Bali Pulendran

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
    Troy Querec
    Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA
    J Exp Med 203:413-24. 2006
  2. pmc Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus
    Marcin Kwissa
    Vaccine Research Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Exp Med 204:2733-46. 2007
  3. pmc Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets
    Murali Gururajan
    Vaccine Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 2:e863. 2007
  4. pmc Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes
    Bali Pulendran
    Emory Vaccine Center, 954 Gatewood Rd, Atlanta, GA 30329, USA
    J Infect Dis 198:500-7. 2008
  5. ncbi request reprint 2008: A MyD88 O, DC
    Bali Pulendran
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Immunity 29:173-5. 2008
  6. ncbi request reprint Translating innate immunity into immunological memory: implications for vaccine development
    Bali Pulendran
    Department of Pathology, Emory Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Cell 124:849-63. 2006
  7. ncbi request reprint Modulating vaccine responses with dendritic cells and Toll-like receptors
    Bali Pulendran
    Department of Pathology and Emory Vaccine Center, Atlanta, GA 30329, USA
    Immunol Rev 199:227-50. 2004
  8. ncbi request reprint Variegation of the immune response with dendritic cells and pathogen recognition receptors
    Bali Pulendran
    Emory Vaccine Center and Department of Pathology, Emory University, Atlanta, GA 30329, USA
    J Immunol 174:2457-65. 2005
  9. ncbi request reprint Modulating TH1/TH2 responses with microbes, dendritic cells, and pathogen recognition receptors
    Bali Pulendran
    Department of Pathology and Emory Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Immunol Res 29:187-96. 2004
  10. pmc Division of labor, plasticity, and crosstalk between dendritic cell subsets
    Bali Pulendran
    Emory Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Curr Opin Immunol 20:61-7. 2008

Detail Information

Publications72

  1. pmc Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
    Troy Querec
    Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA
    J Exp Med 203:413-24. 2006
    ..Together, these data enhance our understanding of the molecular mechanism of action of YF-17D, and highlight the potential of vaccination strategies that use combinations of different TLR ligands to stimulate polyvalent immune responses...
  2. pmc Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus
    Marcin Kwissa
    Vaccine Research Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Exp Med 204:2733-46. 2007
    ..Viral loads were inversely correlated with the magnitude and quality of the immune response. Thus, the immunogenicity of DNA vaccines can be augmented with TLR9-L plus FL...
  3. pmc Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets
    Murali Gururajan
    Vaccine Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 2:e863. 2007
    ..Furthermore, the expression and functional relevance of TLRs on distinct subsets of B cells, which are known to play differential roles in humoral responses is not known...
  4. pmc Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes
    Bali Pulendran
    Emory Vaccine Center, 954 Gatewood Rd, Atlanta, GA 30329, USA
    J Infect Dis 198:500-7. 2008
    ..The mechanisms underlying such events remain a mystery. Here, we present an analysis of the immunologic and genetic factors driving disease in a 64-year-old male who developed viscerotropic symptoms...
  5. ncbi request reprint 2008: A MyD88 O, DC
    Bali Pulendran
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Immunity 29:173-5. 2008
    ..These mice demonstrate that the requirement for Toll-like receptor (TLR) signaling in DCs is dependent on the physical form of the TLR ligand...
  6. ncbi request reprint Translating innate immunity into immunological memory: implications for vaccine development
    Bali Pulendran
    Department of Pathology, Emory Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Cell 124:849-63. 2006
    ..In addition, we point out unanswered questions and identify critical challenges, the solution of which, we believe, will greatly facilitate the rational design of novel vaccines against a multitude of emerging infections...
  7. ncbi request reprint Modulating vaccine responses with dendritic cells and Toll-like receptors
    Bali Pulendran
    Department of Pathology and Emory Vaccine Center, Atlanta, GA 30329, USA
    Immunol Rev 199:227-50. 2004
    ..As such, DCs and TLRs represent attractive immune modulatory targets for vaccinologists. The present review provides a summary of emerging themes in the biology DCs and TLRs, with a particular focus on relevance for vaccine development...
  8. ncbi request reprint Variegation of the immune response with dendritic cells and pathogen recognition receptors
    Bali Pulendran
    Emory Vaccine Center and Department of Pathology, Emory University, Atlanta, GA 30329, USA
    J Immunol 174:2457-65. 2005
    ....
