B D Pearce

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Lymphocytic responses and the gradual hippocampal neuron loss following infection with lymphocytic choriomeningitis virus (LCMV)
    B D Pearce
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neuroimmunol 101:137-47. 1999
  2. pmc The association of Toxoplasma gondii infection with neurocognitive deficits in a population-based analysis
    Brad D Pearce
    Department of Epidemiology, Emory University, Rollins School of Public Health, 1518 002 3BB, Atlanta, GA, 30322, USA
    Soc Psychiatry Psychiatr Epidemiol 49:1001-10. 2014
  3. pmc Toxoplasma gondii exposure affects neural processing speed as measured by acoustic startle latency in schizophrenia and controls
    Bradley D Pearce
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30329, USA Electronic address
    Schizophr Res 150:258-61. 2013
  4. doi request reprint The relationship between Toxoplasma gondii infection and mood disorders in the third National Health and Nutrition Survey
    Brad D Pearce
    Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
    Biol Psychiatry 72:290-5. 2012
  5. pmc Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants
    Ramkumar Menon
    The Perinatal Research Center, Nashville, Tennessee, USA
    Reprod Biol Endocrinol 7:62. 2009
  6. pmc Interrelationship of cytokines, hypothalamic-pituitary-adrenal axis hormones, and psychosocial variables in the prediction of preterm birth
    B D Pearce
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Gynecol Obstet Invest 70:40-6. 2010
  7. ncbi request reprint Schizophrenia and viral infection during neurodevelopment: a focus on mechanisms
    B D Pearce
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr WMB 4000, Atlanta, GA 30322, USA
    Mol Psychiatry 6:634-46. 2001
  8. pmc Serum macrophage migration inhibitory factor in the prediction of preterm delivery
    Brad D Pearce
    Department of Psychology, Emory University, Atlanta, GA 30332, USA
    Am J Obstet Gynecol 199:46.e1-6. 2008
  9. ncbi request reprint 1996 Curt P. Richter Award. Effects of viral infection on corticosterone secretion and glucocorticoid receptor binding in immune tissues
    A H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 22:455-74. 1997
  10. ncbi request reprint Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings
    D L Musselman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Psychiatry 158:1252-7. 2001

Research Grants

  1. EXCITOTOXICITY IN THE HIPPOCAMPUS AFTER VIRAL INFECTION
    Bradley Pearce; Fiscal Year: 2002
  2. Cytokine-HPA Interactions During Pregnanacy
    Bradley Pearce; Fiscal Year: 2006
  3. Neurobiology of MIF in development and disease
    Bradley Pearce; Fiscal Year: 2007
  4. 2/2 Schizophrenia Heterogeneity and Toxoplasma Exposure
    Bradley D Pearce; Fiscal Year: 2011

