Andrew Miller

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C
    A K Smith
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Mol Psychiatry 17:781-9. 2012
  2. pmc CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression
    C L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Psychiatry 15:393-403. 2010
  3. doi request reprint Cytokine targets in the brain: impact on neurotransmitters and neurocircuits
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Depress Anxiety 30:297-306. 2013
  4. pmc Depression and immunity: a role for T cells?
    Andrew H Miller
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 24:1-8. 2010
  5. pmc Norman Cousins Lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute, Emory University School of Medicine, 1701 Uppergate Drive, WCI Building C, 5th Floor, Atlanta, GA 30322, USA
    Brain Behav Immun 23:149-58. 2009
  6. pmc Inflammation versus glucocorticoids as purveyors of pathology during stress: have we reached the tipping point?
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 64:263-5. 2008
  7. pmc Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Rd, 5th Floor, Atlanta, GA 30322, USA
    J Clin Oncol 26:971-82. 2008
  8. ncbi request reprint Elucidating the consequences of chronic stress on immune regulation and behavior in rheumatoid arthritis
    Andrew H Miller
    Psychiatric Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, 5th Floor, Atlanta, GA 30322, USA
    Brain Behav Immun 22:22-3. 2008
  9. pmc Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:732-41. 2009
  10. ncbi request reprint Cytokines and sickness behavior: implications for cancer care and control
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Brain Behav Immun 17:S132-4. 2003

Research Grants

  1. Neuroimmune Mechanisms of Glucocorticoid Resistance
    Andrew Miller; Fiscal Year: 2007
  2. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2010
  3. IFN ALPHA-INDUCED DEPRESSION
    Andrew Miller; Fiscal Year: 2003
  4. ADRENAL STEROID--IMMUNE INTERACTIONS
    Andrew Miller; Fiscal Year: 2003
  5. Fronto-Striatal Dysfunction in IFNa-Induced Depression
    Andrew Miller; Fiscal Year: 2004
  6. Pathophysiology of IFN-alpha-induced Sleep Disturbances
    Andrew Miller; Fiscal Year: 2004
  7. Fronto-Striatal Dysfunction in IFNa-Induced Depression
    Andrew Miller; Fiscal Year: 2005
  8. Pathophysiology of IFN-alpha-induced Sleep Disturbances
    Andrew Miller; Fiscal Year: 2006
  9. Fronto-Striatal Dysfunction in IFNa-Induced Depression
    Andrew Miller; Fiscal Year: 2007
  10. IFN ALPHA-INDUCED DEPRESSION
    Andrew Miller; Fiscal Year: 2002

Detail Information

Publications73

  1. pmc Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C
    A K Smith
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Mol Psychiatry 17:781-9. 2012
    ..The findings in Caucasians further support the notion that IDO has an important role in cytokine-induced behavioral changes...
  2. pmc CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression
    C L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Psychiatry 15:393-403. 2010
    ..In conclusion, peripheral administration of IFN-alpha activated IDO in concert with central cytokine responses, resulting in increased brain KYN and QUIN, which correlated with depressive symptoms...
  3. doi request reprint Cytokine targets in the brain: impact on neurotransmitters and neurocircuits
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Depress Anxiety 30:297-306. 2013
    ..Chronic activation of this innate behavioral and immune response may lead to depression and anxiety disorders in vulnerable individuals...
  4. pmc Depression and immunity: a role for T cells?
    Andrew H Miller
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 24:1-8. 2010
    ..Further elucidation of T cell pathology may lead to new insights into immune system contributions to depression. Moreover, enhancement of T cell function may represent an alternative strategy to treat depression...
  5. pmc Norman Cousins Lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute, Emory University School of Medicine, 1701 Uppergate Drive, WCI Building C, 5th Floor, Atlanta, GA 30322, USA
    Brain Behav Immun 23:149-58. 2009
    ..Depending on the relative balance between these behavioral accoutrements of an activated innate immune response, clinical presentations may be distinct and warrant individualized therapeutic approaches...
