Research Topics
Genomes and Genes
| Adeboye O OsunkoyaSummaryAffiliation: Emory University Country: USA Publications
| Collaborators
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Detail Information
Publications
Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidneyAdeboye O Osunkoya
Department of Pathology, Emory University School of Medicine, Room H174, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
Am J Surg Pathol 33:1103-6. 2009..Overall, these findings support the view that tubulocystic carcinoma and collecting duct carcinoma should be considered as 2 distinct entities at the molecular level...- Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytomaAdeboye O Osunkoya
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Pathol 40:206-10. 2009..It may be necessary to identify additional biomarkers to include with claudin-7 and claudin-8 in a larger immunohistochemical panel to improve diagnostic sensitivity and specificity... - MUC2 expression in primary mucinous and nonmucinous adenocarcinoma of the prostate: an analysis of 50 cases on radical prostatectomyAdeboye O Osunkoya
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Mod Pathol 21:789-94. 2008.... - Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cellsTISHEEKA R GRAHAM
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, 1701 Uppergate Drive, WCI Building C, Atlanta, GA 30322, USA
Breast Cancer Res Treat 123:139-47. 2010..Taken together, these results indicate that ZEB1 and AR regulate each other to promote cell migration in triple negative breast cancer cells... 
Diagnostic biomarkers for renal cell carcinoma: selection using novel bioinformatics systems for microarray data analysisAdeboye O Osunkoya
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Pathol 40:1671-8. 2009..Biomarker expression assays are increasingly important for renal cell carcinoma diagnosis, as needle core biopsies become more common and different therapies for tumor subtypes continue to be developed...- Epidermal growth factor promotes protein degradation of epithelial protein lost in neoplasm (EPLIN), a putative metastasis suppressor, during epithelial-mesenchymal transitionShumin Zhang
Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 288:1469-79. 2013..This study elucidated a novel molecular mechanism for EGF regulation of EMT and invasiveness in PCa cells, indicating that blockade of EGF signaling could be beneficial in preventing and retarding PCa metastasis at early stages... - Expression of C-reactive protein and cyclooxygenase enzyme-2 in clear cell renal cell carcinoma: correlation with pathological parameters in 110 patientsSarfraz Ali
Department of Pathology, Emory University School of Medicine, Room H174 1364 Clifton Road, NE Atlanta, GA 30322, USA
Tumour Biol 32:375-80. 2011.... - CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubulesMichael J Lee
Department of Pathology, Emory University School of Medicine, Room H174, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
Tumour Biol 33:2185-8. 2012.... - Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 casesAdeboye O Osunkoya
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 32:461-7. 2008..Pathologists need to be aware of this rare and unusual phenomenon, which is a potential pitfall in prostate cancer diagnosis... - Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomyQi Long
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA
Am J Pathol 179:46-54. 2011..Importantly, these biomarkers could significantly predict clinical recurrence for Gleason score 7 patients. These biomarkers may increase the accuracy of prognostication following radical prostatectomy using formalin-fixed specimens... - Urothelial carcinoma with villoglandular differentiation: a study of 14 casesMatthew Lim
Department of Pathology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Mod Pathol 22:1280-6. 2009..These relatively rare tumors should be recognized as a variant of urothelial carcinoma... - A clinicopathologic study of preoperative and postoperative findings with minute Gleason 3+3=6 cancer at radical prostatectomyAdeboye O Osunkoya
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
Urology 72:638-40. 2008.... - An unusual presentation of a mixed epithelial and stromal tumor in an elderly maleKelvin A Moses
Department of Urology, Emory University School of Medicine, Atlanta, GA, USA
ScientificWorldJournal 10:1810-3. 2010..We outline the case of an older male who presented with an enlarging abdominal mass causing symptoms that suggested a partial small bowel obstruction. Management of the patient and a brief review are discussed... - Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 casesAdeboye O Osunkoya
Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
Am J Surg Pathol 32:468-72. 2008..4%. This study confirms that mucinous adenocarcinoma of the prostate treated by radical prostatectomy is not more aggressive, and possibly even less aggressive than nonmucinous prostatic adenocarcinoma... - Frequency and determinants of disagreement and error in gleason scores: a population-based study of prostate cancerMichael Goodman
Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Road, NE Atlanta, GA 30322, USA
Prostate 72:1389-98. 2012..To examine factors that affect accuracy and reliability of prostate cancer grade we compared Gleason scores documented in pathology reports and those assigned by urologic pathologists in a population-based study... - Utility of p63 and high molecular weight cytokeratin in the distinction between urothelial carcinoma with prostatic stromal invasion and urothelial carcinoma with colonisation of prostatic ducts and aciniElizabeth C Chastain
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Pathology 44:199-203. 2012.... 
