Shuming Nie

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Engineering luminescent quantum dots for in vivo molecular and cellular imaging
    Andrew M Smith
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    Ann Biomed Eng 34:3-14. 2006
  2. ncbi request reprint Counting single native biomolecules and intact viruses with color-coded nanoparticles
    Amit Agrawal
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, GA 30322, USA
    Anal Chem 78:1061-70. 2006
  3. ncbi request reprint Etching colloidal gold nanocrystals with hyperbranched and multivalent polymers: a new route to fluorescent and water-soluble atomic clusters
    Hongwei Duan
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Atlanta, GA 30322, USA
    J Am Chem Soc 129:2412-3. 2007
  4. ncbi request reprint Nanotechnology applications in cancer
    Shuming Nie
    Department of Biomedical Engineering and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    Annu Rev Biomed Eng 9:257-88. 2007
  5. ncbi request reprint Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry
    Yun Xing
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 1001, Atlanta, Georgia 30322, USA
    Nat Protoc 2:1152-65. 2007
  6. pmc Semiconductor quantum dots for bioimaging and biodiagnostic applications
    Brad A Kairdolf
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    Annu Rev Anal Chem (Palo Alto Calif) 6:143-62. 2013
  7. pmc A folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model
    Xu Wang
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    ACS Nano 5:6184-94. 2011
  8. pmc Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging
    Lily Yang
    Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Small 5:235-43. 2009
  9. pmc Oxidative quenching and degradation of polymer-encapsulated quantum dots: new insights into the long-term fate and toxicity of nanocrystals in vivo
    Michael C Mancini
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle, WMB Suite 2007, Atlanta, Georgia 30322, USA
    J Am Chem Soc 130:10836-7. 2008
  10. pmc HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors
    Xu Wang
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Atlanta, Georgia, USA
    ACS Nano 3:3165-74. 2009

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Engineering luminescent quantum dots for in vivo molecular and cellular imaging
    Andrew M Smith
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    Ann Biomed Eng 34:3-14. 2006
    ..We also discuss recent advances in using quantum dots for in vivo molecular and cellular imaging...
  2. ncbi request reprint Counting single native biomolecules and intact viruses with color-coded nanoparticles
    Amit Agrawal
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, GA 30322, USA
    Anal Chem 78:1061-70. 2006
    ....
  3. ncbi request reprint Etching colloidal gold nanocrystals with hyperbranched and multivalent polymers: a new route to fluorescent and water-soluble atomic clusters
    Hongwei Duan
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Atlanta, GA 30322, USA
    J Am Chem Soc 129:2412-3. 2007
  4. ncbi request reprint Nanotechnology applications in cancer
    Shuming Nie
    Department of Biomedical Engineering and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    Annu Rev Biomed Eng 9:257-88. 2007
    ..These developments raise exciting opportunities for personalized oncology in which genetic and protein biomarkers are used to diagnose and treat cancer based on the molecular profiles of individual patients...
  5. ncbi request reprint Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry
    Yun Xing
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 1001, Atlanta, Georgia 30322, USA
    Nat Protoc 2:1152-65. 2007
    ..In general, QD bioconjugation is completed within 1 day, and multiplexed molecular profiling takes 1-3 days depending on the number of biomarkers and QD probes used...
  6. pmc Semiconductor quantum dots for bioimaging and biodiagnostic applications
    Brad A Kairdolf
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    Annu Rev Anal Chem (Palo Alto Calif) 6:143-62. 2013
    ....
  7. pmc A folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model
    Xu Wang
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    ACS Nano 5:6184-94. 2011
    ..These results indicated that the targeted HFT-T nanoparticle may be promising in minimizing P-gp related drug resistance and enhancing therapeutic efficacy compared with the free form of paclitaxel...
  8. pmc Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging
    Lily Yang
    Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Small 5:235-43. 2009
    ..Efficient internalization of ScFvEGFR nanoparticles into tumor cells after systemic delivery suggests that the EGFR-targeted nanoparticles can also be used for the targeted delivery of therapeutic agents...
