Jeffrey J Olson

Summary

Affiliation: Emory University School of Medicine
Country: USA

Publications

  1. doi request reprint Assessment of a balloon-tipped catheter modified for intracerebral convection-enhanced delivery
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Road, NE, Atlanta, GA, 30322, USA
    J Neurooncol 89:159-68. 2008
  2. doi request reprint Management of newly diagnosed glioblastoma: guidelines development, value and application
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurooncol 93:1-23. 2009
  3. doi request reprint Phase I analysis of BCNU-impregnated biodegradable polymer wafers followed by systemic interferon alfa-2b in adults with recurrent glioblastoma multiforme
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Road, NE Ste 6200, Atlanta, GA 30332, USA
    J Neurooncol 90:293-9. 2008
  4. pmc Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain t
    Weiping Yu
    Department of Radiology, School of Medicine, Emory University, 1364 Clifton Road NE, Atlanta, Georgia 30322, USA
    J Med Chem 53:876-86. 2010
  5. pmc The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Mark E Linskey
    Department of Neurosurgery, University of California Irvine Medical Center, Orange, CA, USA
    J Neurooncol 96:45-68. 2010
  6. pmc The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline
    Mario Ammirati
    Department of Neurosurgery, Ohio State University Medical Center, Columbus, OH, USA
    J Neurooncol 96:85-96. 2010
  7. doi request reprint Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent
    Weiping Yu
    Department of Radiology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem 17:1982-90. 2009
  8. pmc The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Steven N Kalkanis
    Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Blvd, K 11, Detroit, MI 48202, USA
    J Neurooncol 96:33-43. 2010
  9. doi request reprint Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma
    Weiping Yu
    Department of Radiology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 20:2140-3. 2010
  10. ncbi request reprint Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors
    Dawn E Post
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA
    Clin Cancer Res 10:8603-12. 2004

