Andrew Neish

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi request reprint Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited
    J David Lambeth
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322 email
    Annu Rev Pathol 9:119-45. 2014
  2. ncbi request reprint Reactive oxygen production induced by the gut microbiota: pharmacotherapeutic implications
    R M Jones
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Med Chem 19:1519-29. 2012
  3. pmc Microbes in gastrointestinal health and disease
    Andrew S Neish
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 136:65-80. 2009
  4. ncbi request reprint TLRS in the gut. II. Flagellin-induced inflammation and antiapoptosis
    Andrew S Neish
    Dept of Pathology, Emory Univ School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 292:G462-6. 2007
  5. ncbi request reprint Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination
    A S Neish
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 289:1560-3. 2000
  6. ncbi request reprint Bacterial inhibition of eukaryotic pro-inflammatory pathways
    Andrew S Neish
    Department of Pathology, Emory University School of Medicine, 105 F Whitehead Memorial Research Building, 615 Michaels Street, Atlanta, GA 30322, USA
    Immunol Res 29:175-86. 2004
  7. ncbi request reprint Molecular aspects of intestinal epithelial cell-bacterial interactions that determine the development of intestinal inflammation
    Andrew S Neish
    Department of Pathology, Emory University School of Medicine, 105 F Whitehead Memorial Research Building, 615 Michaels St, Atlanta, GA 30322, USA
    Inflamm Bowel Dis 10:159-68. 2004
  8. ncbi request reprint The gut microflora and intestinal epithelial cells: a continuing dialogue
    Andrew S Neish
    Epithelial Pathobiology Unit, Department of Pathology, Emory University School of Medicine, 105F Whitehead Bld, 615 Michaels Street, Atlanta, GA 30322, USA
    Microbes Infect 4:309-17. 2002
  9. pmc Commensal-epithelial signaling mediated via formyl peptide receptors
    Christy C Wentworth
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Pathol 177:2782-90. 2010
  10. pmc Flagellin suppresses epithelial apoptosis and limits disease during enteric infection
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 169:1686-700. 2006

Research Grants

  1. Epithelial specific ubiquitination events
    Andrew S Neish; Fiscal Year: 2010
  2. BACTERIAL MODULATION OF EPITHELIAL SIGNALING PATHWAYS
    Andrew Neish; Fiscal Year: 2000
  3. Intestinal cell response to bacterial apoptotic signals
    Andrew S Neish; Fiscal Year: 2010
  4. Epithelial specific ubiquitination events
    Andrew Neish; Fiscal Year: 2009
  5. Intestinal cell response to bacterial apoptotic signals
    Andrew Neish; Fiscal Year: 2009
  6. Epithelial specific ubiquitination events
    Andrew Neish; Fiscal Year: 2007
  7. Intestinal cell response to bacterial apoptotic signals
    Andrew Neish; Fiscal Year: 2007
  8. Epithelial specific ubiquitination events
    Andrew Neish; Fiscal Year: 2006
  9. Epithelial Responses to Enteric Organisms
    Andrew Neish; Fiscal Year: 2005
  10. Epithelial Responses to Enteric Organisms
    Andrew Neish; Fiscal Year: 2004