  9. ncbi request reprint Modulating TH1/TH2 responses with microbes, dendritic cells, and pathogen recognition receptors
    Bali Pulendran
    Department of Pathology and Emory Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Immunol Res 29:187-96. 2004
    ..Thus, nature appears to have evolved different mechanisms to regulate immune responses via DCs...
  10. pmc Division of labor, plasticity, and crosstalk between dendritic cell subsets
    Bali Pulendran
    Emory Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Curr Opin Immunol 20:61-7. 2008
    ..Here we review the recent advances in this area...
  11. ncbi request reprint Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent CD8+ Tc1 responses in vivo
    Bali Pulendran
    Emory Vaccine Center, Atlanta, GA 30329, USA
    Eur J Immunol 34:66-73. 2004
    ..Together, these data suggest that IL-15 promotes the development of DC, which induce potent Th1 and Tc1 responses in vivo. This suggests potential roles for these IL-15 DC cells in the immunotherapy of tumors and infectious diseases...
  12. ncbi request reprint Immune activation: death, danger and dendritic cells
    Bali Pulendran
    Emory Vaccine Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Curr Biol 14:R30-2. 2004
    ..New evidence indicates that these cells also sense uric acid crystals in dead cells, suggesting that the immune system is conscious not only of pathogens, but also of death and danger...
  13. ncbi request reprint A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells
    Stephanie Dillon
    Vaccine Research Center, Emory University, Atlanta, GA 30329, USA
    J Immunol 172:4733-43. 2004
    ..Interestingly, DCs from c-fos(-/-) mice produce more IL-12(p70), but less IL-10, compared with control DCs. Therefore, different TLR ligands induce distinct cytokines and signaling in DCs, and differentially bias Th responses in vivo...
  14. pmc The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling
    Hua Tang
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:608-17. 2010
    ..Thus, the T(H)2 response to cysteine proteases requires DC-basophil cooperation via ROS-mediated signaling...
  15. pmc Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance
    Stephanie Dillon
    Emory Vaccine Research Center and Department of Pathology, Emory University, Atlanta, Georgia 30329, USA
    J Clin Invest 116:916-28. 2006
    ..These data suggest several targets for pharmacological modulation of immune responses in various clinical settings...
  16. pmc Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine
    Santhakumar Manicassamy
    Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Science 329:849-53. 2010
    ..Thus, beta-catenin signaling programs DCs to a tolerogenic state, limiting the inflammatory response...
  17. pmc Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
    Troy D Querec
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Immunol 10:116-25. 2009
    ..A distinct signature, including B cell growth factor TNFRS17, predicted the neutralizing antibody response with up to 100% accuracy. These data highlight the utility of systems biology approaches in predicting vaccine efficacy...
  18. ncbi request reprint CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling
    Ross W B Lindsay
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:1513-21. 2010
    ..Taken together, these data demonstrate a critical role for CD11c(+) DCs for CD8 responses but striking redundancy for innate cytokines and signaling by TLR and nucleotide-binding oligomerization domain-like receptor pathways...
  19. pmc Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity
    Brian A Norris
    Vaccine Research Center, Emory University, Atlanta, GA 30329, USA
    Immunity 38:309-21. 2013
    ..The reduction of monocytic cells in Ccr2(-/-) mice or after Gr-1 antibody depletion enhanced antiviral T cell function. Thus, innate cells have an important immunomodulatory role throughout chronic infection...
  20. ncbi request reprint Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos
    Sudhanshu Agrawal
    Emory Vaccine Center, Atlanta, GA 30329, USA
    J Immunol 171:4984-9. 2003
    ..Thus, distinct TLR agonists differentially modulate extracellular signal-regulated kinase signaling, c-Fos activity, and cytokine responses in DCs to stimulate different Th responses...
  21. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
    ..Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques...
  22. pmc Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates
    Marcin Kwissa
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Blood 119:2044-55. 2012
    ..Finally, both TLR9-L and TLR7/8-L induced the expression of genes related to chemokines and type-I IFNs in LNs. Thus different TLR-Ls mediate distinct signatures of early innate responses both locally and systemically...
