Michael Owens

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
    Trials 13:106. 2012
  2. ncbi request reprint Neuropharmacology of paroxetine
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Psychopharmacol Bull 37:8-18. 2003
  3. ncbi request reprint Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond
    Michael J Owens
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    J Clin Psychiatry 65:5-10. 2004
  4. doi request reprint Estimates of serotonin and norepinephrine transporter inhibition in depressed patients treated with paroxetine or venlafaxine
    Michael J Owens
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 33:3201-12. 2008
  5. ncbi request reprint Pharmacology of valproate
    Michael J Owens
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Psychopharmacol Bull 37:17-24. 2003
  6. ncbi request reprint Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
    S Neil Vaishnavi
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Biol Psychiatry 55:320-2. 2004
  7. ncbi request reprint Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine
    Michelle L Gilmor
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, WMB Building, Atlanta, GA 30322, USA
    Am J Psychiatry 159:1702-10. 2002
  8. ncbi request reprint Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation
    Lotta Arborelius
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 176:248-55. 2004
  9. ncbi request reprint Effects of paroxetine and venlafaxine XR on heart rate variability in depression
    Jonathan Davidson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychopharmacol 25:480-4. 2005
  10. ncbi request reprint The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 192:385-96. 2007

Research Grants

  1. PSYCHOBIOLOGY OF CORTICOTROPIN-RELEASING FACTOR
    Michael Owens; Fiscal Year: 2007

Detail Information

Publications56

  1. pmc Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
    Trials 13:106. 2012
    ..Consequently, we initiated a randomized clinical trial designed to identify factors that moderate response to three treatments for MDD among patients never treated previously for the condition...
  2. ncbi request reprint Neuropharmacology of paroxetine
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Psychopharmacol Bull 37:8-18. 2003
    ..The application of these findings of in vivo NET inhibition by paroxetine in the treatment of mood and anxiety disorders will be informed by further clinical studies...
  3. ncbi request reprint Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond
    Michael J Owens
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    J Clin Psychiatry 65:5-10. 2004
    ..Nevertheless, the rationale is in place to suggest that antidepressants that block both the serotonin and norepinephrine transporters might provide better efficacy, which can only be determined by empirical testing...
  4. doi request reprint Estimates of serotonin and norepinephrine transporter inhibition in depressed patients treated with paroxetine or venlafaxine
    Michael J Owens
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 33:3201-12. 2008
    ..NET antagonism has been posited to contribute to the antidepressant effects of these compounds. The clinical significance of the magnitude of NET antagonism by both medications remains unclear at present...
  5. ncbi request reprint Pharmacology of valproate
    Michael J Owens
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Psychopharmacol Bull 37:17-24. 2003
    ..Modern tools of basic and clinical neuroscience (eg, genomics, proteomics, functional brain imaging) will rapidly provide valuable insights into the precise mechanism(s) of action of valproate...
  6. ncbi request reprint Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
    S Neil Vaishnavi
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Biol Psychiatry 55:320-2. 2004
    ....
  7. ncbi request reprint Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine
    Michelle L Gilmor
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, WMB Building, Atlanta, GA 30322, USA
    Am J Psychiatry 159:1702-10. 2002
    ..The study examined whether paroxetine inhibits the human norepinephrine transporter in addition to the human serotonin (5-HT) transporter in patients with major depressive disorder...
  8. ncbi request reprint Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation
    Lotta Arborelius
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 176:248-55. 2004
    ..Prolonged, daily maternal separation of rat pups induces several behavioral, endocrine and neurochemical changes similar to those observed in human depression...
  9. ncbi request reprint Effects of paroxetine and venlafaxine XR on heart rate variability in depression
    Jonathan Davidson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychopharmacol 25:480-4. 2005
    ..Further comparisons of selective serotonin reuptake inhibitor and serotonin and norepinephrine reuptake inhibitor drugs on HRV are warranted...
  10. ncbi request reprint The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 192:385-96. 2007
    ....
  11. ncbi request reprint Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment
    Steven C Stout
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 300:1085-92. 2002
    ..Additional studies are required to elucidate the functional consequences and mechanisms of this interaction...
  12. ncbi request reprint The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems
    Michelle L Gilmor
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, WMB Suite 4000, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 305:434-9. 2003
    ..The distinct actions of each drug on CRF systems may underlie their synergistic clinical effects...
  13. ncbi request reprint Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 164:1214-20. 2007
    ..The objectives of the current study were to quantify placental permeability to antipsychotic medications and to document obstetrical outcomes for women taking these agents proximate to delivery...
  14. ncbi request reprint Antidepressants in amniotic fluid: another route of fetal exposure
    Ada M Loughhead
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 163:145-7. 2006
    ..The authors' goal was to determine the concentration of antidepressants in amniotic fluid during maternal treatment of depression...
  15. doi request reprint Cardiac arrest and cardiopulmonary resuscitation dysregulates the hypothalamic-pituitary-adrenal axis
    Gretchen N Neigh
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Cereb Blood Flow Metab 29:1673-82. 2009
