Charles B Nemeroff CB

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi request reprint Fostering foster care outcomes: quality of intervention matters in overcoming early adversity
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Cir, Ste 4000, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 65:623-4. 2008
  2. doi request reprint Understanding the pathophysiology of postpartum depression: implications for the development of novel treatments
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuron 59:185-6. 2008
  3. ncbi request reprint The role of GABA in the pathophysiology and treatment of anxiety disorders
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322 4990, USA
    Psychopharmacol Bull 37:133-46. 2003
  4. ncbi request reprint Neurotensin and dopamine interactions
    E B Binder
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Pharmacol Rev 53:453-86. 2001
  5. ncbi request reprint Neurobiological consequences of childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322 4990, USA
    J Clin Psychiatry 65:18-28. 2004
  6. ncbi request reprint Improving antidepressant adherence
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 64:25-30. 2003
  7. pmc Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
  8. ncbi request reprint Prevalence and management of treatment-resistant depression
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 68:17-25. 2007
  9. ncbi request reprint Advancing the treatment of mood and anxiety disorders: the first 10 years' experience with paroxetine
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Psychopharmacol Bull 37:6-7. 2003
  10. ncbi request reprint Treatment of mood disorders
    Charles B Nemeroff
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, Georgia 30322, USA
    Nat Neurosci 5:1068-70. 2002

Research Grants

Collaborators

Detail Information

Publications100

  1. doi request reprint Fostering foster care outcomes: quality of intervention matters in overcoming early adversity
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Cir, Ste 4000, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 65:623-4. 2008
  2. doi request reprint Understanding the pathophysiology of postpartum depression: implications for the development of novel treatments
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuron 59:185-6. 2008
    ....
  3. ncbi request reprint The role of GABA in the pathophysiology and treatment of anxiety disorders
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322 4990, USA
    Psychopharmacol Bull 37:133-46. 2003
    ..This article reviews the findings implicating the GABA system in the pathophysiology of anxiety disorders and describes the potential role of agents that modulate GABA neurotransmission in the treatment of these disorders...
  4. ncbi request reprint Neurotensin and dopamine interactions
    E B Binder
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Pharmacol Rev 53:453-86. 2001
    ..Last, because of the extensive literature on NT/DA interactions available in the rat, our discussion will be based primarily on studies using this species...
  5. ncbi request reprint Neurobiological consequences of childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322 4990, USA
    J Clin Psychiatry 65:18-28. 2004
    ..The preclinical and clinical studies evaluating the consequences of early-life stress are reviewed...
  6. ncbi request reprint Improving antidepressant adherence
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 64:25-30. 2003
    ....
  7. pmc Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
    ..Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma...
  8. ncbi request reprint Prevalence and management of treatment-resistant depression
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 68:17-25. 2007
    ..Given the public health importance of TRD, the relative absence of adequately powered, double-blind trials is striking...
  9. ncbi request reprint Advancing the treatment of mood and anxiety disorders: the first 10 years' experience with paroxetine
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Psychopharmacol Bull 37:6-7. 2003
    ..Subsequent clinical trials led to the widespread, but short-lived, use of iproniazid for treatment of depression in 1957 and demonstration of its monoamine oxidase inhibitor properties...
  10. ncbi request reprint Treatment of mood disorders
    Charles B Nemeroff
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, Georgia 30322, USA
    Nat Neurosci 5:1068-70. 2002
    ..The mechanisms of action of available medications are directing the field toward new research avenues. This review highlights those areas we believe will influence the field and soon lead to better treatment...
  11. ncbi request reprint Stress, menopause and vulnerability for psychiatric illness
    Charles B Nemeroff
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30322, USA
    Expert Rev Neurother 7:S11-3. 2007
  12. ncbi request reprint Recent advances in the neurobiology of depression
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacol Bull 36:6-23. 2002
    ..Further clarification of the precise neurobiological changes occurring in depression has implications for the use and development of novel effective treatments for this disorder...
