Robert McKeon

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi TGF-beta1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors
    Alick K T Law
    Department of Physiology, Emory University, Atlanta, USA
    BMC Neurosci 5:1. 2004
  2. ncbi The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar
    R J McKeon
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 19:10778-88. 1999

Research Grants

  1. REGULATION OF FUNCTIONALLY REACTIVE GLIOSIS BY TGF-BETA
    Robert McKeon; Fiscal Year: 2002
  2. Astrocyte-mediated neuroprotection after CNS injury
    Robert McKeon; Fiscal Year: 2005

Collaborators

  • Alick K T Law
  • Shawn Levy
  • Charles R Buck
  • Deepak Gupta
  • Douglas C Wallace

Detail Information

Publications2

  1. ncbi TGF-beta1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors
    Alick K T Law
    Department of Physiology, Emory University, Atlanta, USA
    BMC Neurosci 5:1. 2004
    ..In the present study, we describe the molecular mechanisms by which TGF-beta1 regulates Ant1 gene expression in cultured primary rodent astrocytes...
  2. ncbi The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar
    R J McKeon
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 19:10778-88. 1999
    ..Because these CS-PGs are capable of inhibiting neurite outgrowth in vitro, our data suggest that phosphacan and neurocan in areas of reactive gliosis may contribute to axonal regenerative failure after CNS injury...

Research Grants4

  1. REGULATION OF FUNCTIONALLY REACTIVE GLIOSIS BY TGF-BETA
    Robert McKeon; Fiscal Year: 2002
    ....
  2. Astrocyte-mediated neuroprotection after CNS injury
    Robert McKeon; Fiscal Year: 2005
    ..These studies will provide important mechanistic insight into the biological response of reactive astrocytes by examining the requirement for a molecule that facilitates mitochondrial ATP production and mobilization. ..