  23. pmc Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
    Santhakumar Manicassamy
    Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Med 15:401-9. 2009
    ..These data define a new mechanism for the systemic induction of retinoic acid and immune suppression against autoimmunity...
  24. ncbi request reprint Understanding the role of innate immunity in the mechanism of action of the live attenuated Yellow Fever Vaccine 17D
    Troy D Querec
    Department of Pathology and Emory Vaccine Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Adv Exp Med Biol 590:43-53. 2007
  25. ncbi request reprint Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    Timothy L Denning
    Vaccine Research Center and Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Nat Immunol 8:1086-94. 2007
    ..This IL-17 production was suppressed by lamina propria macrophages, indicating that a dynamic interaction between these subsets may influence the balance between immune activation and tolerance...
  26. ncbi request reprint ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis
    Anshu Agrawal
    Emory Vaccine Center and Department of Pathology, 954 Gatewood Road, Atlanta, GA 30329, USA
    J Immunol 176:5788-96. 2006
    ..Taken together, our data suggest that deficiency of ERK1 biases the immune response toward Th1 resulting in increased susceptibility to EAE...
  27. pmc Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation
    Rajesh Ravindran
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Science 343:313-7. 2014
    ..These results reveal an unappreciated link between virus-induced integrated stress response in dendritic cells and the adaptive immune response. ..
  28. pmc Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid
    Richard M Dunham
    Division of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 190:2009-16. 2013
    ..Thus, we conclude that HSCs preferentially generate Foxp3(+) Tregs and, therefore, may play a role in the tolerogenic nature of the liver...
  29. pmc Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway
    Weiping Cao
    Emory Vaccine Center, Atlanta, GA 30329, USA
    Nat Immunol 9:1157-64. 2008
    ..Thus, mTOR signaling is crucial in TLR-mediated IFN-alpha/beta responses by pDCs...
  30. ncbi request reprint Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin
    Anshu Agrawal
    Emory Vaccine Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nature 424:329-34. 2003
    ..These data suggest a role for LT in suppressing host immunity during B. anthracis infections, and represent an immune evasion strategy, where a microbe targets MAP kinases in dendritic cells to disarm the immune response...
  31. pmc Molecular signatures of antibody responses derived from a systems biology study of five human vaccines
    Shuzhao Li
    1 Emory Vaccine Center, Emory University, Atlanta, Georgia, USA 2 Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA 3
    Nat Immunol 15:195-204. 2014
    ..Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling. ..
  32. pmc Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization
    Timothy L Denning
    Vaccine Research Center, Emory University, Atlanta, GA 30329, USA
    J Immunol 187:733-47. 2011
    ..Thus, the functional specializations of APC subsets in the intestine are dependent on the T cell/APC ratio, regional localization, and source of the mouse strain...
  33. pmc Systems vaccinology: learning to compute the behavior of vaccine induced immunity
    Helder I Nakaya
    Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA
    Wiley Interdiscip Rev Syst Biol Med 4:193-205. 2012
    ..Here, we review the recent advances in this area, and highlight the biological and computational challenges posed...
  34. pmc Systems biology of vaccination for seasonal influenza in humans
    Helder I Nakaya
    Emory Vaccine Center, Emory University, Atlanta, Georgia, USA
    Nat Immunol 12:786-95. 2011
    ..Thus, systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines...
  35. ncbi request reprint Programming dendritic cells to induce T(H)2 and tolerogenic responses
    Bali Pulendran
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:647-55. 2010
    ....
  36. pmc Immunological mechanisms of vaccination
    Bali Pulendran
    Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Nat Immunol 12:509-17. 2011
    ..Here we will discuss these advances and emerging themes on the immunology of vaccination...
  37. ncbi request reprint Hexa-acylation and KDO(2)-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid A for human monocyte derived dendritic cells
    Susu Zughaier
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, VAMC 151 I, 1670 Clairmont Road, Atlanta, GA 30033, USA
    Vaccine 24:1291-7. 2006
    ....
  38. pmc Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults
    Jaikumar Duraiswamy
    Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA
    J Immunol 186:4200-12. 2011
    ..In conclusion, our study shows that most PD-1(hi) CD8 T cells in healthy adult humans are effector memory cells rather than exhausted cells...
  39. pmc New paradigms in type 2 immunity
    Bali Pulendran
    Department of Pathology, Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Science 337:431-5. 2012
    ....
