Carlos Moreno

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Genomic promoter analysis predicts functional transcription factor binding
    J Sunil Rao
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Adv Bioinformatics 2008:369830. 2008
  2. pmc The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas
    Lee A D Cooper
    Center for Comprehensive Informatics, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 5:e12548. 2010
  3. doi request reprint Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells
    Birdal Bilir
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Transl Med 11:280. 2013
  4. pmc Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells
    Cornel J Phillip
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    BMC Cancer 12:145. 2012
  5. pmc Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells
    Christopher D Scharer
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Transl Med 6:79. 2008
  6. pmc Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells
    Mohamed Ali-Seyed
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    BMC Cancer 6:54. 2006
  7. pmc Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3
    Johnthan Gordon
    Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    BMC Biochem 12:54. 2011
  8. ncbi request reprint Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56gamma knockdown
    Carlos S Moreno
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 64:6978-88. 2004
  9. ncbi request reprint Institutional profile: the emory biomarker service center
    Carlos S Moreno
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biomark Med 3:567-71. 2009
  10. pmc SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells
    Yu Heng Lai
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    BMC Cell Biol 12:50. 2011

Collaborators

Detail Information

Publications26

  1. pmc Genomic promoter analysis predicts functional transcription factor binding
    J Sunil Rao
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Adv Bioinformatics 2008:369830. 2008
    ..They also show that TFBS cooccurrence can be used to predict transcription factor binding to promoters in vivo...
  2. pmc The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas
    Lee A D Cooper
    Center for Comprehensive Informatics, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 5:e12548. 2010
    ....
  3. doi request reprint Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells
    Birdal Bilir
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Transl Med 11:280. 2013
    ..In this study, we investigated the potential of Wnt pathway inhibitors in effective treatment of TNBC...
  4. pmc Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells
    Cornel J Phillip
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    BMC Cancer 12:145. 2012
    ..In addition, we investigated the effects of combined treatment of genistein with the histone deacetylase inhibitor vorinostat on survival in prostate cancer cells...
  5. pmc Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells
    Christopher D Scharer
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Transl Med 6:79. 2008
    ..Recent data has shown that overexpression of Aurora-A can confer resistance to the taxane paclitaxel...
  6. pmc Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells
    Mohamed Ali-Seyed
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    BMC Cancer 6:54. 2006
    ..To cross-validate and extend our initial findings, we sought to compare the expression profiles of these cell lines using an alternative microarray platform...
  7. pmc Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3
    Johnthan Gordon
    Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    BMC Biochem 12:54. 2011
    ..Little is known about the molecular architecture of the striatin complex and the regulation of these sterile 20-like kinases...
  8. ncbi request reprint Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56gamma knockdown
    Carlos S Moreno
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 64:6978-88. 2004
    ..Our data support a model in which ST promotes survival through constitutive integrin signaling, src phosphorylation, and nuclear factor kappaB activation, while inhibiting cell-cell adhesion pathways...
  9. ncbi request reprint Institutional profile: the emory biomarker service center
    Carlos S Moreno
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biomark Med 3:567-71. 2009
    ..Bioinformatics support is provided to users by a team of analysts using a variety of standard and custom software tools...
  10. pmc SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells
    Yu Heng Lai
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    BMC Cell Biol 12:50. 2011
    ..Thus, the identification of additional SOX4 binding partners is essential for elucidating the mechanism of SOX4-mediated effects in cancer progression...
  11. pmc The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathways
    Carlos S Moreno
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
    Am J Pathol 176:518-27. 2010
    ..The evidence supporting activation of these pathways in prostate cancer progression suggests that combinations of compounds targeting them may be of benefit to patients with aggressive, metastatic disease...
  12. ncbi request reprint Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells
    Pengbo Liu
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:4011-9. 2006
    ..Stable transfection of SOX4 into nontransformed prostate cells enabled colony formation in soft agar, suggesting that, in the proper cellular context, SOX4 can be a transforming oncogene...
  13. pmc An integrative approach for in silico glioma research
    Lee A D Cooper
    Center for Comprehensive Informatics, Atlanta, GA 30322, USA
    IEEE Trans Biomed Eng 57:2617-21. 2010
    ..The preliminary results demonstrate the potential of combining morphometric and molecular characterizations for in silico research...
  14. pmc Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer
    Colleen D McCabe
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 68:1988-96. 2008
    ..HOXC6 regulates genes with both oncogenic and tumor suppressor activities as well as several genes such as CD44 that are important for prostate branching morphogenesis and metastasis to the bone microenvironment...
  15. pmc Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells
    Christopher D Scharer
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 69:709-17. 2009
    ....
  16. pmc Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells
    Lizheng Guo
    Department of Hematology and Oncology, The Winship Cancer Institute, Atlanta VA Medical Center, Atlanta, George, USA
    Mol Cancer Res 6:1421-30. 2008
    ..Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors...
  17. ncbi request reprint MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer
    Naoyuki Fujita
    Emory University School of Medicine, Department of Pathology, Whitehead Biomedical Research Building, Room 142, 615 Michael Street, Atlanta, GA 30322, USA
    Cell 113:207-19. 2003
    ..These results establish a mechanistic link between estrogen receptor status and invasive growth of breast cancers...
  18. doi request reprint Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses
    Chheng Orn Evans
    Department of Neurosurgery and Laboratory of Molecular Neurosurgery and Biotechnology, Emory University School of Medicine, 1365 B Clifton Rd, NE, Suite 6200, Atlanta, GA, 30322, USA
    Pituitary 11:231-45. 2008
    ..In the current era of molecular medicine, these findings greatly enhance our understanding and supercede immunohistochemical diagnosis...
  19. ncbi request reprint Novel molecular signaling and classification of human clinically nonfunctional pituitary adenomas identified by gene expression profiling and proteomic analyses
    Carlos S Moreno
    Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 65:10214-22. 2005
    ....
  20. pmc CONFAC: automated application of comparative genomic promoter analysis to DNA microarray datasets
    Suresh Karanam
    Program in Bioinformatics, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Nucleic Acids Res 32:W475-84. 2004
    ..As a proof-of-principle, we have validated the CONFAC software using gene sets from four separate microarray studies and identified TFBSs known to be functionally important for regulation of each of the four gene sets...
  21. ncbi request reprint Loss of HOXC6 expression induces apoptosis in prostate cancer cells
    Sumathi Ramachandran
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 24:188-98. 2005
    ..Our data suggest that HOXC6 may be a novel potential therapeutic target for prostate cancer...
  22. pmc In silico analysis of nuclei in glioblastoma using large-scale microscopy images improves prediction of treatment response
    Jun Kong
    Emory University, Center for Comprehensive Informatics, Atlanta, GA 30322, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:87-90. 2011
    ..As a result, this analysis method shows potential to facilitate a better understanding of disease progression and patients' response to therapy for glioblastoma...
  23. pmc Molecular classification of renal tumors by gene expression profiling
    Audrey N Schuetz
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Decatur, GA 30033, USA
    J Mol Diagn 7:206-18. 2005
    ..In summary, renal tumor subtypes were classified by distinct gene expression profiles, illustrating tumor pathobiology and translating into novel molecular bioassays using fixed tissue...
  24. pmc Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas
    Carlos S Moreno
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 2:e441. 2007
    ....
  25. ncbi request reprint Expression microarray analysis of brain tumors: what have we learned so far
    Stephen B Hunter
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30087, USA
    Front Biosci 7:c74-82. 2002
    ..Finally, novel roles for a few genes, including insulin growth factor binding protein 2 and apolipoprotein D, have been revealed for the first time by expression microarrays...
  26. pmc Optimization of RNA extraction from FFPE tissues for expression profiling in the DASL assay
    Mark Abramovitz
    VM Institute of Research, Montreal, Quebec, Canada
    Biotechniques 44:417-23. 2008
    ....

