Research Topics
| DONALD NEWPORTSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Venlafaxine in human breast milk and nursing infant plasma: determination of exposureD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road, N E, Suite B6100, Atlanta, GA 30322, USA
J Clin Psychiatry 70:1304-10. 2009..The current study characterizes the level and determinants of venlafaxine and desvenlafaxine concentrations in breast milk and in nursing infant plasma...- Comparison of women with confirmed versus presumably misdiagnosed bipolar disorderD Jeffrey Newport
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
J Clin Psychiatry 73:242-6. 2012..Because bipolar disorder can be difficult to diagnose, we compared characteristics of women with confirmed versus presumably misdiagnosed bipolar disorder... - Maternal depression and anxiety differentially impact fetal exposures during pregnancyD Jeffrey Newport
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
J Clin Psychiatry 73:247-51. 2012..To examine the association between severity of maternal depression and anxiety during pregnancy and the maternal use of medicinal agents and habit-forming substances... 
Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancyD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Psychiatry 162:2162-70. 2005....- Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomesD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Psychiatry 164:1214-20. 2007..The objectives of the current study were to quantify placental permeability to antipsychotic medications and to document obstetrical outcomes for women taking these agents proximate to delivery... - Lamotrigine in bipolar disorder: efficacy during pregnancyD Jeffrey Newport
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
Bipolar Disord 10:432-6. 2008..The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG). We therefore compared recurrence risks among pregnant women with BPD treated with LTG to those discontinuing mood stabilizer therapies... - Maternal depression and medication exposure during pregnancy: comparison of maternal retrospective recall to prospective documentationD J Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
BJOG 115:681-8. 2008..Outcome investigations of prenatal maternal depression and psychotropic exposure rely extensively on maternal retrospective recall. This study compared postnatal recall to prospective documentation of illness and medication exposures... - Lamotrigine in breast milk and nursing infants: determination of exposureD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Rd NE, Suite B6100, Atlanta, GA 30322
Pediatrics 122:e223-31. 2008..We sought to characterize the determinants of lamotrigine concentrations in breast milk and nursing-infant plasma... - The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysisChristine Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
Depress Anxiety 15:117-25. 2002..Our findings suggest that a history of childhood abuse per se is related to increased neuroendocrine stress reactivity, which is further enhanced when additional trauma is experienced in adulthood... - Lithium in breast milk and nursing infants: clinical implicationsAdele C Viguera
Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Simches Research Bldg, Second Fl, Suite 2200, 185 Cambridge St, Boston, MA 02114, USA
Am J Psychiatry 164:342-5. 2007..Current practice guidelines discourage use of lithium during breast-feeding, despite limited data. This study aimed to quantify lithium exposure in nursing infants... - The link between childhood trauma and depression: insights from HPA axis studies in humansChristine Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, WMRB, Suite 4311, Atlanta, GA 30322, USA
Psychoneuroendocrinology 33:693-710. 2008..Taken together, this line of evidence demonstrates that psychoneuroendocrine research may ultimately promote optimized clinical care and help prevent the adverse outcomes of childhood trauma... - Parental depression: animal models of an adverse life eventD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Psychiatry 159:1265-83. 2002..This article reviews findings in preclinical research on the adverse impact of parental depression on the development of offspring, with emphasis on the relevance of this research for the psychiatric care of depressed parents... 
