Kerry Ressler

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Prepulse inhibition deficits in GAD65 knockout mice and the effect of antipsychotic treatment
    Scott A Heldt
    Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA
    Neuropsychopharmacology 29:1610-9. 2004
  2. pmc Beta-catenin is required for memory consolidation
    Kimberly A Maguschak
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Howard Hughes Medical Institute, Emory University, Atlanta, Georgia 30329, USA
    Nat Neurosci 11:1319-26. 2008
  3. pmc The Use of Lentiviral Vectors and Cre/loxP to Investigate the Function of Genes in Complex Behaviors
    Scott A Heldt
    Howard Hughes Medical Institute, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University Atlanta, GA, USA
    Front Mol Neurosci 2:22. 2009
  4. pmc Substance use, childhood traumatic experience, and Posttraumatic Stress Disorder in an urban civilian population
    Lamya Khoury
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Depress Anxiety 27:1077-86. 2010
  5. pmc Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning
    D C Choi
    Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA
    Transl Psychiatry 2:e205. 2012
  6. pmc Civilian PTSD symptoms and risk for involvement in the criminal justice system
    Sachiko Donley
    Department of Psychiatry and Behavioral Sciences, Emory University, 954 Gatewood Drive, Atlanta, GA 30329, USA
    J Am Acad Psychiatry Law 40:522-9. 2012
  7. pmc Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Am J Med Genet B Neuropsychiatr Genet 153:812-24. 2010
  8. ncbi request reprint Regulation of synaptic plasticity genes during consolidation of fear conditioning
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 22:7892-902. 2002
  9. pmc Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, Georgia 30329, USA
    Nat Neurosci 10:1116-24. 2007
  10. pmc Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
    Kerry J Ressler
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
    Nature 470:492-7. 2011

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Prepulse inhibition deficits in GAD65 knockout mice and the effect of antipsychotic treatment
    Scott A Heldt
    Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA
    Neuropsychopharmacology 29:1610-9. 2004
    ..These results lend support to the view that abnormalities in GABAergic systems might contribute to the basic pathophysiological mechanisms in schizophrenia...
  2. pmc Beta-catenin is required for memory consolidation
    Kimberly A Maguschak
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Howard Hughes Medical Institute, Emory University, Atlanta, Georgia 30329, USA
    Nat Neurosci 11:1319-26. 2008
    ..This suggests a general role for beta-catenin in the synaptic remodeling and stabilization underlying long-term memory in adults...
  3. pmc The Use of Lentiviral Vectors and Cre/loxP to Investigate the Function of Genes in Complex Behaviors
    Scott A Heldt
    Howard Hughes Medical Institute, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University Atlanta, GA, USA
    Front Mol Neurosci 2:22. 2009
    ..These conditional gene targeting strategies provide useful tools to study the endogenous mechanisms underlying complex behaviors and to model disease states resulting from aberrant gene expression...
  4. pmc Substance use, childhood traumatic experience, and Posttraumatic Stress Disorder in an urban civilian population
    Lamya Khoury
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Depress Anxiety 27:1077-86. 2010
    ..The present study further examines this relationship between childhood trauma, substance use, and PTSD in a sample of urban primary care patients...
  5. pmc Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning
    D C Choi
    Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA
    Transl Psychiatry 2:e205. 2012
    ..Deficiencies were rescued by the novel TrkB agonist 7,8-dihydroxyflavone, indicating that PL BDNF expression and downstream signaling through the TrkB receptor are required for memory formation in both appetitive and aversive domains...
  6. pmc Civilian PTSD symptoms and risk for involvement in the criminal justice system
    Sachiko Donley
    Department of Psychiatry and Behavioral Sciences, Emory University, 954 Gatewood Drive, Atlanta, GA 30329, USA
    J Am Acad Psychiatry Law 40:522-9. 2012
    ..Trauma and PTSD have important implications for public safety and recidivism...
  7. pmc Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Am J Med Genet B Neuropsychiatr Genet 153:812-24. 2010
    ....
  8. ncbi request reprint Regulation of synaptic plasticity genes during consolidation of fear conditioning
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 22:7892-902. 2002
    ....
  9. pmc Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, Georgia 30329, USA
    Nat Neurosci 10:1116-24. 2007
    ..Although many of these approaches are experimental, the rapidly developing understanding of emotional circuit regulation is likely to provide exciting and powerful future treatments for debilitating mood and anxiety disorders...
  10. pmc Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
    Kerry J Ressler
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
    Nature 470:492-7. 2011
    ..These sex-specific effects may occur via oestrogen regulation of ADCYAP1R1. PACAP levels and ADCYAP1R1 SNPs may serve as useful biomarkers to further our mechanistic understanding of PTSD...