Detail Information

Publications47

  1. doi request reprint Assessment of a balloon-tipped catheter modified for intracerebral convection-enhanced delivery
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Road, NE, Atlanta, GA, 30322, USA
    J Neurooncol 89:159-68. 2008
    ....
  2. doi request reprint Management of newly diagnosed glioblastoma: guidelines development, value and application
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurooncol 93:1-23. 2009
    ....
  3. doi request reprint Phase I analysis of BCNU-impregnated biodegradable polymer wafers followed by systemic interferon alfa-2b in adults with recurrent glioblastoma multiforme
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Road, NE Ste 6200, Atlanta, GA 30332, USA
    J Neurooncol 90:293-9. 2008
    ..This is a report of a phase I dose-finding study for IFNalpha(2b) in combination with surgery and BCNU wafers in patients with recurrent glioblastoma...
  4. pmc Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain t
    Weiping Yu
    Department of Radiology, School of Medicine, Emory University, 1364 Clifton Road NE, Atlanta, Georgia 30322, USA
    J Med Chem 53:876-86. 2010
    ..The (R)-enantiomers of [(18)F]5 and [(18)F]8 demonstrated higher tumor uptake in vivo compared to the (S)-enantiomers...
  5. pmc The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Mark E Linskey
    Department of Neurosurgery, University of California Irvine Medical Center, Orange, CA, USA
    J Neurooncol 96:45-68. 2010
    ....
  6. pmc The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline
    Mario Ammirati
    Department of Neurosurgery, Ohio State University Medical Center, Columbus, OH, USA
    J Neurooncol 96:85-96. 2010
    ..What evidence is available regarding the use of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS), surgical resection or chemotherapy for the treatment of recurrent/progressive brain metastases?..
  7. doi request reprint Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent
    Weiping Yu
    Department of Radiology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem 17:1982-90. 2009
    ..In this model, amino acid syn-[(18)F]FACBC 12 is a promising metabolically based radiotracer for positron emission tomography brain tumor imaging...
  8. pmc The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Steven N Kalkanis
    Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Blvd, K 11, Detroit, MI 48202, USA
    J Neurooncol 96:33-43. 2010
    ..There is insufficient evidence to make a recommendation for patients with poor performance scores, advanced systemic disease, or multiple brain metastases...
  9. doi request reprint Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma
    Weiping Yu
    Department of Radiology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 20:2140-3. 2010
    ..In this model, [(18)F]9 is a potential PET tracer for brain tumor imaging...
  10. ncbi request reprint Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors
    Dawn E Post
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA
    Clin Cancer Res 10:8603-12. 2004
    ....
  11. pmc Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism
    Balveen Kaur
    Department of Neurosurgery, Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 69:1212-20. 2009
    ..These results advance the understanding of brain-specific angiogenic regulation, and suggest that Vstat120 has therapeutic potential in the treatment of brain tumors and other intracerebral vasculopathies...
  12. pmc Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP
    Shaoman Yin
    Departments of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, 30322, USA
    Clin Cancer Res 18:6623-33. 2012
    ....
  13. pmc A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma
    Anita C Bellail
    Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Discov 2:140-55. 2012
    ....
  14. pmc The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline
    Timothy C Ryken
    Department of Neurosurgery, Iowa Spine and Brain Institute, Iowa City, IA, USA
    J Neurooncol 96:103-14. 2010
    ..2) comparison of different doses of steroid therapy...
  15. ncbi request reprint Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model
    Seung Hee Kang
    Department of Hematology Oncology, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:11991-7. 2006
    ....
  16. pmc Synthesis and evaluation of [123I] labeled iodovinyl amino acids syn-, anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid, and 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid as potential SPECT brain tumor imaging agents
    Weiping Yu
    Department of Radiology, Emory University, School of Medicine, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 18:1264-8. 2008
    ..7-7.3:1 at 60 min post-injection). In this model, syn-, anti-, and gem-[(123)I]IVACBC are promising radiotracers for SPECT brain tumor imaging...
  17. pmc Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma
    Erwin G Van Meir
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
    CA Cancer J Clin 60:166-93. 2010
    ....
  18. pmc Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity
    Yuan Rong
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 69:2540-9. 2009
    ..These mechanisms are likely at work in vivo, as EGFR expression was highly correlated with TF expression in human high-grade astrocytoma specimens...
  19. pmc Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation
    Dan Yan
    Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 5:e11397. 2010
    ..In this study, we tested the new hypothesis: identifying the miRNAs to target DNA DSB repair genes could be a new way for sensitizing tumors to ionizing radiation...
  20. ncbi request reprint Delivery systems and molecular targets of mechanism-based therapies for GBM
    Surasak Phuphanich
    Department of Hematology Oncology, Winship Cancer Institute, Suite C 5002, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
    Expert Rev Neurother 4:649-63. 2004
    ..Future goals are to tailor therapies to a tumor's molecular, proteomic or genomic status ,and manage glioblastoma multiformes as in chronic diseases in a multidisciplinary clinical setting...
  21. ncbi request reprint An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and feasibility trial
    Stephen B Tatter
    Department of Neurosurgery, Wake Forest University, Winston Salem, North Carolina, USA
    J Neurosurg 99:297-303. 2003
    ..In this study the authors evaluated the safety and performance of the GliaSite Radiation Therapy System (RTS) in patients with recurrent malignant brain tumors who were undergoing tumor resection...
  22. pmc Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases
    Qi Qi
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 287:6113-27. 2012
    ..Hence, combinatorial inhibition of EGFR and PKCs might provide proof of concept in developing therapeutic agents for treating malignant glioma and other human cancers...
  23. pmc Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients
    Fatima W Khwaja
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road NE, Atlanta, GA 30322, USA
    J Proteome Res 6:559-70. 2007
    ....
  24. ncbi request reprint Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway
    Chalet Tan
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 65:605-12. 2005
    ..Further studies on the mechanism of action of 103D5R will likely provide new insights into its validity/applicability for the pharmacologic targeting of HIF-1alpha for therapeutic purposes...
  25. ncbi request reprint Synthesis and evaluation of 2-amino-4-[(18)F]fluoro-2-methylbutanoic acid (FAMB): relationship of amino acid transport to tumor imaging properties of branched fluorinated amino acids
    Jonathan McConathy
    Department of Radiology, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 30:477-90. 2003
    ..Comparison of [(18)F]FAMB with structurally related (18)F-labeled branched amino acids demonstrated that A type transport in vitro was positively correlated with the tumor to brain ratios observed in vivo...
  26. pmc Early prediction of response to Vorinostat in an orthotopic rat glioma model
    Li Wei
    Department of Biomedical Engineering, Emory University, Atlanta, GA 30322, USA
    NMR Biomed 25:1104-11. 2012
    ..Our study suggests that (1)H MRS can provide reliable metabolic biomarkers at the earliest stage of SAHA treatment to predict the therapeutic response...
  27. pmc Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis
    Ling Qi
    Department of Pathology and Laboratory Medicine, Radiation Oncology, and Neurosurgery, Winship Cancer Institute, Emory University School Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Apoptosis 16:1150-64. 2011
    ..Clinic trials may consider genomic analysis of the cancer tissue to identify the genomic loss of CASP8 and use it as a genomic marker to predict the resistance of glioblastomas to TRAIL apoptosis pathway-targeted therapies...
  28. doi request reprint RNAi-mediated targeting of noncoding and coding sequences in DNA repair gene messages efficiently radiosensitizes human tumor cells
    Zhiming Zheng
    Department of Neurosurgery, Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, China
    Cancer Res 72:1221-8. 2012
    ..Together, our findings establish a general method of gene silencing that is more efficient and particularly suited for suppressing genes that are difficult to downregulate by amiR- or siRNA-based methods alone...
  29. pmc The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
    J Neurooncol 96:115-42. 2010
    ..What evidence is available regarding the emerging and investigational therapies for the treatment of metastatic brain tumors?..
  30. pmc Intravascular thrombosis in central nervous system malignancies: a potential role in astrocytoma progression to glioblastoma
    Mahtab Tehrani
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Pathol 18:164-71. 2008
    ..Thus, intravascular thrombosis is more frequent in GBM than other CNS malignancies. When present in AAs, it appears to indicate aggressive clinical behavior...
  31. doi request reprint Metastasis infiltration: an investigation of the postoperative brain-tumor interface
    Bethwel Raore
    Department of Neurological Surgery, Emory University, Atlanta, GA, USA
    Int J Radiat Oncol Biol Phys 81:1075-80. 2011
    ....
  32. pmc DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas
    Anita C Bellail
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School Medicine, Atlanta, GA 30322, USA
    J Cell Mol Med 14:1303-17. 2010
    ..Taken together, this study indicates that the DISC modification by RIP, c-FLIP and PED/PEA-15 is the most upstream event in TRAIL resistance in glioblastomas...
  33. ncbi request reprint Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes
    Candice E Junge
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 188:94-103. 2004
    ....
