
    ..These results provide evidence for a new link between cyclooxygenase metabolites and the mechanisms controlling neuronal zinc pools...
  9. ncbi request reprint AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells
    Gloria Salazar
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    J Biol Chem 279:25430-9. 2004
    ..In addition, our findings indicate that ClC-3 and ZnT3 reside in a common vesicle population where they functionally interact to determine vesicle luminal composition...
  10. ncbi request reprint The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3
    Adam C Berger
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Sci 120:3640-52. 2007
    ..These results provide information about how the NP-C proteins are targeted to their sites of action and illustrate the possibility that defective sorting of the NP-C proteins along the endocytic route can alter cellular cholesterol...
  11. pmc Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells
    Nikolay Patrushev
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 7:e33211. 2012
    ..Our studies suggest that zinc might also affect other ROS-dependent processes induced by Ang II, such as hypertrophy and migration of smooth muscle cells...
  12. pmc FoxO1 mediates an autofeedback loop regulating SIRT1 expression
    Shiqin Xiong
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:5289-99. 2011
    ..This signaling network may coordinate multiple pathways acting upon immune, inflammatory, regenerative, and metabolic processes...
  13. pmc The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation
    Gloria Salazar
    Department of Cell Biology, Emory University, Atlanta, Georgia 30322, USA
    Mol Biol Cell 15:575-87. 2004
    ..Our evidence indicates that neuroendocrine cells assemble molecularly heterogeneous SV and suggests that this diversity could contribute to the functional variety of synapses...
  14. pmc Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles
    Gloria Salazar
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:3692-704. 2005
    ..Reduction of the cellular content of PI4KIIalpha strongly decreased the punctate distribution of AP-3 observed in PC12 cells. These results indicate that PI4KIIalpha is present on AP-3 organelles where it regulates AP-3 function...
  15. pmc The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton
    Melanie L Styers
    Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 15:5369-82. 2004
    ..Our results reveal a novel role of the intermediate filament cytoskeleton in organelle/adaptor positioning and in regulation of the adaptor complex AP-3...
  16. doi request reprint Isolation of synaptic vesicles
    Branch Craige
    Emory University, Atlanta, Georgia, USA
    Curr Protoc Cell Biol . 2004
    ..This unit describes two well-characterized and widely used synaptic vesicle isolation procedures that are capable of generating membrane fractions that are 20 to 30 times enriched in synaptic vesicles...
  17. pmc Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis
    Stephanie A Zlatic
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 24:2378-88. 2013
    ....
  18. pmc PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy
    Shiqin Xiong
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:2474-87. 2010
    ..We provide novel mechanistic insights by which Ang II may mediate its ROS-dependent pathophysiologic effects on multiple cardiometabolic diseases...