Research Topics
| P B PennellSummaryAffiliation: Emory University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Pharmacology of antiepileptic drugs during pregnancy and lactationPage B Pennell
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Epilepsy Behav 11:263-9. 2007..The report provides an overview of these key topics, highlights gaps in the current knowledge, and provides future directions for needed research...
Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequencyP B Pennell
Emory Epilepsy Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
Neurology 70:2130-6. 2008....- 2005 AES annual course: evidence used to treat women with epilepsyPage B Pennell
Emory Epilepsy Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Epilepsia 47:46-53. 2006..These newly released findings provide the tools to begin to practice evidence-based medicine when treating our female patients during their reproductive and postmenopausal years... - Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 yearsK J Meador
Neurology and Pediatrics, Emory University, Atlanta, GA, USA
Neurology 78:1207-14. 2012..To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure... - Effects of breastfeeding in children of women taking antiepileptic drugsK J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
Neurology 75:1954-60. 2010..Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children... 
Pregnancy registries in epilepsy: a consensus statement on health outcomesK J Meador
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Neurology 71:1109-17. 2008..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...- The impact of pregnancy and childbirth on the metabolism of lamotrigineP B Pennell
Departments of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Neurology 62:292-5. 2004..LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline... - Antiepileptic drug pharmacokinetics during pregnancy and lactationPage B Pennell
Department of Neurology, Emory Epilepsy Center, Emory University School of Medicine, Atlanta, GA 30322, USA
Neurology 61:S35-42. 2003.... - Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsyT R Henry
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Neurology 52:1166-73. 1999..To determine possible sites of therapeutic action of vagus nerve stimulation (VNS), by correlating acute VNS-induced regional cerebral blood flow (rCBF) alterations and chronic therapeutic responses... - Repetitive transcranial magnetic stimulation does not replicate the Wada testC M Epstein
Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Neurology 55:1025-7. 2000..Postoperative language deficits were more consistent with Wada results. Available methods for inducing speech arrest with rTMS do not replicate the results of Wada tests... - Suicidal ideation in pregnancy: assessment and clinical implicationsD J Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Arch Womens Ment Health 10:181-7. 2007..17). Further studies are warranted to identify additional predictors of perinatal suicidality and to clarify the nature of the association between such factors and the presence of SI in pregnant women... - In utero antiepileptic drug exposure: fetal death and malformationsK J Meador
Department of Neurology, University of Florida, Gainesville 32610, USA
Neurology 67:407-12. 2006..Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach... - Pregnancy in women who have epilepsyPage B Pennell
Emory Epilepsy Program, Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6000 Atlanta, GA 30322, USA
Neurol Clin 22:799-820. 2004.... - Gender-specific psychosocial impact of living with epilepsyPage B Pennell
Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
Epilepsy Behav 15:S20-5. 2009..These gender-specific factors should be a key consideration when counseling and treating patients with epilepsy... - Cognitive function at 3 years of age after fetal exposure to antiepileptic drugsKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Suite 6000, Atlanta, GA 30322, USA
N Engl J Med 360:1597-605. 2009.... - Antiepileptic drug therapy in pregnancy I: gestation-induced effects on AED pharmacokineticsPage B Pennell
Emory Epilepsy Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Int Rev Neurobiol 83:227-40. 2008.... - Pregnancy in the woman with epilepsy: maternal and fetal outcomesPage B Pennell
Emory Epilepsy Monitoring Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Semin Neurol 22:299-308. 2002..Careful planning and management of any pregnancy in women with epilepsy are essential to increase the likelihood of a healthy outcome for the mother and infant... - The importance of monotherapy in pregnancyPage B Pennell
Epilepsy Monitoring Unit, Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Neurology 60:S31-8. 2003..Prenatal screening for major malformations should be offered. Careful planning and management of any pregnancy in women with epilepsy is essential to increase the likelihood of a healthy outcome for mother and infant... - Lamotrigine in breast milk and nursing infants: determination of exposureD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Rd NE, Suite B6100, Atlanta, GA 30322
Pediatrics 122:e223-31. 2008..We sought to characterize the determinants of lamotrigine concentrations in breast milk and nursing-infant plasma... - Antiepileptic drug use in women of childbearing ageKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Mail Stop 1930 001 1AN, Atlanta, GA 30322, USA
Epilepsy Behav 15:339-43. 2009..Except for the top two AED monotherapies, there were marked differences in other monotherapies and in polytherapies between U.S. and UK centers. Future investigations are needed to examine reasons for drug choice... - Antiepileptic drugs during pregnancy: what is known and which AEDs seem to be safest?Page B Pennell
Department of Nuerology, Emory Epilepsy Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Epilepsia 49:43-55. 2008..The consistent findings of increased teratogenic risk for VPA should discourage use of this medication as first-line treatment in women of childbearing age... - Remission of intractable partial epilepsy following implantation of intracranial electrodesN M Katariwala
Department of Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA
Neurology 57:1505-7. 2001..No surgical resection was performed, but all had seizure remission ranging from 11 months to 15 years. Invasive monitoring may rarely produce remission of IPE, possibly through interruption of seizure propagation pathways... - Postpartum depression in women with epilepsy: influence of antiepileptic drugs in a prospective studyMelanie Galanti
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Epilepsy Behav 16:426-30. 2009..In conclusion, PPD rates are higher among women with epilepsy than the general population, particularly those who are multiparous or receiving AED polytherapy, and there is no evidence that AED selection modifies this risk... - Hormonal aspects of epilepsyPage B Pennell
Division of Epilepsy, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Neurol Clin 27:941-65. 2009..Additionally, development of the neurosteroid analog ganaxolone provides a novel approach that can potentially be used across both genders and all age groups... - Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunitiesC Lindsay Devane
Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
J Psychopharmacol 20:54-9. 2006.... - Lamotrigine in bipolar disorder: efficacy during pregnancyD Jeffrey Newport
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
Bipolar Disord 10:432-6. 2008..The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG). We therefore compared recurrence risks among pregnant women with BPD treated with LTG to those discontinuing mood stabilizer therapies... - The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patientJun Sheng Wang
Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
Drug Metab Rev 39:723-46. 2007..This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology... - Persistent auditory hallucinations that are unresponsive to antipsychotic drugsStephen E Nicolson
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
Am J Psychiatry 163:1153-9. 2006 - Obstetric risks for women with epilepsy during pregnancyPeter W Kaplan
Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Epilepsy Behav 11:283-91. 2007..More detailed information and guidelines are available elsewhere... - Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsyAndrew G Herzog
Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Epilepsia 47:1945-8. 2006..To compare serum levels of neuroactive steroids among men with epilepsy who take various antiepileptic drugs, untreated men with epilepsy and normal controls (NC)... - Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugsAndrew G Herzog
Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Epilepsia 45:764-8. 2004..We compared sexual function and reproductive hormone levels among men with localization-related epilepsy (LRE) taking various antiepileptic drugs (AEDs) and normal controls (NC)...