  13. ncbi request reprint Quetiapine: preclinical studies, pharmacokinetics, drug interactions, and dosing
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322 4990, USA
    J Clin Psychiatry 63:5-11. 2002
    ..Finally, imaging studies with positron emission tomography confirm significant differences between quetiapine and typical antipsychotics that may be indicative of their differences in mechanism of action and propensity for producing EPS...
  14. ncbi request reprint Safety of available agents used to treat bipolar disorder: focus on weight gain
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 64:532-9. 2003
    ..The potential for excessive weight gain as a side effect of certain psychopharmacologic agents remains a concern to both clinicians and patients...
  15. ncbi request reprint Anxiolytics: past, present, and future agents
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 64:3-6. 2003
    ..The long-sought-after class of anxiolytics that are both effective and safe may be found in the new research being conducted with agents that selectively target GABA receptors and their subtypes...
  16. ncbi request reprint Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    CNS Spectr 9:23-31. 2004
    ..Each SSRI apparently has its own unique pharmacologic properties that likely underlie their observed differences in clinical use...
  17. ncbi request reprint Comprehensive analysis of remission (COMPARE) with venlafaxine versus SSRIs
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 63:424-34. 2008
    ..To compare venlafaxine and selective serotonin reuptake inhibitors (SSRIs; fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram) in the treatment of depression...
  18. ncbi request reprint VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 31:1345-55. 2006
    ..Mechanisms that mediate the beneficial effects of VNS therapy for treatment-resistant depression remain obscure. Suggestions for future research directions are described...
  19. ncbi request reprint Novel treatments of schizophrenia: targeting the neurotensin system
    B Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    CNS Neurol Disord Drug Targets 5:205-18. 2006
    ..The compilation of data suggests that NT receptor agonists may represent a novel class of antipsychotic drugs for the treatment of schizophrenia...
  20. ncbi request reprint Are platelets the link between depression and ischemic heart disease?
    C B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Am Heart J 140:57-62. 2000
    ..The findings of clinical trials evaluating platelet responses to antidepressant treatment are described, and recommendations for future studies are proposed...
  21. ncbi request reprint From clinical research to clinical practice: a 4-year review of ziprasidone
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    CNS Spectr 10:1-20. 2005
    ..This monograph summarizes the efficacy, tolerability, and safety of oral ziprasidone in the treatment of schizophrenia, schizoaffective disorder, and bipolar mania...
  22. ncbi request reprint Use of atypical antipsychotics in refractory depression and anxiety
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:13-21. 2005
    ..Further double-blind, placebo-controlled studies of augmentation of antidepressants with atypical antipsychotics in refractory depression and anxiety are justified based on the available literature...
  23. ncbi request reprint An ever-increasing pharmacopoeia for the management of patients with bipolar disorder
    C B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 61:19-25. 2000
    ..Other recent approaches have included several anticonvulsant agents, as well as conventional and atypical antipsychotic agents...
  24. ncbi request reprint Posttraumatic stress disorder: a state-of-the-science review
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
    J Psychiatr Res 40:1-21. 2006
    ....
  25. ncbi request reprint A double-blind, placebo-controlled comparison of venlafaxine and fluoxetine treatment in depressed outpatients
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Science, Emory University School of Medicine, 101 Woodruff Circle, Room 4115, Atlanta, GA 30322 4990, USA
    J Psychiatr Res 41:351-9. 2007
    ..The efficacy profile of fluoxetine was somewhat less consistent. It is strongly recommended that future studies of comparative antidepressant efficacy be adequately powered to detect modest between-drug differences in efficacy...
  26. ncbi request reprint The burden of severe depression: a review of diagnostic challenges and treatment alternatives
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    J Psychiatr Res 41:189-206. 2007
    ..Improved knowledge and treatment approaches for severe depression are necessary to facilitate remission, the ideal treatment goal...