  34. doi request reprint Diagnosis of malignant glioma: role of neuropathology
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University Hospital, G 169, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
    J Neurooncol 89:287-311. 2008
  35. pmc Group independent component analysis and functional MRI examination of changes in language areas associated with brain tumors at different locations
    Liya Wang
    Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 8:e59657. 2013
    ..This study investigates the effect of tumor location on alterations of language network by brain tumors at different locations using blood oxygenation level dependent (BOLD) fMRI and group independent component analysis (ICA)...
  36. pmc K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas
    Feng Wei
    Department of Hepatobiliary and Pancreas Surgery and Hematology and Oncology, The First Hospital, Jilin University, China
    Cancer Lett 322:58-69. 2012
    ..The results indicate that targeting of K-Ras mutation may lead to the development of therapies that overcome rapalog resistance in PDAC...
  37. ncbi request reprint Correlation of the response of recurrent malignant gliomas treated with interferon alpha with tumor interferon alpha gene content
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, N E, Atlanta, GA 30322, USA
    Int J Oncol 25:419-27. 2004
    ..With current improved understanding of IFNalpha toxicities and ability to measure tumor IFNalpha function, this therapy warrants further evaluation for identifying patients whose tumors are likely to be responsive to IFNalpha therapy...
  38. doi request reprint Surgical management of newly diagnosed glioblastoma in adults: role of cytoreductive surgery
    Timothy C Ryken
    Department of Neurosurgery, University of Iowa College of Medicine, Iowa City, IA, USA
    J Neurooncol 89:271-86. 2008
  39. ncbi request reprint Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers
    Fatima W Khwaja
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proteomics 6:6277-87. 2006
    ..3-13.7 kDa peak range in non-neoplastic CSF and was most prominent in inflammatory conditions. Our approach provides a rational basis for identifying biomarkers that could be used for detection, diagnosis, and monitoring of CNS diseases...
  40. ncbi request reprint Apolipoprotein D expression in primary brain tumors: analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue
    Stephen B Hunter
    Department of Pathology and Laboratory Medicine, Emory University Hospital, H 173, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
    J Histochem Cytochem 53:963-9. 2005
    ..ApoD expression measured by quantitative RT-PCR may be useful in the differential diagnosis of primary brain tumors, particularly pilocytic astrocytomas and gangliogliomas...
  41. ncbi request reprint Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapy (Review)
    Stephen B Hunter
    Department of Pathology and Laboratory Medicine, Emory University Hospital, H 173, NE, Atlanta, GA 30322, USA
    Int J Oncol 23:857-69. 2003
    ..Although at the present no molecular system for the classification of brain tumors has been generally accepted, microarray technologies offer the exciting prospect of practical molecular classification in the future...
  42. doi request reprint Guidelines for the treatment of newly diagnosed glioblastoma: introduction
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Rd, NE, Ste 6200, Atlanta, GA 30322, USA
    J Neurooncol 89:255-8. 2008
  43. pmc Open biopsy in patients with acute progressive neurologic decline and absence of mass lesion
    Albert J Schuette
    Department of Neurological Surgery, Emory University, Atlanta, GA, USA
    Neurology 75:419-24. 2010
    ....
  44. doi request reprint Glioblastoma with oligodendroglioma component (GBM-O): molecular genetic and clinical characteristics
    Christina L Appin
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Pathol 23:454-61. 2013
    ..Among patients with GBM-O, younger age at presentation and 1p deletion were most significant in conferring prolonged survival. Thus, GBM-O represents a subset of GBMs with distinctive morphologic, clinical and molecular characteristics...
  45. ncbi request reprint Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors
    Prithvi Narayan
    Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA
    Oncol Rep 11:97-103. 2004
    ..There is no suggestion of improved survival with thermoradiotherapy over brachytherapy alone. Given the degree of toxicity observed, alternative approaches to improving local control of these tumors are being explored...
  46. ncbi request reprint Results of interstitial brachytherapy for malignant brain tumors
    Matthew T Mayr
    Department of Neurosurgery, Naval Medical Center Portsmouth, Portsmouth, VA 23708, USA
    Int J Oncol 21:817-23. 2002
    ..Certain characteristics, specifically younger age (<55), and a higher KPS (</=70), appear to be associated with longer survival after brachytherapy. Complications, some of which are life-threatening, can and do occur...
  47. ncbi request reprint Efficacy of adenoviral p53 delivery with SCH58500 in the intracranial 9l and RG2 models
    Geoffrey Bowers
    Emory University School of Medicine, Department of Neurosurgery, Atlanta, GA, USA
    Front Biosci 8:a54-61. 2003
    ..Utilization of SCH58500 provides measurable efficacy in these preclinical brain tumor models without significant toxicity...