Colorectal adenocarcinoma involving the prostate: report of 9 casesAdeboye O Osunkoya
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Hum Pathol 38:1836-41. 2007..Immunohistochemical stains for beta-catenin, CDX2, carcinoembryonic antigen, high-molecular-weight cytokeratin, prostate-specific antigen, P501S (prostein), CK20, and CK7 can be helpful in making a definitive diagnosis...- The Symphony protocol for H&E staining of prostatic adenocarcinoma on needle biopsy: a multicentre analysis of 120 casesAdeboye O Osunkoya
Emory University School of Medicine, Atlanta, Georgia, USA
Pathology 40:450-6. 2008..The aim of this study was to determine if the Ventana Symphony H&E protocol can improve on the detection of prominent nucleoli in foci of prostate cancer... - Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cellsShumin Zhang
Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
Mol Cancer 9:9. 2010..Mcl-1 overexpression has been associated with progression in leukemia and some solid tumors including prostate cancer (PCa). However, the regulatory mechanism for Mcl-1 expression in PCa cells remains elusive... - A rare case of solitary metastatic non-seminomatous malignant germ cell tumor to the prostateRyan W Dobbs
Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Can J Urol 19:6471-3. 2012..In this report, we present a case of a 42-year-old man who presented with metastatic testicular cancer to the prostate 8 years after his original diagnosis of a mixed germ cell left testicular tumor... - BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasmsLaleh Ehsani
Department of Pathology, Emory University School of Medicine, Room H174, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
Tumour Biol 34:787-91. 2013..This is the first study to date evaluating the expression of BCA2 in renal oncocytoma. BCA2 could serve as a marker that may be utilized in the distinction between renal oncocytoma and its mimickers... - Accuracy of grading of urothelial carcinoma on urine cytology: an analysis of interobserver and intraobserver agreementMichelle D Reid
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Int J Clin Exp Pathol 5:882-91. 2012..By measuring interobserver and intraobserver agreement among pathologists, compared with the gold standard of biopsy/resection, specimen accuracy and reproducibility of grading in urine was determined... - An inherited heteroplasmic mutation in mitochondrial gene COI in a patient with prostate cancer alters reactive oxygen, reactive nitrogen and proliferationRebecca S Arnold
Department of Urology, School of Medicine, Emory University, 1365 Clifton Rd Building B, Atlanta, GA 30322, USA
Biomed Res Int 2013:239257. 2013..These data suggest that mitochondrial DNA mutations resulting in increased reactive oxygen and reactive nitrogen generation may be involved in prostate cancer biology... - Practical issues and pitfalls in staging tumors of the genitourinary tractAdeboye O Osunkoya
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Semin Diagn Pathol 29:154-66. 2012.... - Molecular mapping of tumor heterogeneity on clinical tissue specimens with multiplexed quantum dotsJian Liu
Department of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, Georgia 30322, USA
ACS Nano 4:2755-65. 2010..For clinical diagnostic applications, multiplexed QD mapping provides correlated molecular and morphological information that is not available from traditional tissue staining and molecular profiling methods... - Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 casesAdeboye O Osunkoya
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 31:1323-9. 2007.... - Residual tumor potentially left behind after local ablation therapy in prostate adenocarcinomaGhil Suk Yoon
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
J Urol 179:2203-6; discussion 2206. 2008..We examined contralateral prostate cancer potentially left behind by focal therapy... - Dysregulation of mammalian target of rapamycin pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladderNilda D Gonzalez-Roibon
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Hum Pathol 44:612-22. 2013..We found dysregulation of mTOR pathway members in urinary bladder plasmacytoid urothelial carcinoma, suggesting that the use of mTOR pathway inhibitors might be beneficial for patients with this aggressive tumor... - Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive reviewKeith D Bohman
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Adv Anat Pathol 19:374-87. 2012.... - Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cellsChristopher D Scharer
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
J Transl Med 6:79. 2008..Recent data has shown that overexpression of Aurora-A can confer resistance to the taxane paclitaxel... - Diagnostic implications of transcription factor Pax 2 protein and transmembrane enzyme complex carbonic anhydrase IX immunoreactivity in adult renal epithelial neoplasmsRuta Gupta
Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Am J Surg Pathol 33:241-7. 2009..These antibodies may reliably discriminate between clinically significant subtypes of RCC with overlapping cytoarchitectural features... - E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinomaMatthew G Lim
Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
Mod Pathol 24:241-7. 2011..Loss of E-cadherin expression may be a marker of plasmacytoid and signet ring cell differentiation in urothelial carcinoma... - Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cellsTISHEEKA R GRAHAM
Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Cancer Res 68:2479-88. 2008..These results identify ZEB1 as a key transcriptional regulator of EMT in prostate cancer and suggest that the aberrant expression of ZEB1 in prostate cancer cells occurs in part in response to IGF-I stimulation... - Rete testis invasion by malignant germ cell tumor and/or intratubular germ cell neoplasia: what is the significance of this finding?Adam P Vogt
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Pathol 41:1339-44. 2010..In this series, elevated tumor markers were more likely associated with angiolymphatic invasion and positive rete testis status. Positive rete testis status does not appear to be an independent predictor of patient outcome... - XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISHRebecca S Arnold
Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Urology 75:755-61. 2010.... - Urothelial carcinoma of the bladder with transmural and direct prostatic stromal invasion: does extent of stromal invasion significantly impact patient outcome?Irma V Oliva
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Pathol 42:51-6. 2011.... - Clear cell, papillary and chromophobe renal cell carcinoma in patients younger than 20 years old: a clinicopathologic study with follow-upJason Wang
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Pediatr Urol 8:531-4. 2012..To perform a clinicopathologic study with follow-up on this rare subset of tumors in the pediatric population... - Pelvic nephroureterectomy for renal cell carcinoma in an ectopic kidneyKevin G Baldie
Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road NE, Decatur, GA 30033, USA Department of Urology, Emory University School of Medicine, Clinic B, 1365 Clifton Road, Atlanta, GA 30322, USA
Case Rep Oncol Med 2012:350916. 2012..3 cm papillary renal cell carcinoma (RCC) with oncocytic features, Fuhrman nuclear grade 3, with angiolymphatic invasion and negative margins. The patient has been recurrence-free for over four years since tumor resection... - ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteinsCharity Duran
Department of Cell Biology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
Am J Physiol Cell Physiol 302:C482-93. 2012..Determining the role of anoctamin family members in ion transport will be critical to understanding their functions in physiology and disease... - C-reactive protein as a clinically useful biomarker of metastasis of renal cell carcinomaTimothy V Johnson
Department of Urology, Emory University, Atlanta, Georgia, USA
Mol Diagn Ther 14:191-3. 2010..His subsequent CT scan revealed "multiple pulmonary nodules consistent with progression of metastatic disease." This case demonstrates the potential for monitoring CRP in addition to, or instead of, standard restaging imaging... - Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 24 casesNeil Edgerton
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Int J Urol 18:49-54. 2011..To stratify patients with micropapillary urothelial carcinoma of the urinary bladder based on the percentage of micropapillary component and to correlate tumor volume with other clinicopathological features... - Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environmentRebecca S Arnold
Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Prostate 69:1-11. 2009..Because prostate cancer frequently metastasizes to bone we tested the hypothesis that mtDNA mutations enhance prostate cancer growth and survival in the bone microenvironment... - Histologic findings on prostate needle core biopsies following cryotherapy as monotherapy for prostatic adenocarcinomaCasey Gooden
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Pathol 44:867-72. 2013..It is therefore conceivable that benign or malignant prostatic glands are either completely destroyed during cryotherapy or left unaltered if not in the direct field of cryoablation... - Epithelioid PEComa (epithelioid angiomyolipoma) of the kidney: a rare tumor subtype for patients presenting with an enhancing renal massAdam B Shrewsberry
Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Can J Urol 20:6643-5. 2013..0 cm right renal mass that was difficult to characterize radiographically preoperatively. The patient underwent a right radical nephrectomy, and pathology revealed a renal epithelioid PEComa... - Smooth muscle neoplasms of the urinary bladder: a clinicopathologic study of 51 casesThomas K Lee
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 34:502-9. 2010..High-grade leiomyosarcomas are highly aggressive neoplasms compared with low-grade leiomyosarcomas; in most cases grade can be accurately determined on TUR... - Tubulocystic carcinoma of the kidney: a case report of natural history and long-term follow-upKelvin A Moses
Department of Urology, Emory University School of Medicine, Atlanta, GA, USA
ScientificWorldJournal 10:586-9. 2010..Long-term follow-up has shown no evidence of disease. A review of the pertinent literature is performed...