  27. ncbi request reprint The neurobiology of depression: inroads to treatment and new drug discovery
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:5-13. 2005
    ..In addition, studies of the CRF system have suggested molecular targets for new drug development, biological risk factors, and predictors of treatment response...
  28. ncbi request reprint Drug development for anxiety disorders: new roles for atypical antipsychotics
    William H Carson
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30322, USA
    Psychopharmacol Bull 38:38-45. 2004
    ..Psychopharmacology Bulletin. 2004;38(Suppl 1): 38-45...
  29. ncbi request reprint Early-Life Adversity, CRF Dysregulation, and Vulnerability to Mood and Anxiety Disorders
    Charles B Nemeroff CB
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30322
    Psychopharmacol Bull 38:14-20. 2004
    ..Psychopharmacology Bulletin. 2004;38(Suppl 1): 14-20...
  30. ncbi request reprint The depressed suicidal patient. Assessment and treatment
    C B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 932:1-23. 2001
    ..Clinicians encountering patients with depressive disorders should be proficient in the assessment and treatment of depression with suicidality...
  31. ncbi request reprint Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
    S Neil Vaishnavi
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Biol Psychiatry 55:320-2. 2004
    ....
  32. ncbi request reprint Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation
    Charlotte O Ladd
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Biol Psychiatry 55:367-75. 2004
    ....
  33. ncbi request reprint Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter
    Jonathan McConathy
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 31:705-18. 2004
    ..Although both compounds displayed high affinity and selectivity for the human NET in vitro, these compounds did not enter the CNS in adequate amounts to be used in PET imaging studies...
  34. ncbi request reprint Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine
    Michelle L Gilmor
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, WMB Building, Atlanta, GA 30322, USA
    Am J Psychiatry 159:1702-10. 2002
    ..The study examined whether paroxetine inhibits the human norepinephrine transporter in addition to the human serotonin (5-HT) transporter in patients with major depressive disorder...
  35. ncbi request reprint Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation
    Lotta Arborelius
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 176:248-55. 2004
    ..Prolonged, daily maternal separation of rat pups induces several behavioral, endocrine and neurochemical changes similar to those observed in human depression...
  36. ncbi request reprint The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 192:385-96. 2007
    ....
  37. pmc Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats
    Becky Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Suite 4000 WMRB, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 33:178-87. 2008
    ..These data support an effect of time of day and estrous cycle stage on PPI in female rats. The estrous cycle variations in PPI are mediated in part by endogenous NT...
  38. ncbi request reprint The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems
    Michelle L Gilmor
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, WMB Suite 4000, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 305:434-9. 2003
    ..The distinct actions of each drug on CRF systems may underlie their synergistic clinical effects...
  39. ncbi request reprint Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms
    Keizo Yoshida
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, USA
    Am J Psychiatry 161:1575-80. 2004
    ....
  40. ncbi request reprint Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agents
    Jonathan McConathy
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:593-605. 2005
    ..Despite high in vitro affinity for the human NET, the uptake of [(11)C]3-BrPA in the brain and the heart was not displaceable with pharmacological doses of NET antagonists...
  41. ncbi request reprint Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment
    Steven C Stout
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 300:1085-92. 2002
    ..Additional studies are required to elucidate the functional consequences and mechanisms of this interaction...
  42. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
    ..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability...
  43. ncbi request reprint Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters
    Nachwa Jarkas
    Center for Positron Emission Tomography, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:211-24. 2005
    ..Carbon-11-labeled N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (HOMADAM) was synthesized as a new serotonin transporter (SERT) imaging agent...
  44. ncbi request reprint Efficacy of risperidone versus olanzapine in patients with schizophrenia previously on chronic conventional antipsychotic therapy: a switch study
    Xiaohong Wang
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, United States
    J Psychiatr Res 40:669-76. 2006
    ..The results indicate that both atypical antipsychotic medications provided significant additional improvement in symptom severity in patients with schizophrenia previously on conventional antipsychotic agents...