  11. pmc Acute and posttraumatic stress symptoms in a prospective gene x environment study of a university campus shooting
    Kristina B Mercer
    School of Medicine, Emory University, Atlanta, Georgia, USA
    Arch Gen Psychiatry 69:89-97. 2012
    ..The ability to detect meaningful associations is largely dependent on reliable measures of preexisting trauma...
  12. pmc Risk and resilience: genetic and environmental influences on development of the stress response
    Charles F Gillespie
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Depress Anxiety 26:984-92. 2009
    ....
  13. pmc Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD
    Tanja Jovanovic
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 35:846-57. 2010
    ..These results suggest that impaired fear inhibition and associated alterations in HPA feedback may reflect amygdala hyperactivity in subjects with PTSD...
  14. pmc Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice
    Scott A Heldt
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Neurosci 30:7139-51. 2010
    ....
  15. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
    ..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability...
  16. pmc Amygdala BDNF signaling is required for consolidation but not encoding of extinction
    Jasmeer P Chhatwal
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, Georgia 30322, USA
    Nat Neurosci 9:870-2. 2006
    ..Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories...
  17. pmc Learning and memory deficits in mice lacking protease activated receptor-1
    Antoine G Almonte
    Department of Pharmacology, Emory University, School of Medicine, Atlanta, GA, USA
    Neurobiol Learn Mem 88:295-304. 2007
    ..These data suggest that PAR1 may play an important role in emotionally motivated learning...
  18. doi request reprint Validity of prototype diagnosis for mood and anxiety disorders
    Jared A DeFife
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    JAMA Psychiatry 70:140-8. 2013
    ....
  19. pmc Trauma exposure and stress-related disorders in inner city primary care patients
    Charles F Gillespie
    Departments of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gen Hosp Psychiatry 31:505-14. 2009
    ..This study was undertaken to increase understanding of environmental risk factors for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) within an urban, impoverished, population...
  20. pmc Learning-dependent structural plasticity in the adult olfactory pathway
    Seth V Jones
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Howard Hughes Medical Institute, Emory University, Atlanta, Georgia 30329, USA
    J Neurosci 28:13106-11. 2008
    ..These data indicate that the primary sensory neuron population and its projections may remain plastic in adults, providing a structural mechanism for learning-enhanced olfactory sensitivity and discrimination...
  21. ncbi request reprint Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning
    Lisa M Rattiner
    Emory University School of Medicine, Center for Behavioral Neuroscience, Yerkes Research Center, Atlanta, Georgia 30329, USA
    J Neurosci 24:4796-806. 2004
    ..T1 lentivirus blocked fear acquisition without disrupting baseline startle or expression of fear. These data suggest that BDNF signaling through TrkB receptors in the amygdala is required for the acquisition of conditioned fear...
  22. pmc Differential regional expression of brain-derived neurotrophic factor following olfactory fear learning
    Seth V Jones
    Department of Psychiatry and Behavioral Sciences, Yerkes Research Center, Emory University, Atlanta, Georgia 30329, USA
    Learn Mem 14:816-20. 2007
    ..We propose that odor exposure increases expression of BDNF in the OB and APC while the PPC and BLA increase BDNF mRNA only when associative learning occurs...
  23. pmc Emotional learning and glutamate: translational perspectives
    Charles F Gillespie
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA
    CNS Spectr 10:831-9. 2005
    ..Glutamate appears to have a central role in both of these processes. The authors review this literature and discuss novel applications of D-cycloserine, a partial N-methyl-D-aspartate agonist, for the treatment of anxiety...
  24. ncbi request reprint Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction
    Jasmeer P Chhatwal
    Department of Psychiatry and Behavioral Sciences and Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 25:502-6. 2005
    ....
  25. pmc Distinct subtypes of cholecystokinin (CCK)-containing interneurons of the basolateral amygdala identified using a CCK promoter-specific lentivirus
    Aaron M Jasnow
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Yerkes Research Center, Emory University School of Medicine, Atlanta, Georgia, USA
    J Neurophysiol 101:1494-506. 2009
    ..These data suggest that CCK interneurons of the BLA are a heterogeneous population and may be functionally distinct subpopulations that differentially contribute to the processing of emotionally salient stimuli...
  26. doi request reprint Construction of cell-type specific promoter lentiviruses for optically guiding electrophysiological recordings and for targeted gene delivery
    Aaron M Jasnow
    Yerkes Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Methods Mol Biol 515:199-213. 2009
    ..We find a high degree of cell-type specificity in vivo using lentiviral approaches in rats and mice...
