John Roback

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Metabolomics of ADSOL (AS-1) red blood cell storage
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA Electronic address
    Transfus Med Rev 28:41-55. 2014
  2. ncbi request reprint Evidence-based guidelines for blood transfusion
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    J Infus Nurs 35:187-90. 2012
  3. pmc Impact of quality of evidence on the strength of recommendations: an empirical study
    Benjamin Djulbegovic
    Center for Evidence based Medicine and Health Outcome Research, Clinical Translational Science Institute, Florida, USA
    BMC Health Serv Res 9:120. 2009
  4. doi request reprint Vascular effects of the red blood cell storage lesion
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hematology Am Soc Hematol Educ Program 2011:475-9. 2011
  5. doi request reprint Insufficient nitric oxide bioavailability: a hypothesis to explain adverse effects of red blood cell transfusion
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 51:859-66. 2011
  6. doi request reprint Evidence-based practice guidelines for plasma transfusion
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 50:1227-39. 2010
  7. ncbi request reprint Multicenter evaluation of PCR methods for detecting CMV DNA in blood donors
    J D Roback
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 41:1249-57. 2001
  8. ncbi request reprint The role of photochemical treatment with amotosalen and UV-A light in the prevention of transfusion-transmitted cytomegalovirus infections
    John D Roback
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Transfus Med Rev 20:45-56. 2006
  9. ncbi request reprint Improved method for fluorescence cytometric immunohematology testing
    John D Roback
    Department of Pathology and Laboratory Medicine, Emory Univerity School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 44:187-96. 2004
  10. ncbi request reprint An automatable format for accurate immunohematology testing by flow cytometry
    John D Roback
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Transfusion 43:918-27. 2003

