Hang Thi Thu Nguyen

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Ecto-phosphorylation of CD98 regulates cell-cell interactions
    Hang Thi Thu Nguyen
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 3:e3895. 2008
  2. pmc CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice
    Hang Thi Thu Nguyen
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    J Clin Invest 121:1733-47. 2011
  3. pmc Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response
    Hang Thi Thu Nguyen
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 137:1435-47.e1-2. 2009
  4. pmc Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e5049. 2009
  5. pmc PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells
    Guillaume Dalmasso
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 299:G687-96. 2010
  6. pmc MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation
    Hang Thi Thu Nguyen
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:1479-89. 2010
  7. pmc Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 173:1013-28. 2008
  8. doi request reprint Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model
    Hamed Laroui
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 138:843-53.e1-2. 2010
  9. pmc MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 300:G52-9. 2011
  10. pmc The PepT1-NOD2 signaling pathway aggravates induced colitis in mice
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 141:1334-45. 2011

Detail Information

Publications19

  1. pmc Ecto-phosphorylation of CD98 regulates cell-cell interactions
    Hang Thi Thu Nguyen
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 3:e3895. 2008
    ..Our findings reveal a novel mechanism involved in regulating the multiple functions of CD98 and raise CD98 as a promising target for therapeutic modulations of cell-cell interactions...
  2. pmc CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice
    Hang Thi Thu Nguyen
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    J Clin Invest 121:1733-47. 2011
    ..Modulation of CD98 expression in IECs therefore represents a promising therapeutic strategy for the treatment and prevention of inflammatory intestinal diseases, such as IBD and colitis-associated cancer...
  3. pmc Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response
    Hang Thi Thu Nguyen
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 137:1435-47.e1-2. 2009
    ..Here, we address the effects of pathogenic bacteria on colonic PepT1 expression together with its functional consequences...
  4. pmc Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e5049. 2009
    ..Together, our data suggest that SPAK, the transcription of which is regulated by hyperosmolarity, plays an important role in epithelial barrier function...
  5. pmc PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells
    Guillaume Dalmasso
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 299:G687-96. 2010
    ..Given that PepT1 is highly expressed in the colon during inflammation, PepT1-mediated Tri-DAP transport may occur more effectively during such conditions, further contributing to intestinal inflammation...
  6. pmc MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation
    Hang Thi Thu Nguyen
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:1479-89. 2010
    ..This study raises microRNAs as a promising target for therapeutic modulations of CD98 expression in intestinal inflammatory disorders...
  7. pmc Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 173:1013-28. 2008
    ..The development of compounds that can either modulate or disrupt the activity of SPAK-mediated pathways is therefore important for the control and attenuation of downstream pathological responses, particularly in IBD...
  8. doi request reprint Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model
    Hamed Laroui
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 138:843-53.e1-2. 2010
    ..We engineered nanoparticles (NPs) to deliver an anti-inflammatory tripeptide Lys-Pro-Val (KPV) to the colon and assessed its therapeutic efficacy in a mouse model of colitis...
  9. pmc MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 300:G52-9. 2011
    ..Altogether, our study provides for the first time evidence for the regulation of PepT1 expression at a posttranscriptional level by miRNAs in intestinal epithelial cells during pathophysiological states...
  10. pmc The PepT1-NOD2 signaling pathway aggravates induced colitis in mice
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 141:1334-45. 2011
    ....
  11. doi request reprint Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice
    Hang Thi Thu Nguyen
    Department of Biology, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA
    Lab Invest 92:1203-12. 2012
    ..In conclusion, we show that CD98 exerts an oncogenic activity in terms of intestinal tumorigenesis, via an ability to regulate tumor growth and survival...
  12. pmc Butyrate transcriptionally enhances peptide transporter PepT1 expression and activity
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2476. 2008
    ..This study aimed at investigating PepT1 regulation by butyrate, a short-chain fatty acid produced by commensal bacteria and accumulated inside inflamed colonocyte...
  13. pmc PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, USA
    Gastroenterology 134:166-78. 2008
    ..The aim of this study was to 1) investigate whether the KPV anti-inflammatory effect is PepT1-mediated in intestinal epithelian and immune cells, and 2) examine the anti-inflammatory effects in two models of mice colitis...
  14. pmc MicroRNAs determine human intestinal epithelial cell fate
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Differentiation 80:147-54. 2010
    ..19A cell phenotype. In conclusion, our study shows that miRNAs might play a role in determining the unique physiological characteristics of IECs...
  15. pmc Microbiota modulate host gene expression via microRNAs
    Guillaume Dalmasso
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 6:e19293. 2011
    ..In conclusion, our study demonstrates that microbiota modulate host microRNA expression, which could in turn regulate host gene expression...
  16. pmc The RNA binding protein CsrA is a pleiotropic regulator of the locus of enterocyte effacement pathogenicity island of enteropathogenic Escherichia coli
    Shantanu Bhatt
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Infect Immun 77:3552-68. 2009
    ..Our findings suggest that CsrA governs virulence factor expression in an A/E pathogen by regulating mRNAs encoding translocators, effectors, or transcription factors...
  17. pmc Intestinal epithelial CD98: an oligomeric and multifunctional protein
    Yutao Yan
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1780:1087-92. 2008
    ..A role for CD98 in intestinal inflammation, such as Intestinal Bowel Disease (IBD), is also proposed...
  18. ncbi request reprint Association of PepT1 with lipid rafts differently modulates its transport activity in polarized and nonpolarized cells
    Hang Thi Thu Nguyen
    Dept of Medicine, Division of Digestive Diseases, Emory Univ School of Medicine, 615 Michael St, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1155-65. 2007
    ..In conclusion, the association of PepT1 with lipid rafts differently modulates its transport activity in polarized and nonpolarized cells...
  19. ncbi request reprint ADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells
    Laetitia Charrier
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:16948-58. 2007
    ..Altogether these findings point to ADAM-15 as a possible therapeutic target for prevention of inappropriate T cell activation involved in some pathologies...