Edward T Morgan
Affiliation: Emory University
Morgan E, Dempsey J, Mimche S, Lamb T, Kulkarni S, Cui J, et al
. Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting. Drug Metab Dispos. 2018;46:503-513 pubmed publisher
..This was demonstrated to occur via a cAMP, protein kinase A/nuclear factor-E2-related factor 2/Sirtuin 1 pathway via antioxidant response elements on the Abcc genes. ..
Morgan E, Ullrich V, Daiber A, Schmidt P, Takaya N, Shoun H, et al
. Cytochromes P450 and flavin monooxygenases--targets and sources of nitric oxide. Drug Metab Dispos. 2001;29:1366-76 pubmed
..Conversely, the mechanisms and relative importance of nitric oxide synthases and P450 enzymes in NO production from endogenous and synthetic substrates were also addressed...
Park J, Byrd A, Lee C, Morgan E. Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14?-demethylase. Biochem J. 2017;474:3241-3252 pubmed publisher
..NO donors also down-regulated CYP51A1 mRNA in Huh7 cells, but to a lesser degree, than the down-regulation of the protein. ..