K J Meador

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study
    Kimford J Meador
    Neurology and Pediatrics, Emory University, Atlanta, GA 30322, USA
    Lancet Neurol 12:244-52. 2013
  2. pmc Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years
    K J Meador
    Neurology and Pediatrics, Emory University, Atlanta, GA, USA
    Neurology 78:1207-14. 2012
  3. doi request reprint Pregnancy registries in epilepsy: a consensus statement on health outcomes
    K J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Neurology 71:1109-17. 2008
  4. pmc Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs
    Kimford J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Suite 6000, Atlanta, GA 30322, USA
    N Engl J Med 360:1597-605. 2009
  5. pmc Antiepileptic drug use in women of childbearing age
    Kimford J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Mail Stop 1930 001 1AN, Atlanta, GA 30322, USA
    Epilepsy Behav 15:339-43. 2009
  6. doi request reprint Neurocognitive effects of brivaracetam, levetiracetam, and lorazepam
    Kimford J Meador
    Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    Epilepsia 52:264-72. 2011
  7. pmc Effects of breastfeeding in children of women taking antiepileptic drugs
    K J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 75:1954-60. 2010
  8. pmc Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age
    Kimford J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Brain 134:396-404. 2011
  9. pmc Relationship of child IQ to parental IQ and education in children with fetal antiepileptic drug exposure
    Kimford J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Epilepsy Behav 21:147-52. 2011
  10. doi request reprint Cognitive effects of carisbamate in randomized, placebo-controlled, healthy-volunteer, multidose studies
    Kimford J Meador
    Emory University, Atlanta, GA 30322, USA
    Epilepsy Behav 22:324-30. 2011

Research Grants

  1. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2004
  2. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2007
  3. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2000
  4. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2009
  5. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2005
  6. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2006
  7. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2005
  8. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2003
  9. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2002
  10. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2001

