Research Topics
Species | Suresh S RamalingamSummaryAffiliation: Emory University Country: USA Publications
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Publications
Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignanciesSuresh S Ramalingam
Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 13:3605-10. 2007..The primary objective of this study was to determine the recommended phase II doses of the novel histone deacetylase inhibitor vorinostat when administered in combination with carboplatin and paclitaxel...
Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results databaseTaofeek K Owonikoko
Emory Winship Cancer Institute, 1365 Clifton Rd, Ste C 5090, Atlanta, GA 30322, USA
J Clin Oncol 25:5570-7. 2007..To study the burden and outcome of lung cancer in the elderly, particularly for patients aged 80 years and older...
Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancerSuresh S Ramalingam
Winship Cancer Institute, Emory University, 1365 Clifton Rd NE, Suite C 3090, Atlanta, GA 30322, USA
J Clin Oncol 30:3337-44. 2012....
Phase II study of Cediranib (AZD 2171), an inhibitor of the vascular endothelial growth factor receptor, for second-line therapy of small cell lung cancer (National Cancer Institute #7097)Suresh S Ramalingam
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Thorac Oncol 5:1279-84. 2010..We evaluated the safety and efficacy of cediranib, a potent small molecule inhibitor of the vascular endothelial growth factor receptor, in patients with refractory or recurrent small cell lung cancer (SCLC)...
Phase I study of vorinostat in patients with advanced solid tumors and hepatic dysfunction: a National Cancer Institute Organ Dysfunction Working Group studySuresh S Ramalingam
Emory University, Winship Cancer Institute, Atlanta, GA 30322, USA
J Clin Oncol 28:4507-12. 2010..We conducted a phase I study to determine the maximum-tolerated dose and pharmacokinetics of vorinostat in patients with hepatic dysfunction...
Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancerSuresh S Ramalingam
Emory University, Winship Cancer Institute, 1365 Clifton Rd, C 3090, Atlanta, GA 30322, USA
J Clin Oncol 28:56-62. 2010..CONCLUSION Vorinostat enhances the efficacy of carboplatin and paclitaxel in patients with advanced NSCLC. HDAC inhibition is a promising therapeutic strategy for treatment of NSCLC...
Cetuximab for the treatment of advanced bronchioloalveolar carcinoma (BAC): an Eastern Cooperative Oncology Group phase II study (ECOG 1504)Suresh S Ramalingam
Emory University, Winship Cancer Institute, Atlanta, GA, USA
J Clin Oncol 29:1709-14. 2011..We conducted a phase II study to evaluate cetuximab for the treatment of advanced BAC...
Bortezomib for patients with advanced-stage bronchioloalveolar carcinoma: a California Cancer Consortium Phase II study (NCI 7003)Suresh S Ramalingam
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA
J Thorac Oncol 6:1741-5. 2011..Bortezomib, a proteasome inhibitor, has demonstrated objective responses in patients with BAC in early-phase clinical trials. We conducted a phase II study of bortezomib in patients with advanced-stage BAC...
The role of the taxanes in the treatment of older patients with advanced stage non-small cell lung cancerSuresh S Ramalingam
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Oncologist 14:412-24. 2009..In addition to the available evidence, prospective evaluation of novel agents in elderly-specific or -enriched studies is necessary to guide the treatment of older patients with NSCLC...
Phase II study of belinostat (PXD101), a histone deacetylase inhibitor, for second line therapy of advanced malignant pleural mesotheliomaSuresh S Ramalingam
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA
J Thorac Oncol 4:97-101. 2009..This class of compounds has demonstrated anticancer activity in malignant mesothelioma. We conducted a phase II study of belinostat in patients with relapsed malignant pleural mesothelioma...
Randomized phase II study of erlotinib in combination with placebo or R1507, a monoclonal antibody to insulin-like growth factor-1 receptor, for advanced-stage non-small-cell lung cancerSuresh S Ramalingam
Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA
J Clin Oncol 29:4574-80. 2011..The strong preclinical evidence supporting coinhibition of IGF-1R and epidermal growth factor receptor (EGFR) as anticancer therapy prompted this study...
Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599Suresh S Ramalingam
Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA
J Clin Oncol 26:60-5. 2008..We conducted a subset analysis of ECOG 4599 to determine the outcome for elderly patients...
A phase I study of 17-allylamino-17-demethoxygeldanamycin combined with paclitaxel in patients with advanced solid malignanciesSuresh S Ramalingam
Authors Affiliations Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Clin Cancer Res 14:3456-61. 2008..We conducted a phase I study in patients with advanced malignancies to determine the recommended phase II dose of the combination of 17-AAG and paclitaxel...
The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivoHui Ren
Department of Respiration, First Affiliated Hospital of Medical College of Xi an Jiaotong University, Shaanxi, PR China
Cancer Lett 325:139-46. 2012..Collectively, we suggest that the combination of RAD001 and BKM120 may be an effective regimen for treatment of lung cancer, hence warranting further evaluation of the combination in the clinic...
Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cellsTaofeek K Owonikoko
University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Int J Cancer 126:743-55. 2010..This likely involves a vorinostat-mediated irreversible increase in DNA damage in the case of carboplatin and a reversible increase in microtubule stability in the case of paclitaxel...
Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancerSuresh S Ramalingam
Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia 30322, USA
Cancer 116:3903-9. 2010..The authors conducted a phase 1 and pharmacokinetic study of everolimus and docetaxel for recurrent NSCLC...
Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagyCheng Xiong Xu
Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA
Cancer Biol Ther 12:549-55. 2011..Thus, induction of autophagy by BEZ235 appears to be a survival mechanism that may counteract its anticancer effects. Based on these, we suggest a strategy to enhance BEZ235's anticancer efficacy by blockade of autophagy...
Cetuximab in combination with carboplatin and docetaxel for patients with metastatic or advanced-stage nonsmall cell lung cancer: a multicenter phase 2 studyChandra P Belani
Department of Medicine, Penn State Hershey Medical Center, Penn State Cancer Institute, Hershey, Pennsylvania 17033 0850, USA
Cancer 113:2512-7. 2008..Therefore, a phase 2 study was conducted to evaluate the efficacy of the combination of cetuximab, carboplatin, and docetaxel for the treatment of advanced NSCLC...
A systematic analysis of efficacy of second-line chemotherapy in sensitive and refractory small-cell lung cancerTaofeek K Owonikoko
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Thorac Oncol 7:866-72. 2012..Potential differences in the efficacy of second-line therapy for refractory and sensitive SCLC have not been well studied...
Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumorsRamesh K Ramanathan
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Oncol 28:1520-6. 2010..To define the maximum tolerated dose, toxicities, pharmacokinetics, and pharmacodynamics of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17DMAG)...
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancerYikun Li
Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA
Cancer Biol Ther 13:272-80. 2012..Taken together, we suggest that elevated eIF4E in NSCLC cells is associated with proliferation, invasion and acquired erlotinib resistance...
A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protection in patients with locally advanced stage III non-small-cell lung cancerAhmad A Tarhini
University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Hum Gene Ther 22:336-42. 2011..There were no dose-limiting toxicities reported in all three dosing tiers. It is concluded that the oral administration of MnSOD PL is feasible and safe. The phase II recommended dose is 30 mg...
Maintenance therapy for advanced non-small cell lung cancer: current status, controversies, and emerging consensusTaofeek K Owonikoko
Emory University Winship Cancer Institute, Atlanta, Georgia, USA
Clin Cancer Res 16:2496-504. 2010..This article reviews recent data with maintenance therapy in advanced NSCLC and discusses the implications for routine patient care and future drug development...
The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivoCheng Xiong Xu
Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, United States of America
PLoS ONE 6:e20899. 2011..Taken together, our results suggest that the combination of RAD001 and BEZ235 is a novel strategy for cancer therapy...
Gender-associated differences in lung cancer: clinical characteristics and treatment outcomes in womenSeema Harichand-Herdt
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Semin Oncol 36:572-80. 2009..This article reviews the gender-related differences in clinical and pathologic factors and outcomes of patients with lung cancer observed in population-based studies and clinical trials...
Targeted therapy for the treatment of non-small cell lung cancer: focus on inhibition of epidermal growth factor receptorSeema Harichand-Herdt
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA
Semin Thorac Cardiovasc Surg 20:217-23. 2008..This article reviews the role of currently available and emerging EGFR inhibitors in the treatment of NSCLC...
Farnesyl transferase expression determines clinical response to the docetaxel-lonafarnib combination in patients with advanced malignanciesJohn Kauh
Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA
Cancer 117:4049-59. 2011..This pilot study evaluated the biological effects of LNF and docetaxel (DTX) combination therapy in refractory solid tumors by comparing pretreatment and post-treatment tumor biopsies...
Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacyXuerong Wang
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Biol Ther 7:1952-8. 2008..Thus, we suggest a therapeutic strategy for enhancing mTOR-targeted cancer therapy by preventing mTOR inhibition-induced feedback activation of several survival mechanisms...
Single agent maintenance therapy for advanced stage non-small cell lung cancer: a meta-analysisMadhusmita Behera
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, GA, USA
Lung Cancer 77:331-8. 2012..Maintenance therapy is a new treatment paradigm for advanced non-small cell lung cancer (NSCLC). We conducted a meta-analysis of randomized studies with single agent maintenance therapy...
Soluble FAS ligand as a biomarker of disease recurrence in differentiated thyroid cancerTaofeek K Owonikoko
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia
Cancer 119:1503-11. 2013..For this study, the authors assessed the association of cellular-based and serum-based immunologic mediators with thyroid cancer recurrence...
Combined inhibition of vascular endothelial growth factor and epidermal growth factor signaling in non-small-cell lung cancer therapySuchita Pakkala
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Clin Lung Cancer 10:S17-23. 2009..Another novel agent, XL647, has demonstrated promising single-agent activity in patients who have been resistant to previous anti-EGFR therapy. Further evaluation of combined EGFR and VEGF inhibition is under investigation...
Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissuesSongqing Fan
Department of Hematology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Biol Ther 8:1463-9. 2009..05). Collectively, these findings suggest that p-eIF4E may play a critical role in cancer development, particularly early stages of tumorigenesis and support p-eIF4E as a good cancer therapeutic target...
Lung cancer: New biological insights and recent therapeutic advancesSuresh S Ramalingam
Department of Hematology and Medical Oncology and the Winship Cancer Institute, Emory University, Atlanta, GA, USA
CA Cancer J Clin 61:91-112. 2011..This article reviews the major strides made in the treatment of lung cancer in the recent past...
Survival analysis of patients with stage I non-small-cell lung cancer using clinical and DNA repair pathway expression variablesMadhusmita Behera
Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA
Clin Lung Cancer 14:128-38. 2013..Lung cancer is the leading cause of cancer-related mortality. Understanding patient attributes that enhance survival and predict recurrence is necessary to individualize treatment options...
Phase II study of docetaxel in combination with everolimus for second- or third-line therapy of advanced non-small-cell lung cancerSuresh S Ramalingam
Department of Hematology and Medical Oncology, Emory University, Winship Cancer Institute, 1365 Clifton Road NE, Atlanta, GA 30322, USA
J Thorac Oncol 8:369-72. 2013..01) but not with progression-free survival or overall survival. The combination of everolimus and docetaxel was tolerated well, but the efficacy was relatively modest in an unselected population of patients with NSCLC...
Human immunodeficiency virus-associated lung cancer in the era of highly active antiretroviral therapySuchita Pakkala
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia, USA
Cancer 118:164-72. 2012..Because highly active antiretroviral therapy (HAART) has improved the survival of patients with human immunodeficiency virus (HIV), the authors evaluated lung cancer outcomes in the HAART era...
Phase 2 study of irinotecan and paclitaxel in patients with recurrent or refractory small cell lung cancerSuresh S Ramalingam
Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA
Cancer 116:1344-9. 2010..Irinotecan and paclitaxel are active as single agents and exhibit preclinical synergy in SCLC cell lines. A phase 2 study was conducted to evaluate this combination in patients with recurrent or refractory SCLC...
The role of cetuximab in the management of non-small-cell lung cancerTaofeek K Owonikoko
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Clin Lung Cancer 10:230-8. 2009..This article reviews the clinical data with cetuximab in NSCLC...
c-Myc Suppression of DNA Double-strand Break RepairZhaozhong Li
Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, GA
Neoplasia 14:1190-202. 2012....
Statistical learning methods as a preprocessing step for survival analysis: evaluation of concept using lung cancer dataMadhusmita Behera
Department of Hematology and Medical Oncology, Emory University, Winship Cancer Institute, 1365 Clifton Road NE, Rm C 3090, Atlanta, GA 30322, USA
Biomed Eng Online 10:97. 2011..Statistical learning (SL) techniques can address non-linear relationships and small datasets but do not provide an output that has an epidemiologic interpretation...
Antiangiogenic agents in the treatment of nonsmall cell lung cancer: reality and hopeSuresh S Ramalingam
Emory University, Winship Cancer Institute, Atlanta, Georgia, USA
Curr Opin Oncol 22:79-85. 2010..This review will provide the relevant interventions targeted against specific angiogenesis pathways with or without known effective therapies for nonsmall cell lung cancer (NSCLC)...
Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expressionLatha Dhandapani
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA
Cancer Res 71:5245-54. 2011..Taken together, our findings establish that ATRA accentuates TRAIL-induced apoptosis, reveal a novel mechanism by which retinoids modulate apoptosis, and suggest a novel strategy to augment the anti-cancer activity of TRAIL...
Recent advances in the treatment of malignant pleural mesotheliomaSuresh S Ramalingam
Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia, USA
J Thorac Oncol 3:1056-64. 2008..It is hoped that the HDAC inhibitors and other novel targeted agents will pave the way for improved outcomes for patients with this disease...
The biology and clinical features of non-small cell lung cancers with EML4-ALK translocationRathi N Pillai
Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA
Curr Oncol Rep 14:105-10. 2012..This article reviews the characteristics, treatment, and ongoing research in patients with ALK-positive NSCLC...
Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinasesQi Qi
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 287:6113-27. 2012..Hence, combinatorial inhibition of EGFR and PKCs might provide proof of concept in developing therapeutic agents for treating malignant glioma and other human cancers...
Lung cancer in HIV-positive patientsSuchita Pakkala
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia, USA
J Thorac Oncol 5:1864-71. 2010..This article reviews the impact of HIV on the incidence, risk factors, clinical presentation, and treatment of lung cancer...
CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLCRathi N Pillai
Department of Hematology and Oncology, Emory University, Atlanta, Georgia 30322, USA
Clin Cancer Res 19:1603-11. 2013..Results were validated in an additional 20 patients who received taxane-based chemotherapy at Emory University Hospital and the Atlanta VAMC...
Monoclonal antibodies versus tyrosine kinase inhibitors concurrent with chemotherapy in non-small-cell lung cancer: exploring divergent resultsPrimo N Lara
Clin Lung Cancer 9:141-3. 2008