  27. pmc Anxiolytic-like effects of the neurokinin 1 receptor antagonist GR-205171 in the elevated plus maze and contextual fear-potentiated startle model of anxiety in gerbils
    Scott A Heldt
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Behav Pharmacol 20:584-95. 2009
    ....
  28. pmc Childhood abuse is associated with increased startle reactivity in adulthood
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Depress Anxiety 26:1018-26. 2009
    ..The acoustic startle response (ASR) is a subcortical reflex modulated by neural systems implicated in posttraumatic stress disorder (PTSD). The ASR is conserved across species and is increased in rodent models of developmental stress...
  29. pmc Differing effects of systemically administered rapamycin on consolidation and reconsolidation of context vs. cued fear memories
    EBONY M GLOVER
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30302, USA
    Learn Mem 17:577-81. 2010
    ..p.). Thus, while rapamycin may prove useful in retarding the development of some PTSD-associated memories, its relative ineffectiveness against cued fear memories may limit its clinical usefulness...
  30. ncbi request reprint The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology
    Elizabeth I Martin
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    Clin Lab Med 30:865-91. 2010
    ..The goal of this article is to describe the key biological similarities and differences between anxiety disorders...
  31. pmc The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology
    Elizabeth I Martin
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    Psychiatr Clin North Am 32:549-75. 2009
    ..The goal of this article is to describe the key biological similarities and differences between anxiety disorders...
  32. ncbi request reprint Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Arch Gen Psychiatry 67:369-79. 2010
    ..The corticotropin-releasing factor (CRF, or corticotropin-releasing hormone) and arginine vasopressin systems have been implicated in the pathophysiology of anxiety and depressive disorders and response to antidepressant treatment...
  33. pmc How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 167:648-62. 2010
    ..The authors also discuss different pharmacological approaches that enhance fear inhibition and may improve treatment outcomes for patients with PTSD...
  34. pmc Impaired fear inhibition is a biomarker of PTSD but not depression
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303
    Depress Anxiety 27:244-51. 2010
    ..Given the high comorbidity between PTSD and depression, our goal was to see whether this impairment is specific to PTSD, or a non-specific symptom associated with both disorders...
  35. pmc Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy
    Michael Davis
    Emory University School of Medicine, Center for Behavioral Neuroscience, and the Yerkes National Primate Center, Atlanta, Georgia 30329, USA
    NeuroRx 3:82-96. 2006
    ..It is concluded that extinction is an excellent model system for the study of fear inhibition and an indispensable tool for the screening of putative pharmacotherapies for clinical use...
  36. ncbi request reprint Brain-derived neurotrophic factor in amygdala-dependent learning
    Lisa M Rattiner
    Emory University School of Medicine, Department of Psychiatry, Center for Behavioral Neuroscience, Atlanta, Georgia 30329, USA
    Neuroscientist 11:323-33. 2005
    ..The focus is primarily on the use of Pavlovian fear conditioning as a learning model that allows for the examination of the role of BDNF in the amygdala, following a single learning session and within a well-understood neural circuit...
  37. pmc Different mechanisms of fear extinction dependent on length of time since fear acquisition
    Karyn M Myers
    Center for Behavioral Neuroscience, Emory University Atlanta, Georgia 30329, USA
    Learn Mem 13:216-23. 2006
    ..These data support a model in which different neural mechanisms are recruited depending on the temporal delay of fear extinction...
  38. pmc Localized injections of midazolam into the amygdala and hippocampus induce differential changes in anxiolytic-like motor activity in mice
    Scott A Heldt
    Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329, USA
    Behav Pharmacol 17:349-56. 2006
    ....
  39. pmc Pain medication use among patients with posttraumatic stress disorder
    Ann C Schwartz
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Psychosomatics 47:136-42. 2006
    ..The authors conclude that there may be a relationship between PTSD and use of pain medications warranting further examination of the endogenous opiate system in the pathophysiology of PTSD...
  40. pmc Olfactory-mediated fear conditioning in mice: simultaneous measurements of fear-potentiated startle and freezing
    Seth V Jones
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Behav Neurosci 119:329-35. 2005
    ..Furthermore, mice were able to discriminate between an odor paired with shock and a nonreinforced odor (Experiment 4)...
  41. pmc Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:13672-6. 2004
    ..These data demonstrate the successful heterologous surface expression of a functional wild-type OR and reveal that persistent physical association with other GPCRs can control OR surface expression...
  42. pmc Training-induced changes in the expression of GABAA-associated genes in the amygdala after the acquisition and extinction of Pavlovian fear
    Scott A Heldt
    Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Eur J Neurosci 26:3631-44. 2007
    ....