  9. pmc Oxidative quenching and degradation of polymer-encapsulated quantum dots: new insights into the long-term fate and toxicity of nanocrystals in vivo
    Michael C Mancini
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle, WMB Suite 2007, Atlanta, Georgia 30322, USA
    J Am Chem Soc 130:10836-7. 2008
    ..These results have important implications regarding the long-term fate and potential toxicity of semiconductor nanocrystals in vivo...
  10. pmc HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors
    Xu Wang
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Atlanta, Georgia, USA
    ACS Nano 3:3165-74. 2009
    ..These results indicate that specific delivery of paclitaxel with a ternary structured nanoparticle (HFT-T) targeting FR-positive tumor is a promising strategy to enhance chemotherapy efficacy and minimize adverse effects...
  11. doi request reprint Minimizing nonspecific cellular binding of quantum dots with hydroxyl-derivatized surface coatings
    Brad A Kairdolf
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    Anal Chem 80:3029-34. 2008
    ....
  12. pmc Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
    Xiang Hong Peng
    Department of Medical Oncology Hematology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Nanomedicine 3:311-21. 2008
    ..We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy...
  13. pmc Minimizing the hydrodynamic size of quantum dots with multifunctional multidentate polymer ligands
    Andrew M Smith
    Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    J Am Chem Soc 130:11278-9. 2008
    ..7 nm with tunable fluorescence emission from the visible (515 nm) to the near-infrared (720 nm). These QDs are well suited for molecular and cellular imaging applications in which the nanoparticle hydrodynamic size must be minimized...
  14. pmc Molecular imaging of pancreatic cancer in an animal model using targeted multifunctional nanoparticles
    Lily Yang
    Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 136:1514-25.e2. 2009
    ....
  15. pmc Molecular profiling of single cancer cells and clinical tissue specimens with semiconductor quantum dots
    Yun Xing
    Departments of Biomedical, Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA
    Int J Nanomedicine 1:473-81. 2006
    ..In this article, we briefly discuss recent developments in bioaffinity QD probes and their applications in molecular profiling of individual cancer cells and clinical tissue specimens...
  16. pmc Visualizing human prostate cancer cells in mouse skeleton using bioconjugated near-infrared fluorescent quantum dots
    Chunmeng Shi
    Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Urology 74:446-51. 2009
    ..To visualize human prostate cancer cells in mouse bone with bioconjugated near-infrared quantum dot (QD) probes. Near-infrared fluorescent probes using QDs can visualize tumors in deep tissues in vivo...
  17. pmc A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands
    Xiaohua Huang
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle Suite 2007, Atlanta, Georgia 30322, United States
    ACS Nano 4:5887-96. 2010
    ..These results suggest that for photothermal cancer therapy, the preferred route of gold nanorod administration is intratumoral injection instead of intravenous injection...
  18. pmc One-pot synthesis, encapsulation, and solubilization of size-tuned quantum dots with amphiphilic multidentate ligands
    Brad A Kairdolf
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    J Am Chem Soc 130:12866-7. 2008
    ....
  19. pmc Molecular mapping of tumor heterogeneity on clinical tissue specimens with multiplexed quantum dots
    Jian Liu
    Department of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, Georgia 30322, USA
    ACS Nano 4:2755-65. 2010
    ..For clinical diagnostic applications, multiplexed QD mapping provides correlated molecular and morphological information that is not available from traditional tissue staining and molecular profiling methods...
  20. pmc Semiconductor nanocrystals: structure, properties, and band gap engineering
    Andrew M Smith
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    Acc Chem Res 43:190-200. 2010
    ..New methodologies such as alloying, doping, strain-tuning, and band-edge warping will likely play key roles in the further development of these particles for optoelectronic and biomedical applications...
  21. pmc Receptor-targeted nanoparticles for in vivo imaging of breast cancer
    Lily Yang
    Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, C 4088, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
    Clin Cancer Res 15:4722-32. 2009
    ..Cell-surface receptor-targeted magnetic iron oxide nanoparticles provide molecular magnetic resonance imaging contrast agents for improving specificity of the detection of human cancer...