  45. ncbi request reprint The role of dopamine in the pathophysiology of depression
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 64:327-37. 2007
  46. ncbi request reprint The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Eur J Pharmacol 571:17-24. 2007
    ....
  47. ncbi request reprint Persistent central nervous system effects of an adverse early environment: clinical and preclinical studies
    David A Gutman
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000 WMRB, Atlanta, GA 30322, USA
    Physiol Behav 79:471-8. 2003
    ..The discussion will be framed in regards to a stress-diathesis model in which early adverse events result in a sensitized stress axis that predisposes individuals to develop mood disorders...
  48. ncbi request reprint Partial response and nonresponse to antidepressant therapy: current approaches and treatment options
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
    J Clin Psychiatry 63:826-37. 2002
    ..Switching to an agent of a different class is probably optimal for those patients who fail to respond to first-line therapy...
  49. pmc Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression
    Jennifer C Felger
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Biol Psychiatry 62:1324-33. 2007
    ..To establish a nonhuman primate model of cytokine-induced depression, we examined the effects of IFN-alpha on rhesus monkeys...
  50. ncbi request reprint The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Depress Anxiety 15:117-25. 2002
    ..Our findings suggest that a history of childhood abuse per se is related to increased neuroendocrine stress reactivity, which is further enhanced when additional trauma is experienced in adulthood...
  51. ncbi request reprint Effects of sodium valproate on corticotropin-releasing factor systems in rat brain
    S C Stout
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 24:624-31. 2001
    ..These results suggest that the mood stabilizing effects of valproic acid may be mediated in part by alterations in CRF neuronal activity...
  52. ncbi request reprint Neurotensin-deficient mice have deficits in prepulse inhibition: restoration by clozapine but not haloperidol, olanzapine, or quetiapine
    Becky Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 315:256-64. 2005
    ..These results provide evidence that the effects of antipsychotic drugs (APDs) may be differentially affected by the state of NT neurotransmission and, moreover, that APDs differ in their dependence on an intact NT system...
  53. ncbi request reprint Hypercortisolemia and depression
    Charles F Gillespie
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000 WMRB, Atlanta, GA 30322, USA
    Psychosom Med 67:S26-8. 2005
    ..The authors review the history of techniques used to assess the functions of the HPA axis, evidence for hypercortisolemia as a state rather than trait component of depression, and treatment implications...
  54. ncbi request reprint Persistent auditory hallucinations that are unresponsive to antipsychotic drugs
    Stephen E Nicolson
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Am J Psychiatry 163:1153-9. 2006
  55. ncbi request reprint A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression
    Dominique L Musselman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 67:288-96. 2006
    ..This study compared the efficacy and safety of paroxetine and desipramine with those of placebo in the treatment of depressive disorders in adult women with breast cancer, stages I-IV...
  56. ncbi request reprint Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 24:9303-12. 2004
    ..The marked increase in CRFergic neurotransmission is hypothesized to play a major role in benzodiazepine withdrawal...
  57. ncbi request reprint Double-blind, placebo-controlled comparison of imipramine and paroxetine in the treatment of bipolar depression
    C B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Suite 4000, Atlanta, GA 30322, USA
    Am J Psychiatry 158:906-12. 2001
    ..However, antidepressant therapy may be beneficial for patients who cannot tolerate high serum lithium levels or who have symptoms that are refractory to the antidepressant effects of lithium...
  58. ncbi request reprint An evaluation of risperidone drug interactions
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425 0742, USA
    J Clin Psychopharmacol 21:408-16. 2001
    ..Adherence to a few guidelines for the design of dosage regimens should limit the effect of drug-drug interactions on patient status and contribute to optimal pharmacotherapy with risperidone...
  59. ncbi request reprint Importance of studying the contributions of early adverse experience to neurobiological findings in depression
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 29:641-8. 2004
    ....
  60. ncbi request reprint Epidemiology of comorbid coronary artery disease and depression
    Bruce Rudisch
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:227-40. 2003
    ....
