Karyn M Myers

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Different mechanisms of fear extinction dependent on length of time since fear acquisition
    Karyn M Myers
    Center for Behavioral Neuroscience, Emory University Atlanta, Georgia 30329, USA
    Learn Mem 13:216-23. 2006
  2. ncbi request reprint Mechanisms of fear extinction
    K M Myers
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA, USA
    Mol Psychiatry 12:120-50. 2007
  3. pmc Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humans
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Behav Neurosci 122:1016-30. 2008
  4. ncbi request reprint Estrogen disrupts the inhibition of fear in female rats, possibly through the antagonistic effects of estrogen receptor alpha (ERalpha) and ERbeta
    Donna J Toufexis
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, and The Center for Behavioral Neuroscience, Atlanta, Georgia 30329, USA
    J Neurosci 27:9729-35. 2007
  5. pmc Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Learn Mem 13:681-5. 2006
  6. ncbi request reprint Partial reversal of phencyclidine-induced impairment of prepulse inhibition by secretin
    Karyn M Myers
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA
    Biol Psychiatry 58:67-73. 2005
  7. pmc AX+, BX- discrimination learning in the fear-potentiated startle paradigm: possible relevance to inhibitory fear learning in extinction
    Karyn M Myers
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Learn Mem 11:464-75. 2004
  8. ncbi request reprint The effect of gonadal hormones and gender on anxiety and emotional learning
    Donna J Toufexis
    Emory University, Department of Psychiatry, Yerkes National Primate Center, 954 Gatewood Drive NE, Atlanta, GA 30329, USA
    Horm Behav 50:539-49. 2006
  9. pmc Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy
    Michael Davis
    Emory University School of Medicine, Center for Behavioral Neuroscience, and the Yerkes National Primate Center, Atlanta, Georgia 30329, USA
    NeuroRx 3:82-96. 2006
  10. pmc Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear
    Dennis C Choi
    Department of Psychiatry and Behavioral Sciences, Howard Hughes Medical Institute, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:2675-80. 2010

