Roberto Pacifici

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency
    M Neale Weitzmann
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri, USA
    J Clin Invest 110:1643-50. 2002
  2. pmc Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation
    Francesco Grassi
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15087-92. 2007
  3. pmc T cells and post menopausal osteoporosis in murine models
    Roberto Pacifici
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arthritis Res Ther 9:102. 2007
  4. ncbi request reprint Estrogen deficiency, T cells and bone loss
    Roberto Pacifici
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine and Molecular Pathogenesis Program, Emory University School of Medicine, 101 Woodruff Circle, Room 1307, Atlanta, GA 30322, USA
    Cell Immunol 252:68-80. 2008
  5. pmc T cells: critical bone regulators in health and disease
    Roberto Pacifici
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Bone 47:461-71. 2010
  6. pmc The immune system and bone
    Roberto Pacifici
    Department of Medicine, Emory University, Atlanta, GA, USA
    Arch Biochem Biophys 503:41-53. 2010
  7. pmc Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss
    Brahmchetna Bedi
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Ann N Y Acad Sci 1192:215-21. 2010
  8. pmc T cells potentiate PTH-induced cortical bone loss through CD40L signaling
    Yuhao Gao
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Cell Metab 8:132-45. 2008
  9. pmc Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand
    Jau Yi Li
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 108:768-73. 2011
  10. pmc Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss
    Hesham Tawfeek
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 5:e12290. 2010