  43. pmc Lesions of the habenula produce stress- and dopamine-dependent alterations in prepulse inhibition and locomotion
    Scott A Heldt
    Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes Research Center, Emory University, 954 Gatewood Dr, Atlanta, GA 30329, USA
    Brain Res 1073:229-39. 2006
    ..Lesioned animals also showed diminished activity at baseline, with hyperlocomotion following apomorphine. These data support the hypothesis that the habenula may be normally involved in stress-dependent regulation of monoamine systems...
  44. pmc Treatment barriers for low-income, urban African Americans with undiagnosed posttraumatic stress disorder
    Regina G Davis
    Department of Psychiatry, Emory University, Grady Memorial Hospital, Atlanta, GA, USA
    J Trauma Stress 21:218-22. 2008
    ..These data highlight the need for an awareness of the high prevalence of trauma and PTSD in this population...
  45. ncbi request reprint Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats
    David L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 22:2343-51. 2002
    ..These results indicate that treatments that promote NMDA receptor activity after either systemic or intra-amygdala administration promote the extinction of conditioned fear...
  46. ncbi request reprint Posttraumatic stress disorder among African Americans in an inner city mental health clinic
    Ann C Schwartz
    Emory University School of Medicine, Atlanta, Georgia, USA
    Psychiatr Serv 56:212-5. 2005
    ..PTSD is a common yet underrecognized and undertreated source of psychiatric morbidity in this urban community of African Americans with low socioeconomic status...
  47. pmc Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity
    Seth D Norrholm
    Atlanta Veterans Affairs Medical Center, Mental Health Service Line, Decatur, Georgia, USA
    Biol Psychiatry 69:556-63. 2011
    ..On the basis of our earlier findings, we employed an established fear extinction paradigm to further explore fear dysregulation in a civilian traumatized population...
  48. ncbi request reprint Effects of D-cycloserine on extinction: translation from preclinical to clinical work
    Michael Davis
    Emory University School of Medicine, Department of Psychiatry, Atlanta, Georgia 30329, USA
    Biol Psychiatry 60:369-75. 2006
    ....
  49. ncbi request reprint Genetics of childhood disorders: L. Learning and memory, part 3: fear conditioning
    Kerry Ressler
    Department of Psychiatry and Behavioral Science, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA, USA
    J Am Acad Child Adolesc Psychiatry 42:612-5. 2003
  50. ncbi request reprint Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
    Jasmeer P Chhatwal
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Yerkes Research Center, Atlanta, GA 30329, USA
    Neuropsychopharmacology 30:516-24. 2005
    ....
  51. pmc Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype
    Xingshun Xu
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:19126-31. 2010
    ..Our findings suggest that impaired endocytic sorting and increased degradation of TrkB can induce depression and that this impaired pathway may serve as a previously uncharacterized therapeutic target for depression...
  52. ncbi request reprint Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA, USA
    Arch Gen Psychiatry 61:1136-44. 2004
    ..However, some disorders, particularly the anxiety-related disorders exemplified by specific phobia, have an emotional learning component to them that can be facilitated with psychotherapy...
  53. pmc The role of neuropeptide Y in the expression and extinction of fear-potentiated startle
    Alisa R Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine and Center for Behavioral Neuroscience, Atlanta, Georgia 30329, USA
    J Neurosci 28:12682-90. 2008
    ..We believe that the role of NPY in the extinction of conditioned fear may, at least in part, explain the mechanism underlying the association between NPY and psychobiological resilience in humans...
  54. ncbi request reprint Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning
    Lisa M Rattiner
    Emory University School of Medicine, Center for Behavioral Neuroscience, Yerkes Research Center, Atlanta, Georgia 30329, USA
    Learn Mem 11:727-31. 2004
    ..These results provide the first evidence of differential splicing and/or differential BDNF promoter usage in response to a behaviorally relevant learning paradigm...
  55. doi request reprint Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning
    Jasmeer P Chhatwal
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Neuropsychopharmacology 34:509-21. 2009
    ..Together, these data suggest that interactions between the endocannabinoid and CCKergic transmitter systems may underlie the process of extinction of conditioned fear...
  56. pmc Psychological resilience and neurocognitive performance in a traumatized community sample
    Aliza P Wingo
    Departments of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Depress Anxiety 27:768-74. 2010
    ..Therefore, we assessed association between neurocognitive performance and resilience in individuals with a history of childhood abuse or trauma exposure...
  57. pmc Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear
    Dennis C Choi
    Department of Psychiatry and Behavioral Sciences, Howard Hughes Medical Institute, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:2675-80. 2010
    ..Moreover, use of site-specific, inducible BDNF deletions shows a powerful mechanism that may further our understanding of the pathophysiology of fear-related disorders...
