S Russ Price

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription
    S R Price
    Renal Division, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 98:1703-8. 1996
  2. ncbi request reprint Differential regulation of branched-chain alpha-ketoacid dehydrogenase kinase expression by glucocorticoids and acidification in LLC-PK1-GR101 cells
    Xiaonan Wang
    Renal Division, Rm 338 Woodruff Memorial Bldg, 1639 Pierce Drive, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 286:F504-8. 2004
  3. ncbi request reprint Molecular mechanisms regulating protein turnover in muscle
    S R Price
    Renal Division, Emory University, Atlanta, GA, USA
    Am J Kidney Dis 37:S112-4. 2001
  4. ncbi request reprint Glucocorticoids and acidification independently increase transcription of branched-chain ketoacid dehydrogenase subunit genes
    S R Price
    Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
    Miner Electrolyte Metab 25:224-7. 1999
  5. ncbi request reprint Increased transcription of ubiquitin-proteasome system components: molecular responses associated with muscle atrophy
    S R Price
    Renal Division, Emory University, Room 338, Woodruff Memorial Research Building, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Int J Biochem Cell Biol 35:617-28. 2003
  6. pmc MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation
    Guangping Chen
    Renal Division, Department of Medicine, Emory University School of Medicine, WMRB Rm 338, 1639 Pierce Dr, NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F1528-34. 2008
  7. pmc XIAP reduces muscle proteolysis induced by CKD
    Junping Hu
    Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 21:1174-83. 2010
  8. ncbi request reprint Molecular signaling pathways regulating muscle proteolysis during atrophy
    Harold A Franch
    Renal Division, Emory University, Atlanta, GA 30322, USA
    Curr Opin Clin Nutr Metab Care 8:271-5. 2005
  9. ncbi request reprint Tissue-specific regulation of ubiquitin (UbC) transcription by glucocorticoids: in vivo and in vitro analyses
    Anne C Marinovic
    Renal Division, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 292:F660-6. 2007
  10. ncbi request reprint Inhibition of PI3-kinase signaling by glucocorticoids results in increased branched-chain amino acid degradation in renal epithelial cells
    Xiaonan Wang
    Renal Division, Emory University, Rm 338, Woodruff Memorial Bldg, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 292:C1874-9. 2007

