Research Topics
| William M McClellanSummaryAffiliation: Emory University Country: USA Publications
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Publications
Treatment center and geographic variability in pre-ESRD care associate with increased mortalityWilliam M McClellan
Emory University School of Medicine, Renal Division, Rollins School of Public Health, Room 476, 1518 Clifton Road, Atlanta, GA 30322, USA
J Am Soc Nephrol 20:1078-85. 2009..Targeting these disparities could have substantial clinical impact, because the absence of > or = 6 mo of pre-ESRD care by a nephrologist is associated with a higher risk for death...
Population-based interventions to reduce socioeconomic disparities in chronic kidney diseaseWilliam M McClellan
Department of Medicine and Epidemiology, Emory University, Atlanta, GA 30322, USA
Semin Nephrol 30:33-41. 2010..This pilot project represents an important step in developing interventions to reduce CKD disparities in the US health care system...
Chronic kidney disease is often unrecognized among patients with coronary heart disease: The REGARDS Cohort StudyWilliam M McClellan
Emory University School of Medicine, Renal Division, Atlanta, GA 30322, USA
Am J Nephrol 29:10-7. 2009..Awareness of CKD may potentially influence diagnostic decisions, life-style changes and pharmacologic interventions targeted at modifiable CHD risk factors. We describe here the degree to which persons with CHD are aware of their CKD...
Prevalence and characteristics of a family history of end-stage renal disease among adults in the United States population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) renal cohort studyWilliam McClellan
Georgia Medical Care Foundation, Emory University, Suite 200, Executive Park South NE, Atlanta, GA 30329 2224, USA
J Am Soc Nephrol 18:1344-52. 2007..If confirmed, then these findings suggest that individuals with FH-ESRD may benefit from interventions to improve the detection and treatment of chronic kidney disease risk factors such as diabetes and obesity...
Physical and psychological burden of chronic kidney disease among older adultsWilliam M McClellan
Departments of Medicine and Epidemiology, Emory University, Atlanta, GA, USA
Am J Nephrol 31:309-17. 2010..The purpose of the study is to determine if functional status and quality of life (QoL) vary with glomerular filtration rate (GFR) among older adults...
Poverty and racial disparities in kidney disease: the REGARDS studyWilliam M McClellan
Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Nephrol 32:38-46. 2010..This study examines whether similar relationships exist between poverty and racial disparities in chronic kidney disease (CKD) prevalence...
Geographic concentration of poverty and arteriovenous fistula use among ESRD patientsWilliam M McClellan
Division of Nephrology, Emory University, Atlanta, GA 30322, USA
J Am Soc Nephrol 21:1776-82. 2010..These results suggest that the Medicare ESRD program may mitigate poverty effects on AVF use...
Albuminuria and racial disparities in the risk for ESRDWilliam M McClellan
Department of Medicine, Rollins School of Public Health, Emory University, Atlanta, GA 30220, USA
J Am Soc Nephrol 22:1721-8. 2011..4-fold (95% CI 0.9 to 2.3) higher risk for ESRD. In conclusion, the increased prevalence of albuminuria may be an important contributor to the higher risk for ESRD experienced by African Americans...
Association of family history of ESRD, prevalent albuminuria, and reduced GFR with incident ESRDWilliam M McClellan
Department of Medicine, Emory University, Atlanta, GA Department of Epidemiology, Emory University, Atlanta, GA 30220, USA
Am J Kidney Dis 59:25-31. 2012..The contribution of albuminuria to the increased risk of incident end-stage renal disease (ESRD) in individuals with a family history of ESRD has not been well studied...
Racial differences in the prevalence of chronic kidney disease among participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort StudyWilliam McClellan
Emory University School of Medicine, Renal Division, Atlanta, Georgia 30322, USA
J Am Soc Nephrol 17:1710-5. 2006..Factors that are responsible for the increasing prevalence of severely impaired kidney function among black patients remain to be determined...
Individuals with a family history of ESRD are a high-risk population for CKD: implications for targeted surveillance and intervention activitiesWilliam M McClellan
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Am J Kidney Dis 53:S100-6. 2009..Individuals interested in population-based CKD control activities should be aware of and use these resources...
