P B Pennell

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint The impact of pregnancy and childbirth on the metabolism of lamotrigine
    P B Pennell
    Departments of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 62:292-5. 2004
  2. ncbi request reprint Pregnancy in women who have epilepsy
    Page B Pennell
    Emory Epilepsy Program, Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6000 Atlanta, GA 30322, USA
    Neurol Clin 22:799-820. 2004
  3. pmc Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years
    K J Meador
    Neurology and Pediatrics, Emory University, Atlanta, GA, USA
    Neurology 78:1207-14. 2012
  4. pmc Effects of breastfeeding in children of women taking antiepileptic drugs
    K J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 75:1954-60. 2010
  5. pmc Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency
    P B Pennell
    Emory Epilepsy Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Neurology 70:2130-6. 2008
  6. doi request reprint Pregnancy registries in epilepsy: a consensus statement on health outcomes
    K J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Neurology 71:1109-17. 2008
  7. ncbi request reprint Suicidal ideation in pregnancy: assessment and clinical implications
    D J Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Womens Ment Health 10:181-7. 2007
  8. ncbi request reprint Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy
    T R Henry
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 52:1166-73. 1999
  9. ncbi request reprint Repetitive transcranial magnetic stimulation does not replicate the Wada test
    C M Epstein
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Neurology 55:1025-7. 2000
  10. pmc In utero antiepileptic drug exposure: fetal death and malformations
    K J Meador
    Department of Neurology, University of Florida, Gainesville 32610, USA
    Neurology 67:407-12. 2006

Detail Information

Publications24

  1. ncbi request reprint The impact of pregnancy and childbirth on the metabolism of lamotrigine
    P B Pennell
    Departments of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 62:292-5. 2004
    ..LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline...
  2. ncbi request reprint Pregnancy in women who have epilepsy
    Page B Pennell
    Emory Epilepsy Program, Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6000 Atlanta, GA 30322, USA
    Neurol Clin 22:799-820. 2004
    ....
  3. pmc Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years
    K J Meador
    Neurology and Pediatrics, Emory University, Atlanta, GA, USA
    Neurology 78:1207-14. 2012
    ..To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure...
  4. pmc Effects of breastfeeding in children of women taking antiepileptic drugs
    K J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 75:1954-60. 2010
    ..Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children...
  5. pmc Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency
    P B Pennell
    Emory Epilepsy Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Neurology 70:2130-6. 2008
    ....
  6. doi request reprint Pregnancy registries in epilepsy: a consensus statement on health outcomes
    K J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Neurology 71:1109-17. 2008
    ..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...
  7. ncbi request reprint Suicidal ideation in pregnancy: assessment and clinical implications
    D J Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Womens Ment Health 10:181-7. 2007
    ..17). Further studies are warranted to identify additional predictors of perinatal suicidality and to clarify the nature of the association between such factors and the presence of SI in pregnant women...
  8. ncbi request reprint Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy
    T R Henry
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 52:1166-73. 1999
    ..To determine possible sites of therapeutic action of vagus nerve stimulation (VNS), by correlating acute VNS-induced regional cerebral blood flow (rCBF) alterations and chronic therapeutic responses...
  9. ncbi request reprint Repetitive transcranial magnetic stimulation does not replicate the Wada test
    C M Epstein
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Neurology 55:1025-7. 2000
    ..Postoperative language deficits were more consistent with Wada results. Available methods for inducing speech arrest with rTMS do not replicate the results of Wada tests...
  10. pmc In utero antiepileptic drug exposure: fetal death and malformations
    K J Meador
    Department of Neurology, University of Florida, Gainesville 32610, USA
    Neurology 67:407-12. 2006
    ..Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach...
  11. ncbi request reprint Remission of intractable partial epilepsy following implantation of intracranial electrodes
    N M Katariwala
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA
    Neurology 57:1505-7. 2001
    ..No surgical resection was performed, but all had seizure remission ranging from 11 months to 15 years. Invasive monitoring may rarely produce remission of IPE, possibly through interruption of seizure propagation pathways...
  12. ncbi request reprint 2005 AES annual course: evidence used to treat women with epilepsy
    Page B Pennell
    Emory Epilepsy Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Epilepsia 47:46-53. 2006
    ..These newly released findings provide the tools to begin to practice evidence-based medicine when treating our female patients during their reproductive and postmenopausal years...
  13. doi request reprint Lamotrigine in breast milk and nursing infants: determination of exposure
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Rd NE, Suite B6100, Atlanta, GA 30322
    Pediatrics 122:e223-31. 2008
    ..We sought to characterize the determinants of lamotrigine concentrations in breast milk and nursing-infant plasma...
  14. ncbi request reprint Pregnancy in the woman with epilepsy: maternal and fetal outcomes
    Page B Pennell
    Emory Epilepsy Monitoring Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Semin Neurol 22:299-308. 2002
    ..Careful planning and management of any pregnancy in women with epilepsy are essential to increase the likelihood of a healthy outcome for the mother and infant...
  15. ncbi request reprint Obstetric risks for women with epilepsy during pregnancy
    Peter W Kaplan
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Epilepsy Behav 11:283-91. 2007
    ..More detailed information and guidelines are available elsewhere...
  16. ncbi request reprint Pharmacology of antiepileptic drugs during pregnancy and lactation
    Page B Pennell
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Epilepsy Behav 11:263-9. 2007
    ..The report provides an overview of these key topics, highlights gaps in the current knowledge, and provides future directions for needed research...
  17. ncbi request reprint The importance of monotherapy in pregnancy
    Page B Pennell
    Epilepsy Monitoring Unit, Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 60:S31-8. 2003
    ..Prenatal screening for major malformations should be offered. Careful planning and management of any pregnancy in women with epilepsy is essential to increase the likelihood of a healthy outcome for mother and infant...
  18. ncbi request reprint Antiepileptic drug pharmacokinetics during pregnancy and lactation
    Page B Pennell
    Department of Neurology, Emory Epilepsy Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 61:S35-42. 2003
    ....
  19. ncbi request reprint Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy
    Andrew G Herzog
    Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Epilepsia 47:1945-8. 2006
    ..To compare serum levels of neuroactive steroids among men with epilepsy who take various antiepileptic drugs, untreated men with epilepsy and normal controls (NC)...
  20. ncbi request reprint The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient
    Jun Sheng Wang
    Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Rev 39:723-46. 2007
    ..This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology...
  21. doi request reprint Lamotrigine in bipolar disorder: efficacy during pregnancy
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bipolar Disord 10:432-6. 2008
    ..The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG). We therefore compared recurrence risks among pregnant women with BPD treated with LTG to those discontinuing mood stabilizer therapies...
  22. ncbi request reprint Persistent auditory hallucinations that are unresponsive to antipsychotic drugs
    Stephen E Nicolson
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Am J Psychiatry 163:1153-9. 2006
  23. ncbi request reprint Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    J Psychopharmacol 20:54-9. 2006
    ....
  24. ncbi request reprint Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs
    Andrew G Herzog
    Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Epilepsia 45:764-8. 2004
    ..We compared sexual function and reproductive hormone levels among men with localization-related epilepsy (LRE) taking various antiepileptic drugs (AEDs) and normal controls (NC)...