Affiliation: Emory University
- TGF-beta1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factorsAlick K T Law
Department of Physiology, Emory University, Atlanta, USA
BMC Neurosci 5:1. 2004..In the present study, we describe the molecular mechanisms by which TGF-beta1 regulates Ant1 gene expression in cultured primary rodent astrocytes...
- The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scarR J McKeon
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 19:10778-88. 1999..Because these CS-PGs are capable of inhibiting neurite outgrowth in vitro, our data suggest that phosphacan and neurocan in areas of reactive gliosis may contribute to axonal regenerative failure after CNS injury...
- REGULATION OF FUNCTIONALLY REACTIVE GLIOSIS BY TGF-BETARobert McKeon; Fiscal Year: 2002....
- Astrocyte-mediated neuroprotection after CNS injuryRobert McKeon; Fiscal Year: 2005..These studies will provide important mechanistic insight into the biological response of reactive astrocytes by examining the requirement for a molecule that facilitates mitochondrial ATP production and mobilization. ..