RICHARD PLEMPER

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Strength of envelope protein interaction modulates cytopathicity of measles virus
    Richard K Plemper
    Molecular Medicine Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Virol 76:5051-61. 2002
  2. pmc Design of a small-molecule entry inhibitor with activity against primary measles virus strains
    Richard K Plemper
    Department of Microbiology and Immunology, 3086 Rollins Research Center, 1510 Clifton Road, Emory University School of Medicine, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 49:3755-61. 2005
  3. pmc Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases
    Stefanie A Krumm
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 6:e20069. 2011
  4. pmc Cell entry of enveloped viruses
    Richard K Plemper
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Opin Virol 1:92-100. 2011
  5. pmc Structural and mechanistic studies of measles virus illuminate paramyxovirus entry
    Richard K Plemper
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Pathog 7:e1002058. 2011
  6. pmc Measles control--can measles virus inhibitors make a difference?
    Richard K Plemper
    Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Curr Opin Investig Drugs 10:811-20. 2009
  7. pmc Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity
    Laura K White
    Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 51:2293-303. 2007
  8. pmc A target site for template-based design of measles virus entry inhibitors
    Richard K Plemper
    Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:5628-33. 2004
  9. pmc High-throughput screening-based identification of paramyxovirus inhibitors
    Jeong Joong Yoon
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory Children s Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biomol Screen 13:591-608. 2008
  10. pmc Target analysis of the experimental measles therapeutic AS-136A
    Jeong Joong Yoon
    Department of Pediatrics, Emory University School of Medicine and Children s Healthcare of Atlanta, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 53:3860-70. 2009

Collaborators

  • Roberto B Cattaneo
  • J P Snyder
  • Aiming Sun
  • P A Rota
  • Thota Ganesh
  • B Bankamp
  • Adele K Fielding
  • D Gerlier
  • Jeong Joong Yoon
  • Andrew Prussia
  • Jin K Lee
  • Stefanie A Krumm
  • Tanja Paal
  • Laura K White
  • Melinda A Brindley
  • Yuhong Du
  • J Maina Ndungu
  • Pahk Thepchatri
  • Serdar Kurtkaya
  • Andrew J Prussia
  • Haian Fu
  • Dennis C Liotta
  • Joshua Doyle
  • Richard W Compans
  • LiTing T Cheng
  • Michael Natchus
  • Melanie Dochow
  • Dominika Gaus
  • Courtney St Clair
  • Blossom Sneed
  • Iestyn Lewis
  • Lian Li
  • Jaeki Min
  • Vanessa Hoffman
  • Raymond Dingledine
  • Maina Ndungu
  • Dhruv Chawla