Collaborators

Detail Information

Publications39

  1. doi request reprint Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited
    J David Lambeth
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322 email
    Annu Rev Pathol 9:119-45. 2014
    ..This review discusses the current knowledge of the role of physiologically generated ROS and the enzymes that form them in both normal biology and disease. ..
  2. ncbi request reprint Reactive oxygen production induced by the gut microbiota: pharmacotherapeutic implications
    R M Jones
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Med Chem 19:1519-29. 2012
    ..We hypothesize that many of the known effects of the normal microbiota on intestinal physiology, and potential beneficial effects of candidate probiotic bacteria, may be at least partially mediated by this ROS-dependent mechanism...
  3. pmc Microbes in gastrointestinal health and disease
    Andrew S Neish
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 136:65-80. 2009
    ....
  4. ncbi request reprint TLRS in the gut. II. Flagellin-induced inflammation and antiapoptosis
    Andrew S Neish
    Dept of Pathology, Emory Univ School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 292:G462-6. 2007
    ....
  5. ncbi request reprint Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination
    A S Neish
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 289:1560-3. 2000
    ..These data suggest that prokaryotic determinants could be responsible for the unique tolerance of the gastrointestinal mucosa to proinflammatory stimuli...
  6. ncbi request reprint Bacterial inhibition of eukaryotic pro-inflammatory pathways
    Andrew S Neish
    Department of Pathology, Emory University School of Medicine, 105 F Whitehead Memorial Research Building, 615 Michaels Street, Atlanta, GA 30322, USA
    Immunol Res 29:175-86. 2004
    ....
  7. ncbi request reprint Molecular aspects of intestinal epithelial cell-bacterial interactions that determine the development of intestinal inflammation
    Andrew S Neish
    Department of Pathology, Emory University School of Medicine, 105 F Whitehead Memorial Research Building, 615 Michaels St, Atlanta, GA 30322, USA
    Inflamm Bowel Dis 10:159-68. 2004
    ..Also important are potential mechanisms by which microbes can influence the intestinal epithelial responses, influences with significant implications for the normal function of the intestine and inflammatory diseases...
  8. ncbi request reprint The gut microflora and intestinal epithelial cells: a continuing dialogue
    Andrew S Neish
    Epithelial Pathobiology Unit, Department of Pathology, Emory University School of Medicine, 105F Whitehead Bld, 615 Michaels Street, Atlanta, GA 30322, USA
    Microbes Infect 4:309-17. 2002
    ..Recent delineation of the mechanisms by which bacteria communicate with their eukaryotic hosts and the cellular sites that microbial signals act in may shed light on these complex interactions...
  9. pmc Commensal-epithelial signaling mediated via formyl peptide receptors
    Christy C Wentworth
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Pathol 177:2782-90. 2010
    ....
  10. pmc Flagellin suppresses epithelial apoptosis and limits disease during enteric infection
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 169:1686-700. 2006
    ..This notion is consistent with the emerging paradigm that specific TLR ligands may have a fundamental cytoprotective effect during inflammatory stress...
  11. pmc Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Infect Immun 76:1276-81. 2008
    ..All together, these results indicate that the resistance of TLR5KO mice to Salmonella-induced typhoid-like illness resulted from alterations in their basal phenotype rather than from the lack of TLR5 ligation during the infection per se...
  12. pmc The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation
    Amrita Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 182:538-46. 2009
    ....
  13. ncbi request reprint Flagellin treatment protects against chemicals, bacteria, viruses, and radiation
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    J Immunol 180:8280-5. 2008
    ..Thus, systemic administration of flagellin may be a relatively safe means of providing temporary non-specific protection against a variety of challenges...
  14. ncbi request reprint Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways
    Hui Zeng
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 105 F Whitehead Bldg, 615 Michaels St, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 290:G96-G108. 2006
    ..Such intertwining of proinflammatory and apoptotic signaling mediated by bacterial products suggests roles for host programmed cell death in the pathogenesis of enteric infections...
  15. ncbi request reprint Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 174:6322-31. 2005
    ....
  16. pmc Deletion of TLR5 results in spontaneous colitis in mice
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 117:3909-21. 2007
    ..That an engineered innate immune deficiency ultimately results in spontaneous intestinal inflammation supports the notion that an innate immune deficiency might underlie some instances of inflammatory bowel disease...
  17. doi request reprint Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade
    Rheinallt M Jones
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Host Microbe 3:233-44. 2008
    ..Our findings suggest that targeting JNK signaling to dampen apoptosis may be a conserved strategy for intracellular pathogens...
  18. ncbi request reprint Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella
    Hui Zeng
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 171:3668-74. 2003
    ..Thus, S. typhimurium flagellin is the major molecular trigger by which this pathogen activates gut epithelial proinflammatory gene expression...
  19. ncbi request reprint Beta defensin-1, parvalbumin, and vimentin: a panel of diagnostic immunohistochemical markers for renal tumors derived from gene expression profiling studies using cDNA microarrays
    Andrew N Young
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Am J Surg Pathol 27:199-205. 2003
    ..This work demonstrates that a useful panel of immunohistochemical markers can be derived from differential gene expression profiles determined using cDNA microarrays...
  20. ncbi request reprint Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Emory University, WRB 10SH, 6125 Michael Street, Atlanta, GA 30322, USA
    J Immunol 168:5260-7. 2002