  40. doi request reprint Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology
    Bali Pulendran
    Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA
    Nat Rev Immunol 9:741-7. 2009
    ..Here I review how these developments are yielding insights into the mechanism of action of the yellow fever vaccine, one of the most successful vaccines ever developed, and the broader implications for vaccinology...
  41. pmc Systems vaccinology
    Bali Pulendran
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Immunity 33:516-29. 2010
    ..Here, we review these advances and critically examine the potential opportunities and challenges posed by systems biology in vaccine development...
  42. pmc Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages
    Santhakumar Manicassamy
    Emory Vaccine Center and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Semin Immunol 21:22-7. 2009
    ..Here, we review these recent advances, in the context of the pleiotropic effects of RA in regulating diverse biological processes...
  43. ncbi request reprint Dengue Virus Infection Induces Expansion of a CD14(+)CD16(+) Monocyte Population that Stimulates Plasmablast Differentiation
    Marcin Kwissa
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Cell Host Microbe 16:115-27. 2014
    ..These findings provide a detailed picture of innate responses to dengue and highlight a role for CD14(+)CD16(+) monocytes in promoting plasmablast differentiation and anti-DENV antibody responses. ..
  44. pmc Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1
    Ranjna Madan-Lala
    Emory Vaccine Center, Emory University, Atlanta, GA 30329
    J Immunol 192:4263-72. 2014
    ..Overall, these data show that M. tuberculosis impairs DC functions and modulates the nature of Ag-specific T cell responses, with important implications for vaccination strategies. ..
  45. ncbi request reprint The science of adjuvants
    Marcin Kwissa
    Emory Vaccine Center, Emory University, 954 Gatewood Rd, Atlanta, GA 30329, USA
    Expert Rev Vaccines 6:673-84. 2007
    ..In this article, we review the latest progress and emerging concepts in adjuvant development, which includes novel findings in innate immune biology and their impact on vaccinology...
  46. pmc Systems biological approaches to measure and understand vaccine immunity in humans
    Shuzhao Li
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Semin Immunol 25:209-18. 2013
    ..In this review, we present a broad review of the methodologies involved in these studies, and discuss the promise and challenges involved in this emerging field of "systems vaccinology." ..
  47. doi request reprint Systems biology of vaccination in the elderly
    Sai S Duraisingham
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA, 30329, USA
    Curr Top Microbiol Immunol 363:117-42. 2013
    ..Moreover, the identification of specific defects may be used to target novel vaccination strategies that improve efficacy in elderly populations...
  48. pmc Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition
    Crystal L Jones
    Department of Microbiology and Immunology, Microbiology and Molecular Genetics Program, Emory University, Atlanta, GA, USA
    Cell Microbiol 14:1531-43. 2012
    ..Taken together, these data reveal a novel mechanism of immune evasion by the downregulation of BLP expression to subvert TLR2 activation, which is likely used by numerous other intracellular bacterial pathogens...
  49. ncbi request reprint CD28-B7 interaction modulates short- and long-lived plasma cell function
    Modesta N Njau
    Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
    J Immunol 189:2758-67. 2012
    ..2. Surprisingly, deficiency of B7.1 and B7.2 in B cells also led to higher Ab levels, analogous to Cd28(-/-) plasma cells. Collectively, our results suggest that the CD28-B7 interaction operates as a key modulator of plasma cell function...
  50. ncbi request reprint Tolls and beyond--many roads to vaccine immunity
    Bali Pulendran
    Emory Vaccine Center, Emory University, Atlanta, USA
    N Engl J Med 356:1776-8. 2007
  51. ncbi request reprint Modulation of adaptive immunity with Toll-like receptors
    Santhakumar Manicassamy
    Emory Vaccine Center, Department of Pathology, Atlanta, GA 30329, USA
    Semin Immunol 21:185-93. 2009
    ....
  52. pmc Dendritic cell control of tolerogenic responses
    Santhakumar Manicassamy
    Emory Vaccine Center, Yerkes National Primate Research Center, Department of Pathology, Emory University School of Medicine, Atlanta, GA 30329, USA
    Immunol Rev 241:206-27. 2011
    ....
