Research Topics
Genomes and GenesSpecies | Carlos MorenoSummaryAffiliation: Emory University Country: USA Publications
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Publications
Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cellsCornel J Phillip
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
BMC Cancer 12:145. 2012..In addition, we investigated the effects of combined treatment of genistein with the histone deacetylase inhibitor vorinostat on survival in prostate cancer cells...- Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cellsChristopher D Scharer
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
J Transl Med 6:79. 2008..Recent data has shown that overexpression of Aurora-A can confer resistance to the taxane paclitaxel... - Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cellsMohamed Ali-Seyed
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
BMC Cancer 6:54. 2006..To cross-validate and extend our initial findings, we sought to compare the expression profiles of these cell lines using an alternative microarray platform... - Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3Johnthan Gordon
Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
BMC Biochem 12:54. 2011..Little is known about the molecular architecture of the striatin complex and the regulation of these sterile 20-like kinases... - The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathwaysCarlos S Moreno
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Am J Pathol 176:518-27. 2010..The evidence supporting activation of these pathways in prostate cancer progression suggests that combinations of compounds targeting them may be of benefit to patients with aggressive, metastatic disease... 
Institutional profile: the emory biomarker service centerCarlos S Moreno
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Biomark Med 3:567-71. 2009..Bioinformatics support is provided to users by a team of analysts using a variety of standard and custom software tools...- Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56gamma knockdownCarlos S Moreno
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Cancer Res 64:6978-88. 2004..Our data support a model in which ST promotes survival through constitutive integrin signaling, src phosphorylation, and nuclear factor kappaB activation, while inhibiting cell-cell adhesion pathways... - SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cellsYu Heng Lai
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
BMC Cell Biol 12:50. 2011..Thus, the identification of additional SOX4 binding partners is essential for elucidating the mechanism of SOX4-mediated effects in cancer progression... - Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cellsPengbo Liu
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 66:4011-9. 2006..Stable transfection of SOX4 into nontransformed prostate cells enabled colony formation in soft agar, suggesting that, in the proper cellular context, SOX4 can be a transforming oncogene... - An integrative approach for in silico glioma researchLee A D Cooper
Center for Comprehensive Informatics, Atlanta, GA 30322, USA
IEEE Trans Biomed Eng 57:2617-21. 2010..The preliminary results demonstrate the potential of combining morphometric and molecular characterizations for in silico research... - Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancerColleen D McCabe
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Res 68:1988-96. 2008..HOXC6 regulates genes with both oncogenic and tumor suppressor activities as well as several genes such as CD44 that are important for prostate branching morphogenesis and metastasis to the bone microenvironment... 
Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analysesChheng Orn Evans
Department of Neurosurgery and Laboratory of Molecular Neurosurgery and Biotechnology, Emory University School of Medicine, 1365 B Clifton Rd, NE, Suite 6200, Atlanta, GA, 30322, USA
Pituitary 11:231-45. 2008..In the current era of molecular medicine, these findings greatly enhance our understanding and supercede immunohistochemical diagnosis...- MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancerNaoyuki Fujita
Emory University School of Medicine, Department of Pathology, Whitehead Biomedical Research Building, Room 142, 615 Michael Street, Atlanta, GA 30322, USA
Cell 113:207-19. 2003..These results establish a mechanistic link between estrogen receptor status and invasive growth of breast cancers... - CONFAC: automated application of comparative genomic promoter analysis to DNA microarray datasetsSuresh Karanam
Program in Bioinformatics, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
Nucleic Acids Res 32:W475-84. 2004..As a proof-of-principle, we have validated the CONFAC software using gene sets from four separate microarray studies and identified TFBSs known to be functionally important for regulation of each of the four gene sets... - Loss of HOXC6 expression induces apoptosis in prostate cancer cellsSumathi Ramachandran
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Oncogene 24:188-98. 2005..Our data suggest that HOXC6 may be a novel potential therapeutic target for prostate cancer... - Novel molecular signaling and classification of human clinically nonfunctional pituitary adenomas identified by gene expression profiling and proteomic analysesCarlos S Moreno
Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 65:10214-22. 2005.... - Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cellsChristopher D Scharer
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 69:709-17. 2009.... - Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cellsLizheng Guo
Department of Hematology and Oncology, The Winship Cancer Institute, Atlanta VA Medical Center, Atlanta, George, USA
Mol Cancer Res 6:1421-30. 2008..Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors... - Molecular classification of renal tumors by gene expression profilingAudrey N Schuetz
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Decatur, GA 30033, USA
J Mol Diagn 7:206-18. 2005..In summary, renal tumor subtypes were classified by distinct gene expression profiles, illustrating tumor pathobiology and translating into novel molecular bioassays using fixed tissue... - Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomasCarlos S Moreno
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
PLoS ONE 2:e441. 2007.... - Expression microarray analysis of brain tumors: what have we learned so farStephen B Hunter
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30087, USA
Front Biosci 7:c74-82. 2002..Finally, novel roles for a few genes, including insulin growth factor binding protein 2 and apolipoprotein D, have been revealed for the first time by expression microarrays... - Optimization of RNA extraction from FFPE tissues for expression profiling in the DASL assayMark Abramovitz
VM Institute of Research, Montreal, Quebec, Canada
Biotechniques 44:417-23. 2008....
Research Grants
- Quality Threshold Analysis of Prostate CancersCarlos Moreno; Fiscal Year: 2004..Identification of genetic profiles associated with prostatic neoplasias that are more likely to result in aggressive disease may lead to improved management of prostate cancer patients. ..
- Developmental Transcription Factors in Prostate CancerCarlos Moreno; Fiscal Year: 2007..Together these experiments will provide new insights into the mechanisms of prostate cancer progression and potentially validate HOXC6 and SOX4 as novel therapeutic targets for prostate cancer. ..
- Developmental Transcription Factors in Prostate CancerCarlos S Moreno; Fiscal Year: 2010..Experiments are directed to determine whether these genes, or the pathways that they influence, are viable therapeutic targets using a variety of approaches, including mouse models. ..
- Developmental Transcription Factors in Prostate CancerCarlos S Moreno; Fiscal Year: 2010..Experiments are directed to determine whether these genes, or the pathways that they influence, are viable therapeutic targets using a variety of approaches, including mouse models. ..