  22. pmc Multiplexed detection and characterization of rare tumor cells in Hodgkin's lymphoma with multicolor quantum dots
    Jian Liu
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, Georgia 30322, USA
    Anal Chem 82:6237-43. 2010
    ..The results indicate that a distinct QD staining pattern (CD15 positive, CD30 positive, CD45 negative, and Pax5 positive) can be used to not only detect Hodgkin's lymphoma but also differentiate it from benign lymphoid hyperplasia...
  23. ncbi request reprint Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging
    Matthew N Rhyner
    Department of Biomedical Engineering, Chemistry, Hematology and Oncology, and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA
    Nanomedicine (Lond) 1:209-17. 2006
    ..g., anticancer) agents. In this review, recent advances in the development and applications of bioconjugated quantum dots and multifunctional nanoparticles for in vivo tumor imaging and targeting are discussed...
  24. ncbi request reprint In vivo molecular and cellular imaging with quantum dots
    Xiaohu Gao
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 1639 Pierce Drive, Suite 2001, Atlanta, GA 30322, USA
    Curr Opin Biotechnol 16:63-72. 2005
    ..Bioconjugated QDs have raised new possibilities for ultrasensitive and multiplexed imaging of molecular targets in living cells, animal models and possibly in humans...
  25. pmc Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect
    Hari Krishna Sajja
    Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Room C 4088, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Curr Drug Discov Technol 6:43-51. 2009
    ....
  26. pmc Surface-enhanced Raman nanoparticle beacons based on bioconjugated gold nanocrystals and long range plasmonic coupling
    Ximei Qian
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    J Am Chem Soc 130:14934-5. 2008
    ....
  27. pmc Bioconjugated quantum dots for in vivo molecular and cellular imaging
    Andrew M Smith
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA
    Adv Drug Deliv Rev 60:1226-40. 2008
    ..We also examine key issues for in vivo imaging and therapy, such as nanoparticle biodistribution, pharmacokinetics, and toxicology...
  28. pmc Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer
    Gee Young Lee
    Departments of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, United States
    ACS Nano 7:2078-89. 2013
    ....
  29. ncbi request reprint In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
    Ximei Qian
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    Nat Biotechnol 26:83-90. 2008
    ....
  30. pmc Targeted delivery of cisplatin to lung cancer using ScFvEGFR-heparin-cisplatin nanoparticles
    Xiang Hong Peng
    Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, United States
    ACS Nano 5:9480-93. 2011
    ..The new EHDDP nanoparticle delivery system significantly enhanced antitumor activity of DDP without weight loss or damage to the kidney and spleen in nude mice bearing H292 cell tumors...
  31. pmc Tuning the optical and electronic properties of colloidal nanocrystals by lattice strain
    Andrew M Smith
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    Nat Nanotechnol 4:56-63. 2009
    ..Lattice-mismatched core-shell quantum dots are expected to have applications in solar energy conversion, multicolour biomedical imaging and super-resolution optical microscopy...
  32. pmc Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment
    John H Phan
    Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, UA Whitaker Building 4106, Atlanta, GA 30332, USA
    Trends Biotechnol 27:350-8. 2009
    ..This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases...
  33. pmc Nanometer-scale mapping and single-molecule detection with color-coded nanoparticle probes
    Amit Agrawal
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 105:3298-303. 2008
    ....
  34. pmc Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles
    Xu Wang
    Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 71:1526-32. 2011
    ..Our technique may provide an important new clinical tool for management of patients with SCCHN and other cancers...
  35. doi request reprint Quantum dots: emerging applications in urologic oncology
    Chunmeng Shi
    Molecular Urology and Therapeutics Program, Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Urol Oncol 26:86-92. 2008
    ..In this article, we describe the development of multifunctional QDs and their potential applications in oncology, with a particular emphasis on the diagnosis, prognosis, and treatment of urologic cancers...