    ..Therefore, sustained changes in activity of the HPA axis and the CRF system after CA/CPR may contribute to the postischemic increase in affective disorders...
  16. doi request reprint Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Arch Gen Psychiatry 67:369-79. 2010
    ..The corticotropin-releasing factor (CRF, or corticotropin-releasing hormone) and arginine vasopressin systems have been implicated in the pathophysiology of anxiety and depressive disorders and response to antidepressant treatment...
  17. pmc Changes in the vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress
    Gretchen N Neigh
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Cereb Blood Flow Metab 30:1100-4. 2010
    ..These data indicate that in addition to the well-documented stress-induced changes in neurons and glia, cerebral vasculature is also altered by exposure to stressors...
  18. ncbi request reprint The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Eur J Pharmacol 571:17-24. 2007
    ....
  19. ncbi request reprint Genetic analysis of the hypothalamic corticotropin-releasing factor system
    Steven J Garlow
    Mood and Anxiety Disorders Program, Department of Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Endocrinology 146:2362-8. 2005
    ..There are QTL for all four targets on chromosome 12. There are a number of neurodevelopmental genes in very close proximity to the transcript abundance QTL that are potential candidate genes...
  20. pmc The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
    Sidney H VanNess
    Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    BMC Genet 6:55. 2005
    ....
  21. ncbi request reprint Treatment of mood disorders
    Charles B Nemeroff
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, Georgia 30322, USA
    Nat Neurosci 5:1068-70. 2002
    ..The mechanisms of action of available medications are directing the field toward new research avenues. This review highlights those areas we believe will influence the field and soon lead to better treatment...
  22. ncbi request reprint Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter
    Jonathan McConathy
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 31:705-18. 2004
    ..Although both compounds displayed high affinity and selectivity for the human NET in vitro, these compounds did not enter the CNS in adequate amounts to be used in PET imaging studies...
  23. ncbi request reprint Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    CNS Spectr 9:23-31. 2004
    ..Each SSRI apparently has its own unique pharmacologic properties that likely underlie their observed differences in clinical use...
  24. ncbi request reprint Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 24:9303-12. 2004
    ..The marked increase in CRFergic neurotransmission is hypothesized to play a major role in benzodiazepine withdrawal...
  25. ncbi request reprint Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism
    Becky Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurosci Methods 151:68-81. 2006
    ....
  26. ncbi request reprint Serotonin and norepinephrine transporter binding profile of SSRIs
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Essent Psychopharmacol 7:35-41. 2006
    ..The rationale for the use of drugs that affect multiple transports is based on the suggestion that antidepressants that block both the SERT and the NET may provide better efficacy. This can only be determined through empirical studies...
  27. ncbi request reprint The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress
    David A Gutman
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University of School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 304:874-80. 2003
    ..These data confirm that R121919 acts as a CRF(1) receptor antagonist in vivo, attenuates HPA axis responsivity, and possesses anxiolytic properties...
  28. ncbi request reprint Placental passage of tricyclic antidepressants
    Ada M Loughhead
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 59:287-90. 2006
    ..The use of antidepressants during pregnancy continues to garner considerable attention, though there are limited investigations that have sought to quantify fetal exposure...
  29. pmc Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats
    Becky Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Suite 4000 WMRB, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 33:178-87. 2008
    ..These data support an effect of time of day and estrous cycle stage on PPI in female rats. The estrous cycle variations in PPI are mediated in part by endogenous NT...
  30. ncbi request reprint The electrophysiological effects of neurotensin on spontaneously active neurons in the nucleus accumbens: an in vivo study
    Zachary N Stowe
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA
    Synapse 58:165-72. 2005
    ..These data provide further evidence that NT functions as a true neuromodulator in the NAc, exerting minimal direct effects, but blocking the actions of DA...
  31. ncbi request reprint Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agents
    Jonathan McConathy
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:593-605. 2005
    ..Despite high in vitro affinity for the human NET, the uptake of [(11)C]3-BrPA in the brain and the heart was not displaceable with pharmacological doses of NET antagonists...
  32. ncbi request reprint Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters
    Nachwa Jarkas
    Center for Positron Emission Tomography, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:211-24. 2005
    ..Carbon-11-labeled N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (HOMADAM) was synthesized as a new serotonin transporter (SERT) imaging agent...
  33. ncbi request reprint Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Research Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:569-76. 2003
    ..These findings support the hypothesis that central CRF hypersecretion is associated with a blunted ACTH response to exogenously administered CRF, explaining almost 60% of the variation in the ACTH response to CRF...
  34. doi request reprint Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000 WMRB, Atlanta, GA 30322, United States
    Psychoneuroendocrinology 33:1093-101. 2008
    ..This effect was observed in both male and female rats. No differences between strains or the effects of R121919 were observed for spontaneous ambulation or in the elevated plus maze test...
  35. ncbi request reprint Alterations in platelet serotonin transporter binding in women with postpartum onset major depression
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road NE, Suite B6100, Atlanta, GA 30322, USA
    J Psychiatr Res 38:467-73. 2004
