Edward Morgan

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2
    Haiyan Sun
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem J 445:377-82. 2012
  2. pmc Selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in severe combined immune-deficient mice
    Beatrice A Nyagode
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Dispos 40:1894-9. 2012
  3. doi request reprint Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer
    Edward T Morgan
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Drug Metab Dispos 36:205-16. 2008
  4. ncbi request reprint Physiological and pathophysiological regulation of cytochrome P450
    E T Morgan
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Dispos 26:1232-40. 1998
  5. ncbi request reprint Cytochromes P450 and flavin monooxygenases--targets and sources of nitric oxide
    E T Morgan
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Dispos 29:1366-76. 2001
  6. ncbi request reprint Mechanisms of cytochrome P450 regulation by inflammatory mediators
    Edward T Morgan
    Department of Pharmacology and Graduate Program in Molecular and Systems Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Toxicology 181:207-10. 2002
  7. ncbi request reprint Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcumin
    Po Yung Cheng
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 307:1205-12. 2003
  8. ncbi request reprint Regulation of drug-metabolizing enzymes and transporters in inflammation
    Alison E Aitken
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Annu Rev Pharmacol Toxicol 46:123-49. 2006
  9. ncbi request reprint Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice
    Terrilyn A Richardson
    Department of Pharmacology, Emory University School of Medicine, 5119 O Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 314:703-9. 2005
  10. pmc Roles of nitric oxide in inflammatory downregulation of human cytochromes P450
    Alison E Aitken
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 44:1161-8. 2008