  36. ncbi request reprint Nanotechnology for targeted cancer therapy
    May D Wang
    Georgia Institute of Technology, Department of Biomedical Engineering, and Emory University, Atlanta, GA 30332, USA
    Expert Rev Anticancer Ther 7:833-7. 2007
    ....
  37. pmc Examining expression of folate receptor in squamous cell carcinoma of the head and neck as a target for a novel nanotherapeutic drug
    Nabil F Saba
    Winship Cancer Institute at Emory University, Atlanta, Georgia, USA
    Head Neck 31:475-81. 2009
    ..We investigated expression levels of folate receptor in squamous cell carcinoma of the head and neck (SCCHN) to evaluate folate receptor as a target for nanotherapy...
  38. ncbi request reprint Multicolor quantum dots for molecular diagnostics of cancer
    Andrew M Smith
    Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA
    Expert Rev Mol Diagn 6:231-44. 2006
    ..Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging...
  39. ncbi request reprint Emerging use of nanoparticles in diagnosis and treatment of breast cancer
    Maksym V Yezhelyev
    Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Lancet Oncol 7:657-67. 2006
    ..In this review, we give an overview of the use of clinically applicable nanoparticles in oncology, with particular focus on the diagnosis and treatment of breast cancer...
  40. pmc Anchoring molecular chromophores to colloidal gold nanocrystals: surface-enhanced Raman evidence for strong electronic coupling and irreversible structural locking
    Ximei Qian
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    J Am Chem Soc 134:2000-3. 2012
    ..These results indicate that ITC is indeed an unusual anchoring group that enables strong electronic coupling between gold and the adsorbed dye, leading to more efficient chemical enhancement and higher overall enhancement factors...
  41. doi request reprint Quality control of highly multiplexed proteomic immunostaining with quantum dots: correcting for crosstalk
    Richard A Moffitt
    Department of Biomedical Engineering at the Georgia Institute of Technology, Atlanta, GA 30332, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6739-42. 2009
    ..This work is expected to improve the overall reproducibility and quantification of multiplexed QD staining...
  42. ncbi request reprint Quantum dot-encoded beads
    Xiaohu Gao
    Department of Biomedical Engineering, Emory University, Atlanta, GA, USA
    Methods Mol Biol 303:61-71. 2005
    ..This spectral coding technology is expected to open new opportunities in gene expression studies, high-throughput screening, and medical diagnostics...
  43. pmc Multidentate-protected colloidal gold nanocrystals: pH control of cooperative precipitation and surface layer shedding
    Brad A Kairdolf
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    J Am Chem Soc 133:7268-71. 2011
    ..These insights are important in regard to the design of "smart" imaging and therapeutic nanoparticles that are activated by small pH changes in the tumor interstitial space or endocytic organelles...
  44. ncbi request reprint Quantum dot nanocrystals for in vivo molecular and cellular imaging
    Andrew M Smith
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, GA 30332, USA
    Photochem Photobiol 80:377-85. 2004
    ..Here, we discuss recent developments in QD synthesis and bioconjugation, applications in molecular and cellular imaging as well as promising directions for future research...
  45. ncbi request reprint Imaging and tracking of tat peptide-conjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding
    Gang Ruan
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    J Am Chem Soc 129:14759-66. 2007
    ..These results provide new insights into the mechanisms of Tat peptide-mediated delivery as well as toward the design of functionalized nanoparticles for molecular imaging and targeted therapy...
  46. ncbi request reprint Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery
    Rajni Sinha
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Room 3090, Atlanta, GA 30322, USA
    Mol Cancer Ther 5:1909-17. 2006
    ..In this article, we briefly discuss the use of bioconjugated nanoparticles for the delivery and targeting of anticancer drugs...
  47. pmc Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging
    Maksym V Yezhelyev
    Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    J Am Chem Soc 130:9006-12. 2008
    ..These new insights and capabilities represent a major step toward nanoparticle engineering for imaging and therapeutic applications...
  48. doi request reprint Therapeutic nanoparticles for drug delivery in cancer
    Kwangjae Cho
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 14:1310-6. 2008
    ..Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment...
  49. ncbi request reprint Single-bead immunoassays using magnetic microparticles and spectral-shifting quantum dots
    Amit Agrawal
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Suite 2001, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
    J Agric Food Chem 55:3778-82. 2007
    ..This sensitivity is almost 1000 times higher that that of traditional immunoabsorbent assays and more than 100 times higher than immunofluorescent assays using organic dyes...
  50. ncbi request reprint Chemical analysis and cellular imaging with quantum dots
    Andrew M Smith
    Department of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA
    Analyst 129:672-7. 2004
    ....
  51. ncbi request reprint Bio-nano-informatics: an integrated information management system for personalized oncology
    Todd H Stokes
    Sch of Electr and Comput Eng, Georgia Inst of Technol, Atlanta, GA 30332, USA
    Conf Proc IEEE Eng Med Biol Soc 1:3325-8. 2006
    ..Here we have developed an "intelligent" information system for data management, interpretation, and for translation of new results to clinical applications...
  52. doi request reprint Biomedical nanotechnology for molecular imaging, diagnostics, and targeted therapy
    Shuming Nie
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, GA 30322 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4578-9. 2009
    ..g., optical, radioisotopic, or magnetic) and therapeutic (e.g., anticancer) agents...
  53. pmc Bright and compact alloyed quantum dots with broadly tunable near-infrared absorption and fluorescence spectra through mercury cation exchange
    Andrew M Smith
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    J Am Chem Soc 133:24-6. 2011
    ..5 nm nanocrystal size and 10 nm hydrodynamic diameter) and very bright (60-80% quantum yield), with narrow and symmetric fluorescence spectra tunable across the wavelength range from 700 to 1150 nm...
  54. ncbi request reprint Mesoporous silica beads embedded with semiconductor quantum dots and iron oxide nanocrystals: dual-function microcarriers for optical encoding and magnetic separation
    Tushar R Sathe
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    Anal Chem 78:5627-32. 2006
    ..By combining the multiplexing capability of QDs with the superparamagnetic properties of iron oxide nanocrystals, this class of encoded beads is expected to find broad applications in high-throughput and multiplexed biomolecular assays...
  55. ncbi request reprint Nanomolecular histopathology for renal tumor classification
    Andrew Young
    Emory University and the Atlanta VA Medical Center, Decatur, GA 30033 USA phone 404 321 6111 ext 3441 fax 404 235 3007 e mail
    Conf Proc IEEE Eng Med Biol Soc 1:723-6. 2005
    ..Our preliminary data suggests that SERS-IHC can be performed using standard microscopic equipment, with potential for sensitive, quantitative multiplex assays on fixed tissues...
  56. pmc Stimuli-responsive SERS nanoparticles: conformational control of plasmonic coupling and surface Raman enhancement
    Ximei Qian
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle Suite 2001, Atlanta, Georgia 30322, USA
    J Am Chem Soc 131:7540-1. 2009
    ....
  57. ncbi request reprint Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings
    Hongwei Duan
    Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    J Am Chem Soc 129:3333-8. 2007
    ..These insights are important toward the design and development of nanoparticle agents for intracellular imaging and therapeutic applications...
  58. ncbi request reprint A new class of far-red and near-infrared biological labels based on alloyed semiconductor quantum dots
    Robert E Bailey
    Department of Biomedical Engineering, Emory University, Atlanta, Georgia 30322, USA
    J Nanosci Nanotechnol 4:569-74. 2004
    ..A cadmium-rich surface is found to improve mercapto ligand binding and the long-term stability of water-soluble dots...
  59. ncbi request reprint Quantitative 3D fluorescence technique for the analysis of en face preparations of arterial walls using quantum dot nanocrystals and two-photon excitation laser scanning microscopy
    Dardo E Ferrara
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 290:R114-23. 2006
    ..This is a promising technique to define the spatial and temporal interactions of endothelial inflammatory markers and quantify the effects of different interventions on the endothelium...