Collaborators

Detail Information

Publications37

  1. pmc Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription
    S R Price
    Renal Division, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 98:1703-8. 1996
    ..We conclude that the mechanism for muscle protein wasting in insulinopenia includes activation of the ubiquitin-proteasome pathway with increased expression of the ubiquitin gene...
  2. ncbi request reprint Differential regulation of branched-chain alpha-ketoacid dehydrogenase kinase expression by glucocorticoids and acidification in LLC-PK1-GR101 cells
    Xiaonan Wang
    Renal Division, Rm 338 Woodruff Memorial Bldg, 1639 Pierce Drive, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 286:F504-8. 2004
    ..These responses lead to an increase in the activation state of BCKD and a resulting acceleration of BCAA degradation...
  3. ncbi request reprint Molecular mechanisms regulating protein turnover in muscle
    S R Price
    Renal Division, Emory University, Atlanta, GA, USA
    Am J Kidney Dis 37:S112-4. 2001
    ..Together, these responses increase the breakdown of muscle, contributing to protein malnutrition in CRF...
  4. ncbi request reprint Glucocorticoids and acidification independently increase transcription of branched-chain ketoacid dehydrogenase subunit genes
    S R Price
    Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
    Miner Electrolyte Metab 25:224-7. 1999
    ..In summary, catabolic responses to low extracellular pH and glucocorticoids include enhanced expression of genes encoding BCKAD subunits...
  5. ncbi request reprint Increased transcription of ubiquitin-proteasome system components: molecular responses associated with muscle atrophy
    S R Price
    Renal Division, Emory University, Room 338, Woodruff Memorial Research Building, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Int J Biochem Cell Biol 35:617-28. 2003
    ..This review summaries the evidence that cachectic signals activate a program of selective transcriptional responses in muscle that frequently occurs coordinately with increased protein destruction...
  6. pmc MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation
    Guangping Chen
    Renal Division, Department of Medicine, Emory University School of Medicine, WMRB Rm 338, 1639 Pierce Dr, NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F1528-34. 2008
    ..The mechanism is likely to be physiologically important as UT-A1 ubiquitination was identified in kidney inner medullary tissue. The ubiquitin-proteasome degradation pathway provides an important novel mechanism for UT-A1 regulation...
  7. pmc XIAP reduces muscle proteolysis induced by CKD
    Junping Hu
    Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 21:1174-83. 2010
    ..In summary, these results demonstrate that XIAP inhibits multiple aspects of protein degradation in skeletal muscle during CKD...
  8. ncbi request reprint Molecular signaling pathways regulating muscle proteolysis during atrophy
    Harold A Franch
    Renal Division, Emory University, Atlanta, GA 30322, USA
    Curr Opin Clin Nutr Metab Care 8:271-5. 2005
    ..This review will discuss recent findings on the molecular signaling pathways regulating proteolysis during muscle atrophy...
  9. ncbi request reprint Tissue-specific regulation of ubiquitin (UbC) transcription by glucocorticoids: in vivo and in vitro analyses
    Anne C Marinovic
    Renal Division, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 292:F660-6. 2007
    ..Thus glucocorticoids increase UbC transcription by a mechanism involving Sp1 that is unique to muscle...
  10. ncbi request reprint Inhibition of PI3-kinase signaling by glucocorticoids results in increased branched-chain amino acid degradation in renal epithelial cells
    Xiaonan Wang
    Renal Division, Emory University, Rm 338, Woodruff Memorial Bldg, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 292:C1874-9. 2007
    ..Thus, glucocorticoids inhibit signaling through the IRS-1/PI3K/Akt pathway with a consequence of increased branched-chain amino acid catabolism...
  11. ncbi request reprint Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1
    Anne C Marinovic
    Renal Division, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 277:16673-81. 2002
    ..Thus, glucocorticoids increase UbC expression in muscle cells by a novel transcriptional mechanism involving Sp1 and MEK1...
  12. pmc miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export
    Matthew B Hudson
    Renal Division, Department of Medicine, Emory University, Atlanta, Georgia
    Am J Physiol Cell Physiol 306:C551-8. 2014
    ..Dex did not alter the number of exosomes released into the media. We conclude that atrophy-inducing conditions downregulate miR-23a in muscle by mechanisms involving attenuated Cn/NFAT signaling and selective packaging into exosomes. ..
  13. ncbi request reprint Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy
    James L Bailey
    Renal Division, Emory University School of Medicine, WMB 338, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Am Soc Nephrol 17:1388-94. 2006
    ..It is concluded that in CKD, acidosis and an increase in the PI3-K p85 subunit are mechanisms that contribute to suppression of PI3-K activity in muscle, and this leads to accelerated muscle proteolysis...
  14. pmc Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes
    Tiffany K Roberts-Wilson
    Renal Division, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1803:960-7. 2010
    ..These findings demonstrate that Cn activity is a major determinant of PGC-1alpha expression in skeletal muscle during diabetes and possibly other conditions associated with loss of muscle mass...
  15. pmc Nutritional intervention restores muscle but not kidney phenotypes in adult calcineurin Aα null mice
    Kirsten Madsen
    Department of Medicine Division of Nephrology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 8:e62503. 2013
    ..This study illustrates the importance of re-examining the phenotypes of CnAα-/- mice and the advances that are now possible with the use of adult, rescued knockout animals...
  16. ncbi request reprint Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis
    Harold A Franch
    Renal Divisioin, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 287:F700-6. 2004
    ..We conclude that acidosis accelerates protein degradation by impairing insulin signaling through PI3K in muscle cells...
  17. pmc Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation
    Mitsi A Blount
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F295-9. 2008
    ..We conclude that the phosphorylation of UT-A1 on both serines 486 and 499 is important for activity and that this phosphorylation may be involved in UT-A1 membrane accumulation...
  18. pmc FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy
    Bin Zheng
    Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
    FASEB J 24:2660-9. 2010
    ..We conclude that FOXO3a mediates a reciprocal communication between the IRS-1/PI3K/Akt and IRS-2/MEK/ERK pathways that coordinates AT-1 and ubiquitin expression during muscle atrophy...
