Research Topics
Genomes and Genes | Jeffrey J OlsonSummaryAffiliation: Emory University School of Medicine Country: USA Publications
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Publications
Phase I analysis of BCNU-impregnated biodegradable polymer wafers followed by systemic interferon alfa-2b in adults with recurrent glioblastoma multiformeJeffrey J Olson
Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Road, NE Ste 6200, Atlanta, GA 30332, USA
J Neurooncol 90:293-9. 2008..This is a report of a phase I dose-finding study for IFNalpha(2b) in combination with surgery and BCNU wafers in patients with recurrent glioblastoma...- Assessment of a balloon-tipped catheter modified for intracerebral convection-enhanced deliveryJeffrey J Olson
Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Road, NE, Atlanta, GA, 30322, USA
J Neurooncol 89:159-68. 2008.... - Management of newly diagnosed glioblastoma: guidelines development, value and applicationJeffrey J Olson
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
J Neurooncol 93:1-23. 2009.... 
Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain tWeiping Yu
Department of Radiology, School of Medicine, Emory University, 1364 Clifton Road NE, Atlanta, Georgia 30322, USA
J Med Chem 53:876-86. 2010..The (R)-enantiomers of [(18)F]5 and [(18)F]8 demonstrated higher tumor uptake in vivo compared to the (S)-enantiomers...- The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guidelineMark E Linskey
Department of Neurosurgery, University of California Irvine Medical Center, Orange, CA, USA
J Neurooncol 96:45-68. 2010.... - The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guidelineMario Ammirati
Department of Neurosurgery, Ohio State University Medical Center, Columbus, OH, USA
J Neurooncol 96:85-96. 2010..What evidence is available regarding the use of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS), surgical resection or chemotherapy for the treatment of recurrent/progressive brain metastases?.. - Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agentWeiping Yu
Department of Radiology, School of Medicine, Emory University, Atlanta, GA 30322, USA
Bioorg Med Chem 17:1982-90. 2009..In this model, amino acid syn-[(18)F]FACBC 12 is a promising metabolically based radiotracer for positron emission tomography brain tumor imaging... - Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcomaWeiping Yu
Department of Radiology, School of Medicine, Emory University, Atlanta, GA 30322, USA
Bioorg Med Chem Lett 20:2140-3. 2010..In this model, [(18)F]9 is a potential PET tracer for brain tumor imaging... - The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guidelineSteven N Kalkanis
Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Blvd, K 11, Detroit, MI 48202, USA
J Neurooncol 96:33-43. 2010..There is insufficient evidence to make a recommendation for patients with poor performance scores, advanced systemic disease, or multiple brain metastases... - Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanismBalveen Kaur
Department of Neurosurgery, Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 69:1212-20. 2009..These results advance the understanding of brain-specific angiogenic regulation, and suggest that Vstat120 has therapeutic potential in the treatment of brain tumors and other intracerebral vasculopathies... 
Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumorsDawn E Post
Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA
Clin Cancer Res 10:8603-12. 2004....- A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastomaAnita C Bellail
Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
Cancer Discov 2:140-55. 2012.... - Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor modelSeung-Hee Kang
Department of Hematology/Oncology, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 66:11991-7. 2006.... - The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guidelineTimothy C Ryken
Department of Neurosurgery, Iowa Spine and Brain Institute, Iowa City, IA, USA
J Neurooncol 96:103-14. 2010..2) comparison of different doses of steroid therapy... - Synthesis and evaluation of [123I] labeled iodovinyl amino acids syn-, anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid, and 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid as potential SPECT brain tumor imaging agentsWeiping Yu
Department of Radiology, Emory University, School of Medicine, Atlanta, GA 30322, USA
Bioorg Med Chem Lett 18:1264-8. 2008..7-7.3:1 at 60 min post-injection). In this model, syn-, anti-, and gem-[(123)I]IVACBC are promising radiotracers for SPECT brain tumor imaging... - Delivery systems and molecular targets of mechanism-based therapies for GBMSurasak Phuphanich
Department of Hematology Oncology, Winship Cancer Institute, Suite C 5002, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
Expert Rev Neurother 4:649-63. 2004..Future goals are to tailor therapies to a tumor's molecular, proteomic or genomic status ,and manage glioblastoma multiformes as in chronic diseases in a multidisciplinary clinical setting... - Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activityYuan Rong
