Alberto Moreno

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Plasmodium coatneyi in rhesus macaques replicates the multisystemic dysfunction of severe malaria in humans
    Alberto Moreno
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Infect Immun 81:1889-904. 2013
  2. pmc Recombinant peptide replicates immunogenicity of synthetic linear peptide chimera for use as pre-erythrocytic stage malaria vaccine
    Luciana M Silva-Flannery
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Microbes Infect 11:83-91. 2009
  3. ncbi request reprint Comparison of IgG reactivities to Plasmodium vivax merozoite invasion antigens in a Brazilian Amazon population
    Tuan M Tran
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 73:244-55. 2005
  4. pmc Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate
    Balwan Singh
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States
    Vaccine 28:2580-92. 2010
  5. pmc A hybrid multistage protein vaccine induces protective immunity against murine malaria
    Balwan Singh
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Infect Immun 80:1491-501. 2012
  6. ncbi request reprint Disseminated intravascular coagulation complicated by peripheral gangrene in a rhesus macaque (Macaca mulatta) experimentally infected with Plasmodium coatneyi
    Alberto Moreno
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 76:648-54. 2007
  7. ncbi request reprint Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria
    Ivette Caro-Aguilar
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Microbes Infect 7:1324-37. 2005
  8. pmc Polymeric linear Peptide chimeric vaccine-induced antimalaria immunity is associated with enhanced in vitro antigen loading
    Luciana M Silva-Flannery
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Infect Immun 77:1798-806. 2009
  9. ncbi request reprint Detection of a Plasmodium vivax erythrocyte binding protein by flow cytometry
    Tuan M Tran
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Cytometry A 63:59-66. 2005

Research Grants

Collaborators

  • Anapatricia Garcia
  • Mary Galinski
  • Balwan Singh
  • Monica Cabrera-Mora
  • Luciana M Silva-Flannery
  • Jianlin Jiang
  • Tuan M Tran
  • Chetan E Chitnis
  • Syed S Yazdani
  • Ivette Caro-Aguilar
  • John W Barnwell
  • Megan Dickherber
  • Esmeralda V S Meyer
  • John D Altman
  • Stacey Lapp
  • Joseli Oliveira-Ferreira
  • Fatima Santos
  • Jan Pohl

Detail Information

Publications9

  1. pmc Plasmodium coatneyi in rhesus macaques replicates the multisystemic dysfunction of severe malaria in humans
    Alberto Moreno
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Infect Immun 81:1889-904. 2013
    ..Together with high-throughput postgenomic technologies, such investigations hold promise for the identification of new clinical interventions and adjunctive therapies...
  2. pmc Recombinant peptide replicates immunogenicity of synthetic linear peptide chimera for use as pre-erythrocytic stage malaria vaccine
    Luciana M Silva-Flannery
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Microbes Infect 11:83-91. 2009
    ..yoelii sporozoites. Recombinant LPCs reproduced the immunogenicity of synthetic LPC(cys+) without requiring polymerization, improving prospects for use as malaria vaccines...
  3. ncbi request reprint Comparison of IgG reactivities to Plasmodium vivax merozoite invasion antigens in a Brazilian Amazon population
    Tuan M Tran
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 73:244-55. 2005
    ....
  4. pmc Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate
    Balwan Singh
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States
    Vaccine 28:2580-92. 2010
    ..These studies show that protective efficacy can be significantly improved by inclusion of an array of autologous promiscuous T cell epitopes in vaccine constructs...
  5. pmc A hybrid multistage protein vaccine induces protective immunity against murine malaria
    Balwan Singh
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Infect Immun 80:1491-501. 2012
    ..These data support our strategy of using an array of autologous T helper epitopes to maximize the response to multistage malaria vaccines...
  6. ncbi request reprint Disseminated intravascular coagulation complicated by peripheral gangrene in a rhesus macaque (Macaca mulatta) experimentally infected with Plasmodium coatneyi
    Alberto Moreno
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 76:648-54. 2007
    ..DIC with peripheral gangrene is very rare in Plasmodium-infected individuals. Our results indicate that the experimental model of P. coatneyi infection of rhesus monkeys is important for studies of malarial anemia and coagulopathy...
  7. ncbi request reprint Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria
    Ivette Caro-Aguilar
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Microbes Infect 7:1324-37. 2005
    ..berghei or P. yoelii sporozoites. Collectively, these results suggest that polymeric polypeptide chimeras can be used as a platform to deliver subunit vaccines...
  8. pmc Polymeric linear Peptide chimeric vaccine-induced antimalaria immunity is associated with enhanced in vitro antigen loading
    Luciana M Silva-Flannery
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Infect Immun 77:1798-806. 2009
    ..Spontaneous polymerization of synthetic antimalarial-peptide constructs to target professional antigen-presenting cells shows promise for simple delivery of subunit malaria vaccines...
  9. ncbi request reprint Detection of a Plasmodium vivax erythrocyte binding protein by flow cytometry
    Tuan M Tran
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Cytometry A 63:59-66. 2005
    ..vivax Duffy binding protein region II (PvDBP-RII) recombinant protein as a model. This protein binds to all erythrocytes that express the Duffy receptor (Fy) and discriminates binding between normocytes and reticulocytes...

Research Grants9

  1. Novel Linear Peptide Universal Malaria Vaccines
    Alberto Moreno; Fiscal Year: 2005
    ..falciparum, respectively. These approaches will provide strong data to evaluate the LPC approach as a ways forward for clinical trials, whether used singly or in combination with other malaria vaccine platforms. ..
  2. Modular Chimeric Vaccines tailored for malaria parasites
    Alberto Moreno; Fiscal Year: 2007
    ..The emergence of P. vivax chloroquine and primaquine drug resistant strains has brought increased emphasis to the need for alternative prophylactic and therapeutic strategies to control this infection. ..
  3. Modular Chimeric Vaccines tailored for malaria parasites
    Alberto Moreno; Fiscal Year: 2010
    ..The emergence of P. vivax chloroquine and primaquine drug resistant strains has brought increased emphasis to the need for alternative prophylactic and therapeutic strategies to control this infection. ..