Detail Information

Publications30

  1. pmc Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study
    Kimford J Meador
    Neurology and Pediatrics, Emory University, Atlanta, GA 30322, USA
    Lancet Neurol 12:244-52. 2013
    ..We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age...
  2. pmc Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years
    K J Meador
    Neurology and Pediatrics, Emory University, Atlanta, GA, USA
    Neurology 78:1207-14. 2012
    ..To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure...
  3. doi request reprint Pregnancy registries in epilepsy: a consensus statement on health outcomes
    K J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Neurology 71:1109-17. 2008
    ..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...
  4. pmc Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs
    Kimford J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Suite 6000, Atlanta, GA 30322, USA
    N Engl J Med 360:1597-605. 2009
    ....
  5. pmc Antiepileptic drug use in women of childbearing age
    Kimford J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Mail Stop 1930 001 1AN, Atlanta, GA 30322, USA
    Epilepsy Behav 15:339-43. 2009
    ..Except for the top two AED monotherapies, there were marked differences in other monotherapies and in polytherapies between U.S. and UK centers. Future investigations are needed to examine reasons for drug choice...
  6. doi request reprint Neurocognitive effects of brivaracetam, levetiracetam, and lorazepam
    Kimford J Meador
    Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    Epilepsia 52:264-72. 2011
    ..Although BRV is an analog of levetiracetam (LEV), in addition to being an SV2A ligand, it also inhibits sodium channels in a voltage-dependent manner. The cognitive effects of BRV are uncertain...
  7. pmc Effects of breastfeeding in children of women taking antiepileptic drugs
    K J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 75:1954-60. 2010
    ..Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children...
  8. pmc Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age
    Kimford J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Brain 134:396-404. 2011
    ..Additional research is needed to confirm these findings, extend the study to other drugs, define the risks associated with drug treatment for seizures in the neonates, and understand the underlying mechanisms...
  9. pmc Relationship of child IQ to parental IQ and education in children with fetal antiepileptic drug exposure
    Kimford J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Epilepsy Behav 21:147-52. 2011
    ....
  10. doi request reprint Cognitive effects of carisbamate in randomized, placebo-controlled, healthy-volunteer, multidose studies
    Kimford J Meador
    Emory University, Atlanta, GA 30322, USA
    Epilepsy Behav 22:324-30. 2011
    ..Carisbamate did not produce clinically significant adverse effects on cognitive performance at doses <1000 mg/day. Effects were mild to modest at the higher doses tested...
  11. pmc Disparities in NIH funding for epilepsy research
    Kimford J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 77:1305-7. 2011
    ..The disparity cannot be explained by differences in the overall impact of these diseases on US citizens. Greater transparency in the review and funding process is needed to disclose the reason for this disparity...
  12. ncbi request reprint Differential cognitive effects of carbamazepine and gabapentin
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta 30912, USA
    Epilepsia 40:1279-85. 1999
    ..The cognitive effects of the newer antiepileptic drugs (AEDs) compared with the older standard AEDs are uncertain...
  13. ncbi request reprint Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers
    K J Meador
    Department of Neurology, Georgetown University, Washington, DC, USA
    Neurology 64:2108-14. 2005
    ..The relative cognitive and behavioral effects of lamotrigine (LTG) and topiramate (TPM) are unclear...
  14. pmc In utero antiepileptic drug exposure: fetal death and malformations
    K J Meador
    Department of Neurology, University of Florida, Gainesville 32610, USA
    Neurology 67:407-12. 2006
    ..Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach...
  15. ncbi request reprint Differential cognitive and behavioral effects of carbamazepine and lamotrigine
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta, 30912, USA
    Neurology 56:1177-82. 2001
    ..The relative cognitive and behavioral effects of lamotrigine compared with the older standard antiepileptic drugs (AED) are uncertain...
  16. ncbi request reprint Differential cognitive and behavioral effects of topiramate and valproate
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta, USA
    Neurology 60:1483-8. 2003
    ..Cognitive effects have been reported during topiramate (TPM) treatment, but effects relative to standard antiepileptic drugs are unclear...
  17. ncbi request reprint Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam
    K J Meador
    Department of Neurology, University of Florida, McKnight Brain Institute L3 100, 100 South Newell Drive, Gainesville, FL 32610, USA
    Neurology 69:2076-84. 2007
    ..The relative effects of levetiracetam (LEV) and carbamazepine (CBZ) on cognitive and neurophysiologic measures are uncertain...
  18. ncbi request reprint Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsy
    D L Drane
    Medical College of Georgia, Department of Neurology, Gainesville, USA
    J Clin Exp Neuropsychol 21:385-96. 1999
    ..These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network...
  19. pmc Antiepileptic drug clearance and seizure frequency during pregnancy in women with epilepsy
    T L Reisinger
    Emory University School of Medicine, Atlanta, GA, USA
    Epilepsy Behav 29:13-8. 2013
    ..Monitoring of AED serum concentrations with dose adjustment is recommended in pregnant women with epilepsy. Further studies are needed for many AEDs...
  20. ncbi request reprint Relationship of extinction to perceptual thresholds for single stimuli
    K J Meador
    Section of Behavioral Neurology, Department of Neurology, Medical College of Georgia, Augusta 30912-3280, USA
    Neurology 56:1044-7. 2001
    ..Asymmetries in mask and target intensities (relative to single-stimulus perceptual thresholds) affect extinction in RBS patients less for left targets but more for right targets as compared with control subjects...
  21. ncbi request reprint Limb and hemispatial hypometria
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta 30912 3280, USA
    J Int Neuropsychol Soc 6:71-5. 2000
    ..No effect was found for direction of sensory input. The results suggest that the directional hypometria is predominantly produced by hemispatial output deficits...
  22. pmc Topiramate dose effects on cognition: a randomized double-blind study
    D W Loring
    Department of Neurology, Emory University, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 76:131-7. 2011
    ..Topiramate (TPM), a broad-spectrum antiepileptic drug, has been associated with neuropsychological impairment in patients with epilepsy and in healthy volunteers...
  23. ncbi request reprint Epilepsy in cortical dysplasia: factors affecting surgical outcome
    K N Fountas
    Department of Neurosurgery, Medical College of Georgia, Augusta, GA, USA
    Stereotact Funct Neurosurg 82:26-30. 2004
    ..To determine the factors influencing the outcome of cortical dysplasia resection for medically refractory epilepsy...
  24. ncbi request reprint Pre-surgical evaluation for epilepsy surgery
    D W Loring
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912 3275, USA
    Saudi Med J 21:609-16. 2000
    ....
  25. ncbi request reprint Negative seizures
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta 30912, USA
    J Int Neuropsychol Soc 6:731-3. 2000
    ..One had repeated episodes with PLEDs but no parenchymal lesions. Clinicians should consider seizures in the setting of unexplained deficits, even if there are no positive ictal phenomena...
  26. ncbi request reprint Gamma coherence and conscious perception
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta, USA
    Neurology 59:847-54. 2002
    ..In addition, controversy exists as to whether the primary sensory cortices are involved directly in the mechanisms of conscious perception or just in processes prior to conscious awareness...
  27. ncbi request reprint Pathophysiology of altered consciousness during seizures: Subtraction SPECT study
    K H Lee
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    Neurology 59:841-6. 2002
    ..The mechanisms underlying altered consciousness during seizures are poorly understood. Previous clinicopathologic studies suggest a role for the thalamus and upper brainstem in consciousness mechanisms...
  28. doi request reprint A test of the mechanisms of sensory extinction to simultaneous stimulation
    B M Kluger
    Department of Neurology, University of Florida College of Medicine, Box 100236, Gainesville, FL 32610 0236, USA
    Neurology 70:1644-5. 2008
  29. ncbi request reprint Adverse effects of antiepileptic drugs
    E Perucca
    Department of Internal Medicine and Therapeutics, Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
    Acta Neurol Scand Suppl 181:30-5. 2005
    ..However, further research is needed to confirm the apparent improvement in tolerability offered by some of the newer AEDs...
  30. ncbi request reprint What constitutes high quality of care for adults with epilepsy?
    M J V Pugh
    Department of Veterans Affairs, South Texas Veterans Health Care System Verdict, San Antonio, TX 78229 4404, USA
    Neurology 69:2020-7. 2007
    ..As most care is provided in primary and general neurology care, we focused our assessment of quality on care within primary care and general neurology clinics...

Research Grants11

  1. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2004
    ..The results of the study will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  2. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2007
    ..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  3. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2000
    ..The results of the study will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  4. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2009
    ..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  5. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2005
    ..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  6. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2006
    ..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  7. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2005
    ..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  8. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2003
    ..The results of the study will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  9. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2002
    ..The results of the study will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  10. NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGS
    Kimford Meador; Fiscal Year: 2001
    ..The results of the study will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  11. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2009
    ..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..