Racial differences in albuminuria, kidney function, and risk of strokeORLANDO M GUTIERREZ
Departments of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Neurology 79:1686-92. 2012..The objective of this study was to examine the joint associations of estimated glomerular filtration rate (eGFR) and urinary albumin excretion with incident stroke in a large national cohort study...
CKD risk factors reported by primary care physicians: do guidelines make a difference?Janice P Lea
Renal Division, Department of Medicine, Rollins School of Public Health, Emory University, Atlanta, GA, USA
Am J Kidney Dis 47:72-7. 2006....
Medicare patients with cardiovascular disease have a high prevalence of chronic kidney disease and a high rate of progression to end-stage renal diseaseWilliam M McClellan
Georgia Medical Care Foundation, Atlanta, Georgia 30346, USA
J Am Soc Nephrol 15:1912-9. 2004..This study suggests that opportunities may exist to improve the detection of CKD in these patients who are hospitalized with cardiovascular disease...
Delay in time to receipt of thrombolytic medication among Medicare patients with kidney diseaseBritt B Newsome
Division of Nephrology, Department of Medicine, Birmingham Veterans Affairs Medical Center, University of Alabama, Birmingham, AL, USA
Am J Kidney Dis 46:595-602. 2005..Our goal is to identify potential differences in thrombolytic medication delays and thrombolytic-associated bleeding events by severity of kidney disease...
Use of secondary prevention medications among adults with reduced kidney functionTara I Chang
Division of Nephrology, Department of Medicine, Stanford University, Palo Alto, California, USA
Clin J Am Soc Nephrol 7:604-11. 2012....
Prevalence and severity of chronic kidney disease and anemia in the nursing home populationWilliam M McClellan
Department ofEpidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA
J Am Med Dir Assoc 11:33-41. 2010..This study was designed to describe the prevalence of CKD and associated comorbidities in a representative sample of NH residents...
Obesity, end-stage renal disease, and survival in an elderly cohort with cardiovascular diseaseJanice P Lea
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Obesity (Silver Spring) 17:2216-22. 2009..However, both obese blacks and whites, in this population, experience a survival benefit. Further studies need to explore this obesity paradox...
Anemia and cardiovascular and kidney diseaseClaudine Jurkovitz
Department of Medicine, Division of Cardiology, Rollins School of Public Health, Division of Nephrology, Emory University, Atlanta, Georgia 30322, USA
Curr Opin Nephrol Hypertens 15:117-22. 2006..Current evidence is insufficient to demonstrate a conclusive benefit of treatment with erythropoietin on risk of cardiovascular disease or progression of kidney disease. Future research is needed to further clarify these issues...
Impact of a patient education program on disparities in kidney transplant evaluationRachel E Patzer
Emory Transplant Center, Emory University, Atlanta, Georgia 30322, USA
Clin J Am Soc Nephrol 7:648-55. 2012..The purpose of this study was to evaluate the association of the ETC education program on completion of the transplant evaluation process...
Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarctionBritt B Newsome
Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Arch Intern Med 168:609-16. 2008..We assessed the relationship between change in serum creatinine levels up to 3.0 mg/dL and death and ESRD among elderly survivors of hospitalization for acute myocardial infarction...
Prevalence of family history of kidney disease and perception of risk for kidney disease: a population-based studyClaudine Jurkovitz
Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Kidney Dis 46:11-7. 2005..However, it is unclear whether blacks are more likely to have a family history of ESRD than other groups independently of kidney disease risk factors. Moreover, their risk perception for kidney disease is unknown...
Predictors of improved HbA1c testing by primary care physiciansW Dana Flanders
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, USA
J Health Care Poor Underserved 16:720-33. 2005..Physicians in counties with more people on Medicaid, or with fewer physicians per capita tended to have less improvement in HbA1c testing among Medicare beneficiaries over the three year study period...
Obesity is associated with family history of ESRD in incident dialysis patientsRebecca A Speckman
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Am J Kidney Dis 48:50-8. 2006..This finding also suggests that management of obesity may be even more important for patients with a family history of ESRD than for the general population...
