DONALD NEWPORT

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi request reprint Venlafaxine in human breast milk and nursing infant plasma: determination of exposure
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road, N E, Suite B6100, Atlanta, GA 30322, USA
    J Clin Psychiatry 70:1304-10. 2009
  2. doi request reprint Comparison of women with confirmed versus presumably misdiagnosed bipolar disorder
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 73:242-6. 2012
  3. doi request reprint Maternal depression and anxiety differentially impact fetal exposures during pregnancy
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 73:247-51. 2012
  4. ncbi request reprint Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 162:2162-70. 2005
  5. ncbi request reprint Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 164:1214-20. 2007
  6. doi request reprint Lamotrigine in bipolar disorder: efficacy during pregnancy
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bipolar Disord 10:432-6. 2008
  7. doi request reprint Maternal depression and medication exposure during pregnancy: comparison of maternal retrospective recall to prospective documentation
    D J Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    BJOG 115:681-8. 2008
  8. doi request reprint Lamotrigine in breast milk and nursing infants: determination of exposure
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Rd NE, Suite B6100, Atlanta, GA 30322
    Pediatrics 122:e223-31. 2008
  9. ncbi request reprint The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Depress Anxiety 15:117-25. 2002
  10. ncbi request reprint Lithium in breast milk and nursing infants: clinical implications
    Adele C Viguera
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Simches Research Bldg, Second Fl, Suite 2200, 185 Cambridge St, Boston, MA 02114, USA
    Am J Psychiatry 164:342-5. 2007

Research Grants

  1. Development Psychopharmacology
    DONALD NEWPORT; Fiscal Year: 2005
  2. Bipolar Disorder in Pregnancy: Predictors of Morbidity
    DONALD NEWPORT; Fiscal Year: 2009