Collaborators

Detail Information

Publications37

  1. pmc Metabolomics of ADSOL (AS-1) red blood cell storage
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA Electronic address
    Transfus Med Rev 28:41-55. 2014
    ....
  2. ncbi request reprint Evidence-based guidelines for blood transfusion
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    J Infus Nurs 35:187-90. 2012
    ..In this article, the author discusses the process of developing the recently published guidelines for plasma transfusion using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) methodology...
  3. pmc Impact of quality of evidence on the strength of recommendations: an empirical study
    Benjamin Djulbegovic
    Center for Evidence based Medicine and Health Outcome Research, Clinical Translational Science Institute, Florida, USA
    BMC Health Serv Res 9:120. 2009
    ..Surprisingly, and despite the widespread penetration of EBM in health care, there has been no empirical research to date investigating the impact of quality of evidence on the strength of recommendations made by guidelines panels...
  4. doi request reprint Vascular effects of the red blood cell storage lesion
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hematology Am Soc Hematol Educ Program 2011:475-9. 2011
    ..If confirmed, the INOBA hypothesis may lead to improved methods for blood storage and collection, as well as new screening and matching tools for blood donors and transfusion recipients...
  5. doi request reprint Insufficient nitric oxide bioavailability: a hypothesis to explain adverse effects of red blood cell transfusion
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 51:859-66. 2011
    ....
  6. doi request reprint Evidence-based practice guidelines for plasma transfusion
    John D Roback
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 50:1227-39. 2010
    ..To address this issue, the AABB commissioned the development of clinical practice guidelines to help direct appropriate transfusion of plasma...
  7. ncbi request reprint Multicenter evaluation of PCR methods for detecting CMV DNA in blood donors
    J D Roback
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 41:1249-57. 2001
    ..However, there is currently no consensus on the optimal assay method for accurate detection of CMV DNA in donors...
  8. ncbi request reprint The role of photochemical treatment with amotosalen and UV-A light in the prevention of transfusion-transmitted cytomegalovirus infections
    John D Roback
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Transfus Med Rev 20:45-56. 2006
    ..Because PCT is a technology that targets nucleic acids, it also offers a proactive process for the inactivation of a broad range of viral, bacterial, and protozoan pathogens in addition to CMV...
  9. ncbi request reprint Improved method for fluorescence cytometric immunohematology testing
    John D Roback
    Department of Pathology and Laboratory Medicine, Emory Univerity School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 44:187-96. 2004
    ..Nevertheless, the use of vacuum filtration to wash RBCs and a standard-flow cytometer for data acquisition hindered efforts to incorporate this method into an automated platform...
  10. ncbi request reprint An automatable format for accurate immunohematology testing by flow cytometry
    John D Roback
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Transfusion 43:918-27. 2003
    ..Furthermore, current automated and semiautomated workstations cannot accommodate many other tests relevant to blood transfusion...
  11. ncbi request reprint CMV and blood transfusions
    John D Roback
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, WMB 2307, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Rev Med Virol 12:211-9. 2002
    ....
  12. ncbi request reprint CMV DNA is rarely detected in healthy blood donors using validated PCR assays
    John D Roback
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 43:314-21. 2003
    ..NAT of blood components for CMV DNA has been proposed to further reduce the risks of TT-CMV. However, large-scale studies to determine the utility of validated CMV NAT assays for donor screening have not been reported...
  13. ncbi request reprint Allogeneic T cells treated with amotosalen prevent lethal cytomegalovirus disease without producing graft-versus-host disease following bone marrow transplantation
    John D Roback
    Department of Pathology and Laboratory Medicine, Transfusion Medicine Program, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 171:6023-31. 2003
    ..Thus, amotosalen treatment rapidly eliminates the GVHD activity of polyclonal T cells, while preserving long-term antiviral and graft facilitation effects, and may be clinically useful for routine adoptive immunotherapy...
  14. pmc Chronic GvHD decreases antiviral immune responses in allogeneic BMT
    Mohammad S Hossain
    Department of Hematology and Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 109:4548-56. 2007
    ..These results indicate that cGvHD causes an intrinsic immunosuppression and explain, in part, the functional immunodeficiency in allogeneic transplant recipients...
  15. ncbi request reprint Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells
    Jeanne E Hendrickson
    Department of Pediatric Hematology Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, Georgia 30322, USA
    Transfusion 46:1526-36. 2006
    ..In this context, it was hypothesized that the inflammatory status of a transfusion recipient would influence immunization to transfused RBCs...
  16. ncbi request reprint Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model
    Cetherine T Jordan
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 44:1159-65. 2004
    ..This study investigated the effects of amotosalen/UVA treatment on free and latent murine CMV (MCMV) in PLT preparations using a murine model of transfusion-transmitted CMV (TT-CMV)...
  17. ncbi request reprint Host and donor immune responses contribute to antiviral effects of amotosalen-treated donor lymphocytes following early posttransplant cytomegalovirus infection
    Mohammad S Hossain
    Department of Hematology and Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 180:6892-902. 2008
    ..Thus, adoptive immunotherapy with treated T cells is a novel therapeutic approach that facilitates hematopoietic engraftment and permits antiviral immunity of both donor and host T cells without graft-vs-host disease...
  18. doi request reprint Hereditary angioedema: current and emerging treatment options
    Jerrold H Levy
    FAHA, Department of Anesthesiology, Emory University Hospital, Atlanta, GA 30322, USA
    Anesth Analg 110:1271-80. 2010
    ..Specific attention is given to the perioperative management of patients with HAE...
  19. ncbi request reprint Transfusion-induced autoantibodies and differential immunogenicity of blood group antigens: a novel hypothesis
    James C Zimring
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 47:2189-96. 2007
    ..The scientific basis, existing evidence, approaches to testing, and predicted biology of this hypothesis are presented...
  20. doi request reprint Discrete Toll-like receptor agonists have differential effects on alloimmunization to transfused red blood cells
    Jeanne E Hendrickson
    Department of Pediatric Hematology Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, Georgia, USA
    Transfusion 48:1869-77. 2008
    ..To determine whether a different subtype of inflammation also enhances RBC alloimmunization, we investigated the effects of the bacterial endotoxin lipopolysaccharide (LPS) on alloimmunization...
  21. ncbi request reprint Facilitating T-cell immune reconstitution after haploidentical transplantation in adults
    Edmund K Waller
