KENNETH MOBERG

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi The Drosophila F box protein archipelago regulates dMyc protein levels in vivo
    Kenneth H Moberg
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129 USA
    Curr Biol 14:965-74. 2004
  2. ncbi Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth
    Kenneth H Moberg
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Dev Cell 9:699-710. 2005
  3. ncbi The gang of four gene regulates growth and patterning of the developing Drosophila eye
    Carolyn K Beam
    Emory University School of Medicine, Department of Cell Biology, Atlanta, GA, USA
    Fly (Austin) 4:104-16. 2010
  4. ncbi Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7039. 2009
  5. ncbi Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7083. 2009
  6. ncbi The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system
    Nathan T Mortimer
    Department of Cell Biology, Emory University School of Medicine, 615 Michael St WBRB 442, Atlanta, GA 30322, USA
    Dev Biol 312:560-71. 2007
  7. ncbi ESCRTing cell proliferation off the beaten path: lessons from the drosophila eye
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cell Cycle 5:283-7. 2006
  8. ncbi The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues
    Sarah C Nicholson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 19:1503-10. 2009
  9. ncbi Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
    Brian S Robinson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 20:582-90. 2010
  10. ncbi Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, CNY-7, 13th Street, Charlestown, MA 02129, USA
    Gynecol Oncol 98:124-8. 2005

Research Grants

  1. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    KENNETH MOBERG; Fiscal Year: 2007
  2. Control of tissue growth and architecture by Drosophila Tsg101
    KENNETH MOBERG; Fiscal Year: 2007
  3. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    KENNETH MOBERG; Fiscal Year: 2009
  4. Control of tissue growth and architecture by Drosophila Tsg101
    KENNETH MOBERG; Fiscal Year: 2009
  5. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    Kenneth H Moberg; Fiscal Year: 2010
  6. Control of tissue growth and architecture by Drosophila Tsg101
    Kenneth H Moberg; Fiscal Year: 2010

Collaborators

  • ISWAR HARIHARAN
  • M Melissa Gilbert
  • Brian S Robinson
  • Nathan T Mortimer
  • Carolyn K Beam
  • Rebekah F Kushner
  • Sarah C Nicholson
  • Eunice L Kwak
  • Rebecca D Sanders
  • Jennifer M I Sefton
  • Juang Huang
  • Judith L Fridovich-Keil
  • Yang Hong
  • Patricia Jumbo Lucioni
  • Emily L Ryan
  • Maxim V Frolov
  • Brandon N Nicolay
  • Paula M Gilmore
  • Doke C R Wahrer
  • Jennifer E Quinn
  • Daniel A Haber
  • D Paul Harkin
  • Colin A Graham
  • Daphne W Bell

Detail Information

Publications13

  1. ncbi The Drosophila F box protein archipelago regulates dMyc protein levels in vivo
    Kenneth H Moberg
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129 USA
    Curr Biol 14:965-74. 2004
    ..Its levels and activity are tightly controlled in vivo by a variety of mechanisms. In normal cells, Myc protein is rapidly degraded, but the mechanism of its degradation is not well understood...
  2. ncbi Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth
    Kenneth H Moberg
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Dev Cell 9:699-710. 2005
    ..Activation of JAK-STAT signaling in surrounding wild-type cells correlates with their overgrowth. These findings define a pathway by which changes in endocytic trafficking can regulate tissue growth in a non-cell-autonomous manner...
  3. ncbi The gang of four gene regulates growth and patterning of the developing Drosophila eye
    Carolyn K Beam
    Emory University School of Medicine, Department of Cell Biology, Atlanta, GA, USA
    Fly (Austin) 4:104-16. 2010
    ..Genetic reduction of bru-3 suppresses phenotypes caused by gfr alleles, and like gfr alleles, overexpression of bru-3 depresses levels of Cic protein, indicating that overexpression of bru-3 is central to gfr mutant phenotypes...
  4. ncbi Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7039. 2009
    ..Excess cell division is postulated to be a primary cause of these 'neoplastic' phenotypes, but the autonomous effect of these mutations on cell cycle control has not been examined...
  5. ncbi Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7083. 2009
    ..A full understanding of pathways deregulated by loss of Drosophila ept will aid in understanding potential links between mammalian TSG101 and growth control...
  6. ncbi The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system
    Nathan T Mortimer
    Department of Cell Biology, Emory University School of Medicine, 615 Michael St WBRB 442, Atlanta, GA 30322, USA
    Dev Biol 312:560-71. 2007
    ....
  7. ncbi ESCRTing cell proliferation off the beaten path: lessons from the drosophila eye
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cell Cycle 5:283-7. 2006
    ..These connections touch major cell biological processes, including cell division, growth, death, and polarity, and have begun to paint a complex, yet intriguing, picture of how defective endocytic sorting can affect developing tissues...
  8. ncbi The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues
    Sarah C Nicholson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 19:1503-10. 2009
    ..Its human ortholog, Fbw7, is commonly lost in cancers, suggesting that failure to degrade ago/Fbw7 targets drives excess tissue growth...
  9. ncbi Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
    Brian S Robinson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 20:582-90. 2010
    ....
  10. ncbi Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, CNY-7, 13th Street, Charlestown, MA 02129, USA
    Gynecol Oncol 98:124-8. 2005
    ..Reconstitution experiments, rather than measuring tumor levels of cyclin E and c-Myc, provide an effective approach to determine the functional significance of AGO mutations identified in human cancers...
  11. ncbi Big things from a little RNA
    Kenneth H Moberg
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Trends Cell Biol 13:455-7. 2003
    ....
  12. ncbi Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia
    Nathan T Mortimer
    Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Dev Biol 329:294-305. 2009
    ..The identification of an early stage of tracheal development that is vulnerable to hypoxia is an important addition to models of the invertebrate hypoxic response...
  13. ncbi A Drosophila melanogaster model of classic galactosemia
    Rebekah F Kushner
    Graduate Program in Biochemistry, Cell and Developmental Biology, Emory University, Atlanta, GA 30322, USA
    Dis Model Mech 3:618-27. 2010
    ..Using this new Drosophila model, we have begun to dissect the timing, extent and mechanism(s) of galactose sensitivity in the absence of GALT activity...

Research Grants9

  1. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    KENNETH MOBERG; Fiscal Year: 2007
    ..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..
  2. Control of tissue growth and architecture by Drosophila Tsg101
    KENNETH MOBERG; Fiscal Year: 2007
    ....
  3. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    KENNETH MOBERG; Fiscal Year: 2009
    ..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..
  4. Control of tissue growth and architecture by Drosophila Tsg101
    KENNETH MOBERG; Fiscal Year: 2009
    ....
  5. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    Kenneth H Moberg; Fiscal Year: 2010
    ..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..
  6. Control of tissue growth and architecture by Drosophila Tsg101
    Kenneth H Moberg; Fiscal Year: 2010
    ....