    ..Thus, LXA(4) analog-mediated down-regulation of proinflammatory gene expression via inhibition of the NF-kappaB pathway can be therapeutic for diseases characterized by mucosal inflammation...
  21. pmc The probiotic Lactobacillus GG may augment intestinal host defense by regulating apoptosis and promoting cytoprotective responses in the developing murine gut
    Patricia W Lin
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Res 64:511-6. 2008
    ..Because apoptosis may be a precursor to NEC, understanding the mechanism behind probiotic modulation of apoptotic pathways may allow for development of more specifically targeted therapies or preventive strategies in the future...
  22. pmc Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation
    Patricia W Lin
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 47:1205-11. 2009
    ....
  23. pmc Toll-like receptor 5-dependent regulation of inflammation in systemic Salmonella enterica Serovar typhimurium infection
    Benedicte Fournier
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Infect Immun 77:4121-9. 2009
    ..Thus, the characteristic inflammatory pathology of Salmonella infection occurs only in PPs and to a lesser extent in MLN during the initial phases of infection and these early responses are dependent on TLR5...
  24. pmc Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species
    Amrita Kumar
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    EMBO J 26:4457-66. 2007
    ....
  25. ncbi request reprint TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression
    Yimin Yu
    Epithelial Pathobiology Division, Department of Pathology, Emory University School of Medicine, 6156 Michael Street, Atlanta, GA 30322, USA
    J Immunol 176:6194-201. 2006
    ..Thus, TLR5's rapid activation of PI3K serves to limit MAPK signaling, thus limiting proinflammatory gene expression and reducing the potential negative consequences of proinflammatory gene expression...
  26. ncbi request reprint Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway
    Lauren S Collier-Hyams
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 169:2846-50. 2002
    ..We suggest that AvrA may limit virulence in vertebrates in a manner analogous to avirulence factors in plants, and as such, is the first bacterial effector from a mammalian pathogen that has been ascribed such a function...
  27. ncbi request reprint Activation of toll-like receptor 3 protects against DSS-induced acute colitis
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Inflamm Bowel Dis 13:856-64. 2007
    ....
  28. ncbi request reprint STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-alpha-induced epithelial gene expression
    Yimin Yu
    Department of Pathology, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:35210-8. 2004
    ..Together, these results indicate that epithelial cell induction of flagellin-specific gene expression is mediated, in part, by STAT activation that results from autocrine activation via IL-6...
  29. ncbi request reprint TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism
    Yimin Yu
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 285:G282-90. 2003
    ..Together, these results indicate that epithelial TLR5 mediates p38 activation and subsequently regulates flagellin-induced IL-8 expression independently of NF-kappaB, probably by influencing IL-8 mRNA translation...
  30. ncbi request reprint Plasmid DNA and siRNA transfection of intestinal epithelial monolayers by electroporation
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Int J Pharm 315:122-33. 2006
    ....
  31. ncbi request reprint Cutting edge: bacterial modulation of epithelial signaling via changes in neddylation of cullin-1
    Lauren S Collier-Hyams
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 3032, USA
    J Immunol 175:4194-8. 2005
    ..This observation may explain the ability of intestinal bacterial communities to influence diverse eukaryotic processes in general and inflammatory tolerance of the mammalian intestinal epithelia specifically...
  32. ncbi request reprint Increased permeability of intestinal epithelial monolayers mediated by electroporation
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech, Atlanta, GA 30332, USA
    J Control Release 103:177-90. 2005
    ..These findings could form the basis for the development of electroporation as a clinical tool to increase intestinal permeability and, thereby, increase the absorption of poorly absorbed drugs...
  33. ncbi request reprint Bacterial activation of beta-catenin signaling in human epithelia
    Jun Sun
    Dept of Pathology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 287:G220-7. 2004
    ..These data suggest that nonvirulent bacterial-epithelial interactions can influence beta-catenin signaling and cell growth control in a manner previously unsuspected...
  34. doi request reprint Flagellin administration protects gut mucosal tissue from irradiation-induced apoptosis via MKP-7 activity
    Rheinallt M Jones
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gut 60:648-57. 2011
    ..Previously, it has been shown that flagellin limits ionising radiation-induced mortality in mice, but the cellular mechanism of protection remained unknown...
  35. ncbi request reprint Mechanisms of active intestinal inflammation and potential down-regulation via lipoxins
    Andrew T Gewirtz
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Adv Exp Med Biol 507:229-36. 2002
    ....
  36. ncbi request reprint Electroporation-mediated delivery of molecules to model intestinal epithelia
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Int J Pharm 270:127-38. 2004
    ..These findings suggest that electroporation may be useful for intracellular delivery into monolayers to study epithelial biology and, possibly, for drug delivery to intestinal epithelium...
  37. ncbi request reprint Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response
    Patricia W Lin
    Gastrointestinal Cell Biology Department, Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Biol Chem 279:19902-7. 2004
    ..These results show that selective cryptdins may amplify their roles in innate immunity by acting as novel paracrine agonists to coordinate an inflammatory response with the antimicrobial secretions of Paneth cells...
  38. pmc Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation
    Joseph Khoury
    Department of Anesthesiology, Perioperative and Pain Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 117:703-11. 2007
    ..These results define a molecular regulatory pathway by which Ado provides potent antiinflammatory properties...

