Charles Raison

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint The neuroimmunology of stress and depression
    C L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30335, USA
    Semin Clin Neuropsychiatry 6:277-94. 2001
  2. pmc Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 67:1211-24. 2010
  3. doi request reprint Association of peripheral inflammatory markers with chronic fatigue in a population-based sample
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365C Clifton Road, Room 5004, Atlanta, GA 30322, USA
    Brain Behav Immun 23:327-37. 2009
  4. pmc Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior
    C L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Psychiatry 15:535-47. 2010
  5. pmc Is depression an inflammatory disorder?
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365C Clifton Road, Fifth Floor, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 13:467-75. 2011
  6. pmc Neuropsychiatric adverse effects of interferon-alpha: recognition and management
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    CNS Drugs 19:105-23. 2005
  7. pmc IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C
    Matthias Majer
    Department of Psychiatry and Behavioural Sciences, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Brain Behav Immun 22:870-80. 2008
  8. pmc Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 65:296-303. 2009
  9. pmc Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:732-41. 2009
  10. ncbi request reprint Depression in cancer: new developments regarding diagnosis and treatment
    Charles L Raison
    Mind Body Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:283-94. 2003

Research Grants

  1. Glucocorticoid Resistance in Immune-Based Depression
    Charles Raison; Fiscal Year: 2006
  2. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2007
  3. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2009
  4. Mechanisms of Meditation
    Charles Raison; Fiscal Year: 2009
  5. Mechanisms of Meditation
    Charles Raison; Fiscal Year: 2010
  6. Mechanisms of Meditation
    Charles Raison; Fiscal Year: 2009

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The neuroimmunology of stress and depression
    C L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30335, USA
    Semin Clin Neuropsychiatry 6:277-94. 2001
    ....
  2. pmc Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 67:1211-24. 2010
    ..However, MDD may be so prevalent in the modern world not just because proinflammatory factors are widespread, but also because we have lost contact with previously available sources of anti-inflammatory, immunoregulatory signaling...
  3. doi request reprint Association of peripheral inflammatory markers with chronic fatigue in a population-based sample
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365C Clifton Road, Room 5004, Atlanta, GA 30322, USA
    Brain Behav Immun 23:327-37. 2009
    ..These findings support a role for innate immune activation in unexplained fatigue and unwellness, but do not suggest that immune activation is specific to CFS...
  4. pmc Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior
    C L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Psychiatry 15:535-47. 2010
    ..However, given the lack of correlation between HPA axis and immune measures, the mechanism by which chronic cytokine exposure influences HPA axis function remains to be determined...
  5. pmc Is depression an inflammatory disorder?
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365C Clifton Road, Fifth Floor, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 13:467-75. 2011
    ..Finally, the treatment implications of these various possibilities are discussed...
  6. pmc Neuropsychiatric adverse effects of interferon-alpha: recognition and management
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    CNS Drugs 19:105-23. 2005
    ..When this occurs, IFN alpha and antidepressants should be stopped, an emergency psychiatric consultation should be obtained, and treatment with a mood stabilizer should be initiated...
  7. pmc IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C
    Matthias Majer
    Department of Psychiatry and Behavioural Sciences, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Brain Behav Immun 22:870-80. 2008
    ..Motor slowing and its correlation with psychiatric symptoms suggest that altered basal ganglia function may contribute to the pathogenesis of IFN-alpha-induced behavioural changes...
  8. pmc Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 65:296-303. 2009
    ..Moreover, the relationship among IFN-alpha-associated CNS inflammatory responses, neurotransmitter metabolism, and behavior has yet to be established...
  9. pmc Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:732-41. 2009
    ....
  10. ncbi request reprint Depression in cancer: new developments regarding diagnosis and treatment
    Charles L Raison
    Mind Body Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:283-94. 2003
    ..Finally, recent data suggest that aggressive treatment strategies initiated before inflammation-inducing cancer treatments might prevent behavioral alterations, including depression, before they occur...
  11. ncbi request reprint Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings
    Keizo Yoshida
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Neuropsychobiology 52:55-61. 2005
    ..Defining relevant risk factors for IFN-alpha-induced depression is essential for designing preventative treatment strategies...
  12. doi request reprint Psychiatric comorbidity in persons with chronic fatigue syndrome identified from the Georgia population
    Urs M Nater
    Chronic Viral Diseases Branch, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Psychosom Med 71:557-65. 2009
    ..Previous studies in CFS patients from primary and tertiary care clinics have found high rates of psychiatric disturbance, but this may reflect referral bias rather than true patterns of comorbidity with CFS...
  13. pmc Innate immune, neuroendocrine and behavioral responses to psychosocial stress do not predict subsequent compassion meditation practice time
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Center, 1365C Clifton Road, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 35:310-5. 2010
    ....
  14. pmc Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:41-8. 2005
    ..Newer, pegylated preparations of IFN-alpha have a longer half-life, require once-per-week dosing, and may be associated with reduced neuropsychiatric burden. Limited data exist on depression during pegylated IFN-alpha therapy...
  15. pmc Cytokines sing the blues: inflammation and the pathogenesis of depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Trends Immunol 27:24-31. 2006
    ..These findings suggest that targeting proinflammatory cytokines and their signaling pathways might represent a novel strategy to treat depression...
  16. ncbi request reprint Depressive symptoms and viral clearance in patients receiving interferon-alpha and ribavirin for hepatitis C
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Brain Behav Immun 19:23-7. 2005
    ....
  17. doi request reprint Shattered Shangri-la: differences in depressive and anxiety symptoms in students born in Tibet compared to Tibetan students born in exile
    Dabney Evans
    Institute of Human Rights, Emory University, Atlanta, GA, USA
    Soc Psychiatry Psychiatr Epidemiol 43:429-36. 2008
    ..However, it is not known whether depressive and anxiety symptoms are more prevalent in these refugees than in ethnic Tibetans born and raised in the relative political and social stability of exile communities in North India and Nepal...
  18. ncbi request reprint When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Psychiatry 160:1554-65. 2003
    ....
  19. ncbi request reprint Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Psychiatry 160:1342-5. 2003
    ..The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment...
  20. pmc Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365C Clifton Road, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 34:87-98. 2009
    ....
  21. ncbi request reprint Ribavirin may be an important factor in IFN-induced neuropsychiatric effects
    Gregory M Asnis
    J Clin Psychiatry 65:581; author reply 581-2. 2004

Research Grants9

  1. Glucocorticoid Resistance in Immune-Based Depression
    Charles Raison; Fiscal Year: 2006
    ....
  2. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2007
    ..abstract_text> ..
  3. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2009
    ..abstract_text> ..
  4. Mechanisms of Meditation
    Charles Raison; Fiscal Year: 2009
    ..e. vascular disease, diabetes, cancer, HIV, major depression) to which meditation is being increasingly applied as an intervention. ..
  5. Mechanisms of Meditation
    Charles Raison; Fiscal Year: 2010
    ..e. vascular disease, diabetes, cancer, HIV, major depression) to which meditation is being increasingly applied as an intervention. ..
  6. Mechanisms of Meditation
    Charles Raison; Fiscal Year: 2009
    ....