  58. pmc Modulation of fear and anxiety by the endogenous cannabinoid system
    Jasmeer P Chhatwal
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
    CNS Spectr 12:211-20. 2007
    ..Preclinical studies suggest that these may provide important emerging targets for new treatments of anxiety disorders...
  59. pmc Attachment anxiety moderates the relationship between childhood maltreatment and attention bias for emotion in adults
    Jennifer S Davis
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA Electronic address
    Psychiatry Res 217:79-85. 2014
    ....
  60. pmc Virtual reality exposure therapy using a virtual Iraq: case report
    Maryrose Gerardi
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    J Trauma Stress 21:209-13. 2008
    ..1990) and the PTSD Symptom Scale Self-Report (PSS-SR; Foa, Riggs, Dancu, & Rothbaum, 1993). These results indicate preliminary promise for this treatment...
  61. ncbi request reprint Treating posttraumatic stress disorder in urban African American mental health patients
    Ann Schwartz
    Emory University School of Medicine, USA
    J Am Psychoanal Assoc 52:464-5. 2004
  62. pmc The protective role of friendship on the effects of childhood abuse and depression
    Abigail Powers
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Depress Anxiety 26:46-53. 2009
    ..This study explored the relationships between childhood maltreatment (sexual, physical, and emotional abuse, as well as neglect), adult depression, and perceived social support from family and friends...
  63. pmc RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory
    Sarah Emerson Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:16994-8. 2010
    ..These results demonstrate that RGS14 is a key regulator of signaling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory but distinct from the canonical DG-CA3-CA1 circuit...
  64. pmc Deoxygedunin, a natural product with potent neurotrophic activity in mice
    Sung Wuk Jang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS ONE 5:e11528. 2010
    ..Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases...
  65. ncbi request reprint Specificity of olfactory receptor interactions with other G protein-coupled receptors
    Cristina F Bush
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:19042-51. 2007
    ..These studies shed light on the specificity of OR interactions with other GPCRs and the mechanisms governing olfactory receptor trafficking...
  66. pmc Effect of Childhood Trauma on Adult Depression and Neuroendocrine Function: Sex-Specific Moderation by CRH Receptor 1 Gene
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine Atlanta, GA, USA
    Front Behav Neurosci 3:41. 2009
    ..Gender differences in environmental exposures could thus be reflected in sex-specific CRHR1 x child abuse interactions...
  67. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
    ..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...

Research Grants12

  1. Genetic and Trauma-Related Risk Factors for PTSD
    Kerry Ressler; Fiscal Year: 2005
    ....
  2. Molecular Regulation of GABA(A) Receptor Function in Amygdala
    Kerry J Ressler; Fiscal Year: 2010
    ..Understanding the mechanisms shared by stress and drug response is critical for understanding pathophysiology and proposing new treatments for these highly comorbid disorders. ..
  3. Genetic and Trauma-Related Risk Factors for PTSD
    Kerry Ressler; Fiscal Year: 2009
    ....
  4. Molecular Regulation of GABA(A) Receptor Function in Amygdala
    Kerry Ressler; Fiscal Year: 2009
    ..Understanding the mechanisms shared by stress and drug response is critical for understanding pathophysiology and proposing new treatments for these highly comorbid disorders. ..
  5. Genetic and Trauma-Related Risk Factors for PTSD
    Kerry Ressler; Fiscal Year: 2007
    ....
  6. Molecular Regulation of GABAalpha Function in Amygdala
    Kerry Ressler; Fiscal Year: 2007
    ..Understanding the mechanisms shared by stress and drug response is critical for understanding pathophysiology and proposing new treatments for these highly comorbid disorders. ..
  7. Synaptic Plasticity and Extinction of Fear
    Kerry Ressler; Fiscal Year: 2007
    ..Emory University and the Center for Behavioral Neuroscience provide an excellent environment for career development and training in the field of behavioral neuroscience. ..
  8. Molecular Regulation of GABA(A) Receptor Function in Amygdala
    Kerry Ressler; Fiscal Year: 2006
    ..Understanding the mechanisms shared by stress and drug response is critical for understanding pathophysiology and proposing new treatments for these highly comorbid disorders. ..
  9. Genetic and Trauma-Related Risk Factors for PTSD
    Kerry Ressler; Fiscal Year: 2006
    ....
  10. Genetic and Trauma-Related Risk Factors for Posttraumatic Stress Disorder
    Kerry J Ressler; Fiscal Year: 2010
    ....