Bali Pulendran


Affiliation: Emory University
Country: USA


  1. Kazmin D, Nakaya H, Lee E, Johnson M, van der Most R, van den Berg R, et al. Systems analysis of protective immune responses to RTS,S malaria vaccination in humans. Proc Natl Acad Sci U S A. 2017;114:2425-2430 pubmed publisher
    ..These results suggest that protective immunity against P. falciparum can be achieved via multiple mechanisms and highlight the utility of systems approaches in defining molecular correlates of protection to vaccination. ..
  2. Hagan T, Nakaya H, Subramaniam S, Pulendran B. Systems vaccinology: Enabling rational vaccine design with systems biological approaches. Vaccine. 2015;33:5294-301 pubmed publisher
    ..Such discoveries, along with the improved understanding of immune responses to vaccination they impart, will play an instrumental role in development of the next generation of rationally designed vaccines. ..
  3. Nakaya H, Pulendran B. Vaccinology in the era of high-throughput biology. Philos Trans R Soc Lond B Biol Sci. 2015;370: pubmed publisher
    ..Here, we review these advances and discuss the potential of this systems vaccinology approach in defining novel correlates of protection in clinical trials, and in infection-induced 'experimental challenge models' in humans. ..
  4. Oh J, Ravindran R, Chassaing B, Carvalho F, Maddur M, Bower M, et al. TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity. 2014;41:478-492 pubmed publisher
    ..These results reveal an unappreciated role for gut microbiota in promoting immunity to vaccination. ..
  5. Pulendran B. The varieties of immunological experience: of pathogens, stress, and dendritic cells. Annu Rev Immunol. 2015;33:563-606 pubmed publisher
    ..Immunity or tolerance can then be represented as a complex function of each of these hierarchies. ..
  6. Nakaya H, Hagan T, Duraisingham S, Lee E, Kwissa M, Rouphael N, et al. Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures. Immunity. 2015;43:1186-98 pubmed publisher
    ..These results identify shared vaccine-induced signatures across multiple seasons and in diverse populations and might help guide the development of next-generation vaccines that provide persistent immunity against influenza. ..
  7. Pulendran B, Maddur M. Innate immune sensing and response to influenza. Curr Top Microbiol Immunol. 2015;386:23-71 pubmed publisher
    ..These studies will complement the existing work in mice and facilitate the quest to design improved vaccines and therapeutic strategies against influenza. ..
  8. Pulendran B, Tang H, Manicassamy S. Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat Immunol. 2010;11:647-55 pubmed publisher
  9. Kasturi S, Kozlowski P, Nakaya H, Burger M, Russo P, Pham M, et al. Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques. J Virol. 2017;91: pubmed publisher
    ..These results highlight the potential for such NP TLR L adjuvants in promoting robust and durable antibody responses against HIV in the next generation of HIV immunogens currently being developed. ..

More Information


  1. Ho I, Bunker J, Erickson S, Neu K, Huang M, Cortese M, et al. Refined protocol for generating monoclonal antibodies from single human and murine B cells. J Immunol Methods. 2016;438:67-70 pubmed publisher
    ..Together, these refinements significantly increase single-cell antibody expression efficiency and are easily integrated into established and novel pipelines. ..
  2. Pulendran B, Artis D. New paradigms in type 2 immunity. Science. 2012;337:431-5 pubmed publisher
  3. Pulendran B, Ahmed R. Immunological mechanisms of vaccination. Nat Immunol. 2011;12:509-17 pubmed
    ..Here we will discuss these advances and emerging themes on the immunology of vaccination. ..
  4. Pulendran B, Li S, Nakaya H. Systems vaccinology. Immunity. 2010;33:516-29 pubmed publisher
    ..Here, we review these advances and critically examine the potential opportunities and challenges posed by systems biology in vaccine development. ..
  5. Pulendran B. Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology. Nat Rev Immunol. 2009;9:741-7 pubmed publisher
    ..Here I review how these developments are yielding insights into the mechanism of action of the yellow fever vaccine, one of the most successful vaccines ever developed, and the broader implications for vaccinology. ..
  6. Li S, Sullivan N, Rouphael N, Yu T, Banton S, Maddur M, et al. Metabolic Phenotypes of Response to Vaccination in Humans. Cell. 2017;169:862-877.e17 pubmed publisher
    ..Our approach is broadly applicable to study human immunity and can help to identify predictors of efficacy as well as mechanisms controlling immunity to vaccination. ..
  7. Sinclair C, Bommakanti G, Gardinassi L, Loebbermann J, Johnson M, Hakimpour P, et al. mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation. Science. 2017;357:1014-1021 pubmed publisher
    ..mTOR therefore mediates metabolic adaptation of APCs in distinct tissues, influencing the immunological character of allergic inflammation. ..
  8. Pulendran B, Oh J, Nakaya H, Ravindran R, Kazmin D. Immunity to viruses: learning from successful human vaccines. Immunol Rev. 2013;255:243-55 pubmed publisher
    ..Vaccines that have been proven to be of immense benefit in saving lives offer us a new fringe benefit: lessons in viral immunology. ..