Collaborators

Detail Information

Publications24

  1. pmc Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2
    Haiyan Sun
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem J 445:377-82. 2012
    ..The results show that LMP2 contributes to the NO-dependent degradation of CYP2B proteins, and suggest that induction of LMP2 may be involved in the potentiation of this degradation by IL-1...
  2. pmc Selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in severe combined immune-deficient mice
    Beatrice A Nyagode
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Dispos 40:1894-9. 2012
    ..rodentium infection...
  3. doi request reprint Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer
    Edward T Morgan
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Drug Metab Dispos 36:205-16. 2008
    ..It is fitting that, in honoring the career contributions and achievements of Dr. Kenneth W. Renton, this symposium reinforced the clinical relevance of this field...
  4. ncbi request reprint Physiological and pathophysiological regulation of cytochrome P450
    E T Morgan
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Dispos 26:1232-40. 1998
    ..Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs...
  5. ncbi request reprint Cytochromes P450 and flavin monooxygenases--targets and sources of nitric oxide
    E T Morgan
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Dispos 29:1366-76. 2001
    ..Conversely, the mechanisms and relative importance of nitric oxide synthases and P450 enzymes in NO production from endogenous and synthetic substrates were also addressed...
  6. ncbi request reprint Mechanisms of cytochrome P450 regulation by inflammatory mediators
    Edward T Morgan
    Department of Pharmacology and Graduate Program in Molecular and Systems Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Toxicology 181:207-10. 2002
    ..Studies were conducted in control and NOS2-null mice to determine the contributions of these different mechanisms to CYP2B suppression in vivo...
  7. ncbi request reprint Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcumin
    Po Yung Cheng
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 307:1205-12. 2003
    ....
  8. ncbi request reprint Regulation of drug-metabolizing enzymes and transporters in inflammation
    Alison E Aitken
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Annu Rev Pharmacol Toxicol 46:123-49. 2006
    ....
  9. ncbi request reprint Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice
    Terrilyn A Richardson
    Department of Pharmacology, Emory University School of Medicine, 5119 O Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 314:703-9. 2005
    ....
  10. pmc Roles of nitric oxide in inflammatory downregulation of human cytochromes P450
    Alison E Aitken
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 44:1161-8. 2008
    ..No evidence was found for regulation of CYP2E1 mRNA or protein by NO. NOC-18 treatment downregulated CYP3A4 mRNA to 50% of control. However, NOS inhibitors failed to block the effects of ILmix on CYP3A4 expression...
  11. ncbi request reprint Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase
    Tong Li-Masters
    Department of Pharmacology, School of Medicine and Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, GA 30322, USA
    Biochem Pharmacol 64:1703-11. 2002
    ..Unlike rat hepatocytes, the contribution of a rapid, NO-dependent mechanism of CYP2B protein suppression in mouse liver appears to be minor or non-existent...
  12. pmc Regulation of hepatic cytochrome P450 expression in mice with intestinal or systemic infections of citrobacter rodentium
    Madhusudana R Chaluvadi
    Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    Drug Metab Dispos 37:366-74. 2009
    ....
  13. pmc Dual mechanisms of CYP3A protein regulation by proinflammatory cytokine stimulation in primary hepatocyte cultures
    Choon Myung Lee
    Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    Drug Metab Dispos 37:865-72. 2009
    ..Taken together, these observations show a novel dual mode of post-transcriptional CYP3A down-regulation by cytokines: NO- and proteasome-dependent at earlier time points and NO- and proteasome-independent at later times...
  14. pmc Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins
    Choon Myung Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:889-98. 2008
    ..These data are consistent with the hypothesis that NO-dependent CYP2B ubiquitination and proteasomal degradation are dependent on protein modification by reactive nitrogen species...
  15. pmc Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice
    Terrilyn A Richardson
    Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    Drug Metab Dispos 34:354-60. 2006
    ..These data indicate that hepatic inflammation induced by C. rodentium infection is mainly TLR4-independent and suggest that hepatic P450 down-regulation in this model may be cytokine-mediated...
  16. pmc Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes
    Alison E Aitken
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Dispos 35:1687-93. 2007
    ..Our results show that human CYP2C8, 2C9, 2C18, 2C19, 2B6, and 3A4 responses to inflammation are independently regulated and indicate that this fine control may have a critical effect on human drug responses in disease states...
  17. pmc Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice
    Beatrice A Nyagode
    Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 335:480-8. 2010
    ..It is therefore possible that part of the IFNγ(-/-) and IL6(-/-) phenotypes could be attributed to the reduced levels of TNFα and part of the IFNγ(-/-) phenotype could be caused by reduced levels of IL6...
  18. pmc TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease
    Madhusudana R Chaluvadi
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Pharmacol 77:464-71. 2009
    ..Thus, our results indicate that the pattern of hepatic P450 expression, and the mechanism of regulation, during inflammation of the bowel depend on the etiology of the disease...
  19. pmc Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney
    Terrilyn A Richardson
    Department of Pharmacology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    Drug Metab Dispos 34:351-3. 2006
    ..Regulation of UGTs during the inflammatory response exhibits similarities to and differences from regulation of P450s, and may be cytokine-mediated...
  20. pmc Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis
    Chi Chen
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:135-47. 2008
    ....
  21. ncbi request reprint Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals
    David S Riddick
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
    Drug Metab Dispos 32:367-75. 2004
    ..Mechanistic studies of CYP gene suppression can enhance our understanding of how organisms respond to xenobiotics as well as to perturbations in endogenous chemicals involved in maintaining homeostasis...
  22. ncbi request reprint Inflammatory prompts produce isoform-specific changes in the expression of leukotriene B(4) omega-hydroxylases in rat liver and kidney
    Auinash Kalsotra
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, TX 77030, USA
    FEBS Lett 555:236-42. 2003
    ..Treatment of hepatocytes with 5 ng/ml of interleukin-1beta mimics the in vivo effects of LPS on CYP4F expression...
  23. pmc Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes
    Auinash Kalsotra
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, TX 77225, USA
    Arch Biochem Biophys 461:104-12. 2007
    ....
  24. ncbi request reprint A role for one or more p450 enzymes in the response to sepsis
    Edward T Morgan
    Crit Care Med 33:268-9. 2005