  60. ncbi request reprint In vivo cancer targeting and imaging with semiconductor quantum dots
    Xiaohu Gao
    Department of Biomedical Engineering, and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, 1639 Pierce Drive, Suite 2001, Atlanta, Georgia 30322, USA
    Nat Biotechnol 22:969-76. 2004
    ..These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo...
  61. ncbi request reprint Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4
    Zhongxing Liang
    Department of Hematology Oncology, Winship Cancer Institute, Atlanta, Georgia 30322, USA
    Cancer Res 64:4302-8. 2004
    ....
  62. ncbi request reprint Molecular profiling of single cells and tissue specimens with quantum dots
    Xiaohu Gao
    Department of Biomedical Engineering, Emory University, 1639 Pierce Drive, Suite 2001, Atlanta, GA 30322, USA
    Trends Biotechnol 21:371-3. 2003
    ..These bioconjugates raise new possibilities for studying genes, proteins and drug targets in single cells, tissue specimens and even in living animals...
  63. ncbi request reprint Quantum-dot nanocrystals for ultrasensitive biological labeling and multicolor optical encoding
    Xiaohu Gao
    Georgia Institute of Technology Emory University School of Medicine, Departments of Biomedical Engineering, Chemistry, Hematology, Oncology, and the Winship Cancer Institute, 1639 Pierce Drive, Suite 2001 Atlanta, Georgia 30322, USA
    J Biomed Opt 7:532-7. 2002
    ..For multiplexed optical encoding, we have prepared large microbeads with sizes similar to that of mammalian cells, and small nanobeads with sizes similar to that of viruses...
  64. ncbi request reprint Spectroscopic tags using dye-embedded nanoparticles and surface-enhanced Raman scattering
    William E Doering
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 1639 Pierce Drive, Suite 2001, Atlanta, Georgia 30322, USA
    Anal Chem 75:6171-6. 2003
    ..In comparison with fluorescent dyes and quantum dots, enhanced Raman probes contain a built-in mechanism for signal amplification and provide rich spectroscopic information under ambient experimental conditions...
  65. pmc Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells
    Nitin Nitin
    Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Nucleic Acids Res 32:e58. 2004
    ..The peptide-linked molecular beacons approach promises to open new and exciting opportunities in sensitive gene detection and quantification in vivo...
  66. ncbi request reprint Using solution-phase nanoparticles, surface-confined nanoparticle arrays and single nanoparticles as biological sensing platforms
    Amanda J Haes
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    J Fluoresc 14:355-67. 2004
    ..Specifically, the color associated with solution-phase nanoparticles, surface-confined nanoparticle arrays, and single nanoparticles will be shown to be tunable and useful as platforms for biological sensing...
  67. ncbi request reprint New technology and clinical applications of nanomedicine: highlights of the second annual meeting of the American Academy of Nanomedicine (Part I)
    Chiming Wei
    Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nanomedicine 2:253-63. 2006
    ..We believe that nanomedicine research will develop rapidly in the future. The AANM invites basic and clinical researchers from the world to join this exciting research...

Research Grants18

  1. METAL NANOPARTICLES FOR ULTRATRACE BIOMOLECULE DETECTION
    Shuming Nie; Fiscal Year: 2002
    ..A potential clinical application i to determine the viral RNA load in infectious diseases such as HIV and hepatitis. ..
  2. LUMINESCENT QUANTUM DOTS AS BIOLOGICAL LABELS
    Shuming Nie; Fiscal Year: 2003
    ..Quantum dot bioconjugates are expected to be available in large quantities and in lyphophilized forms, for broad distribution to the scientific community. ..
  3. Bioaffinity Nanoparticle Probes for Bioimaging
    Shuming Nie; Fiscal Year: 2007
    ..abstract_text> ..
  4. Nanotechnology Linking Biomarkers with Cancer Behavior
    Shuming Nie; Fiscal Year: 2007
    ..abstract_text> ..
  5. Emory-GA Tech Nanotechnology Center for Personalized an*
    Shuming Nie; Fiscal Year: 2007
    ....