  19. pmc Muscle atrophy in chronic kidney disease results from abnormalities in insulin signaling
    S Russ Price
    Renal Division, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Ren Nutr 20:S24-8. 2010
    ..In this review, the proteolytic systems that are activated during chronic kidney disease and the key insulin signaling pathways that regulate the protein degradative processes are described...
  20. ncbi request reprint Acidification and glucocorticoids independently regulate branched-chain alpha-ketoacid dehydrogenase subunit genes
    X Wang
    Renal Division, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 280:C1176-83. 2001
    ..Thus acidification and glucocorticoids independently enhance BCKAD subunit gene expression, and the glucocorticoid response in the E2 subunit involves interference with NF-kappaB, which may act as a transrepressor...
  21. ncbi request reprint Regulation of epithelial sodium channels by the ubiquitin-proteasome proteolytic pathway
    B Malik
    Dept of Physiology, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 290:F1285-94. 2006
    ....
  22. doi request reprint Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney
    Ramesh N Reddy
    Department of Medicine Division of Nephrology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Mol Med 15:414-22. 2011
    ..Therefore, while multiple signals appear to regulate matrix, calcineurin β appears to be a central mechanism involved in organ hypertrophy...
  23. pmc Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2
    Yongmei Gao
    Renal Division, Rm 338, Woodruff Memorial Research Bldg, 1639 Pierce Dr, Emory Univ, Atlanta, GA 30322, USA
    J Appl Physiol (1985) 105:1772-8. 2008
    ..In summary, our findings indicate that insulin regulates caspase-3 activity by a multistep process that is unique to skeletal muscle, thus providing insights about the muscle-specific nature of the atrophy process...
  24. ncbi request reprint Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes
    Myra E Woodworth-Hobbs
    Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, USA Department of Medicine, Renal Division, Emory University, Atlanta, GA, USA Electronic address
    J Nutr Biochem 25:868-74. 2014
    ..These data indicate that palmitate induces myotube atrophy, at least in part, by activating multiple proteolytic systems and that DHA counters the catabolic effects of palmitate by restoring Akt/FoxO signaling. ..
  25. pmc Calcineurin: a poorly understood regulator of muscle mass
    Matthew B Hudson
    Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, GA 30322, United States
    Int J Biochem Cell Biol 45:2173-8. 2013
    ..This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..
  26. ncbi request reprint Proteolysis, the ubiquitin-proteasome system, and renal diseases
    Richard Debigare
    Renal Division, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 285:F1-8. 2003
    ..These examples are indicative of the diverse roles of the ubiquitin-proteasome system in renal-associated pathological conditions...
  27. ncbi request reprint Enac degradation in A6 cells by the ubiquitin-proteosome proteolytic pathway
    B Malik
    Department of Physiology and Renal Division, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 276:12903-10. 2001
    ..Inhibitors of lysosomal function did not reproduce these findings. Our results suggest that in native renal cells the proteosomal pathway is an important regulator of ENaC function...
  28. ncbi request reprint Pitfall of an internal control plasmid: response of Renilla luciferase (pRL-TK) plasmid to dihydrotestosterone and dexamethasone
    N M Ibrahim
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biotechniques 29:782-4. 2000
    ..In transfection studies, internal control plasmid expression in response to treatment must be carefully monitored to ensure proper interpretation of normalized results...
  29. ncbi request reprint Mechanisms activated by kidney disease and the loss of muscle mass
    W E Mitch
    Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Kidney Dis 38:1337-42. 2001
    ..New information identifying mechanisms that activate protein breakdown and the rebuilding of muscle fibers would lead to therapies that successfully prevent the loss of muscle mass in kidney disease and other catabolic illnesses...
  30. ncbi request reprint Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting
    W E Mitch
    Renal Division, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol 276:C1132-8. 1999
    ..Thus acidification is not necessary for these responses, but glucocorticoids and a low insulin level in tandem activate the ubiquitin-proteasome proteolytic system...
  31. ncbi request reprint Role of Nedd4-2 and polyubiquitination in epithelial sodium channel degradation in untransfected renal A6 cells expressing endogenous ENaC subunits
    B Malik
    Dept of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 289:F107-16. 2005
    ..The results reported here suggest that the ubiquitin-proteasome proteolytic pathway is an important determinant of ENaC function in untransfected renal cells expressing endogenous ENaC...
  32. ncbi request reprint The balance between glucocorticoids and insulin regulates muscle proteolysis via the ubiquitin-proteasome pathway
    J L Bailey
    Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
    Miner Electrolyte Metab 25:220-3. 1999
    ..The balance between these stimuli could regulate muscle proteolysis in uremia...
  33. pmc Cyclooxygenase-2 in the kidney: good, BAD, or both?
    S Russ Price
    Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Kidney Int 80:905-7. 2011
    ..However, the PGE(2)/PKA pathway is not the only means to inactivate BAD and limit cell death. This Commentary shows a broader picture of this pathway to examine the kidney's BAD options...
  34. ncbi request reprint Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus
    Sira Sooparb
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, and Atlanta Veterans Afffairs Medical Center, Decatur, Georgia, USA
    Kidney Int 65:2135-44. 2004
    ..Because the lysosomal proteolytic pathway of chaperone-mediated autophagy is suppressed by growth factors in cultured cells, we investigated whether the abundance of substrates of this pathway increase in diabetic hypertrophy...
  35. pmc Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney
    Mitsi A Blount
    Emory Univ School of Medicine, Renal Division, 1639 Pierce Drive, NE, WMB Rm 3319B, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 294:F1448-52. 2008
    ..These changes may represent a previously unrecognized beneficial effect of type 1 ARBs in DM...
  36. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
    ..Treatment strategies that increase tetrahydrobiopterin or prevent its oxidation may prove useful in preventing vascular complications of this common disease...
  37. ncbi request reprint Type II cadherin ectodomain structures: implications for classical cadherin specificity
    Saurabh D Patel
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 124:1255-68. 2006
    ....