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Cancer Res 69:2540-9. 2009..These mechanisms are likely at work in vivo, as EGFR expression was highly correlated with TF expression in human high-grade astrocytoma specimens... - Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiationDan Yan
Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia, United States of America
PLoS ONE 5:e11397. 2010..In this study, we tested the new hypothesis: identifying the miRNAs to target DNA DSB repair genes could be a new way for sensitizing tumors to ionizing radiation... - Exciting new advances in neuro-oncology: the avenue to a cure for malignant gliomaErwin G Van Meir
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
CA Cancer J Clin 60:166-93. 2010.... - An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and feasibility trialStephen B Tatter
Department of Neurosurgery, Wake Forest University, Winston Salem, North Carolina, USA
J Neurosurg 99:297-303. 2003..In this study the authors evaluated the safety and performance of the GliaSite Radiation Therapy System (RTS) in patients with recurrent malignant brain tumors who were undergoing tumor resection... - Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinasesQi Qi
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 287:6113-27. 2012..Hence, combinatorial inhibition of EGFR and PKCs might provide proof of concept in developing therapeutic agents for treating malignant glioma and other human cancers... - Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathwayChalet Tan
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Res 65:605-12. 2005..Further studies on the mechanism of action of 103D5R will likely provide new insights into its validity/applicability for the pharmacologic targeting of HIF-1alpha for therapeutic purposes... - Synthesis and evaluation of 2-amino-4-[(18)F]fluoro-2-methylbutanoic acid (FAMB): relationship of amino acid transport to tumor imaging properties of branched fluorinated amino acidsJonathan McConathy
Department of Radiology, Emory University, Atlanta, GA 30322, USA
Nucl Med Biol 30:477-90. 2003..Comparison of [(18)F]FAMB with structurally related (18)F-labeled branched amino acids demonstrated that A type transport in vitro was positively correlated with the tumor to brain ratios observed in vivo... - Early prediction of response to Vorinostat in an orthotopic rat glioma modelLi Wei
Department of Biomedical Engineering, Emory University, Atlanta, GA 30322, USA
NMR Biomed 25:1104-11. 2012..Our study suggests that (1)H MRS can provide reliable metabolic biomarkers at the earliest stage of SAHA treatment to predict the therapeutic response... - Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosisLing Qi
Department of Pathology and Laboratory Medicine, Radiation Oncology, and Neurosurgery, Winship Cancer Institute, Emory University School Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
Apoptosis 16:1150-64. 2011..Clinic trials may consider genomic analysis of the cancer tissue to identify the genomic loss of CASP8 and use it as a genomic marker to predict the resistance of glioblastomas to TRAIL apoptosis pathway-targeted therapies... - RNAi-mediated targeting of noncoding and coding sequences in DNA repair gene messages efficiently radiosensitizes human tumor cellsZhiming Zheng
Department of Neurosurgery, Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, China
Cancer Res 72:1221-8. 2012..Together, our findings establish a general method of gene silencing that is more efficient and particularly suited for suppressing genes that are difficult to downregulate by amiR- or siRNA-based methods alone... - Metastasis infiltration: an investigation of the postoperative brain-tumor interfaceBethwel Raore
Department of Neurological Surgery, Emory University, Atlanta, GA, USA
Int J Radiat Oncol Biol Phys 81:1075-80. 2011.... - Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patientsFatima W Khwaja
Laboratory of Molecular Neuro Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road NE, Atlanta, GA 30322, USA
J Proteome Res 6:559-70. 2007.... - Intravascular thrombosis in central nervous system malignancies: a potential role in astrocytoma progression to glioblastomaMahtab Tehrani
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Pathol 18:164-71. 2008..Thus, intravascular thrombosis is more frequent in GBM than other CNS malignancies. When present in AAs, it appears to indicate aggressive clinical behavior... - Diagnosis of malignant glioma: role of neuropathologyDaniel J Brat
Department of Pathology and Laboratory Medicine, Emory University Hospital, G-169, 1364 Clifton Rd. NE, Atlanta, GA 30322, USA
J Neurooncol 89:287-311. 2008 - Protease-activated receptor-1 in human brain: localization and functional expression in astrocytesCandice E Junge
Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
Exp Neurol 188:94-103. 2004.... - DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomasAnita C Bellail
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School Medicine, Atlanta, GA 30322, USA