Research Grants28

  1. Regulation of CYP proteins by reactive nitrogen species
    Edward T Morgan; Fiscal Year: 2010
    ..This project will help us to understand what causes this change, and so allow us to predict what patients will need to have their drug doses adjusted to avoid this problem. ..
  2. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 2004
    ..Lastly, we will study the role of rat and human P450 enzymes in the inflammatory response itself, specifically in the generation of nitric oxide by hepatocytes stimulated with endotoxin or cytokines. ..
  3. Regulation of CYP proteins by reactive nitrogen species
    Edward Morgan; Fiscal Year: 2005
    ..They also have important implications for the broader field of NO biology, since knowledge in the area of NO-stimulated protein degradation is limited. ..
  4. Hepatic CYP enzymes and host-pathogen interactions
    Edward Morgan; Fiscal Year: 2006
    ..rodentium infection, using the nonspecific CYP inhibitor 1-aminobenzotriazole, and mice in which the hepatic NADPH-cytochrome P450 reductase (CPR) gene has been selectively deleted. ..
  5. Regulation of CYP proteins by reactive nitrogen species
    Edward Morgan; Fiscal Year: 2007
    ..They also have important implications for the broader field of NO biology, since knowledge in the area of NO-stimulated protein degradation is limited. ..
  6. Graduate Training in the Pharmacological Studies
    Edward Morgan; Fiscal Year: 2007
    ..By preparing young scientists to contribute to and lead the nation's efforts in these areas, this training program will help to ensure that our ability to improve the nation's health remains strong in the future. ..
  7. Regulation of CYP proteins by reactive nitrogen species
    Edward Morgan; Fiscal Year: 2006
    ..They also have important implications for the broader field of NO biology, since knowledge in the area of NO-stimulated protein degradation is limited. ..
  8. Regulation of CYP proteins by reactive nitrogen species
    Edward Morgan; Fiscal Year: 2009
    ..This project will help us to understand what causes this change, and so allow us to predict what patients will need to have their drug doses adjusted to avoid this problem. ..
  9. Regulation of CYP proteins by reactive nitrogen species
    Edward Morgan; Fiscal Year: 2004
    ..They also have important implications for the broader field of NO biology, since knowledge in the area of NO-stimulated protein degradation is limited. ..
  10. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 1992
    ..Lastly, the nuclear proteins that bind to these regions, and whose binding is modulated by inflammation, will be identified and purified...
  11. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 1993
    ..Lastly, the nuclear proteins that bind to these regions, and whose binding is modulated by inflammation, will be identified and purified...
  12. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 1999
    ..The PI will also investigate whether the CYP4A mRNAs can be induced by cytokines in cultured hepatocytes. ..
  13. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 2001
    ..Lastly, we will study the role of rat and human P450 enzymes in the inflammatory response itself, specifically in the generation of nitric oxide by hepatocytes stimulated with endotoxin or cytokines. ..
  14. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 2002
    ..Lastly, we will study the role of rat and human P450 enzymes in the inflammatory response itself, specifically in the generation of nitric oxide by hepatocytes stimulated with endotoxin or cytokines. ..
  15. Hepatic CYP enzymes and host-pathogen interactions
    Edward T Morgan; Fiscal Year: 2010
    ..This project will increase our understanding of how liver metabolism changes during infection or inflammation, and may discover new strategies to treat infectious and inflammatory diseases. ..
  16. Hepatic CYP enzymes and host-pathogen interactions
    Edward Morgan; Fiscal Year: 2007
    ..rodentium infection, using the nonspecific CYP inhibitor 1-aminobenzotriazole, and mice in which the hepatic NADPH-cytochrome P450 reductase (CPR) gene has been selectively deleted. ..
  17. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 2003
    ..Lastly, we will study the role of rat and human P450 enzymes in the inflammatory response itself, specifically in the generation of nitric oxide by hepatocytes stimulated with endotoxin or cytokines. ..
  18. Regulation of CYP proteins by reactive nitrogen species
    Edward Morgan; Fiscal Year: 2006
    ..They also have important implications for the broader field of NO biology, since knowledge in the area of NO-stimulated protein degradation is limited. ..
  19. Hepatic CYP enzymes and host-pathogen interactions
    Edward Morgan; Fiscal Year: 2005
    ..rodentium infection, using the nonspecific CYP inhibitor 1-aminobenzotriazole, and mice in which the hepatic NADPH-cytochrome P450 reductase (CPR) gene has been selectively deleted. ..
  20. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 2003
    ..Lastly, we will study the role of rat and human P450 enzymes in the inflammatory response itself, specifically in the generation of nitric oxide by hepatocytes stimulated with endotoxin or cytokines. ..