Research Topics
| K J MeadorSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational studyKimford J Meador
Neurology and Pediatrics, Emory University, Atlanta, GA 30322, USA
Lancet Neurol 12:244-52. 2013..We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age...
Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 yearsK J Meador
Neurology and Pediatrics, Emory University, Atlanta, GA, USA
Neurology 78:1207-14. 2012..To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure...- Cognitive function at 3 years of age after fetal exposure to antiepileptic drugsKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Suite 6000, Atlanta, GA 30322, USA
N Engl J Med 360:1597-605. 2009.... - Antiepileptic drug use in women of childbearing ageKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Mail Stop 1930 001 1AN, Atlanta, GA 30322, USA
Epilepsy Behav 15:339-43. 2009..Except for the top two AED monotherapies, there were marked differences in other monotherapies and in polytherapies between U.S. and UK centers. Future investigations are needed to examine reasons for drug choice... - Neurocognitive effects of brivaracetam, levetiracetam, and lorazepamKimford J Meador
Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
Epilepsia 52:264-72. 2011..Although BRV is an analog of levetiracetam (LEV), in addition to being an SV2A ligand, it also inhibits sodium channels in a voltage-dependent manner. The cognitive effects of BRV are uncertain... - Effects of breastfeeding in children of women taking antiepileptic drugsK J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
Neurology 75:1954-60. 2010..Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children... - Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of ageKimford J Meador
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Brain 134:396-404. 2011..Additional research is needed to confirm these findings, extend the study to other drugs, define the risks associated with drug treatment for seizures in the neonates, and understand the underlying mechanisms... - Relationship of child IQ to parental IQ and education in children with fetal antiepileptic drug exposureKimford J Meador
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Epilepsy Behav 21:147-52. 2011.... - Disparities in NIH funding for epilepsy researchKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
Neurology 77:1305-7. 2011..The disparity cannot be explained by differences in the overall impact of these diseases on US citizens. Greater transparency in the review and funding process is needed to disclose the reason for this disparity... - Cognitive effects of carisbamate in randomized, placebo-controlled, healthy-volunteer, multidose studiesKimford J Meador
Emory University, Atlanta, GA 30322, USA
Epilepsy Behav 22:324-30. 2011..Carisbamate did not produce clinically significant adverse effects on cognitive performance at doses <1000 mg/day. Effects were mild to modest at the higher doses tested... - Pregnancy registries in epilepsy: a consensus statement on health outcomesK J Meador
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Neurology 71:1109-17. 2008..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED... 
Differential cognitive effects of carbamazepine and gabapentinK J Meador
Department of Neurology, Medical College of Georgia, Augusta 30912, USA
Epilepsia 40:1279-85. 1999..The cognitive effects of the newer antiepileptic drugs (AEDs) compared with the older standard AEDs are uncertain...- Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteersK J Meador
Department of Neurology, Georgetown University, Washington, DC, USA
Neurology 64:2108-14. 2005..The relative cognitive and behavioral effects of lamotrigine (LTG) and topiramate (TPM) are unclear... - In utero antiepileptic drug exposure: fetal death and malformationsK J Meador
Department of Neurology, University of Florida, Gainesville 32610, USA
Neurology 67:407-12. 2006..Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach... - Differential cognitive and behavioral effects of carbamazepine and lamotrigineK J Meador
Department of Neurology, Medical College of Georgia, Augusta, 30912, USA
Neurology 56:1177-82. 2001..The relative cognitive and behavioral effects of lamotrigine compared with the older standard antiepileptic drugs (AED) are uncertain... - Differential cognitive and behavioral effects of topiramate and valproateK J Meador
Department of Neurology, Medical College of Georgia, Augusta, USA
Neurology 60:1483-8. 2003..Cognitive effects have been reported during topiramate (TPM) treatment, but effects relative to standard antiepileptic drugs are unclear... - Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetamK J Meador
Department of Neurology, University of Florida, McKnight Brain Institute L3 100, 100 South Newell Drive, Gainesville, FL 32610, USA
Neurology 69:2076-84. 2007..The relative effects of levetiracetam (LEV) and carbamazepine (CBZ) on cognitive and neurophysiologic measures are uncertain... - Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsyD L Drane
Medical College of Georgia, Department of Neurology, Gainesville, USA
J Clin Exp Neuropsychol 21:385-96. 1999..These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network... - Relationship of extinction to perceptual thresholds for single stimuliK J Meador
Section of Behavioral Neurology, Department of Neurology, Medical College of Georgia, Augusta 30912-3280, USA
Neurology 56:1044-7. 2001..Asymmetries in mask and target intensities (relative to single-stimulus perceptual thresholds) affect extinction in RBS patients less for left targets but more for right targets as compared with control subjects... - Limb and hemispatial hypometriaK J Meador
Department of Neurology, Medical College of Georgia, Augusta 30912 3280, USA
J Int Neuropsychol Soc 6:71-5. 2000..No effect was found for direction of sensory input. The results suggest that the directional hypometria is predominantly produced by hemispatial output deficits... - Topiramate dose effects on cognition: a randomized double-blind studyD W Loring
Department of Neurology, Emory University, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
Neurology 76:131-7. 2011..Topiramate (TPM), a broad-spectrum antiepileptic drug, has been associated with neuropsychological impairment in patients with epilepsy and in healthy volunteers... - Epilepsy in cortical dysplasia: factors affecting surgical outcomeK N Fountas
Department of Neurosurgery, Medical College of Georgia, Augusta, GA, USA
Stereotact Funct Neurosurg 82:26-30. 2004..To determine the factors influencing the outcome of cortical dysplasia resection for medically refractory epilepsy... - Pre-surgical evaluation for epilepsy surgeryD W Loring
Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912 3275, USA
Saudi Med J 21:609-16. 2000.... - Gamma coherence and conscious perceptionK J Meador
Department of Neurology, Medical College of Georgia, Augusta, USA
Neurology 59:847-54. 2002..In addition, controversy exists as to whether the primary sensory cortices are involved directly in the mechanisms of conscious perception or just in processes prior to conscious awareness... - Negative seizuresK J Meador
Department of Neurology, Medical College of Georgia, Augusta 30912, USA
J Int Neuropsychol Soc 6:731-3. 2000..One had repeated episodes with PLEDs but no parenchymal lesions. Clinicians should consider seizures in the setting of unexplained deficits, even if there are no positive ictal phenomena... - A test of the mechanisms of sensory extinction to simultaneous stimulationB M Kluger
Department of Neurology, University of Florida College of Medicine, Box 100236, Gainesville, FL 32610-0236, USA
Neurology 70:1644-5. 2008 - Pathophysiology of altered consciousness during seizures: Subtraction SPECT studyK H Lee
Department of Neurology, Medical College of Georgia, Augusta, GA, USA
Neurology 59:841-6. 2002..Variance in the results may be due to differences in timing of radioisotope injection, sensitivity of the subtraction SPECT technique, and the ability to clinically assess the conscious state... - Adverse effects of antiepileptic drugsE Perucca
Department of Internal Medicine and Therapeutics, Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
Acta Neurol Scand Suppl 181:30-5. 2005..However, further research is needed to confirm the apparent improvement in tolerability offered by some of the newer AEDs... - What constitutes high quality of care for adults with epilepsy?M J V Pugh
Department of Veterans Affairs, South Texas Veterans Health Care System Verdict, San Antonio, TX 78229 4404, USA
Neurology 69:2020-7. 2007..As most care is provided in primary and general neurology care, we focused our assessment of quality on care within primary care and general neurology clinics...
Research Grants
- NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGSKimford Meador; Fiscal Year: 2004..The results of the study will impact the clinical management of women receiving these medications, and improve the health of their children. ..
- Neurodevelopmental Effects of Antiepileptic Drugs IIKimford Meador; Fiscal Year: 2007..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..
- Neurodevelopmental Effects of Antiepileptic Drugs IIKimford Meador; Fiscal Year: 2009..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..