J Cell Mol Med 14:1303-17. 2010..Taken together, this study indicates that the DISC modification by RIP, c-FLIP and PED/PEA-15 is the most upstream event in TRAIL resistance in glioblastomas... - The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topicsJeffrey J Olson
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
J Neurooncol 96:115-42. 2010..What evidence is available regarding the emerging and investigational therapies for the treatment of metastatic brain tumors?.. - K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomasFeng Wei
Department of Hepatobiliary and Pancreas Surgery and Hematology and Oncology, The First Hospital, Jilin University, China
Cancer Lett 322:58-69. 2012..The results indicate that targeting of K-Ras mutation may lead to the development of therapies that overcome rapalog resistance in PDAC... - Apolipoprotein D expression in primary brain tumors: analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissueStephen B Hunter
Department of Pathology and Laboratory Medicine, Emory University Hospital, H 173, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
J Histochem Cytochem 53:963-9. 2005..ApoD expression measured by quantitative RT-PCR may be useful in the differential diagnosis of primary brain tumors, particularly pilocytic astrocytomas and gangliogliomas... - Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markersFatima W Khwaja
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
Proteomics 6:6277-87. 2006..3-13.7 kDa peak range in non-neoplastic CSF and was most prominent in inflammatory conditions. Our approach provides a rational basis for identifying biomarkers that could be used for detection, diagnosis, and monitoring of CNS diseases... - Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapy (Review)Stephen B Hunter
Department of Pathology and Laboratory Medicine, Emory University Hospital, H 173, NE, Atlanta, GA 30322, USA
Int J Oncol 23:857-69. 2003..Although at the present no molecular system for the classification of brain tumors has been generally accepted, microarray technologies offer the exciting prospect of practical molecular classification in the future... - Correlation of the response of recurrent malignant gliomas treated with interferon alpha with tumor interferon alpha gene contentJeffrey J Olson
Department of Neurosurgery, Emory University School of Medicine, N E, Atlanta, GA 30322, USA
Int J Oncol 25:419-27. 2004..With current improved understanding of IFNalpha toxicities and ability to measure tumor IFNalpha function, this therapy warrants further evaluation for identifying patients whose tumors are likely to be responsive to IFNalpha therapy... - Surgical management of newly diagnosed glioblastoma in adults: role of cytoreductive surgeryTimothy C Ryken
Department of Neurosurgery, University of Iowa College of Medicine, Iowa City, IA, USA
J Neurooncol 89:271-86. 2008 - Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBPShaoman Yin
Departments of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, 30322, USA
Clin Cancer Res 18:6623-33. 2012.... - Group independent component analysis and functional MRI examination of changes in language areas associated with brain tumors at different locationsLiya Wang
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America Center for Systems Imaging, Emory University School of Medicine, Atlanta, Georgia, United States of America Department of Radiology, Baoan Hospital, Shenzhen, Guangdong, China
PLoS ONE 8:e59657. 2013..This study investigates the effect of tumor location on alterations of language network by brain tumors at different locations using blood oxygenation level dependent (BOLD) fMRI and group independent component analysis (ICA)... - Open biopsy in patients with acute progressive neurologic decline and absence of mass lesionAlbert J Schuette
Department of Neurological Surgery, Emory University, Atlanta, GA, USA
Neurology 75:419-24. 2010.... - Guidelines for the treatment of newly diagnosed glioblastoma: introductionJeffrey J Olson
Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Rd, NE, Ste. 6200, Atlanta, GA 30322, USA
J Neurooncol 89:255-8. 2008 - Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumorsPrithvi Narayan
Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA
Oncol Rep 11:97-103. 2004..There is no suggestion of improved survival with thermoradiotherapy over brachytherapy alone. Given the degree of toxicity observed, alternative approaches to improving local control of these tumors are being explored... - Efficacy of adenoviral p53 delivery with SCH58500 in the intracranial 9l and RG2 modelsGeoffrey Bowers
Emory University School of Medicine, Department of Neurosurgery, Atlanta, GA, USA
Front Biosci 8:a54-61. 2003..Utilization of SCH58500 provides measurable efficacy in these preclinical brain tumor models without significant toxicity... - Results of interstitial brachytherapy for malignant brain tumorsMatthew T Mayr
Department of Neurosurgery, Naval Medical Center Portsmouth, Portsmouth, VA 23708, USA
Int J Oncol 21:817-23. 2002..Certain characteristics, specifically younger age (<55), and a higher KPS (</=70), appear to be associated with longer survival after brachytherapy. Complications, some of which are life-threatening, can and do occur...