Renal insufficiency and anemia are independent risk factors for death among patients with acute myocardial infarctionRobert D Langston
Georgia Medical Care Foundation, Atlanta, Georgia 30346, USA
Kidney Int 64:1398-405. 2003..CONCLUSION: CKD and decreasing hematocrit were frequent among older patients hospitalized for acute myocardial infarction and are independent predictors of subsequent risk of death...
Arteriovenous fistula use is associated with lower cardiovascular mortality compared with catheter use among ESRD patientsHaimanot Wasse
Department of Medicine, Division of Nephrology, Emory University, Atlanta, Georgia 30322, USA
Semin Dial 21:483-9. 2008..These findings suggest that vascular access type influences cause-specific mortality beyond that of infection, and support existing guidelines recommending the use of an AVF early in the course of chronic end-stage renal disease therapy...
Kidney function, albuminuria, and all-cause mortality in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) studyDavid G Warnock
Division of Nephrology, Department of Medicine, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Kidney Dis 56:861-71. 2010..Chronic kidney disease and albuminuria are associated with increased risk of all-cause mortality...
Low income and albuminuria among REGARDS (Reasons for Geographic and Racial Differences in Stroke) study participantsDeidra C Crews
Division of Nephrology, Department of Medicine, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
Am J Kidney Dis 60:779-86. 2012..We sought to determine the association between low income and albuminuria and whether this association differs for blacks and whites...
Screening for chronic kidney disease: unresolved issuesWilliam M McClellan
Georgia Medical Care Foundation, Atlanta, USA
J Am Soc Nephrol 14:S81-7. 2003..Finally, the cost-effectiveness of screening needs to be demonstrated and the effectiveness of screening as a means of achieving reductions in CKD should be proven in randomized trials...
Neighborhood poverty and racial disparities in kidney transplant waitlistingRachel E Patzer
Emory University, Rollins School of Public Health, Division of Epidemiology, Atlanta, GA 30312, USA
J Am Soc Nephrol 20:1333-40. 2009..This study suggests that improving the allocation of kidneys may require a focus on poor communities...
Risk factors for progressive chronic kidney diseaseWilliam M McClellan
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
J Am Soc Nephrol 14:S65-70. 2003..This should include active extension of our current understanding of health care, social, and economic risk factors at both the individual and the community level...
Variations in the quality of care of patients with acute myocardial infarction among Swiss university hospitalsJean Christophe Luthi
Georgia Medical Care Foundation, Atlanta, GA, USA
Int J Qual Health Care 17:229-34. 2005..The objective of our study was to assess hospital variations in the quality of care delivered to acute myocardial infarction (AMI) patients among three Swiss academic medical centres...
Improving the care of ESRD patients: a success storyWilliam M McClellan
Georgia Medical Care Foundation, 57 Executive Park South, Suite 200, Atlanta, GA 30329, USA
Health Care Financ Rev 24:89-100. 2003..This article describes the evolution of the ESRD HCQIP and its successful application in the ESRD program...
Predictors of central venous catheter use at the initiation of hemodialysisHaimanot Wasse
Division of Nephrology, Emory University, Atlanta, Georgia 30322, USA
Semin Dial 21:346-51. 2008..001). Overall, female gender, ischemic heart disease, lack of obesity, factors suggesting poor pre-ESRD care, and successive year of dialysis initiation were predictive of CVC use at hemodialysis initiation...
Influence of race, ethnicity and socioeconomic status on kidney diseaseRachel E Patzer
Emory University School of Medicine, Department of Surgery, Emory Transplant Center, 101 Woodruff Circle, 5125 WMB, Atlanta, GA 30322, USA
Nat Rev Nephrol 8:533-41. 2012....
Epidemiology, geography and chronic kidney diseaseAnn C McClellan
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Curr Opin Nephrol Hypertens 21:323-8. 2012..Geographic attributes may be as diverse as the physical, socioeconomic, and medical care characteristics of an environment. This review summarizes the recent literature pertaining to geographic risk factors and CKD...