  61. ncbi request reprint Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:906-14. 2003
    ..Tryptophan (TRP) degradation into kynurenine (KYN) by the enzyme, indoleamine-2,3-dioxygenase, during immune activation may contribute to development of depressive symptoms during interferon (IFN)-alpha therapy...
  62. ncbi request reprint Involvement of neuropeptide systems in schizophrenia: human studies
    Ricardo Caceda
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine Atlanta, Georgia 30322, USA
    Int Rev Neurobiol 78:327-76. 2007
    ..Clearly, additional investigation into the role of neuropeptide systems in the etiology, pathophysiology, and treatment of schizophrenia is warranted...
  63. pmc Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:41-8. 2005
    ..Newer, pegylated preparations of IFN-alpha have a longer half-life, require once-per-week dosing, and may be associated with reduced neuropsychiatric burden. Limited data exist on depression during pegylated IFN-alpha therapy...
  64. ncbi request reprint Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 55:10-20. 2004
    ..Our aim was to determine whether altered glucocorticoid feedback mediates the neuroendocrine sequelae of childhood trauma...
  65. ncbi request reprint Serotonin transporter: a potential substrate in the biology of suicide
    David C Purselle
    Department of Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:613-9. 2003
    ..This paper provides a review of several studies that have evaluated the role of the SERT in the pathophysiology of suicide...
  66. ncbi request reprint Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0188, USA
    Biol Psychiatry 51:123-33. 2002
    ..This study compared efficacy of nefazodone, psychotherapy, and their combination in improving psychosocial functioning in chronically depressed outpatients...
  67. ncbi request reprint The simultaneous determination of neurotensin and its major fragments by on-line trace enrichment HPLC with electrochemical detection
    C D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Life Sci 59:911-20. 1996
    ..The improvements in assay specificity, signal-to-noise ratios, biomatrix compatibility and assayable sample volume compared to non-enrichment HPLC-EC are discussed...
  68. ncbi request reprint Sensitivity to glucocorticoid-mediated fast-feedback regulation of the hypothalamic-pituitary-adrenal axis is dependent upon stressor specific neurocircuitry
    K V Thrivikraman
    Stress Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, WMB 4000, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Brain Res 870:87-101. 2000
    ....
  69. doi request reprint Lower CSF oxytocin concentrations in women with a history of childhood abuse
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, WMRB, Atlanta, GA 30322, USA
    Mol Psychiatry 14:954-8. 2009
    ..If replicated, the association of lower adult CSF OT levels with childhood trauma might indicate that alterations in central OT function may be involved in the adverse outcomes of childhood adversity...
  70. ncbi request reprint The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain
    B Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res Dev Brain Res 124:1-10. 2000
    ..These results demonstrate that there is a critical time point in development before which the NT system does not respond to antipsychotic drug administration in the same manner as the mature rat...
  71. ncbi request reprint Synthesis and characterization of fluorinated and iodinated pyrrolopyrimidines as PET/SPECT ligands for the CRF1 receptor
    L Martarello
    Department of Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, 1634 Clifton Road N E, Atlanta, Georgia 30322, USA
    Nucl Med Biol 28:187-95. 2001
    ..However, the accumulation of radioactivity in the brain for both radiotracers was very low at all time points of the study, which demonstrated the difficulties for these radiopharmaceuticals to penetrate the blood brain barrier (BBB)...
  72. ncbi request reprint Neurokinin(1) receptor antagonists as potential antidepressants
    S C Stout
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 41:877-906. 2001
    ..The ongoing clinical trials with NK(1) receptor antagonists have served as an impetus for much needed, basic research in this field...
  73. pmc Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes
    E Keen-Rhinehart
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Mol Psychiatry 14:37-50. 2009
    ..Molecular Psychiatry (2009) 14, 37-50; doi:10.1038/mp.2008.91; published online 12 August 2008...