Collaborators

Detail Information

Publications25

  1. pmc Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency
    M Neale Weitzmann
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri, USA
    J Clin Invest 110:1643-50. 2002
    ..Thus, because it targets both the osteoclast and the osteoblast pathways, IL-7 is central to the altered bone turnover characteristic of estrogen deficiency...
  2. pmc Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation
    Francesco Grassi
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15087-92. 2007
    ....
  3. pmc T cells and post menopausal osteoporosis in murine models
    Roberto Pacifici
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arthritis Res Ther 9:102. 2007
    ..The experimental evidence that suggests that estrogen prevents bone loss by regulating T cell function and the interactions between immune cells and bone is reviewed here...
  4. ncbi request reprint Estrogen deficiency, T cells and bone loss
    Roberto Pacifici
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine and Molecular Pathogenesis Program, Emory University School of Medicine, 101 Woodruff Circle, Room 1307, Atlanta, GA 30322, USA
    Cell Immunol 252:68-80. 2008
    ..This review presents our current understanding of the process of estrogen deficiency mediated bone destruction and explores some of the most recent findings and hypotheses to explain estrogen action in bone...
  5. pmc T cells: critical bone regulators in health and disease
    Roberto Pacifici
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Bone 47:461-71. 2010
    ..This article examines the connection between T cells and bone in health and disease and reviews the evidence in favor of the hypothesis that T cells play an unexpected critical role in the mechanism of action of estrogen and PTH in bone...
  6. pmc The immune system and bone
    Roberto Pacifici
    Department of Medicine, Emory University, Atlanta, GA, USA
    Arch Biochem Biophys 503:41-53. 2010
    ....
  7. pmc Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss
    Brahmchetna Bedi
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Ann N Y Acad Sci 1192:215-21. 2010
    ....
  8. pmc T cells potentiate PTH-induced cortical bone loss through CD40L signaling
    Yuhao Gao
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Cell Metab 8:132-45. 2008
    ..T cell-SC crosstalk pathways may thus provide pharmacological targets for PTH-induced bone disease...
  9. pmc Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand
    Jau Yi Li
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 108:768-73. 2011
    ..Therefore, cross-talk between T cells and SCs mediated by CD40L plays a pivotal role in the disregulation of osteoblastogenesis and osteoclastogenesis induced by ovx...
  10. pmc Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss
    Hesham Tawfeek
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 5:e12290. 2010
    ..However it is unknown whether direct PTH stimulation of T cells is required for cPTH to induce bone loss, and whether T cells contribute to the bone catabolic activity of PTH with mechanisms other than induction of CD40 signaling in SCs...
  11. pmc Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH
    Brahmchetna Bedi
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 109:E725-33. 2012
    ....
  12. pmc An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency
    Michaela Robbie Ryan
    Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:16735-40. 2005
    ..We conclude that IL-7 is a pivotal upstream target through which estrogen regulates hematopoietic and immune functions that are critical for bone homeostasis...
  13. pmc Estrogen prevents bone loss through transforming growth factor beta signaling in T cells
    Yuhao Gao
    Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:16618-23. 2004
    ....
  14. ncbi request reprint Estrogen regulation of immune cell bone interactions
    M Neale Weitzmann
    Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, 1639 Pierce Drive, Room 1309, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1068:256-74. 2006
    ..Herein we review the experimental evidence that suggests that estrogen prevents bone loss by regulating T cell function and immune cell bone interactions...
  15. pmc IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation
    Yuhao Gao
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 117:122-32. 2007
    ..Inhibition of IFN-gamma signaling may thus represent a novel strategy to simultaneously reduce inflammation and bone loss in common forms of osteoporosis...
  16. ncbi request reprint The role of T lymphocytes in bone metabolism
    M Neale Weitzmann
    Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunol Rev 208:154-68. 2005
    ..Herein, we review the experimental evidence that suggests estrogen prevents bone loss by regulating T-cell function and immune cell bone interactions...
  17. ncbi request reprint Role of the immune system in postmenopausal bone loss
    M Neale Weitzmann
    Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, WMRB 1305, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Curr Osteoporos Rep 3:92-7. 2005
    ..This paper presents recent findings pertaining to this new view of postmenopausal osteoporosis...
  18. ncbi request reprint T cells: unexpected players in the bone loss induced by estrogen deficiency and in basal bone homeostasis
    M Neale Weitzmann
    Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1116:360-75. 2007
    ....
  19. pmc PTH expands short-term murine hemopoietic stem cells through T cells
    Jau Yi Li
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Blood 120:4352-62. 2012
    ..In summary, direct PPR signaling in T cells and the resulting production of Wnt10b play a pivotal role in the mechanism by which iPTH expands ST-HSPCs. The data suggest that T cells may provide pharmacologic targets for HSPC expansion...
  20. pmc T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling
    Masakazu Terauchi
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Cell Metab 10:229-40. 2009
    ....
  21. ncbi request reprint IL-7 drives T cell-mediated bone loss following ovariectomy
    Michaela Robbie-Ryan
    Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322 0001, USA
    Ann N Y Acad Sci 1068:348-51. 2006
    ..The mechanisms of IL-7 action are intricate and poorly defined. We present herein an overview of our current understanding of IL-7 action on bone turnover and the role of IL-7 in ovariectomy-induced bone loss...
  22. pmc Estrogen deficiency and bone loss: an inflammatory tale
    M Neale Weitzmann
    Division of Endocrinology, Metabolism, and Lipids and Molecular Pathogenesis Program, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 116:1186-94. 2006
    ..Due to the inherent difficulties associated with human investigation, many of the lessons learned have been in animal models. Consequently, many of these principles await further validation in humans...
  23. pmc Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator
    Simone Cenci
    Division of Endocrinology and Metabolism, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 100:10405-10. 2003
    ..Thus, increased IFN-gamma-induced class II transactivator expression and the resulting enhanced T cell proliferation and lifespan are critical to the bone wasting effect of estrogen deficiency...
  24. pmc IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells
    Gianluca Toraldo
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:125-30. 2003
    ..Importantly, T cell adoptive transfer into nude mice restored IL-7-induced bone loss, and RANKL and TNF-alpha secretion, demonstrating that T cells are essential mediators of IL-7-induced bone loss in vivo...
  25. ncbi request reprint Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study
    Dario Maggio
    Gerontology and Geriatrics, University of Perugia, 06122 Perugia, Italy
    J Clin Endocrinol Metab 88:1523-7. 2003
    ..Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation...