Ana L Mora

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice
    Ana L Mora
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University, 615 Michael Street, Suite 205K, Atlanta, GA 30322, USA
    Am J Respir Crit Care Med 175:1139-50. 2007
  2. pmc Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis
    Ana L Mora
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Research of the Lung, Emory University, 615 Michael Street Suite 215, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 35:466-73. 2006
  3. ncbi Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice
    Ana L Mora
    Center for Translational Research of the Lung, Division of Pulmonary, Allergy, and Critical Care, Dept of Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 289:L711-21. 2005
  4. ncbi Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice
    Jianguo Xu
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 293:L131-41. 2007
  5. pmc Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis
    Smita S Iyer
    Nutrition and Health Sciences Program, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 296:L37-45. 2009
  6. ncbi Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet
    Jianguo Xu
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Translational Research of the Lung, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 291:L658-67. 2006
  7. pmc Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis
    Laurie T Krug
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA
    Am J Pathol 177:608-21. 2010
  8. pmc Bone marrow-derived mesenchymal stem cells in repair of the injured lung
    Mauricio Rojas
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Research of the Lung, Department of Medicine, Emory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 33:145-52. 2005
  9. pmc A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology
    Andrew G Evans
    Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:669-84. 2008
  10. pmc Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice
    Jianguo Xu
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Gerontol A Biol Sci Med Sci 64:731-9. 2009

Research Grants

  1. Immunobiology of Lung Fibrosis
    Ana Mora; Fiscal Year: 2007

Collaborators

Detail Information

Publications24

  1. pmc Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice
    Ana L Mora
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University, 615 Michael Street, Suite 205K, Atlanta, GA 30322, USA
    Am J Respir Crit Care Med 175:1139-50. 2007
    ..Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disorder of unknown cause. Several studies suggest an association between Epstein-Barr virus pulmonary infection and the development of IPF...
  2. pmc Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis
    Ana L Mora
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Research of the Lung, Emory University, 615 Michael Street Suite 215, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 35:466-73. 2006
    ..These results suggest that virus-induced upregulation of arginase I could be a mechanism driving lung fibrogenesis...
  3. ncbi Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice
    Ana L Mora
    Center for Translational Research of the Lung, Division of Pulmonary, Allergy, and Critical Care, Dept of Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 289:L711-21. 2005
    ..In summary, chronic herpesvirus pulmonary infection in IFN-gammaR-/- mice causes progressive pulmonary fibrosis and many of the pathological features seen in IPF...
  4. ncbi Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice
    Jianguo Xu
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 293:L131-41. 2007
    ..We speculate that mobilization of this population of BMDMSCs may be a general mechanism for modulating an acute inflammatory response...
  5. pmc Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis
    Smita S Iyer
    Nutrition and Health Sciences Program, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 296:L37-45. 2009
    ..Thus the data show that decreased precursor availability and enhanced oxidation of Cys each contribute to the oxidation of extracellular Cys/CySS redox state in bleomycin-induced lung fibrosis...
  6. ncbi Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet
    Jianguo Xu
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Translational Research of the Lung, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 291:L658-67. 2006
    ..These data suggest that the T-bet pathway in CD4+ T lymphocytes can confer resistance to BLM-induced lung fibrosis in BALB/c mice...
  7. pmc Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis
    Laurie T Krug
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA
    Am J Pathol 177:608-21. 2010
    ..Host determinants of latency might therefore represent new therapeutic targets for gammaherpesvirus-associated pulmonary fibrosis...
  8. pmc Bone marrow-derived mesenchymal stem cells in repair of the injured lung
    Mauricio Rojas
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Research of the Lung, Department of Medicine, Emory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 33:145-52. 2005
    ..BMDMSC localize to the injured lung and assume lung cell phenotypes, but protection from injury and fibrosis also involves suppression of inflammation and triggering production of reparative growth factors...
  9. pmc A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology
    Andrew G Evans
    Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:669-84. 2008
    ....
  10. pmc Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice
    Jianguo Xu
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Gerontol A Biol Sci Med Sci 64:731-9. 2009
    ..This study provides the novel observation that apart from increases in inflammatory and fibrotic factors in response to injury, the increased mobilization of fibrocytes may be involved in age-related susceptibility to lung fibrosis...
  11. pmc Attenuation of early airway obstruction by mesenchymal stem cells in a murine model of heterotopic tracheal transplantation
    Daniel A Grove
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Heart Lung Transplant 30:341-50. 2011
    ..We hypothesized that the injection of MSC would prevent development of early airway obstruction (AO) in the heterotopic tracheal transplant model...
  12. ncbi Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses
    Mauricio Rojas
    Division of Pulmonary, Allergy and Critical Care, Center for Translational Research of the Lung, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 288:L333-41. 2005
    ..The response is characterized by successive waves of cytokine release into the circulation, early evidence of lung fibrogenesis, and prolonged increases in growth factors that may participate in lung repair...
  13. ncbi Prevention of NF-kappaB activation in vivo by a cell-permeable NF-kappaB inhibitor peptide
    Ana L Mora
    Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 289:L536-44. 2005
    ..These data demonstrate that activation of NF-kappaB can be inhibited using a recombinant protein designed to penetrate into cells. This technology may provide a new approach to NF-kappaB pathway-targeted therapies...
  14. doi Aging and lung injury repair: a role for bone marrow derived mesenchymal stem cells
    Ana L Mora
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Center for Translational Research in the Lung, McKelvey Center for Lung Transplantation, Emory University, Atlanta, Georgia 30322, USA
    J Cell Biochem 105:641-7. 2008
    ..The understanding of these age related changes must be considered in the rationale for the development of therapeutic interventions to control lung injury and fibrosis...
  15. pmc Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis
    Veronika Pozharskaya
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7559. 2009
    ..We hypothesize that EMT in this model of virus-induced pulmonary fibrosis is driven by the expression of the transcription factor Twist...
  16. pmc Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis
    Edilson Torres-González
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, Georgia, USA
    Am J Respir Cell Mol Biol 46:748-56. 2012
    ..These results indicate that the aging lung is more susceptible to injury and fibrosis associated with endoplasmic reticulum stress, apoptosis of type II lung epithelial cells, and activation of profibrotic pathways...
  17. pmc Effect of bone marrow-derived mesenchymal stem cells on endotoxin-induced oxidation of plasma cysteine and glutathione in mice
    Smita S Iyer
    Nutrition and Health Sciences Program, Emory University, Atlanta, GA 30322, USA
    Stem Cells Int 2010:868076. 2010
    ..The findings are the first to demonstrate that BMDMSC have antioxidant effects in vivo, and add to our understanding of the systemic effects of BMDMSC in lung injury...
  18. pmc Attenuation of obliterative bronchiolitis by a CXCR4 antagonist in the murine heterotopic tracheal transplant model
    Jianguo Xu
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Heart Lung Transplant 27:1302-10. 2008
    ..We hypothesized that the SDF-1/CXCR4 axis also plays a role in the pathogenesis of OB...
  19. doi Influence of age on wound healing and fibrosis
    Maria G Kapetanaki
    Dorothy P and Richard P Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Pathol 229:310-22. 2013
    ..This review summarizes what is known about age-related molecular changes that are implicated in the pathobiology of lung fibrosis in lung tissue...
  20. ncbi Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells
    Mark A Aronica
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Allergy Clin Immunol 114:1441-8. 2004
    ..Microbial infections are associated with the initial susceptibility to and flares of asthma. However, immunologic mechanisms whereby infections might alter the asthmatic phenotype are lacking...
  21. ncbi An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation
    Linda Stephenson
    Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Immunol 173:4523-8. 2004
    ..The data further suggest that for such variants, any mechanistic involvement is based on a role in cellular targets of Th2 cytokines...
  22. ncbi New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines
    Ana L Mora
    Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Immunol 171:1891-900. 2003
    ..Furthermore, the data suggest that one pathway by which such new programming may be achieved is mediated by extracellular signal-regulated mitogen-activated protein kinases...
  23. ncbi Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes
    Linda M Stephenson
    Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, TN 37232 3463, USA
    J Immunol 175:5178-85. 2005
    ....
  24. ncbi NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes
    Aleksandar K Stanic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 172:2265-73. 2004
    ..Thus, antiapoptotic signals relayed by NF-kappaB critically control cell fate specification and molecular differentiation of iNKT cells and, hence, reveal a novel role for such signals within the immune system...

Research Grants1

  1. Immunobiology of Lung Fibrosis
    Ana Mora; Fiscal Year: 2007
    ..4. Using IL-4 receptor deficient mice with and without adoptive transfer of normal Th2 cells, to determine whether IL-4 signaling in cells other than T lymphocytes is important to the lung fibrogenic response to MHV68 or bleomycin. ..