  74. pmc The CRF system, stress, depression and anxiety-insights from human genetic studies
    E B Binder
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:574-88. 2010
    ..In-depth characterization of these variants will likely be important in furthering our understanding of the long-term consequences of adverse experience...
  75. doi request reprint Emerging targets for antidepressant therapies
    Jeffrey J Rakofsky
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 2004 Ridgewood Dr, Suite 218, Atlanta, GA 30322, United States
    Curr Opin Chem Biol 13:291-302. 2009
    ..Focal brain stimulation therapies include vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS), magnetic seizure therapy (MST), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS)...
  76. ncbi request reprint Neuropharmacology of paroxetine
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Psychopharmacol Bull 37:8-18. 2003
    ..The application of these findings of in vivo NET inhibition by paroxetine in the treatment of mood and anxiety disorders will be informed by further clinical studies...
  77. ncbi request reprint New directions in the development of antidepressants: the interface of neurobiology and psychiatry
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322 4990, USA
    Hum Psychopharmacol 17:S13-6. 2002
    ..These are just two of the many new directions that will likely lead to the development of antidepressants in the near future...
  78. ncbi request reprint Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot study
    J Douglas Bremner
    Department of Psychiatry, Radiology and Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    J Psychopharmacol 19:159-65. 2005
    ..However, treatment associated improvements in memory and cognition did not achieve statistical significance. These findings suggest that phenytoin treatment may be associated with changes in brain structure in patients with PTSD...
  79. ncbi request reprint Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugs
    Elisabeth B Binder
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 29:2200-7. 2004
    ..The effects of the NT receptor antagonist were paralleled by its effects on catalepsy in olanzapine--but not haloperidol--treated animals...
  80. doi request reprint The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology
    Elizabeth I Martin
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    Clin Lab Med 30:865-91. 2010
    ..The goal of this article is to describe the key biological similarities and differences between anxiety disorders...
  81. ncbi request reprint Neurobiological effects of childhood abuse: implications for the pathophysiology of depression and anxiety
    K M Penza
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Womens Ment Health 6:15-22. 2003
    ..These physiological maladaptations likely represent long-term risk factors for the development of psychopathology after exposure to additional stress...
  82. ncbi request reprint The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 49:1023-39. 2001
    ..The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults...
  83. ncbi request reprint Clinical pharmacokinetics of quetiapine: an atypical antipsychotic
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    Clin Pharmacokinet 40:509-22. 2001
    ..Subsequent clinical studies of the plasma concentration versus effect relationships for quetiapine may help to further define guidelines for dosage regimen design...
  84. ncbi request reprint The evaluation and treatment of depression in primary care
    M T Compton
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin Cornerstone 3:10-22. 2001
    ..Appropriate treatment of depression can result in improvement in emotional, cognitive, and behavioral symptoms of depression and reduce psychosocial impairment, disability, and associated medical morbidity...
  85. ncbi request reprint Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Psychiatry 158:575-81. 2001
    ..On subsequent stress exposure, women with a history of childhood abuse may hypersecrete CRF, resulting in down-regulation of adenohypophyseal CRF receptors and symptoms of depression and anxiety...
  86. ncbi request reprint Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter
    M J Owens
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Clin Chem 40:288-95. 1994
    ..In a pilot study, this deficit predicted treatment response to an experimental antidepressant. These findings support the hypothesis that alterations in 5-HT neurons play a role in the pathophysiology of depression...
  87. ncbi request reprint The effects of glutamate receptor agonists on neurotensin release using in vivo microdialysis
    J M Radke
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, P.O. Box AF, 1639 Pierce Drive, 30322-4990, Atlanta, GA, USA
    Eur J Pharmacol 411:129-134. 2001
    ..These findings indicate that activation of glutamate receptors may indirectly stimulate neurotensin release...
  88. ncbi request reprint Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings
    D L Musselman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Psychiatry 158:1252-7. 2001
    ..CONCLUSIONS: Higher than normal plasma IL-6 concentrations were associated with a diagnosis of major depression in cancer patients. IL-6 may contribute to sickness behavior that has overlapping symptoms with major depression...