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Lymphocytic responses and the gradual hippocampal neuron loss following infection with lymphocytic choriomeningitis virus (LCMV)
    B D Pearce
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neuroimmunol 101:137-47. 1999
    ..These data suggest that T lymphocytes control glial infection and mediate degeneration in the cerebellum but not the hippocampus...
  2. pmc The association of Toxoplasma gondii infection with neurocognitive deficits in a population-based analysis
    Brad D Pearce
    Department of Epidemiology, Emory University, Rollins School of Public Health, 1518 002 3BB, Atlanta, GA, 30322, USA
    Soc Psychiatry Psychiatr Epidemiol 49:1001-10. 2014
    ..To examine the relationship between infection with Toxoplasma gondii (toxo) and cognition...
  3. pmc Toxoplasma gondii exposure affects neural processing speed as measured by acoustic startle latency in schizophrenia and controls
    Bradley D Pearce
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30329, USA Electronic address
    Schizophr Res 150:258-61. 2013
    ..Latency was likewise slower in SCZ subjects than in controls. These findings indicate a slowing of neural processing speed with chronic TOXO infection; the slowest startle latency was seen in the TOXO seropositive SCZ group...
  4. doi request reprint The relationship between Toxoplasma gondii infection and mood disorders in the third National Health and Nutrition Survey
    Brad D Pearce
    Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
    Biol Psychiatry 72:290-5. 2012
    ..A substantial literature suggests that schizophrenia is associated with increased seroprevalence of T. gondii, but a possible link of the parasite with mood disorders has not been as thoroughly investigated...
  5. pmc Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants
    Ramkumar Menon
    The Perinatal Research Center, Nashville, Tennessee, USA
    Reprod Biol Endocrinol 7:62. 2009
    ..To study pathophysiologic pathways in spontaneous preterm birth and possibly the racial disparity associating with maternal and fetal genetic variations, using bioinformatics tools...
  6. pmc Interrelationship of cytokines, hypothalamic-pituitary-adrenal axis hormones, and psychosocial variables in the prediction of preterm birth
    B D Pearce
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Gynecol Obstet Invest 70:40-6. 2010
    ....
  7. ncbi request reprint Schizophrenia and viral infection during neurodevelopment: a focus on mechanisms
    B D Pearce
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr WMB 4000, Atlanta, GA 30322, USA
    Mol Psychiatry 6:634-46. 2001
    ....
  8. pmc Serum macrophage migration inhibitory factor in the prediction of preterm delivery
    Brad D Pearce
    Department of Psychology, Emory University, Atlanta, GA 30332, USA
    Am J Obstet Gynecol 199:46.e1-6. 2008
    ..We determined whether maternal macrophage migration inhibitory factor levels predicted subsequent preterm delivery...
  9. ncbi request reprint 1996 Curt P. Richter Award. Effects of viral infection on corticosterone secretion and glucocorticoid receptor binding in immune tissues
    A H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 22:455-74. 1997
    ..Taken together, the results indicate that interactions between the neuroendocrine and immune systems can be modified at the level of the GR in the context of an ongoing immune response such as during a viral infection...
  10. ncbi request reprint Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings
    D L Musselman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Psychiatry 158:1252-7. 2001
    ..CONCLUSIONS: Higher than normal plasma IL-6 concentrations were associated with a diagnosis of major depression in cancer patients. IL-6 may contribute to sickness behavior that has overlapping symptoms with major depression...
  11. ncbi request reprint Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine
    C M Pariante
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Pharmacol 52:571-81. 1997
    ....
  12. ncbi request reprint Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression
    A H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Adv Exp Med Biol 461:107-16. 1999
    ..Taken together, these findings suggest that factors which modulate glucocorticoid action (e.g. cytokines and antidepressants) will be relevant contributors to disease expression including behavioral toxicity and sickness behavior...
  13. ncbi request reprint The phosphodiesterase type 4 inhibitor, rolipram, enhances glucocorticoid receptor function
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Suite 4000, Atlanta, GA 30322, USA
    Neuropsychopharmacology 27:939-48. 2002
    ..These findings broaden the potential pathways by which PDE type 4 inhibitors can influence cellular function and indicate that these agents may have special utility in disorders associated with impaired GR-mediated feedback inhibition...
  14. ncbi request reprint Glucocorticoid receptors are differentially expressed in the cells and tissues of the immune system
    A H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cell Immunol 186:45-54. 1998
    ..In addition, neutrophils were found to have fewer GR than lymphocytes and monocytes. These results indicate a meaningful relationship between receptor expression and known sensitivity to glucocorticoids...
  15. doi request reprint Dysregulated biomarkers induce distinct pathways in preterm birth
    L Brou
    Department of Epidemiology, Rollins School of Public Health, Atlanta, Georgia, USA
    BJOG 119:458-73. 2012
    ....

Research Grants4

  1. EXCITOTOXICITY IN THE HIPPOCAMPUS AFTER VIRAL INFECTION
    Bradley Pearce; Fiscal Year: 2002
    ..These studies aim to provide clues to the mechanisms by which an early viral infection could be involved in certain neurodevelopmental disorders. ..
  2. Cytokine-HPA Interactions During Pregnanacy
    Bradley Pearce; Fiscal Year: 2006
    ..Moreover, this study opens a new potential direction for therapeutics aimed at depression and obstetric complications. ..
  3. Neurobiology of MIF in development and disease
    Bradley Pearce; Fiscal Year: 2007
    ..Besides schizophrenia, these studies could provide insight into Parkinson's disease, and maternal mental illnesses. ..
  4. 2/2 Schizophrenia Heterogeneity and Toxoplasma Exposure
    Bradley D Pearce; Fiscal Year: 2011
    ....