  53. pmc Immunity to viruses: learning from successful human vaccines
    Bali Pulendran
    Emory Vaccine Center, Atlanta, GA 30329, USA
    Immunol Rev 255:243-55. 2013
    ..Vaccines that have been proven to be of immense benefit in saving lives offer us a new fringe benefit: lessons in viral immunology. ..
  54. ncbi request reprint Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses
    Siddhartha Mahanty
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 170:2797-801. 2003
    ..These data represent the first evidence for a mechanism by which Ebola and Lassa viruses target DC to impair adaptive immunity...
  55. pmc Predicting network activity from high throughput metabolomics
    Shuzhao Li
    Emory Vaccine Center, Emory University, Atlanta, Georgia, USA
    PLoS Comput Biol 9:e1003123. 2013
    ..The algorithms were experimentally validated on the activation of innate immune cells. ..
  56. pmc Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis
    Helder I Nakaya
    Emory Vaccine Center at Yerkes National Primate Research Center, Atlanta, Georgia, USA
    Arthritis Rheum 64:3553-63. 2012
    ....
  57. pmc Learning vaccinology from viral infections
    Rafi Ahmed
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 208:2347-9. 2011
    ..One particular collaborative effort between the Steinman and Sekaly laboratories resulted in a paper published in this issue of the journal...
  58. pmc Systems vaccinology: its promise and challenge for HIV vaccine development
    Helder I Nakaya
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Curr Opin HIV AIDS 7:24-31. 2012
    ....
  59. ncbi request reprint Ebola virus-like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies
    Ling Ye
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 351:260-70. 2006
    ..These results show that production of Ebola VLPs in insect cells using recombinant baculoviruses represents a promising approach for vaccine development against Ebola virus infection...
  60. pmc The stimulation of CD8+ T cells by dendritic cells pulsed with polyketal microparticles containing ion-paired protein antigen and poly(inosinic acid)-poly(cytidylic acid)
    Michael J Heffernan
    Wallace H Coulter Department of Biomedical Engineering and Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
    Biomaterials 30:910-8. 2009
    ..These data demonstrate the potential of polyketal microparticles in formulating effective CD8(+) T cell-inducing vaccines comprising protein antigens and dsRNA adjuvants...
  61. ncbi request reprint Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand
    Mohan S Maddur
    1 Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris F 75006, France 2 Centre de Recherche des Cordeliers, Equipe 16 Immunopathology and Therapeutic Immunointervention, Universite Pierre et Marie Curie Paris 6, UMR S 1138, 15 Rue de l Ecole de Medicine, Paris F 75006, France 3 Université Paris Descartes, UMR S 1138, Paris F 75006, France 4 Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Commun 5:4092. 2014
    ..Collectively, our results suggest that B cells have the ability to control their own effector functions by enhancing the ability of human DCs to mediate Th2 differentiation. ..
  62. pmc Peptide crosslinked micelles: a new strategy for the design and synthesis of peptide vaccines
    Jihua Hao
    Georgia Institute of Technology, Department of Biomedical Engineering, Atlanta, GA 30332 0535, USA
    Int J Nanomedicine 1:97-103. 2006
    ..Cell culture studies demonstrated that the PCMs greatly enhance the uptake of peptide antigens into human dendritic cells...
  63. pmc Restraining order for dendritic cells: all quiet on the fetal front
    Rana Chakraborty
    Division of Pediatric Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA
    J Clin Invest 119:1854-7. 2009
    ..in this issue of the JCI describes a novel mechanism of avoiding immune surveillance in which the migratory capacity of dendritic cells at the maternal/fetal interface is restrained (see the related article beginning on page 2062)...
  64. ncbi request reprint Immunological mechanisms of vaccination
    Bali Pulendran
    1 Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA 2 Department of Pathology, Emory University, Atlanta, Georgia, USA
    Nat Immunol 131:509-17. 2011
    ..Here we will discuss these advances and emerging themes on the immunology of vaccination...
  65. doi request reprint A shot in the arm for mast cells
    Bali Pulendran
    Nat Med 14:489-90. 2008
  66. ncbi request reprint Cross-presentation: avoiding trafficking chaos?
