Research Topics
| Charles RaisonSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
The neuroimmunology of stress and depressionC L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30335, USA
Semin Clin Neuropsychiatry 6:277-94. 2001....
Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depressionCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Arch Gen Psychiatry 67:1211-24. 2010..However, MDD may be so prevalent in the modern world not just because proinflammatory factors are widespread, but also because we have lost contact with previously available sources of anti-inflammatory, immunoregulatory signaling...- Association of peripheral inflammatory markers with chronic fatigue in a population-based sampleCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365C Clifton Road, Room 5004, Atlanta, GA 30322, USA
Brain Behav Immun 23:327-37. 2009..These findings support a role for innate immune activation in unexplained fatigue and unwellness, but do not suggest that immune activation is specific to CFS... 
Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behaviorC L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Psychiatry 15:535-47. 2010..However, given the lack of correlation between HPA axis and immune measures, the mechanism by which chronic cytokine exposure influences HPA axis function remains to be determined...- Is depression an inflammatory disorder?Charles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365C Clifton Road, Fifth Floor, Atlanta, GA 30322, USA
Curr Psychiatry Rep 13:467-75. 2011..Finally, the treatment implications of these various possibilities are discussed... - Neuropsychiatric adverse effects of interferon-alpha: recognition and managementCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
CNS Drugs 19:105-23. 2005..When this occurs, IFN alpha and antidepressants should be stopped, an emergency psychiatric consultation should be obtained, and treatment with a mood stabilizer should be initiated... - IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis CMatthias Majer
Department of Psychiatry and Behavioural Sciences, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
Brain Behav Immun 22:870-80. 2008..Motor slowing and its correlation with psychiatric symptoms suggest that altered basal ganglia function may contribute to the pathogenesis of IFN-alpha-induced behavioural changes... - Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depressionCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
Biol Psychiatry 65:296-303. 2009..Moreover, the relationship among IFN-alpha-associated CNS inflammatory responses, neurotransmitter metabolism, and behavior has yet to be established... - Inflammation and its discontents: the role of cytokines in the pathophysiology of major depressionAndrew H Miller
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 65:732-41. 2009.... - Depression in cancer: new developments regarding diagnosis and treatmentCharles L Raison
Mind-Body Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 54:283-94. 2003..Finally, recent data suggest that aggressive treatment strategies initiated before inflammation-inducing cancer treatments might prevent behavioral alterations, including depression, before they occur... - Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findingsKeizo Yoshida
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Neuropsychobiology 52:55-61. 2005..Defining relevant risk factors for IFN-alpha-induced depression is essential for designing preventative treatment strategies... - Psychiatric comorbidity in persons with chronic fatigue syndrome identified from the Georgia populationUrs M Nater
Chronic Viral Diseases Branch, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Psychosom Med 71:557-65. 2009..Previous studies in CFS patients from primary and tertiary care clinics have found high rates of psychiatric disturbance, but this may reflect referral bias rather than true patterns of comorbidity with CFS... - Innate immune, neuroendocrine and behavioral responses to psychosocial stress do not predict subsequent compassion meditation practice timeThaddeus W W Pace
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Center, 1365C Clifton Road, Atlanta, GA 30322, USA
Psychoneuroendocrinology 35:310-5. 2010.... - Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and predictionCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
J Clin Psychiatry 66:41-8. 2005..All of these factors can be evaluated and addressed to limit neuropsychiatric morbidity during HCV treatment... - Cytokines sing the blues: inflammation and the pathogenesis of depressionCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
Trends Immunol 27:24-31. 2006..These findings suggest that targeting proinflammatory cytokines and their signaling pathways might represent a novel strategy to treat depression... - Depressive symptoms and viral clearance in patients receiving interferon-alpha and ribavirin for hepatitis CCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Brain Behav Immun 19:23-7. 2005.... - Shattered Shangri-la: differences in depressive and anxiety symptoms in students born in Tibet compared to Tibetan students born in exileDabney Evans
Institute of Human Rights, Emory University, Atlanta, GA, USA
Soc Psychiatry Psychiatr Epidemiol 43:429-36. 2008..However, it is not known whether depressive and anxiety symptoms are more prevalent in these refugees than in ethnic Tibetans born and raised in the relative political and social stability of exile communities in North India and Nepal... - When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disordersCharles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
Am J Psychiatry 160:1554-65. 2003..Emphasis on insufficient glucocorticoid signaling in stress-related pathology encourages development of therapeutic strategies to enhance glucocorticoid signaling pathways... - Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapyLucile Capuron
Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am J Psychiatry 160:1342-5. 2003..CONCLUSIONS: The HPA axis response to the acute administration of IFN-alpha reveals a vulnerability to IFN-alpha-induced depression, possibly due to sensitization of corticotropin-releasing factor pathways... - Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stressThaddeus W W Pace
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365C Clifton Road, Atlanta, GA 30322, USA
Psychoneuroendocrinology 34:87-98. 2009.... - Ribavirin may be an important factor in IFN-induced neuropsychiatric effectsGregory M Asnis
J Clin Psychiatry 65:581; author reply 581-2. 2004
Research Grants
- Glucocorticoid Resistance in Immune-Based DepressionCharles Raison; Fiscal Year: 2006....
- Cytokine-CRH Interactions in IFN-alfa-Induced DepressionCharles Raison; Fiscal Year: 2007..abstract_text> ..
- Cytokine-CRH Interactions in IFN-alfa-Induced DepressionCharles Raison; Fiscal Year: 2009..abstract_text> ..
- Mechanisms of MeditationCharles Raison; Fiscal Year: 2009..e. vascular disease, diabetes, cancer, HIV, major depression) to which meditation is being increasingly applied as an intervention. ..
- Mechanisms of MeditationCharles Raison; Fiscal Year: 2010..e. vascular disease, diabetes, cancer, HIV, major depression) to which meditation is being increasingly applied as an intervention. ..
- Mechanisms of MeditationCharles Raison; Fiscal Year: 2009....