Research Grants8

  1. Quality Threshold Analysis of Prostate Cancers
    Carlos Moreno; Fiscal Year: 2004
    ..Identification of genetic profiles associated with prostatic neoplasias that are more likely to result in aggressive disease may lead to improved management of prostate cancer patients. ..
  2. Developmental Transcription Factors in Prostate Cancer
    Carlos Moreno; Fiscal Year: 2005
    ..Together these experiments will provide new insights into the mechanisms of prostate cancer progression and potentially validate HOXC6 and SOX4 as novel therapeutic targets for prostate cancer. ..
  3. Developmental Transcription Factors in Prostate Cancer
    Carlos Moreno; Fiscal Year: 2006
    ..Together these experiments will provide new insights into the mechanisms of prostate cancer progression and potentially validate HOXC6 and SOX4 as novel therapeutic targets for prostate cancer. ..
  4. Developmental Transcription Factors in Prostate Cancer
    Carlos Moreno; Fiscal Year: 2007
    ..Together these experiments will provide new insights into the mechanisms of prostate cancer progression and potentially validate HOXC6 and SOX4 as novel therapeutic targets for prostate cancer. ..
  5. Developmental Transcription Factors in Prostate Cancer
    Carlos Moreno; Fiscal Year: 2009
    ..Experiments are directed to determine whether these genes, or the pathways that they influence, are viable therapeutic targets using a variety of approaches, including mouse models. ..
  6. Developmental Transcription Factors in Prostate Cancer
    Carlos S Moreno; Fiscal Year: 2010
    ..Experiments are directed to determine whether these genes, or the pathways that they influence, are viable therapeutic targets using a variety of approaches, including mouse models. ..
  7. Developmental Transcription Factors in Prostate Cancer
    Carlos S Moreno; Fiscal Year: 2010
    ..Experiments are directed to determine whether these genes, or the pathways that they influence, are viable therapeutic targets using a variety of approaches, including mouse models. ..