Research Grants17

  1. Epithelial specific ubiquitination events
    Andrew S Neish; Fiscal Year: 2010
    ..Elucidation of these host-microbe interactions will increase our understanding of the epithelial and bacterial factors involved in human enterocolitis, and potentially in idiopathic inflammatory intestinal disease. ..
  2. BACTERIAL MODULATION OF EPITHELIAL SIGNALING PATHWAYS
    Andrew Neish; Fiscal Year: 2000
    ..Finally, a novel electroporation based method to introduce purified proteins into intact model epithelia will be used to dissect the cellular responses to internalization of a variety of bacterial effector proteins. ..
  3. Intestinal cell response to bacterial apoptotic signals
    Andrew S Neish; Fiscal Year: 2010
    ..These studies will increase our understanding of the pathogenesis of enteric bacterial infections, and possibly illuminate means by which commensal bacteria contribute to the health of the Gl tract. ..
  4. Epithelial specific ubiquitination events
    Andrew Neish; Fiscal Year: 2009
    ..Elucidation of these host-microbe interactions will increase our understanding of the epithelial and bacterial factors involved in human enterocolitis, and potentially in idiopathic inflammatory intestinal disease. ..
  5. Intestinal cell response to bacterial apoptotic signals
    Andrew Neish; Fiscal Year: 2009
    ..These studies will increase our understanding of the pathogenesis of enteric bacterial infections, and possibly illuminate means by which commensal bacteria contribute to the health of the Gl tract. ..
  6. Epithelial specific ubiquitination events
    Andrew Neish; Fiscal Year: 2007
    ..Elucidation of these host-microbe interactions will increase our understanding of the epithelial and bacterial factors involved in human enterocolitis, and potentially in idiopathic inflammatory intestinal disease. ..
  7. Intestinal cell response to bacterial apoptotic signals
    Andrew Neish; Fiscal Year: 2007
    ..These studies will increase our understanding of the pathogenesis of enteric bacterial infections, and possibly illuminate means by which commensal bacteria contribute to the health of the Gl tract. ..
  8. Epithelial specific ubiquitination events
    Andrew Neish; Fiscal Year: 2006
    ..Elucidation of these host-microbe interactions will increase our understanding of the epithelial and bacterial factors involved in human enterocolitis, and potentially in idiopathic inflammatory intestinal disease. ..
  9. Epithelial Responses to Enteric Organisms
    Andrew Neish; Fiscal Year: 2005
    ..More significantly, these data will be invaluable in the recognition of these signatures in human diseases potentially associated with infection by known and unknown organisms. ..
  10. Epithelial Responses to Enteric Organisms
    Andrew Neish; Fiscal Year: 2004
    ..More significantly, these data will be invaluable in the recognition of these signatures in human diseases potentially associated with infection by known and unknown organisms. ..
  11. BACTERIAL MODULATION OF EPITHELIAL SIGNALING PATHWAYS
    Andrew Neish; Fiscal Year: 2003
    ..Finally, a novel electroporation based method to introduce purified proteins into intact model epithelia will be used to dissect the cellular responses to internalization of a variety of bacterial effector proteins. ..
  12. Epithelial Responses to Enteric Organisms
    Andrew Neish; Fiscal Year: 2003
    ..More significantly, these data will be invaluable in the recognition of these signatures in human diseases potentially associated with infection by known and unknown organisms. ..
  13. BACTERIAL MODULATION OF EPITHELIAL SIGNALING PATHWAYS
    Andrew Neish; Fiscal Year: 2002
    ..Finally, a novel electroporation based method to introduce purified proteins into intact model epithelia will be used to dissect the cellular responses to internalization of a variety of bacterial effector proteins. ..
  14. Epithelial Responses to Enteric Organisms
    Andrew Neish; Fiscal Year: 2002
    ..More significantly, these data will be invaluable in the recognition of these signatures in human diseases potentially associated with infection by known and unknown organisms. ..
  15. BACTERIAL MODULATION OF EPITHELIAL SIGNALING PATHWAYS
    Andrew Neish; Fiscal Year: 2001
    ..Finally, a novel electroporation based method to introduce purified proteins into intact model epithelia will be used to dissect the cellular responses to internalization of a variety of bacterial effector proteins. ..