    ..These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium...
  36. ncbi request reprint Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    J Psychopharmacol 20:54-9. 2006
    ....
  37. ncbi request reprint Virally mediated increased neurotensin 1 receptor in the nucleus accumbens decreases behavioral effects of mesolimbic system activation
    Ricardo Caceda
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 25:11748-56. 2005
    ..In addition, the NT1 receptor vector might be a valuable tool for understanding the mechanism of action of antipsychotic drugs and drugs of abuse and may have potential therapeutic applications...
  38. ncbi request reprint Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugs
    Elisabeth B Binder
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 29:2200-7. 2004
    ..The effects of the NT receptor antagonist were paralleled by its effects on catalepsy in olanzapine--but not haloperidol--treated animals...
  39. ncbi request reprint The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations
    Zachary N Stowe
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta GA, USA
    J Clin Psychiatry 64:73-80. 2003
    ....
  40. pmc Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk
    Catherine F Capello
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 339:275-85. 2011
    ....
  41. pmc Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus
    Nicola D Hanson
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 337:180-6. 2011
    ..They also confirm and extend previous reports of lithium-induced increases in cell proliferation but not survival...
  42. pmc Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomog
    Jeffrey S Stehouwer
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Med Chem 53:5549-57. 2010
    ..During the time period 40-80 min postinjection of [(18)F]9, the ratio of uptake in the putamen and caudate vs cerebellum uptake was > or = 4...
  43. doi request reprint The antidepressant sertraline downregulates Akt and has activity against melanoma cells
    Kalpana K Reddy
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
    Pigment Cell Melanoma Res 21:451-6. 2008
    ..Use of antidepressants that decrease Akt may improve the efficacy of interferon and other therapies against melanoma. Further studies are needed to elucidate whether sertraline acts as an Akt inhibitor in melanoma...
  44. ncbi request reprint Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent
    Christophe Plisson
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Med Chem 50:4553-60. 2007
    ..The in vivo evaluation of [18F]1 indicates that this radiotracer is a good candidate for mapping and quantifying CNS SERT...
  45. ncbi request reprint Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 17:3044-7. 2007
    ..Despite high in vitro affinity for the human NET, the high uptake of [(11)C]1 in the caudate and putamen excludes its use as an in vivo PET imaging agent for the NET...
  46. pmc Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomograph
    Jeffrey S Stehouwer
    Department of Radiology, Emory University, Atlanta, GA, USA
    J Med Chem 51:7788-99. 2008
    ..Chase studies with the SERT ligand 15 displaced [(18)F]1-[(18)F]4, but chase studies with the DAT ligand 16 did not displace [(18)F]1-[(18)F]4 thus indicating that the tracers were binding specifically to the SERT...
  47. ncbi request reprint Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography
    Jeffrey S Stehouwer
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 49:6760-7. 2006
    ..Chase studies with citalopram and methylphenidate demonstrated that this uptake is the result of preferential binding to the SERT...
  48. ncbi request reprint Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults
    Audrey R Tyrka
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
    Biol Psychiatry 56:531-4. 2004
    ..This study examined the effect of tryptophan depletion, which acutely reduces brain serotonin concentrations, on serial cerebrospinal fluid concentrations of corticotropin-releasing factor in healthy humans...
  49. ncbi request reprint Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand
    Jeremy D Coplan
    Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    CNS Spectr 10:530-6. 2005
    ..Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident...
  50. pmc Designing human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulators
    Karen A Selz
    Cielo Institute, Asheville, North Carolina 28804, USA
    Biophys J 86:1308-31. 2004
    ....
  51. ncbi request reprint Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects
    Linda L Carpenter
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI 02906, USA
    Neuropsychopharmacology 29:777-84. 2004
    ..More work is needed to elucidate the critical nature and timing of early events that may be associated with enduring neuroendocrine changes in humans...
  52. ncbi request reprint Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques
    Leonard A Rosenblum
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, State University of New York, 450 Clarkson Avenue, Brooklyn 11203 2098, USA
    Psychoneuroendocrinology 27:651-60. 2002
    ....
  53. ncbi request reprint Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing
    Sanjay J Mathew
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stress 5:185-93. 2002
    ..Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation...
  54. ncbi request reprint Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations
    Jeremy D Coplan
    State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Ann N Y Acad Sci 1071:525-33. 2006
    ..However, absolute cortisol change was greater in early versus late VFD. Timing of the VFD stressor differentially affects maternal neuroendocrine response, with potential implications for the offspring's developmental trajectory...
  55. ncbi request reprint Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands
    Arnold J Mandell
    Cielo Institute, 486 Sunset Drive, Asheville, NC 28804 3727, USA
    Neuropsychopharmacology 28:S98-107. 2003
    ....
  56. ncbi request reprint Preparation of antidepressants for use in preclinical research
    Jonathan McConathy
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Int J Neuropsychopharmacol 10:759-63. 2007
    ..This procedure provides these antidepressants in gram quantities in recovered yields ranging from 53% to 100% at over 99% purity and is in principle applicable to other drugs as well...

Research Grants3

  1. PSYCHOBIOLOGY OF CORTICOTROPIN-RELEASING FACTOR
    Michael Owens; Fiscal Year: 2007
    ....