Maternal depression and infant cortisol: influences of timing, comorbidity and treatmentPatricia A Brennan
Psychology Department, Emory University, Atlanta, GA 30322, USA
J Child Psychol Psychiatry 49:1099-107. 2008..The potential roles of comorbid maternal anxiety disorders, timing of maternal depression, and maternal treatment with psychotropic medications during pregnancy are addressed...- The impact of maternal childhood abuse on maternal and infant HPA axis function in the postpartum periodSarah R Brand
Department of Psychology, Emory University, United States
Psychoneuroendocrinology 35:686-93. 2010..The majority of previous studies in this area focus on adult offspring, and the degree to which the effects of parental child abuse can be detected earlier in the development of the offspring remains obscure... - The neural correlates of social anxiety disorder and response to pharmacotherapyClinton D Kilts
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 31:2243-53. 2006.... - Maternal depression: a child's first adverse life eventD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Semin Clin Neuropsychiatry 7:113-9. 2002..Paralleling the preclinical literature are human studies indicating similar acute effects. The clinical implications for the psychiatric treatment of depressed women who have children will be discussed... - Antidepressants in amniotic fluid: another route of fetal exposureAda M Loughhead
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Am J Psychiatry 163:145-7. 2006..Although the significance of amniotic fluid exposure remains to be determined, these results demonstrate that maternally administered antidepressants are accessible to the fetus in a manner not previously appreciated... - The treatment of postpartum depression: minimizing infant exposuresD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
J Clin Psychiatry 63:31-44. 2002..Infant exposure and limitations to monitoring infant sera are reviewed. Lastly, a model and guide for reducing fetal and infant exposures is presented... - The onset of postpartum depression: Implications for clinical screening in obstetrical and primary careZachary N Stowe
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Am J Obstet Gynecol 192:522-6. 2005..Inconsistent diagnostic criteria fail to delineate guidelines for postpartum depression surveillance. This study evaluates the validity of commonly accepted postpartum onset criteria... - Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuseD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 55:10-20. 2004.... - Zolpidem (Ambien) in pregnancy: placental passage and outcomeSandra Juric
Dept of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Arch Womens Ment Health 12:441-6. 2009..Pregnant women with psychiatric illness treated with zolpidem may have less optimal obstetrical outcome, though it is unclear if this was related to the medication... - The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patientJun Sheng Wang
Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
Drug Metab Rev 39:723-46. 2007..This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology... - Clinical management of perinatal depression: focus on paroxetineD Jeffrey Newport
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
Psychopharmacol Bull 37:148-66. 2003..In contrast, the amniotic fluid, umbilical cord, and nursing infant sera literature demonstrated significantly different exposures to individual medications... - Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysisD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Research Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
Neuropsychopharmacology 28:569-76. 2003..These findings support the hypothesis that central CRF hypersecretion is associated with a blunted ACTH response to exogenously administered CRF, explaining almost 60% of the variation in the ACTH response to CRF... - Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatmentLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
JAMA 295:499-507. 2006..However, systematic delineation of risk of relapse in women who maintain or discontinue pharmacological treatment during pregnancy is necessary... - Venlafaxine in the treatment of depressive and vasomotor symptoms in women with perimenopausal depressionCharlotte O Ladd
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Depress Anxiety 22:94-7. 2005..Further studies are warranted to investigate the utility of venlafaxine in perimenopausal depression... - Placental passage of tricyclic antidepressantsAda M Loughhead
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 59:287-90. 2006..CONCLUSIONS: The in vivo ratios of umbilical cord to maternal serum drug concentrations demonstrate considerable fetal exposure and differ greatly from previous results utilizing ex vivo perfusion... - The fetus and maternal depression: implications for antenatal treatment guidelinesAutumn L Henry
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Clin Obstet Gynecol 47:535-46. 2004 - Postpartum depression in women with epilepsy: influence of antiepileptic drugs in a prospective studyMelanie Galanti
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Epilepsy Behav 16:426-30. 2009..In conclusion, PPD rates are higher among women with epilepsy than the general population, particularly those who are multiparous or receiving AED polytherapy, and there is no evidence that AED selection modifies this risk... - Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunitiesC Lindsay Devane
Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
J Psychopharmacol 20:54-9. 2006.... - Alterations in platelet serotonin transporter binding in women with postpartum onset major depressionD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road NE, Suite B6100, Atlanta, GA 30322, USA
J Psychiatr Res 38:467-73. 2004..These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium... - Psychiatric disorders in pregnancyLori Levey
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Neurol Clin 22:863-93. 2004..These basic guidelines can help decrease the number of exposures and aid in conducting clinical care with at least some reproductive safety data...
Research Grants
- Development PsychopharmacologyDONALD NEWPORT; Fiscal Year: 2005..These study procedures will furthermore be applicable to future research investigating other classes of psychotropic medications. ..
- Bipolar Disorder in Pregnancy: Predictors of MorbidityDONALD NEWPORT; Fiscal Year: 2009..Furthermore, the novel PK data will expand our understanding of prenatal drug metabolism, and the project will establish a cohort of children of women with BPD with detailed prospective prenatal histories. ..