Research Grants

Detail Information

Publications18

  1. pmc Different mechanisms of fear extinction dependent on length of time since fear acquisition
    Karyn M Myers
    Center for Behavioral Neuroscience, Emory University Atlanta, Georgia 30329, USA
    Learn Mem 13:216-23. 2006
    ..These data support a model in which different neural mechanisms are recruited depending on the temporal delay of fear extinction...
  2. ncbi request reprint Mechanisms of fear extinction
    K M Myers
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA, USA
    Mol Psychiatry 12:120-50. 2007
    ..The present paper will cover behavioral, theoretical and neurobiological work, and will conclude with a discussion of clinical implications...
  3. pmc Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humans
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Behav Neurosci 122:1016-30. 2008
    ..Thus, the results remain inconclusive regarding spontaneous recovery and the timing of extinction and are discussed in terms of performing translational studies of fear in humans...
  4. ncbi request reprint Estrogen disrupts the inhibition of fear in female rats, possibly through the antagonistic effects of estrogen receptor alpha (ERalpha) and ERbeta
    Donna J Toufexis
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, and The Center for Behavioral Neuroscience, Atlanta, Georgia 30329, USA
    J Neurosci 27:9729-35. 2007
    ..In contrast, neither E nor ERalpha and ERbeta agonists affected single-cue fear conditioning in either sex. These data suggest that E does not enhance fear in emotional learning but acts to disrupt the inhibition of fear in females only...
  5. pmc Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Learn Mem 13:681-5. 2006
    ..This is the first demonstration of fear extinction and reinstatement in humans using startle measures...
  6. ncbi request reprint Partial reversal of phencyclidine-induced impairment of prepulse inhibition by secretin
    Karyn M Myers
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA
    Biol Psychiatry 58:67-73. 2005
    ..Very recently secretin also was administered to schizophrenic patients and found to increase social interaction in some individuals...
  7. pmc AX+, BX- discrimination learning in the fear-potentiated startle paradigm: possible relevance to inhibitory fear learning in extinction
    Karyn M Myers
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Learn Mem 11:464-75. 2004
    ..We believe this method is a viable alternative to the traditional conditioned inhibition training procedure and will be useful for studying the neural mechanisms of fear inhibition...
  8. ncbi request reprint The effect of gonadal hormones and gender on anxiety and emotional learning
    Donna J Toufexis
    Emory University, Department of Psychiatry, Yerkes National Primate Center, 954 Gatewood Drive NE, Atlanta, GA 30329, USA
    Horm Behav 50:539-49. 2006
    ....
  9. pmc Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy
    Michael Davis
    Emory University School of Medicine, Center for Behavioral Neuroscience, and the Yerkes National Primate Center, Atlanta, Georgia 30329, USA
    NeuroRx 3:82-96. 2006
    ..It is concluded that extinction is an excellent model system for the study of fear inhibition and an indispensable tool for the screening of putative pharmacotherapies for clinical use...
  10. pmc Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear
    Dennis C Choi
    Department of Psychiatry and Behavioral Sciences, Howard Hughes Medical Institute, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:2675-80. 2010
    ..Moreover, use of site-specific, inducible BDNF deletions shows a powerful mechanism that may further our understanding of the pathophysiology of fear-related disorders...
  11. ncbi request reprint Fear potentiation and fear inhibition in a human fear-potentiated startle paradigm
    Tanja Jovanovic
    Emory University School of Medicine, Atlanta, GA, USA
    Biol Psychiatry 57:1559-64. 2005
    ..For this reason, we sought to develop a behavioral procedure in humans that would render a stimulus primarily inhibitory...
  12. ncbi request reprint Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction
    Jasmeer P Chhatwal
    Department of Psychiatry and Behavioral Sciences and Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 25:502-6. 2005
    ....
  13. ncbi request reprint Role of the amygdala in fear extinction measured with potentiated startle
    Michael Davis
    Department of Psychiatry, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 985:218-32. 2003
    ....
  14. pmc Contingency awareness and fear inhibition in a human fear-potentiated startle paradigm
    Tanja Jovanovic
    Mental Health Service 116A, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Behav Neurosci 120:995-1004. 2006
    ..A response keypad was used to assess contingency awareness on a trial-by-trial basis. Both aware and unaware subjects showed fear-potentiated startle. However, awareness was related to stimulus discrimination and fear inhibition...
  15. pmc Posttraumatic stress disorder may be associated with impaired fear inhibition: relation to symptom severity
    Tanja Jovanovic
    Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Psychiatry Res 167:151-60. 2009
    ..However, the high-symptom PTSD group did not show fear inhibition: these subjects had significantly greater fear potentiation on the AB trials than both the controls and the low-symptom PTSD patients...
  16. ncbi request reprint Behavioral and neural analysis of extinction
    Karyn M Myers
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Neuron 36:567-84. 2002
    ..This review considers the behavioral, cellular, and molecular literatures on extinction and presents the most recent advances in our understanding while identifying issues that require considerable further research...
  17. ncbi request reprint The role of glutamate and gamma-aminobutyric acid in fear extinction: clinical implications for exposure therapy
    Michael Davis
    Department of Psychology, Emory University, Atlanta, Georgia, USA
    Biol Psychiatry 52:998-1007. 2002
    ..These insights have significant implications for the conduct of extinction-based clinical interventions for fear disorders...
  18. ncbi request reprint Systems-level reconsolidation: reengagement of the hippocampus with memory reactivation
    Karyn M Myers
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Neuron 36:340-3. 2002
    ..Two studies in the current issue of Neuron make important advances in our understanding of reconsolidation but reach different conclusions about the modifiability of old memories...

Research Grants1

  1. Mechanisms of short and long interval fear extinction
    Karyn Myers; Fiscal Year: 2007
    ..This proposal aims to employ a combination of biochemical and pharmacologic techniques to dissect the mechanisms of extinction as inhibition vs. erasure of fear. ..