    Sudhir Pai Kasturi
    Nat Immunol 9:461-3. 2008
  67. ncbi request reprint Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro
    Ravi Jotwani
    Department of Periodontics, Stony Brook University Health Science Center, Stony Brook, NY 11794 8703, USA
    Eur J Immunol 33:2980-6. 2003
    ..gingivalisLPS-pulsed MDDC. These results suggest that human MDDC can be polarized by LPS from the mucosal pathogen P. gingivalis to induce a Th2 effector response in vitro...
  68. ncbi request reprint Dendritic cells at the host-pathogen interface
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Immunol 7:117-20. 2006
    ..How DCs integrate information from pathogens, tissues, and innate leukocytes for the induction of immune responses was presented at the second International Conference on Dendritic Cells at the Host-Pathogen Interface...
  69. ncbi request reprint Division of labor and cooperation between dendritic cells
    Bali Pulendran
    Nat Immunol 7:699-700. 2006
  70. pmc Improving defences at the portal of HIV entry: mucosal and innate immunity
    Robin J Shattock
    St George s, University of London, London, United Kingdom
    PLoS Med 5:e81. 2008
  71. ncbi request reprint Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Eur J Immunol 33:2717-26. 2003
    ..These results demonstrate that stimulation of TLR-2 by lipopeptides represents a novel way for possible treatment of allergy and asthma by regulating the disrupted cytokine balance...
  72. ncbi request reprint Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease
    Jon L Belsher
    Mayo Clinic College of Medicine, Rochester, MN, United States
    Vaccine 25:8480-5. 2007
    ..The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD...

Research Grants26

  1. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2009
    ..Such insights should be of great value in the design of novel therapeutic approaches in the control and prevention of autoimmune diseases. ..
  2. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2005
    ..Such insights should be of great value in the design of novel therapeutic approaches in the control and prevention of autoimmune diseases. ..
  3. ANTHRAX TOXIN, DENDRITIC CELLS AND ADAPTIVE IMMUNITY
    Bali Pulendran; Fiscal Year: 2006
    ....
  4. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2006
    ..Such insights should be of great value in the design of novel therapeutic approaches in the control and prevention of autoimmune diseases. ..
  5. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2007
    ....
  6. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2003
    ..It should also offer novel strategies for manipulating immune responses in clinical settings. ..
  7. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2002
    ..It should also ultimately permit more effective use of DCs for the immunotherapy of autoimmunity and infectious diseases. ..
  8. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2001
    ..It should also offer novel strategies for manipulating immune responses in clinical settings. ..
  9. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2002
    ..It should also offer novel strategies for manipulating immune responses in clinical settings. ..
  10. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2001
    ..It should also offer novel strategies for manipulating immune responses in clinical settings. ..
  11. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2007
    ..Such insights should be of great value in the design of novel therapeutic approaches in the control and prevention of autoimmune diseases. ..
  12. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2006
    ....
  13. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2000
    ..It should also ultimately permit more effective use of DCs for the immunotherapy of autoimmunity and infectious diseases. ..
  14. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2005
    ....
  15. ANTHRAX TOXIN, DENDRITIC CELLS AND ADAPTIVE IMMUNITY
    Bali Pulendran; Fiscal Year: 2005
    ....
  16. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2001
    ..It should also ultimately permit more effective use of DCs for the immunotherapy of autoimmunity and infectious diseases. ..
  17. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2001
    ..It should also ultimately permit more effective use of DCs for the immunotherapy of autoimmunity and infectious diseases. ..
  18. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2003
    ..It should also ultimately permit more effective use of DCs for the immunotherapy of autoimmunity and infectious diseases. ..
  19. ANTHRAX TOXIN, DENDRITIC CELLS AND ADAPTIVE IMMUNITY
    Bali Pulendran; Fiscal Year: 2003
    ....
  20. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2004
    ..It should also ultimately permit more effective use of DCs for the immunotherapy of autoimmunity and infectious diseases. ..
  21. MODULATING HIV-IMMUNITY WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2004
    ..If successful, such a strategy will likely greatly advance the design of effective vaccines against HIV/AIDS in humans in the future. ..
  22. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2004
    ....
  23. ANTHRAX TOXIN, DENDRITIC CELLS AND ADAPTIVE IMMUNITY
    Bali Pulendran; Fiscal Year: 2004
    ....
  24. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2010
    ..The focus of the present proposal is to understand how this signaling pathway in DCs, regulates inflammation, immunological tolerance and vaccine induced immunity. ..