  89. ncbi request reprint Paroxetine for the prevention of depression induced by high-dose interferon alfa
    D L Musselman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    N Engl J Med 344:961-6. 2001
    ..85). The incidence of adverse events was similar in the two groups. CONCLUSIONS: In patients with malignant melanoma, pretreatment with paroxetine appears to be an effective strategy for minimizing depression induced by interferon alfa...
  90. ncbi request reprint Neurotensin receptor binding abnormalities in the entorhinal cortex in schizophrenia and affective disorders
    Emad H Hamid
    Clinical Brain Disorders Branch IRP, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 4S237A, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 51:795-800. 2002
    ..We have previously reported decreased neurotensin receptor density in layer II of the intermediate entorhinal cortex (ERC) in schizophrenia, a finding seen elsewhere but not seen in more caudal ERC...
  91. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
    ..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...
  92. ncbi request reprint Effects of risperidone augmentation in patients with treatment-resistant depression: Results of open-label treatment followed by double-blind continuation
    Mark Hyman Rapaport
    Department of Psychiatry, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Neuropsychopharmacology 31:2505-13. 2006
    ..1 and 64.1%, respectively (p < or = 0.05). Open-label risperidone augmentation substantially enhanced response in treatment-resistant patients, but the longer-term benefits of augmentation were not demonstrated in this study...
  93. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases
    Martin B Keller
    Brown University, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1371-9. 2007
    ..We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment...
  94. ncbi request reprint Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
    J Clin Psychiatry 68:1014-23. 2007
    ..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
  95. ncbi request reprint Maintenance efficacy of divalproex in the prevention of bipolar depression
    Laszlo Gyulai
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1374-82. 2003
    ....
  96. ncbi request reprint Are mood disorders and obesity related? A review for the mental health professional
    Susan L McElroy
    Psychopharmacology Research and Eating Disorders and Obesity Research and Treatment Programs, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 65:634-51, quiz 730. 2004
    ..We reviewed evidence regarding a possible relationship between mood disorders and obesity to better inform mental health professionals about their overlap...
  97. ncbi request reprint Long-term behavioural and molecular alterations associated with maternal separation in rats
    Melanie Lippmann
    Department of Psychiatry, The University of Texas South Western Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Eur J Neurosci 25:3091-8. 2007
    ..Recognition of these adaptations begins to define the brain regions, and neural circuitry, associated with persistent alterations induced by early life stressors and the development of mood disorders...
  98. ncbi request reprint Self-reported depressive symptom measures: sensitivity to detecting change in a randomized, controlled trial of chronically depressed, nonpsychotic outpatients
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Neuropsychopharmacology 30:405-16. 2005
    ..Global patient ratings such as the PGI-I, as opposed to specific item-based ratings, provide less valid findings...
  99. ncbi request reprint Aripiprazole augmentation of antidepressants for the treatment of partially responding and nonresponding patients with major depressive disorder
    Jeffrey S Simon
    Northbrooke Research Center, Brown Deer, WI 53223, USA
    J Clin Psychiatry 66:1216-20. 2005
    ..To determine the efficacy and tolerability of aripiprazole, a dopamine D2 and 5-HT1A receptor partial agonist, as augmentation of antidepressant treatment of partially responding and nonresponding patients with major depressive disorder...
  100. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 68:1246-56. 2007
    ..To report second-year results from the 2-year maintenance phase of a long-term study to evaluate the efficacy and safety of venlafaxine extended release (ER) in preventing recurrence of depression...

Research Grants4

  1. Emory-GSK-NIMH Collaborative Mood Disorders Initiative
    Clinton Kilts; Fiscal Year: 2007
    ..abstract_text> ..
  2. Special Scientific Procedures: Statistical Modeling Core
    Charles Nemeroff; Fiscal Year: 2007
    ..abstract_text> ..