  6. pmc Inflammation versus glucocorticoids as purveyors of pathology during stress: have we reached the tipping point?
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 64:263-5. 2008
  7. pmc Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Rd, 5th Floor, Atlanta, GA 30322, USA
    J Clin Oncol 26:971-82. 2008
    ....
  8. ncbi request reprint Elucidating the consequences of chronic stress on immune regulation and behavior in rheumatoid arthritis
    Andrew H Miller
    Psychiatric Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, 5th Floor, Atlanta, GA 30322, USA
    Brain Behav Immun 22:22-3. 2008
  9. pmc Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:732-41. 2009
    ....
  10. ncbi request reprint Cytokines and sickness behavior: implications for cancer care and control
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Brain Behav Immun 17:S132-4. 2003
  11. ncbi request reprint Glucocorticoid receptors are differentially expressed in the cells and tissues of the immune system
    A H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cell Immunol 186:45-54. 1998
    ..In addition, neutrophils were found to have fewer GR than lymphocytes and monocytes. These results indicate a meaningful relationship between receptor expression and known sensitivity to glucocorticoids...
  12. ncbi request reprint Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression
    A H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Adv Exp Med Biol 461:107-16. 1999
    ..Taken together, these findings suggest that factors which modulate glucocorticoid action (e.g. cytokines and antidepressants) will be relevant contributors to disease expression including behavioral toxicity and sickness behavior...
  13. ncbi request reprint The phosphodiesterase type 4 inhibitor, rolipram, enhances glucocorticoid receptor function
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Suite 4000, Atlanta, GA 30322, USA
    Neuropsychopharmacology 27:939-48. 2002
    ..These findings broaden the potential pathways by which PDE type 4 inhibitors can influence cellular function and indicate that these agents may have special utility in disorders associated with impaired GR-mediated feedback inhibition...
  14. ncbi request reprint When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Psychiatry 160:1554-65. 2003
    ....
  15. pmc IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C
    Matthias Majer
    Department of Psychiatry and Behavioural Sciences, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Brain Behav Immun 22:870-80. 2008
    ..Motor slowing and its correlation with psychiatric symptoms suggest that altered basal ganglia function may contribute to the pathogenesis of IFN-alpha-induced behavioural changes...
  16. pmc Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 65:296-303. 2009
    ..Moreover, the relationship among IFN-alpha-associated CNS inflammatory responses, neurotransmitter metabolism, and behavior has yet to be established...
  17. ncbi request reprint Cytokines and psychopathology: lessons from interferon-alpha
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biol Psychiatry 56:819-24. 2004
    ....
  18. ncbi request reprint Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Psychiatry 160:1342-5. 2003
    ..The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment...
  19. ncbi request reprint Increased early life stress and depressive symptoms in patients with comorbid substance abuse and schizophrenia
    Geraldine Scheller-Gilkey
    Emory University, School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA
    Schizophr Bull 28:223-31. 2002
    ..The results emphasize the importance of early life stress and affective symptoms and their potential relationship to substance abuse disorders in schizophrenia patients...
  20. pmc Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
    Marni N Silverman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
    Viral Immunol 18:41-78. 2005
    ....
  21. pmc Common genetic contributions to depressive symptoms and inflammatory markers in middle-aged men: the Twins Heart Study
    Shaoyong Su
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1256 Briarcliff Road NE, Suite 1 North, Atlanta, GA 30306, USA
    Psychosom Med 71:152-8. 2009
    ..Recent data suggested that MDD and inflammation share common genes...
  22. pmc Cytokines and glucocorticoid receptor signaling. Relevance to major depression
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann N Y Acad Sci 1179:86-105. 2009
    ....
  23. pmc Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:41-8. 2005
    ..Newer, pegylated preparations of IFN-alpha have a longer half-life, require once-per-week dosing, and may be associated with reduced neuropsychiatric burden. Limited data exist on depression during pegylated IFN-alpha therapy...
  24. doi request reprint Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome
    Urs M Nater
    Chronic Viral Diseases Branch, Centers for Disease Control and Prevention, Mail Stop A 15, Atlanta, GA 30333, USA
    Psychosom Med 70:298-305. 2008
    ..Previous studies of CFS patients have implicated the hypothalamic-pituitary-adrenal axis and the immune system in the pathophysiology of CFS, although results have been equivocal...
  25. pmc Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins
    Shaoyong Su
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30306, USA
    Atherosclerosis 200:213-20. 2008
    ..The aims of this study were to determine the relative influence of genetic and environmental contributions to inflammatory biomarkers, and to what extent correlations among these markers are due to genetic or environmental factors...
  26. ncbi request reprint Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress
    Thaddeus W W Pace
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 163:1630-3. 2006
    ..The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress...
  27. doi request reprint The link between childhood trauma and depression: insights from HPA axis studies in humans
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, WMRB, Suite 4311, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 33:693-710. 2008
    ..Taken together, this line of evidence demonstrates that psychoneuroendocrine research may ultimately promote optimized clinical care and help prevent the adverse outcomes of childhood trauma...
  28. pmc Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute, Emory University School of Medicine, 101 Woodruff Cricle, Suite 4000, Atlanta, GA 30322, USA
    Brain Behav Immun 21:9-19. 2007
    ....
  29. pmc Neuropsychiatric adverse effects of interferon-alpha: recognition and management
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    CNS Drugs 19:105-23. 2005
    ..When this occurs, IFN alpha and antidepressants should be stopped, an emergency psychiatric consultation should be obtained, and treatment with a mood stabilizer should be initiated...
  30. pmc Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study
    Viola Vaccarino
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    Biol Psychiatry 64:476-83. 2008
    ..We sought to examine whether MPO and other markers of inflammation are associated with MDD and whether the association is confounded by genetic or other shared familial factors...
  31. ncbi request reprint Depressive symptoms and viral clearance in patients receiving interferon-alpha and ribavirin for hepatitis C
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Brain Behav Immun 19:23-7. 2005
    ....
  32. ncbi request reprint Relationship of clinical symptoms and substance use in schizophrenia patients on conventional versus atypical antipsychotics
    Geraldine Scheller-Gilkey
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, Georgia 30335, USA
    Am J Drug Alcohol Abuse 29:553-66. 2003
    ..conventional antipsychotic medications...
  33. ncbi request reprint Depression in cancer: new developments regarding diagnosis and treatment
    Charles L Raison
    Mind Body Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:283-94. 2003
    ..Finally, recent data suggest that aggressive treatment strategies initiated before inflammation-inducing cancer treatments might prevent behavioral alterations, including depression, before they occur...
  34. ncbi request reprint [Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression]
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30033, USA
    J Soc Biol 197:151-6. 2003
    ..In addition, some behavioral and biological markers of the vulnerability for IFN-alpha-induced depression were identified. These findings provide important information concerning the relationship between cytokines and depression...
  35. ncbi request reprint Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:906-14. 2003
    ..Tryptophan (TRP) degradation into kynurenine (KYN) by the enzyme, indoleamine-2,3-dioxygenase, during immune activation may contribute to development of depressive symptoms during interferon (IFN)-alpha therapy...
  36. ncbi request reprint Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Neuropsychopharmacology 26:643-52. 2002
    ..quot;..
  37. ncbi request reprint Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 18:205-13. 2004
    ....
  38. pmc Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression
    Jennifer C Felger
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Biol Psychiatry 62:1324-33. 2007
    ..To establish a nonhuman primate model of cytokine-induced depression, we examined the effects of IFN-alpha on rhesus monkeys...
  39. ncbi request reprint Breast cancer and depression
    Wendy Somerset
    Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Oncology (Williston Park) 18:1021-34; discussion 1035-6, 1047-8. 2004
    ....
  40. ncbi request reprint The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Depress Anxiety 15:117-25. 2002
    ..Our findings suggest that a history of childhood abuse per se is related to increased neuroendocrine stress reactivity, which is further enhanced when additional trauma is experienced in adulthood...
  41. ncbi request reprint Early life stress and PTSD symptoms in patients with comorbid schizophrenia and substance abuse
    Geraldine Scheller-Gilkey
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Emory at Grady Florida Hall, 60 Coca Cola Pl, Atlanta, GA 30335, USA
    Schizophr Res 69:167-74. 2004
    ..While the etiology for this association is unknown, one possible mechanism relates to traumatic early life experiences, which have been shown to predispose individuals to both psychosis and substance abuse...
  42. pmc Anterior cingulate activation and error processing during interferon-alpha treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1001 Woodruff Circle, Atlanta, GA 30322, USA
    Biol Psychiatry 58:190-6. 2005
    ..Interferon (IFN)-alpha is notorious for causing behavioral symptoms, including depression, fatigue, and cognitive dysfunction, and has been used to investigate the effects of cytokines on the brain...
  43. ncbi request reprint Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings
    Keizo Yoshida
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Neuropsychobiology 52:55-61. 2005
    ..Defining relevant risk factors for IFN-alpha-induced depression is essential for designing preventative treatment strategies...
  44. doi request reprint Neuropsychological performance in persons with chronic fatigue syndrome: results from a population-based study
    Matthias Majer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Psychosom Med 70:829-36. 2008
    ..Objective measures of neuropsychological performance have yielded inconsistent results possibly due to sample selection bias, diagnostic heterogeneity, comorbid psychiatric disorders, and medication usage...
  45. ncbi request reprint Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 55:10-20. 2004
    ..Our aim was to determine whether altered glucocorticoid feedback mediates the neuroendocrine sequelae of childhood trauma...
  46. pmc Interferon-alpha inhibits glucocorticoid receptor-mediated gene transcription via STAT5 activation in mouse HT22 cells
    Fang Hu
    Department of Psychiatry and Behavioral Sciences, 1365 C Clifton Rd, 5th Floor, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 23:455-63. 2009
    ..Given the role of GR in depressive disorders, IFN-alpha effects on GR function in cells of hippocampal origin may contribute to HPA axis alterations and depressive symptoms in IFN-alpha-treated patients...
  47. pmc Cytokines sing the blues: inflammation and the pathogenesis of depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Trends Immunol 27:24-31. 2006
    ..These findings suggest that targeting proinflammatory cytokines and their signaling pathways might represent a novel strategy to treat depression...
  48. ncbi request reprint Efficacy of risperidone versus olanzapine in patients with schizophrenia previously on chronic conventional antipsychotic therapy: a switch study
    Xiaohong Wang
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, United States
    J Psychiatr Res 40:669-76. 2006
    ..The results indicate that both atypical antipsychotic medications provided significant additional improvement in symptom severity in patients with schizophrenia previously on conventional antipsychotic agents...
  49. pmc Sequential multiple-assignment randomized trial design of neurobehavioral treatment for patients with metastatic malignant melanoma undergoing high-dose interferon-alpha therapy
    S Freda Auyeung
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin Trials 6:480-90. 2009
    ..Interferon-alpha effects on serotonin metabolism appear to contribute to the mood and anxiety syndrome, while the neurovegetative syndrome appears to be related to interferon-alpha effects on dopamine...
  50. ncbi request reprint Treatment of cytokine-induced depression
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Brain Behav Immun 16:575-80. 2002
    ....
  51. pmc Adherence to the mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin study
    Jun Dai
    Nutrition and Health Sciences Program, Emory University School of Medicine, Atlanta, GA, USA
    Circulation 117:169-75. 2008
    ..It is unknown to what extent the association between the Mediterranean diet and inflammation is due to genetic or other familial factors...
  52. pmc Serotonin transporter gene, depressive symptoms, and interleukin-6
    Shaoyong Su
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Circ Cardiovasc Genet 2:614-20. 2009
    ..We explored the relationship of genetic variants of the serotonin transporter gene SLC6A4, a key regulator of the serotonergic neurotransmission, with both depressive symptoms and plasma interleukin-6 (IL-6) levels...
  53. ncbi request reprint Characterization of an interleukin-6- and adrenocorticotropin-dependent, immune-to-adrenal pathway during viral infection
    Marni N Silverman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Endocrinology 145:3580-9. 2004
    ..However, the presence of ACTH appears to serve as a necessary permissive factor, enabling direct cytokine actions on the adrenal gland...
  54. ncbi request reprint Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 32:2384-92. 2007
    ..These data indicate that IFN-alpha as well as other cytokines of the innate immune response may target basal ganglia nuclei, thereby contributing to fatigue-related symptoms in medically ill patients...
  55. ncbi request reprint Improved separation and detection of picolinic acid and quinolinic acid by capillary electrophoresis-mass spectrometry: application to analysis of human cerebrospinal fluid
    Xiaochun Wang
    Center of Diagnostics and Therapeutics, Georgia State University, 50 Decatur Street, Atlanta, GA 30303, USA
    J Chromatogr A 1316:147-53. 2013
    ..02-10 μM for PA and 0.4-40 μM for QA. The method was then successfully applied to analyze PA and QA in human CSF, demonstrating the potential of this CE-ESI-MS/MS method to accurately quantitate with high specificity and sensitivity...
  56. ncbi request reprint Paroxetine use in medically ill patients
    Steven Stout Stout
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacol Bull 37:108-22. 2003
    ..This article reviews published studies of SSRIs in the treatment of depression in patients with medical illnesses, with a focus on the contributions of paroxetine...
  57. ncbi request reprint Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Research Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:569-76. 2003
    ..These findings support the hypothesis that central CRF hypersecretion is associated with a blunted ACTH response to exogenously administered CRF, explaining almost 60% of the variation in the ACTH response to CRF...
  58. ncbi request reprint Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Neuropsychopharmacology 31:1777-84. 2006
    ....
  59. ncbi request reprint Inhibition of Jun N-terminal kinase (JNK) enhances glucocorticoid receptor-mediated function in mouse hippocampal HT22 cells
    Xiaohong Wang
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 30:242-9. 2005
    ..Moreover, JNK pathways may represent a therapeutic target for normalization of GR function in these disorders...
  60. ncbi request reprint Neonatal viral infection decreases neuronal progenitors and impairs adult neurogenesis in the hippocampus
    Anup Sharma
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Neurobiol Dis 11:246-56. 2002
    ..The LCMV model could be exploited to examine pathophysiological mechanisms of neurodegeneration and to test pharmacological strategies aimed at increasing neurogenesis or rescuing multipotent progenitors...
  61. ncbi request reprint Antipsychotic-induced hyperprolactinemia and sexual dysfunction
    Michael T Compton
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Emory West Campus, 1256 Briarcliff Road, Suite 165, Atlanta, GA 30306, USA
    Psychopharmacol Bull 36:143-64. 2002
    ..Because hyperprolactinemia may cause clinically significant side effects in patients treated with antipsychotic medications, clinicians should be familiar with the evaluation and treatment of antipsychotic-induced hyperprolactinemia...
  62. ncbi request reprint On redefining the role of the immune system in psychiatric disease
    Andrew H Miller
    Biol Psychiatry 60:796-8. 2006
  63. ncbi request reprint Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms
    Charles S Cleeland
    Department of Symptom Research, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer 97:2919-25. 2003
    ..These symptoms include pain, wasting, fatigue, cognitive impairment, anxiety, and depression, many of which co-occur. There is growing recognition that at least some of these symptoms may share common biologic mechanisms...
  64. pmc Identification and treatment of symptoms associated with inflammation in medically ill patients
    Robert Dantzer
    Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Psychoneuroendocrinology 33:18-29. 2008
    ..This resulted in a number of recommendations that should improve the recognition and management of inflammation-associated symptoms in medically ill patients...
  65. ncbi request reprint Ribavirin may be an important factor in IFN-induced neuropsychiatric effects
    Gregory M Asnis
    J Clin Psychiatry 65:581; author reply 581-2. 2004
  66. pmc Childhood trauma associated with smaller hippocampal volume in women with major depression
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 159:2072-80. 2002
    ..In this study, the volumes of the hippocampus and of control brain regions were measured in depressed women with and without childhood abuse and in healthy nonabused comparison subjects...
  67. ncbi request reprint Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
    ....
  68. ncbi request reprint Depressive disorders and immunity: 20 years of progress and discovery
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California Los Angeles, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA, USA
    Brain Behav Immun 21:374-83. 2007
    ..Moreover, the work has served to instantiate brain-immune interactions as an essential component in psychiatric and medical co-morbidities and their impact on health and illness...
  69. ncbi request reprint Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha
    Barbara Frick
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    J Interferon Cytokine Res 24:311-7. 2004
    ..These results indicate that IFN-alpha directly activates macrophages to release neopterin and to degrade tryptophan, but obviously treatment with INF-alpha did not affect homocysteine metabolism...
  70. ncbi request reprint A cytokine-based neuroimmunologic mechanism of cancer-related symptoms
    Bang Ning Lee
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neuroimmunomodulation 11:279-92. 2004
    ..These concepts open exciting new avenues for translational research in the pathophysiology and treatment of cancer-related symptoms...
  71. ncbi request reprint Letter to the Editor Re: "an inflammatory review of glucocorticoids in the CNS" by Sorrells et al. Brain, Behavior and Immunity 21, 259-272, 2007
    Andrew H Miller
    Brain Behav Immun 21:988-9; author reply 990. 2007
  72. ncbi request reprint Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs
    Charles J Malemud
    Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Department of Medicine, Division of Rheumatic Diseases, 2061 Cornell Road, Cleveland, Ohio 44106 5076, USA
    Expert Opin Ther Targets 12:171-83. 2008
    ..Peripheral inflammation in RA may influence neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, as well as growth factor production, which can modify neural circuitry and contribute to depression...
  73. ncbi request reprint Cytokines, p38 MAP kinase and the pathophysiology of depression
    Andrew H Miller
    Neuropsychopharmacology 31:2089-90. 2006

Research Grants37

  1. Neuroimmune Mechanisms of Glucocorticoid Resistance
    Andrew Miller; Fiscal Year: 2007
    ..Taken together, these studies will help identify novel targets for the treatment of mood disorders in both medically ill and medically healthy patients. ..
  2. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2010
    ....
  3. IFN ALPHA-INDUCED DEPRESSION
    Andrew Miller; Fiscal Year: 2003
    ....
  4. ADRENAL STEROID--IMMUNE INTERACTIONS
    Andrew Miller; Fiscal Year: 2003
    ..Further understanding of neuroendocrine- immune interactions in viral infections will provide the foundation for developing new therapeutic strategies to limit the immunologic and behavioral morbidity of viral diseases. ..
  5. Fronto-Striatal Dysfunction in IFNa-Induced Depression
    Andrew Miller; Fiscal Year: 2004
    ..abstract_text> ..
  6. Pathophysiology of IFN-alpha-induced Sleep Disturbances
    Andrew Miller; Fiscal Year: 2004
    ..Moreover, this work will identify novel targets for the development of treatment strategies for sleep alterations in medically ill patients. ..
  7. Fronto-Striatal Dysfunction in IFNa-Induced Depression
    Andrew Miller; Fiscal Year: 2005
    ..abstract_text> ..
  8. Pathophysiology of IFN-alpha-induced Sleep Disturbances
    Andrew Miller; Fiscal Year: 2006
    ..Moreover, this work will identify novel targets for the development of treatment strategies for sleep alterations in medically ill patients. ..
  9. Fronto-Striatal Dysfunction in IFNa-Induced Depression
    Andrew Miller; Fiscal Year: 2007
    ..abstract_text> ..
  10. IFN ALPHA-INDUCED DEPRESSION
    Andrew Miller; Fiscal Year: 2002
    ....
  11. ADRENAL STEROID-IMMUNE INTERACTIONS IN VIRAL INFECTIONS
    Andrew Miller; Fiscal Year: 2002
    ..Taken together, these studies will provide the foundation for developing new treatment strategies for immunomodulation drawing upon advances in neuroendocrinology and the neurosciences. ..
  12. ADRENAL STEROID-IMMUNE INTERACTIONS IN VIRAL INFECTIONS
    Andrew Miller; Fiscal Year: 2001
    ..Taken together, these studies will provide the foundation for developing new treatment strategies for immunomodulation drawing upon advances in neuroendocrinology and the neurosciences. ..
  13. Neuroimmune Mechanisms of Glucocorticoid Resistance
    Andrew H Miller; Fiscal Year: 2010
    ..Taken together, these studies will help identify novel targets for the treatment of mood disorders in both medically ill and medically healthy patients. ..
  14. HIV/AIDS CLINICAL RESEARCH TRAINING PROGRAM
    Andrew Miller; Fiscal Year: 2007
    ....
  15. ADRENAL STEROID-IMMUNE INTERACTIONS IN VIRAL INFECTIONS
    Andrew Miller; Fiscal Year: 1999
    ..Taken together, these studies will provide the foundation for developing new treatment strategies for immunomodulation drawing upon advances in neuroendocrinology and the neurosciences. ..
  16. ADRENAL STEROID-IMMUNE INTERACTIONS IN VIRAL INFECTIONS
    Andrew Miller; Fiscal Year: 2000
    ..Taken together, these studies will provide the foundation for developing new treatment strategies for immunomodulation drawing upon advances in neuroendocrinology and the neurosciences. ..
  17. IFN ALPHA-INDUCED DEPRESSION
    Andrew Miller; Fiscal Year: 2000
    ....
  18. Neuroimmune Mechanisms of Glucocorticoid Resistance
    Andrew Miller; Fiscal Year: 2009
    ..Taken together, these studies will help identify novel targets for the treatment of mood disorders in both medically ill and medically healthy patients. ..
  19. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2010
    ..abstract_text> ..
  20. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew Miller; Fiscal Year: 2009
    ..abstract_text> ..
  21. Pathophysiology of IFN-alpha-induced Sleep Disturbances
    Andrew Miller; Fiscal Year: 2007
    ..Moreover, this work will identify novel targets for the development of treatment strategies for sleep alterations in medically ill patients. ..
  22. ADRENAL STEROID-IMMUNE INTERACTIONS IN VIRAL INFECTIONS
    Andrew Miller; Fiscal Year: 2001
    ..Taken together, these studies will provide the foundation for developing new treatment strategies for immunomodulation drawing upon advances in neuroendocrinology and the neurosciences. ..
  23. IFN ALPHA-INDUCED DEPRESSION
    Andrew Miller; Fiscal Year: 2001
    ....
  24. Pathophysiology of IFN-alpha-induced Sleep Disturbances
    Andrew Miller; Fiscal Year: 2005
    ..Moreover, this work will identify novel targets for the development of treatment strategies for sleep alterations in medically ill patients. ..
  25. Fronto-Striatal Dysfunction in IFNa-Induced Depression
    Andrew Miller; Fiscal Year: 2006
    ..abstract_text> ..
  26. Neuroimmune Mechanisms of Glucocorticoid Resistance
    Andrew Miller; Fiscal Year: 2006
    ..Taken together, these studies will help identify novel targets for the treatment of mood disorders in both medically ill and medically healthy patients. ..
  27. Pathology and Treatment of Cytokine-Induced Depression
    Andrew Miller; Fiscal Year: 2007
    ..abstract_text> ..