Research Topics
| Edward MorganSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in severe combined immune-deficient miceBeatrice A Nyagode
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Drug Metab Dispos 40:1894-9. 2012..rodentium infection...
Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancerEdward T Morgan
Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
Drug Metab Dispos 36:205-16. 2008..It is fitting that, in honoring the career contributions and achievements of Dr. Kenneth W. Renton, this symposium reinforced the clinical relevance of this field...
Physiological and pathophysiological regulation of cytochrome P450E T Morgan
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Drug Metab Dispos 26:1232-40. 1998..Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs...- Mechanisms of cytochrome P450 regulation by inflammatory mediatorsEdward T Morgan
Department of Pharmacology and Graduate Program in Molecular and Systems Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
Toxicology 181:207-10. 2002..Studies were conducted in control and NOS2-null mice to determine the contributions of these different mechanisms to CYP2B suppression in vivo... - Cytochromes P450 and flavin monooxygenases--targets and sources of nitric oxideE T Morgan
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Drug Metab Dispos 29:1366-76. 2001..Conversely, the mechanisms and relative importance of nitric oxide synthases and P450 enzymes in NO production from endogenous and synthetic substrates were also addressed... - Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcuminPo-Yung Cheng
Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
J Pharmacol Exp Ther 307:1205-12. 2003.... - Regulation of drug-metabolizing enzymes and transporters in inflammationAlison E Aitken
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Annu Rev Pharmacol Toxicol 46:123-49. 2006.... - Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout miceTerrilyn A Richardson
Department of Pharmacology, Emory University School of Medicine, 5119 O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta, GA 30322, USA
J Pharmacol Exp Ther 314:703-9. 2005.... - Roles of nitric oxide in inflammatory downregulation of human cytochromes P450Alison E Aitken
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Free Radic Biol Med 44:1161-8. 2008..No evidence was found for regulation of CYP2E1 mRNA or protein by NO. NOC-18 treatment downregulated CYP3A4 mRNA to 50% of control. However, NOS inhibitors failed to block the effects of ILmix on CYP3A4 expression... - Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant miceTerrilyn A Richardson
Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
Drug Metab Dispos 34:354-60. 2006..These data indicate that hepatic inflammation induced by C. rodentium infection is mainly TLR4-independent and suggest that hepatic P450 down-regulation in this model may be cytokine-mediated... - Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthaseTong Li-Masters
Department of Pharmacology, School of Medicine and Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, GA 30322, USA
Biochem Pharmacol 64:1703-11. 2002..Unlike rat hepatocytes, the contribution of a rapid, NO-dependent mechanism of CYP2B protein suppression in mouse liver appears to be minor or non-existent... - Dual mechanisms of CYP3A protein regulation by proinflammatory cytokine stimulation in primary hepatocyte culturesChoon Myung Lee
Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
Drug Metab Dispos 37:865-72. 2009..Taken together, these observations show a novel dual mode of post-transcriptional CYP3A down-regulation by cytokines: NO- and proteasome-dependent at earlier time points and NO- and proteasome-independent at later times... - Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteinsChoon Myung Lee
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 283:889-98. 2008..These data are consistent with the hypothesis that NO-dependent CYP2B ubiquitination and proteasomal degradation are dependent on protein modification by reactive nitrogen species... - Regulation of hepatic cytochrome P450 expression in mice with intestinal or systemic infections of citrobacter rodentiumMadhusudana R Chaluvadi
Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
Drug Metab Dispos 37:366-74. 2009.... - Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null miceBeatrice A Nyagode
Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
J Pharmacol Exp Ther 335:480-8. 2010..It is therefore possible that part of the IFNγ(-/-) and IL6(-/-) phenotypes could be attributed to the reduced levels of TNFα and part of the IFNγ(-/-) phenotype could be caused by reduced levels of IL6... - TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel diseaseMadhusudana R Chaluvadi
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Biochem Pharmacol 77:464-71. 2009..Thus, our results indicate that the pattern of hepatic P450 expression, and the mechanism of regulation, during inflammation of the bowel depend on the etiology of the disease... - Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytesAlison E Aitken
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Drug Metab Dispos 35:1687-93. 2007..Our results show that human CYP2C8, 2C9, 2C18, 2C19, 2B6, and 3A4 responses to inflammation are independently regulated and indicate that this fine control may have a critical effect on human drug responses in disease states... - Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidneyTerrilyn A Richardson
Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
Drug Metab Dispos 34:351-3. 2006..Regulation of UGTs during the inflammatory response exhibits similarities to and differences from regulation of P450s, and may be cytokine-mediated... - Inflammatory prompts produce isoform-specific changes in the expression of leukotriene B(4) omega-hydroxylases in rat liver and kidneyAuinash Kalsotra
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, TX 77030, USA
FEBS Lett 555:236-42. 2003..Treatment of hepatocytes with 5 ng/ml of interleukin-1beta mimics the in vivo effects of LPS on CYP4F expression... - Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitisChi Chen
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell Metab 7:135-47. 2008.... - Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicalsDavid S Riddick
Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
Drug Metab Dispos 32:367-75. 2004..Mechanistic studies of CYP gene suppression can enhance our understanding of how organisms respond to xenobiotics as well as to perturbations in endogenous chemicals involved in maintaining homeostasis... - Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytesAuinash Kalsotra
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, TX 77225, USA
Arch Biochem Biophys 461:104-12. 2007.... - A role for one or more p450 enzymes in the response to sepsisEdward T Morgan
Crit Care Med 33:268-9. 2005
Research Grants
- Regulation of CYP proteins by reactive nitrogen speciesEdward Morgan; Fiscal Year: 2007..They also have important implications for the broader field of NO biology, since knowledge in the area of NO-stimulated protein degradation is limited. ..
- Graduate Training in the Pharmacological StudiesEdward Morgan; Fiscal Year: 2007..By preparing young scientists to contribute to and lead the nation's efforts in these areas, this training program will help to ensure that our ability to improve the nation's health remains strong in the future. ..
- Hepatic CYP enzymes and host-pathogen interactionsEdward Morgan; Fiscal Year: 2007..rodentium infection, using the nonspecific CYP inhibitor 1-aminobenzotriazole, and mice in which the hepatic NADPH-cytochrome P450 reductase (CPR) gene has been selectively deleted. ..
- Regulation of CYP proteins by reactive nitrogen speciesEdward Morgan; Fiscal Year: 2009..This project will help us to understand what causes this change, and so allow us to predict what patients will need to have their drug doses adjusted to avoid this problem. ..
- Hepatic CYP enzymes and host-pathogen interactionsEdward T Morgan; Fiscal Year: 2010..This project will increase our understanding of how liver metabolism changes during infection or inflammation, and may discover new strategies to treat infectious and inflammatory diseases. ..
- SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORSEdward Morgan; Fiscal Year: 2004..Lastly, we will study the role of rat and human P450 enzymes in the inflammatory response itself, specifically in the generation of nitric oxide by hepatocytes stimulated with endotoxin or cytokines. ..
- SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORSEdward Morgan; Fiscal Year: 1993..Lastly, the nuclear proteins that bind to these regions, and whose binding is modulated by inflammation, will be identified and purified...
- SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORSEdward Morgan; Fiscal Year: 1999..The PI will also investigate whether the CYP4A mRNAs can be induced by cytokines in cultured hepatocytes. ..
- Regulation of CYP proteins by reactive nitrogen speciesEdward T Morgan; Fiscal Year: 2010..This project will help us to understand what causes this change, and so allow us to predict what patients will need to have their drug doses adjusted to avoid this problem. ..