Research Grants15

  1. Muscle-Specific Nutritional Adaptations to Catabolic States
    S Price; Fiscal Year: 2009
    ..New information regarding the mechanisms of muscle atrophy may identify therapeutic targets to reduce morbidity and mortality of chronically ill patients and improve their quality of life. ..
  2. Muscle-Specific Nutritional Adaptations to Catabolic States
    S Price; Fiscal Year: 2007
    ..New information regarding the mechanisms of muscle atrophy may identify therapeutic targets to reduce morbidity and mortality of chronically ill patients and improve their quality of life. ..
  3. Signaling Mechanisms Regulation Muscle Protein Turnover
    S Price; Fiscal Year: 2005
    ..Lastly, we will study adrenalectomized rats to determine if glucocorticoids can be linked to inhibition of SGK activity or activation of the MEK/ERK MAPK pathway in skeletal muscle. ..
  4. Signaling Mechanisms Regulation Muscle Protein Turnover
    S Price; Fiscal Year: 2004
    ..Lastly, we will study adrenalectomized rats to determine if glucocorticoids can be linked to inhibition of SGK activity or activation of the MEK/ERK MAPK pathway in skeletal muscle. ..
  5. Signaling Mechanisms Regulation Muscle Protein Turnover
    S Price; Fiscal Year: 2003
    ..Lastly, we will study adrenalectomized rats to determine if glucocorticoids can be linked to inhibition of SGK activity or activation of the MEK/ERK MAPK pathway in skeletal muscle. ..
  6. TISSUE SPECIFIC NUTRITIONAL ADAPTATIONS IN RENAL FAILURE
    S Price; Fiscal Year: 2003
    ..The investigators findings will define cellular mechanisms regulating BCAA degradation in uremia, acute diabetes and other catabolic conditions. ..
  7. Signaling Mechanisms Regulation Muscle Protein Turnover
    S Price; Fiscal Year: 2002
    ..Lastly, we will study adrenalectomized rats to determine if glucocorticoids can be linked to inhibition of SGK activity or activation of the MEK/ERK MAPK pathway in skeletal muscle. ..
  8. TISSUE SPECIFIC NUTRITIONAL ADAPTATIONS IN RENAL FAILURE
    S Price; Fiscal Year: 2002
    ..The investigators findings will define cellular mechanisms regulating BCAA degradation in uremia, acute diabetes and other catabolic conditions. ..
  9. TISSUE SPECIFIC NUTRITIONAL ADAPTATIONS IN RENAL FAILURE
    S Price; Fiscal Year: 2001
    ..The investigators findings will define cellular mechanisms regulating BCAA degradation in uremia, acute diabetes and other catabolic conditions. ..
  10. TISSUE SPECIFIC NUTRITIONAL ADAPTATIONS IN RENAL FAILURE
    S Price; Fiscal Year: 1999
    ..Results from these studies should elucidate mechanisms that influence how amino acid metabolism can change even when dietary protein restriction should suppress BCAA oxidation. ..
  11. Muscle-Specific Nutritional Adaptations to Catabolic States
    S Russ Price; Fiscal Year: 2010
    ..New information regarding the mechanisms of muscle atrophy may identify therapeutic targets to reduce morbidity and mortality of chronically ill patients and improve their quality of life. ..