Detail Information

Publications32

  1. doi request reprint Venlafaxine in human breast milk and nursing infant plasma: determination of exposure
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road, N E, Suite B6100, Atlanta, GA 30322, USA
    J Clin Psychiatry 70:1304-10. 2009
    ..The current study characterizes the level and determinants of venlafaxine and desvenlafaxine concentrations in breast milk and in nursing infant plasma...
  2. doi request reprint Comparison of women with confirmed versus presumably misdiagnosed bipolar disorder
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 73:242-6. 2012
    ..Because bipolar disorder can be difficult to diagnose, we compared characteristics of women with confirmed versus presumably misdiagnosed bipolar disorder...
  3. doi request reprint Maternal depression and anxiety differentially impact fetal exposures during pregnancy
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 73:247-51. 2012
    ..To examine the association between severity of maternal depression and anxiety during pregnancy and the maternal use of medicinal agents and habit-forming substances...
  4. ncbi request reprint Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 162:2162-70. 2005
    ....
  5. ncbi request reprint Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 164:1214-20. 2007
    ..The objectives of the current study were to quantify placental permeability to antipsychotic medications and to document obstetrical outcomes for women taking these agents proximate to delivery...
  6. doi request reprint Lamotrigine in bipolar disorder: efficacy during pregnancy
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bipolar Disord 10:432-6. 2008
    ..The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG). We therefore compared recurrence risks among pregnant women with BPD treated with LTG to those discontinuing mood stabilizer therapies...
  7. doi request reprint Maternal depression and medication exposure during pregnancy: comparison of maternal retrospective recall to prospective documentation
    D J Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    BJOG 115:681-8. 2008
    ..Outcome investigations of prenatal maternal depression and psychotropic exposure rely extensively on maternal retrospective recall. This study compared postnatal recall to prospective documentation of illness and medication exposures...
  8. doi request reprint Lamotrigine in breast milk and nursing infants: determination of exposure
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Rd NE, Suite B6100, Atlanta, GA 30322
    Pediatrics 122:e223-31. 2008
    ..We sought to characterize the determinants of lamotrigine concentrations in breast milk and nursing-infant plasma...
  9. ncbi request reprint The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Depress Anxiety 15:117-25. 2002
    ..Our findings suggest that a history of childhood abuse per se is related to increased neuroendocrine stress reactivity, which is further enhanced when additional trauma is experienced in adulthood...
  10. ncbi request reprint Lithium in breast milk and nursing infants: clinical implications
    Adele C Viguera
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Simches Research Bldg, Second Fl, Suite 2200, 185 Cambridge St, Boston, MA 02114, USA
    Am J Psychiatry 164:342-5. 2007
    ..Current practice guidelines discourage use of lithium during breast-feeding, despite limited data. This study aimed to quantify lithium exposure in nursing infants...
  11. doi request reprint The link between childhood trauma and depression: insights from HPA axis studies in humans
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, WMRB, Suite 4311, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 33:693-710. 2008
    ..Taken together, this line of evidence demonstrates that psychoneuroendocrine research may ultimately promote optimized clinical care and help prevent the adverse outcomes of childhood trauma...
  12. ncbi request reprint Parental depression: animal models of an adverse life event
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 159:1265-83. 2002
    ..This article reviews findings in preclinical research on the adverse impact of parental depression on the development of offspring, with emphasis on the relevance of this research for the psychiatric care of depressed parents...
  13. pmc Maternal depression and infant cortisol: influences of timing, comorbidity and treatment
    Patricia A Brennan
    Psychology Department, Emory University, Atlanta, GA 30322, USA
    J Child Psychol Psychiatry 49:1099-107. 2008
    ..The potential roles of comorbid maternal anxiety disorders, timing of maternal depression, and maternal treatment with psychotropic medications during pregnancy are addressed...
  14. pmc The impact of maternal childhood abuse on maternal and infant HPA axis function in the postpartum period
    Sarah R Brand
    Department of Psychology, Emory University, United States
    Psychoneuroendocrinology 35:686-93. 2010
    ..The majority of previous studies in this area focus on adult offspring, and the degree to which the effects of parental child abuse can be detected earlier in the development of the offspring remains obscure...
  15. ncbi request reprint The neural correlates of social anxiety disorder and response to pharmacotherapy
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 31:2243-53. 2006
    ....
  16. ncbi request reprint Maternal depression: a child's first adverse life event
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Clin Neuropsychiatry 7:113-9. 2002
    ..Paralleling the preclinical literature are human studies indicating similar acute effects. The clinical implications for the psychiatric treatment of depressed women who have children will be discussed...
  17. ncbi request reprint Antidepressants in amniotic fluid: another route of fetal exposure
    Ada M Loughhead
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 163:145-7. 2006
    ..The authors' goal was to determine the concentration of antidepressants in amniotic fluid during maternal treatment of depression...
  18. ncbi request reprint The treatment of postpartum depression: minimizing infant exposures
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 63:31-44. 2002
    ..Infant exposure and limitations to monitoring infant sera are reviewed. Lastly, a model and guide for reducing fetal and infant exposures is presented...
  19. ncbi request reprint The onset of postpartum depression: Implications for clinical screening in obstetrical and primary care
    Zachary N Stowe
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am J Obstet Gynecol 192:522-6. 2005
    ..Inconsistent diagnostic criteria fail to delineate guidelines for postpartum depression surveillance. This study evaluates the validity of commonly accepted postpartum onset criteria...
  20. ncbi request reprint Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 55:10-20. 2004
    ..Our aim was to determine whether altered glucocorticoid feedback mediates the neuroendocrine sequelae of childhood trauma...
  21. doi request reprint Zolpidem (Ambien) in pregnancy: placental passage and outcome
    Sandra Juric
    Dept of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Arch Womens Ment Health 12:441-6. 2009
    ..Pregnant women with psychiatric illness treated with zolpidem may have less optimal obstetrical outcome, though it is unclear if this was related to the medication...
  22. ncbi request reprint The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient
    Jun Sheng Wang
    Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Rev 39:723-46. 2007
    ..This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology...
  23. ncbi request reprint Clinical management of perinatal depression: focus on paroxetine
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacol Bull 37:148-66. 2003
    ..In contrast, the amniotic fluid, umbilical cord, and nursing infant sera literature demonstrated significantly different exposures to individual medications...
  24. ncbi request reprint Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Research Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:569-76. 2003
    ..These findings support the hypothesis that central CRF hypersecretion is associated with a blunted ACTH response to exogenously administered CRF, explaining almost 60% of the variation in the ACTH response to CRF...
  25. ncbi request reprint Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    JAMA 295:499-507. 2006
    ..However, systematic delineation of risk of relapse in women who maintain or discontinue pharmacological treatment during pregnancy is necessary...
  26. ncbi request reprint Venlafaxine in the treatment of depressive and vasomotor symptoms in women with perimenopausal depression
    Charlotte O Ladd
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Depress Anxiety 22:94-7. 2005
    ..Further studies are warranted to investigate the utility of venlafaxine in perimenopausal depression...
  27. ncbi request reprint Placental passage of tricyclic antidepressants
    Ada M Loughhead
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 59:287-90. 2006
    ..The use of antidepressants during pregnancy continues to garner considerable attention, though there are limited investigations that have sought to quantify fetal exposure...
  28. ncbi request reprint The fetus and maternal depression: implications for antenatal treatment guidelines
    Autumn L Henry
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Obstet Gynecol 47:535-46. 2004
  29. pmc Postpartum depression in women with epilepsy: influence of antiepileptic drugs in a prospective study
    Melanie Galanti
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Epilepsy Behav 16:426-30. 2009
    ..In conclusion, PPD rates are higher among women with epilepsy than the general population, particularly those who are multiparous or receiving AED polytherapy, and there is no evidence that AED selection modifies this risk...
  30. ncbi request reprint Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    J Psychopharmacol 20:54-9. 2006
    ....
  31. ncbi request reprint Alterations in platelet serotonin transporter binding in women with postpartum onset major depression
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road NE, Suite B6100, Atlanta, GA 30322, USA
    J Psychiatr Res 38:467-73. 2004
    ..These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium...
  32. ncbi request reprint Psychiatric disorders in pregnancy
    Lori Levey
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Neurol Clin 22:863-93. 2004
    ..These basic guidelines can help decrease the number of exposures and aid in conducting clinical care with at least some reproductive safety data...

Research Grants6

  1. Development Psychopharmacology
    DONALD NEWPORT; Fiscal Year: 2005
    ..These study procedures will furthermore be applicable to future research investigating other classes of psychotropic medications. ..
  2. Bipolar Disorder in Pregnancy: Predictors of Morbidity
    DONALD NEWPORT; Fiscal Year: 2009
    ..Furthermore, the novel PK data will expand our understanding of prenatal drug metabolism, and the project will establish a cohort of children of women with BPD with detailed prospective prenatal histories. ..