Detail Information

Publications23

  1. pmc Strength of envelope protein interaction modulates cytopathicity of measles virus
    Richard K Plemper
    Molecular Medicine Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Virol 76:5051-61. 2002
    ..Similar analyses of glycoproteins derived from MV strains with reduced cytopathicities confirm that the strength of H and F glycoprotein interaction is a modulator of viral fusogenicity...
  2. pmc Design of a small-molecule entry inhibitor with activity against primary measles virus strains
    Richard K Plemper
    Department of Microbiology and Immunology, 3086 Rollins Research Center, 1510 Clifton Road, Emory University School of Medicine, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 49:3755-61. 2005
    ..6 to 3.0 microM, depending on the MV genotype) against a panel of wild-type MV strains representative of viruses that are currently endemic in the field...
  3. pmc Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases
    Stefanie A Krumm
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 6:e20069. 2011
    ..Viral adaptation attempts did not induce resistance after prolonged exposure, in contrast to rapid adaptation to a pathogen-directed inhibitor of RdRp activity...
  4. pmc Cell entry of enveloped viruses
    Richard K Plemper
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Opin Virol 1:92-100. 2011
    ....
  5. pmc Structural and mechanistic studies of measles virus illuminate paramyxovirus entry
    Richard K Plemper
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Pathog 7:e1002058. 2011
    ..Here, we review these advances in our molecular understanding of MeV entry in the context of diverse entry strategies employed by other members of the paramyxovirus family...
  6. pmc Measles control--can measles virus inhibitors make a difference?
    Richard K Plemper
    Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Curr Opin Investig Drugs 10:811-20. 2009
    ....
  7. pmc Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity
    Laura K White
    Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 51:2293-303. 2007
    ..Singly or in combination with the fusion inhibitors, this novel compound class has high developmental potential as a potent therapeutic against MV and will likely further the mechanistic characterization of the viral polymerase complex...
  8. pmc A target site for template-based design of measles virus entry inhibitors
    Richard K Plemper
    Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:5628-33. 2004
    ..This template-based design approach for MV may be applicable to other clinically relevant members of the paramyxovirus family...
  9. pmc High-throughput screening-based identification of paramyxovirus inhibitors
    Jeong Joong Yoon
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory Children s Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biomol Screen 13:591-608. 2008
    ..Representatives of the last class may open avenues for the development of broad-range paramyxovirus inhibitors through hit-to-lead chemistry...
  10. pmc Target analysis of the experimental measles therapeutic AS-136A
    Jeong Joong Yoon
    Department of Pediatrics, Emory University School of Medicine and Children s Healthcare of Atlanta, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 53:3860-70. 2009
    ..Taken together, these data support the hypothesis that acquiring mutations in these L domains may reduce virus fitness...
  11. pmc Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex
    Aiming Sun
    Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA
    J Med Chem 51:3731-41. 2008
    ..Elaborating on the preliminary structure-activity (SAR) study, the present work presents the synthesis and SAR of a much broader range of low nanomolar nonpeptidic MV inhibitors and speculates on the role of the CF 3 functionality...
  12. pmc Mutations in the putative HR-C region of the measles virus F2 glycoprotein modulate syncytium formation
    Richard K Plemper
    Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Virol 77:4181-90. 2003
    ..We propose that the conformational changes in MV F protein required to expose the fusion peptide involve the C-terminal half of the HR-C helix, specifically amino acid 94...
  13. pmc Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation
    Aiming Sun
    Department of Chemistry, 1515 Dickey Drive, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 17:5199-203. 2007
    ..The synthesis of 16677 and several analogs together with effects on MV replication is described. The most potent analog displays nanomolar inhibition against the MV and a selectivity ratio (CC(50)/IC(50)) of ca. 16,500...
  14. pmc Reversible inhibition of the fusion activity of measles virus F protein by an engineered intersubunit disulfide bridge
    Jin K Lee
    Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, 520 Children s Center, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    J Virol 81:8821-6. 2007
    ..Noncovalent small molecules mimicking this behavior may constitute a potent strategy for preventing paramyxovirus entry...
  15. ncbi request reprint Nonpeptide inhibitors of measles virus entry
    Aiming Sun
    Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA
    J Med Chem 49:5080-92. 2006
    ....
  16. pmc Two domains that control prefusion stability and transport competence of the measles virus fusion protein
    Joshua Doyle
    Department of Microbiology and Immunology, 3086 Rollins Research Center, 1510 Clifton Road, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Virol 80:1524-36. 2006
    ..The data support the conclusion that residues located in the head domain of the F trimer and the HR-B region contribute jointly to controlling F conformational stability...
  17. ncbi request reprint Structural features of paramyxovirus F protein required for fusion initiation
    Richard K Plemper
    Department of Microbiology and Immunology, School of Medicine, 3001 Rollins Research Center, 1510 Clifton Road, Emory University, Atlanta, Georgia 30322, USA
    Biochemistry 42:6645-55. 2003
    ..5, while at pH 7.2 fusion is blocked, suggesting that functionality requires low charge in the cavity. These results indicate that specific structural features of the cavity are essential for paramyxovirus fusion initiation...
  18. pmc Probing the spatial organization of measles virus fusion complexes
    Tanja Paal
    Department of Pediatrics, Emory University School of Medicine and Children s Healthcare of Atlanta, Atlanta, Georgia 30322, USA
    J Virol 83:10480-93. 2009
    ....
  19. doi request reprint Measles virus entry inhibitors: a structural proposal for mechanism of action and the development of resistance
    Andrew J Prussia
    Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
    Biochemistry 47:13573-83. 2008
    ..This viewpoint is supported by the temperature-dependent differential fusion activities of MV F variants harboring these mutations...
  20. pmc Atypical fusion peptide of Nelson Bay virus fusion-associated small transmembrane protein
    LiTing T Cheng
    Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd, Rm 3001, Atlanta, GA 30322, USA
    J Virol 79:1853-60. 2005
    ..Taken together, our results suggest that the HD is involved in both syncytium formation and in determining p10 transport and surface expression...
  21. pmc Blue native PAGE and biomolecular complementation reveal a tetrameric or higher-order oligomer organization of the physiological measles virus attachment protein H
    Melinda A Brindley
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 84:12174-84. 2010
    ..Results are interpreted in light of a model in which receptor binding may affect the oligomeric organization of the attachment protein complex...
  22. pmc Functional interaction between paramyxovirus fusion and attachment proteins
    Jin K Lee
    Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 283:16561-72. 2008
    ..Their localization in structural models of F and H suggests that placement in particular of F residue 233 in close proximity to the 110-114 region of H is structurally conceivable...
  23. ncbi request reprint Cancer and virus leads by HTS, chemical design and SEA data mining
    Pahk Thepchatri
    Chemical Biology Discovery Center, 1510 Clifton Road, Emory University, Atlanta, GA 30322, USA
    Curr Top Med Chem 9:1159-71. 2009
    ..In parallel with HTS, a unique component of the Emory virtual screening (VS) effort, namely, substructure enrichment analysis (SEA) program has been utilized in several cases...

Research Grants7

  1. Structure-Based Design of Nipah Virus Entry Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2006
    ..These will be characterized for their activity against live Nipah (aim 3). ..
  2. Identification and Pre-Clinical Evaluation of Measles Virus Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2007
    ..Characteristic viral escape patterns will be identified for efficacious compounds that warrant future clinical development, and cross-resistance between structurally distinct therapeutic leads will be assessed. ..
  3. High Throughput Screening-Based Identification of Measles Virus Probes
    RICHARD PLEMPER; Fiscal Year: 2007
    ....
  4. Identification and Pre-Clinical Evaluation of Measles Virus Inhibitors
    Richard K Plemper; Fiscal Year: 2010
    ..Characteristic viral escape patterns will be identified for efficacious compounds that warrant future clinical development, and cross-resistance between structurally distinct therapeutic leads will be assessed. ..