Seth D Norrholm

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Versatility of fear-potentiated startle paradigms for assessing human conditioned fear extinction and return of fear
    Seth D Norrholm
    Trauma Recovery Program, Mental Health Service Line, Atlanta Veterans Affairs Medical Center Decatur, GA, USA
    Front Behav Neurosci 5:77. 2011
  2. pmc Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity
    Seth D Norrholm
    Atlanta Veterans Affairs Medical Center, Mental Health Service Line, Decatur, Georgia, USA
    Biol Psychiatry 69:556-63. 2011
  3. pmc Posttraumatic stress disorder may be associated with impaired fear inhibition: relation to symptom severity
    Tanja Jovanovic
    Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Psychiatry Res 167:151-60. 2009
  4. pmc Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humans
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Behav Neurosci 122:1016-30. 2008
  5. pmc Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since trauma
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Depress Anxiety 30:217-24. 2013
  6. pmc Inhibition of fear is differentially associated with cycling estrogen levels in women
    EBONY M GLOVER
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    J Psychiatry Neurosci 38:341-8. 2013
  7. pmc Acoustic startle reduction in cocaine dependence persists for 1 year of abstinence
    Sarah Corcoran
    Mental Health Service, Atlanta VA Medical Center, Decatur, GA 30033, USA
    Psychopharmacology (Berl) 215:93-103. 2011
  8. pmc Differences in startle reflex and prepulse inhibition in European-Americans and African-Americans
    Wendy Hasenkamp
    Atlanta Department of Veterans Affairs Medical Center, Atlanta, Georgia, USA
    Psychophysiology 45:876-82. 2008
  9. pmc Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
    Kerry J Ressler
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
    Nature 470:492-7. 2011
  10. pmc Impaired fear inhibition is a biomarker of PTSD but not depression
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303
    Depress Anxiety 27:244-51. 2010

Detail Information

Publications17

  1. pmc Versatility of fear-potentiated startle paradigms for assessing human conditioned fear extinction and return of fear
    Seth D Norrholm
    Trauma Recovery Program, Mental Health Service Line, Atlanta Veterans Affairs Medical Center Decatur, GA, USA
    Front Behav Neurosci 5:77. 2011
    ..We discuss the current results as they relate to future investigations of PTSD-related impairments in fear processing in populations with diverse medical and psychiatric histories...
  2. pmc Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity
    Seth D Norrholm
    Atlanta Veterans Affairs Medical Center, Mental Health Service Line, Decatur, Georgia, USA
    Biol Psychiatry 69:556-63. 2011
    ..On the basis of our earlier findings, we employed an established fear extinction paradigm to further explore fear dysregulation in a civilian traumatized population...
  3. pmc Posttraumatic stress disorder may be associated with impaired fear inhibition: relation to symptom severity
    Tanja Jovanovic
    Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Psychiatry Res 167:151-60. 2009
    ..However, the high-symptom PTSD group did not show fear inhibition: these subjects had significantly greater fear potentiation on the AB trials than both the controls and the low-symptom PTSD patients...
  4. pmc Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humans
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Behav Neurosci 122:1016-30. 2008
    ..Thus, the results remain inconclusive regarding spontaneous recovery and the timing of extinction and are discussed in terms of performing translational studies of fear in humans...
  5. pmc Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since trauma
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Depress Anxiety 30:217-24. 2013
    ..This is the first study to use a conditioned inhibition paradigm with traumatized individuals within a month of trauma exposure. We hypothesized that impaired fear inhibition would be evident in PTSD, but not ASD...
  6. pmc Inhibition of fear is differentially associated with cycling estrogen levels in women
    EBONY M GLOVER
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    J Psychiatry Neurosci 38:341-8. 2013
    ....
  7. pmc Acoustic startle reduction in cocaine dependence persists for 1 year of abstinence
    Sarah Corcoran
    Mental Health Service, Atlanta VA Medical Center, Decatur, GA 30033, USA
    Psychopharmacology (Berl) 215:93-103. 2011
    ....
  8. pmc Differences in startle reflex and prepulse inhibition in European-Americans and African-Americans
    Wendy Hasenkamp
    Atlanta Department of Veterans Affairs Medical Center, Atlanta, Georgia, USA
    Psychophysiology 45:876-82. 2008
    ..These findings support the idea of racial differences in startle response. Implications for study design are highlighted, and possible environmental and genetic influences are considered...
  9. pmc Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
    Kerry J Ressler
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
    Nature 470:492-7. 2011
    ..These sex-specific effects may occur via oestrogen regulation of ADCYAP1R1. PACAP levels and ADCYAP1R1 SNPs may serve as useful biomarkers to further our mechanistic understanding of PTSD...
  10. pmc Impaired fear inhibition is a biomarker of PTSD but not depression
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303
    Depress Anxiety 27:244-51. 2010
    ..Given the high comorbidity between PTSD and depression, our goal was to see whether this impairment is specific to PTSD, or a non-specific symptom associated with both disorders...
  11. pmc Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD
    Tanja Jovanovic
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 35:846-57. 2010
    ..These results suggest that impaired fear inhibition and associated alterations in HPA feedback may reflect amygdala hyperactivity in subjects with PTSD...
  12. pmc Childhood abuse is associated with increased startle reactivity in adulthood
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Depress Anxiety 26:1018-26. 2009
    ..The acoustic startle response (ASR) is a subcortical reflex modulated by neural systems implicated in posttraumatic stress disorder (PTSD). The ASR is conserved across species and is increased in rodent models of developmental stress...
  13. pmc Altered resting psychophysiology and startle response in Croatian combat veterans with PTSD
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30303, USA
    Int J Psychophysiol 71:264-8. 2009
    ..Startle habituation and baseline heart-rate appear to offer the most reliable psychophysiological indices of PTSD. This finding replicates trends in the literature in a new population of PTSD patients...
  14. pmc Physiological markers of anxiety are increased in children of abused mothers
    Tanja Jovanovic
    Emory University School of Medicine, Dept of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, USA
    J Child Psychol Psychiatry 52:844-52. 2011
    ..The current study employed psychophysiological methods to describe biomarkers of anxiety in children of traumatized mothers...
  15. pmc Contingency awareness and fear inhibition in a human fear-potentiated startle paradigm
    Tanja Jovanovic
    Mental Health Service 116A, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Behav Neurosci 120:995-1004. 2006
    ..A response keypad was used to assess contingency awareness on a trial-by-trial basis. Both aware and unaware subjects showed fear-potentiated startle. However, awareness was related to stimulus discrimination and fear inhibition...
  16. pmc PTSD and gene variants: new pathways and new thinking
    Kelly Skelton
    Atlanta VA Medical Center, 1670 Clairmont Rd, Decatur, GA 30033, USA
    Neuropharmacology 62:628-37. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  17. pmc Tailoring therapeutic strategies for treating posttraumatic stress disorder symptom clusters
    Seth D Norrholm
    Atlanta VA Medical Center, Mental Health Service Line, Decatur, GA, USA
    Neuropsychiatr Dis Treat 6:517-32. 2010
    ..Finally, the review will also address potential genetic approaches to treatment as another form of individualized treatment...