Association of high serum creatinine and anemia increases the risk of coronary events: results from the prospective community-based atherosclerosis risk in communities (ARIC) studyClaudine T Jurkovitz
Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30306, USA
J Am Soc Nephrol 14:2919-25. 2003..86 to 1.67). In conclusion, this study indicates that high Scr is associated with almost a threefold risk of CHD among middle-aged people with anemia, whereas no increased risk is found in people with high Scr in the absence of anemia...
Hemodialysis treatment center early mortality rates for incident hemodialysis patients are associated with the quality of care prior to starting but not following onset of dialysisEiichiro Kanda
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Am J Nephrol 33:390-7. 2011..We examined the independent contribution of pre-ESRD (end-stage renal disease) care and care after starting hemodialysis (post-HD) with facility-specific mortality among incident patients...
Diabetes is the strongest risk factor for lower-extremity amputation in new hemodialysis patientsRebecca A Speckman
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
Diabetes Care 27:2198-203. 2004....
Association of duration of residence in the southeastern United States with chronic kidney disease may differ by race: the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort studyLaura Plantinga
Department of Epidemiology, Rollins School of Public Health, Emory University School of Medicine, Emory University, Atlanta, GA, USA
Int J Health Geogr 12:17. 2013..We postulated that a similar association would exist for chronic kidney disease (CKD)...
Predictors of delayed transition from central venous catheter use to permanent vascular access among ESRD patientsHaimanot Wasse
Division of Nephrology, Emory University, Atlanta, GA 30322, USA
Am J Kidney Dis 49:276-83. 2007..We sought to examine patient characteristics that may influence persistent CVC use 90 days after dialysis therapy initiation among patients using a CVC...
Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysisKunihiro Matsushita
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
Lancet 375:2073-81. 2010..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality...
A randomized evaluation of two health care quality improvement program (HCQIP) interventions to improve the adequacy of hemodialysis care of ESRD patients: feedback alone versus intensive interventionWilliam M McClellan
Georgia Medical Care Foundation, Atlanta, GA 30329, USA
J Am Soc Nephrol 15:754-60. 2004..03). These results demonstrate that Network feedback, coupled with the intensive intervention, resulted in improvement in care that would otherwise not have occurred...
Healthy behaviors, risk factor control and awareness of chronic kidney diseaseDelphine S Tuot
Department of Medicine, University of California at San Francisco, San Francisco, CA 94110, USA
Am J Nephrol 37:135-43. 2013..To encourage adoption of healthy behaviors, a better understanding of barriers to participation in CKD-healthy behaviors is needed...
Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart failure admitted to community hospitals: a population-based studyWilliam M McClellan
Georgia Medical Care Foundation, 57 Executive Park South, Suite 200, Atlanta, GA 30329, USA
J Am Soc Nephrol 13:1928-36. 2002..In conclusion, CKD and anemia are frequent among older patients with heart failure and are independent predictors of subsequent risk of death...
Diabetes management by residents in training in a municipal hospital primary care site (IPCAAD 2)Christopher D Miller
Divisions of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Ethn Dis 15:649-55. 2005....
Chronic kidney disease: issues and establishing programs and clinics for improved patient outcomesWendy L St Peter
College of Pharmacy, University of Minnesota, Division of Nephrology, Hennepin County Medical Center, Minneapolis, MN 55404, USA
Am J Kidney Dis 41:903-24. 2003....
Low medication adherence and hypertension control among adults with CKD: data from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) StudyPaul Muntner
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Am J Kidney Dis 56:447-57. 2010..Low adherence to antihypertensive medication is an important barrier to achieving blood pressure control. Few data are available for medication adherence in adults with chronic kidney disease (CKD)...
High one year mortality in adults with sickle cell disease and end-stage renal diseaseAnn C McClellan
Centers for Disease Control and Prevention, Atlanta, GA, USA
Br J Haematol 159:360-7. 2012..The one-year mortality rate following an ESRD diagnosis was almost three times higher in individuals with SCD when compared to those without SCD but with ESRD and could be attenuated by pre-dialysis nephrology care...