    Division of Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Blood Cells Mol Dis 33:233-7. 2004
    ..A planned clinical phase 1 trial of adoptive therapy utilizing ex vivo psoralen-treated donor T-cells in recipients of T-cell-depleted haploidentical HPCT is presented...
  22. ncbi request reprint Effect of mediators of innate immunity and inflammation on CD8+ veto cells
    James C Zimring
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Woodruff Memorial Building, Room 7301, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Transplantation 78:1597-600. 2004
    ..Unlike other strategies, veto cells promote long-term allograft survival in primates. Accordingly, the authors hypothesized that veto cells are resistant to the effects of innate immune activation...
  23. ncbi request reprint Amotosalen-treated donor T cells have polyclonal antigen-specific long-term function without graft-versus-host disease after allogeneic bone marrow transplantation
    Mohammad Sohrab Hossain
    Department of Hematology and Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory Universiy School of Medicine, Atlanta, Georgia, USA
    Biol Blood Marrow Transplant 11:169-80. 2005
    ..This is a novel approach to adoptive immunotherapy in allogeneic BMT...
  24. ncbi request reprint Separating antiviral and GVHD activities of donor T cells prior to bone marrow transplantation
    Catherine T Jordan
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Immunol Res 29:209-18. 2004
    ..Emphasis is placed on whether these approaches can simultaneously transfer broad-spectrum immunity to the recipient without producing GVHD...
  25. ncbi request reprint Nonhemolytic antibody-induced loss of erythrocyte surface antigen
    James C Zimring
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Woodruff Memorial Bldg Ste 7301, 101 Woodruff Cir, Atlanta, GA 30322, USA
    Blood 106:1105-12. 2005
    ..These studies provide mechanistic insight into the phenomenon of antigen loss during incompatible transfusion in humans...
  26. ncbi request reprint Description and investigation of white particulate matter in additive solution-1 red blood cell units
    Christopher D Hillyer
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Transfusion 44:977-83. 2004
    ..In this report, these events, their chronology, pertinent observations and investigations, and summaries and conclusions associated with WPM during the 2-week observation period are described...
  27. ncbi request reprint Comparison of cytomegalovirus polymerase chain reaction and serology for screening umbilical cord blood components
    John D Roback
    Transfusion Medicine Program, The Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Transfusion 45:1722-8. 2005
    ..To prevent CMV transmission from UCB donors, most laboratories perform serology on corresponding maternal samples and quarantine units when the mother has immunoglobulin M (IgM) anti-CMV...
  28. pmc Latent cytomegalovirus infection exacerbates experimental colitis
    Chukwuma Onyeagocha
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 175:2034-42. 2009
    ..Thus, underlying CMV infection can alter mucosal immunity, potentially increasing the tendency of CMV-infected hosts to develop colitis...
  29. ncbi request reprint Inflammation enhances consumption and presentation of transfused RBC antigens by dendritic cells
    Jeanne E Hendrickson
    Department of Pediatric Hematology Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, GA 30322, USA
    Blood 110:2736-43. 2007
    ..Together, these data provide additional insight into the nature of transfused RBCs as an immunogen and provide a mechanism by which viral-like inflammation enhances alloimmunization to transfused RBCs...
  30. ncbi request reprint Transfusion-transmitted cytomegalovirus (CMV) infections in a murine model: characterization of CMV-infected donor mice
    John D Roback
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 46:889-95. 2006
    ..The kinetics of murine CMV (MCMV) infection in the peripheral blood of donor mice were investigated to determine the utility of this model for studying TT-CMV...
  31. ncbi request reprint Transfusion medicine illustrated. Detection of mixed-field agglutination due to loss of red cell antigen in hematopoietic malignancy
    Chelsea A Sheppard
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 46:1463-4. 2006
  32. doi request reprint Quantitation of human herpesvirus 8 (HHV-8) antibody in patients transfused with HHV-8-seropositive blood
    Ashley L Fowlkes
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Transfusion 49:2208-13. 2009
    ..It was observed that several HHV-8-seronegative patients were unexpectedly HHV-8 seropositive after blood transfusion...
  33. ncbi request reprint Leukoreduction filtration of blood with sickle cell trait
    Audrey N Schuetz
    Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Transfus Med Rev 18:168-76. 2004
    ..This review concludes with a discussion of different approaches to screening blood units for sickle cell trait...
  34. ncbi request reprint Transfusion-transmitted cytomegalovirus: lessons from a murine model
    John D Roback
    Department of Pathology and Laboratory Medicine, Transfusion Medicine Program, Emory University School of Medicine, Atlanta, GA 30322, USA
    Transfus Med Rev 21:26-36. 2007
    ..In this review, we discuss a mouse blood transfusion model, which can be used to investigate these issues as well as to validate methods to prevent TT-CMV in at-risk patients...
  35. ncbi request reprint Posttransplant thrombopoiesis predicts survival in patients undergoing autologous hematopoietic progenitor cell transplantation
    Mary J Ninan
    Atlanta Medical Center, Atlanta, Georgia 30322, USA
    Biol Blood Marrow Transplant 13:895-904. 2007
    ....
  36. ncbi request reprint Towards the prevention of transfusion-transmitted infectious diseases
    Audrey Schuetz
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Expert Rev Anti Infect Ther 1:267-74. 2003
    ..This review summarizes these advances in an historical context, describes new methodologies on the horizon, and discusses residual infectious risks associated with blood transfusion...
  37. ncbi request reprint Optimizing the timing of chemotherapy for mobilizing autologous blood hematopoietic progenitor cells
    Michelle L Hicks
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Transfusion 47:629-35. 2007
    ..Postchemotherapy mobilization results were reviewed in patients undergoing apheresis before planned autologous hematopoietic progenitor cell (HPC) transplantation to improve the timing of collection procedures...

Research Grants11

  1. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2002
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  2. Adverse effects of RBC transfusions: A unifying hypothesis
    John Roback; Fiscal Year: 2009
    ..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..
  3. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
    ..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. ..
  4. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ....
  5. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2005
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  6. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2004
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  7. Rapid quantitation of residual WBCs in filtered blood
    John Roback; Fiscal Year: 2004
    ....
  8. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2004
    ..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
  9. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2003
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  10. Adverse effects of RBC transfusions: A unifying hypothesis
    John D Roback; Fiscal Year: 2010
    ..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..