Improved diabetes care by primary care physicians: results of a group-randomized evaluation of the Medicare Health Care Quality Improvement Program (HCQIP)William M McClellan
Georgia Medical Care Foundation, 1455 Lincoln Parkway, Suite 500, Atlanta, GA 30346, USA
J Clin Epidemiol 56:1210-7. 2003..Determine if an intervention that includes claims-based feedback about patterns of HbA1C measurement results in more frequent monitoring of HbA1C in diabetic Medicare beneficiaries...
Vascular access and increased risk of death among hemodialysis patientsStephen Pastan
Renal Division, Department of Medicine, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Kidney Int 62:620-6. 2002..1, 1.9) and 3.0 (1.4, 6.6), respectively, compared to those with an arteriovenous (AV) fistula. CONCLUSION: Venous catheters are associated with an increased risk of all-cause and infection-related mortality among hemodialysis patients...
The Improving Primary Care of African Americans with Diabetes (IPCAAD) project: rationale and designLawrence S Phillips
Division of Endocrinology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Control Clin Trials 23:554-69. 2002..We will compare two readily generalizable program interventions that should delineate approaches effective in a primary care setting as needed to improve care and prevent complications in urban African Americans with type 2 diabetes...
Association of the insulin resistance syndrome and microalbuminuria among nondiabetic native Americans. The Inter-Tribal Heart ProjectChristine M Hoehner
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30329, USA
J Am Soc Nephrol 13:1626-34. 2002..Health promotion efforts should focus on lowering the prevalence of hypertension, as well as glucose intolerance and obesity, in this population at high risk for renal and cardiovascular disease...
Measuring the efficacy of a quality improvement program in dialysis adequacy with changes in center effectsJeffrey C Fink
Division of Nephrology, Department of Medicine, University of Maryland, Baltimore, Maryland, USA
J Am Soc Nephrol 13:2338-44. 2002....
Prevalence and prognosis of unrecognized myocardial infarctions in chronic kidney diseaseDana V Rizk
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Nephrol Dial Transplant 27:3482-8. 2012..The purpose of this study was to determine the prevalence and prognosis for mortality of UMI among adults with CKD...
Mortality associated with the quality of care of patients hospitalized with congestive heart failureJean Christophe Luthi
Kerr L White Institute for Health Services Research, Decatur, GA, USA
Int J Qual Health Care 14:15-24. 2002..This study examined the association between use of angiotensin converting enzyme inhibitors (ACEIs) and risk of death in elderly patients hospitalized with left ventricular systolic dysfunction (LVSD)...
Discrepancy between Medical Evidence Form 2728 and renal biopsy for glomerular diseasesJ Bradley Layton
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Clin J Am Soc Nephrol 5:2046-52. 2010....
HIV intervention research for men who have sex with men: a 7-year updateWayne D Johnson
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30312, USA
AIDS Educ Prev 17:568-89. 2005..The other 16 interventions reduced unprotected sex by 17% beyond changes observed in standard or other HIV prevention interventions (CI = 5-27%). Behavioral interventions reduce self-reported unprotected sex among MSM...
Psychosocial predictors of non-compliance in haemodialysis and peritoneal dialysis patientsNancy G Kutner
Department of Rehabilitation Medicine, School of Medicine, 1441 Clifton Road NE, Emory University, Atlanta, GA 30322, USA
Nephrol Dial Transplant 17:93-9. 2002..Non-compliance with prescribed therapy significantly impacts dialysis patient care and outcomes. The underlying psychosocial issues leading to non-compliance are not well understood, especially in peritoneal dialysis (PD) patients...
Epidemiology and risk factors for chronic kidney diseaseWilliam M McClellan
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Med Clin North Am 89:419-45. 2005..Achieving high levels of medically appropriate care of CKD patients and reduction in risk of progression to ESRD may be delayed by barriers created by individual and regional poverty...
Age affects outcomes in chronic kidney diseaseANN M O'HARE
Department of Medicine, University of Washington, VA Puget Sound Healthcare System, Division of Nephrology, Building 100 Room 5B113, 1660 S Columbian Way, Seattle, WA 98108, USA
J Am Soc Nephrol 18:2758-65. 2007..73 m(2). In conclusion, age is a major effect modifier among patients with an eGFR of <60 ml/min per 1.73 m(2), challenging us to move beyond a uniform stage-based approach to managing CKD...
