Research Topics
| Helen MaybergSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Neural stimulation successfully treats depression in patients with prior ablative cingulotomyJoseph S Neimat
Toronto Western Hospital, 399 Bathurst St, WW4-425, Toronto, Ontario M5T 2S8, Canada
Am J Psychiatry 165:687-93. 2008- Deep brain stimulation for treatment-resistant depressionHelen S Mayberg
Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
Neuron 45:651-60. 2005.... - Posttraumatic stress disorder: a state-of-the-science reviewCharles B Nemeroff
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
J Psychiatr Res 40:1-21. 2006.... - Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with unipolar depressionMichael C Gemar
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Depress Anxiety 24:597-601. 2007..Previously reported mediofrontal changes in remitted patients are unlikely to be a consequence of maintenance medication and more likely are evidence of relapse vulnerability... - Defining the neural circuitry of depression: toward a new nosology with therapeutic implicationsHelen S Mayberg
Biol Psychiatry 61:729-30. 2007 
Targeted electrode-based modulation of neural circuits for depressionHelen S Mayberg
Department of Psychiatry and Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Clin Invest 119:717-25. 2009..Discussed here are converging imaging findings that established a rationale for testing a targeted neuromodulation strategy, deep brain stimulation, for treatment-resistant major depression...
The subcallosal cingulate gyrus in the context of major depressionClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
Biol Psychiatry 69:301-8. 2011..Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region...- Attending to the present: mindfulness meditation reveals distinct neural modes of self-referenceNorman A S Farb
Department of Psychology, University of Toronto, ON M5S 3G3, Canada
Soc Cogn Affect Neurosci 2:313-22. 2007..These results suggest a fundamental neural dissociation between two distinct forms of self-awareness that are habitually integrated but can be dissociated through attentional training: the self across time and in the present moment... - Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traitsPhilippe Fossati
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada M6A 2E1
Neuroimage 22:1596-604. 2004..Our results indicate that personally relevant words may signal important emotional clues and support the notion of a widely distributed set of brain regions involved in maintaining the concepts of self... - Disease state prediction from resting state functional connectivityR Cameron Craddock
School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Magn Reson Med 62:1619-28. 2009..The proposed framework for applying support vector classification to functional connectivity data is applicable to other disease states beyond major depression... - Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depressionAndres M Lozano
Division of Neurosurgery, University of Toronto, Toronto, Canada
Biol Psychiatry 64:461-7. 2008..We now report the results of these and an additional 14 patients with extended follow-up... - VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanismsCharles B Nemeroff
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 31:1345-55. 2006..Mechanisms that mediate the beneficial effects of VNS therapy for treatment-resistant depression remain obscure. Suggestions for future research directions are described... - A tractography analysis of two deep brain stimulation white matter targets for depressionDavid A Gutman
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 65:276-82. 2009..Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets... - Exploratory structural equation modeling of resting-state fMRI: applicability of group models to individual subjectsG Andrew James
Biomedical Imaging Technology Center, Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA 30322 4600, USA
Neuroimage 45:778-87. 2009..These results suggest that exploratory SEM is a viable technique for neuroimaging connectivity analyses of individual subjects' resting-state fMRI data... - Stuck in a rut: rethinking depression and its treatmentPaul E Holtzheimer
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle NE, Suite 4000, Atlanta, GA 30322, USA
Trends Neurosci 34:1-9. 2011..We also discuss the implications of this revised definition for future clinical and basic research... - Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorderBoadie W Dunlop
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road NE, Building A, 3rd Floor, Atlanta, GA 30322, USA
J Psychiatr Res 45:24-8. 2011..However, a comprehensive analysis of the safety of this test in psychiatric patients has not previously been performed... - Treatment resistant depression as a failure of brain homeostatic mechanisms: implications for deep brain stimulationPeter Giacobbe
Department of Psychiatry, University Health Network, University of Toronto, Canada
Exp Neurol 219:44-52. 2009.... - Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinicKerry J Ressler
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, Georgia 30329, USA
Nat Neurosci 10:1116-24. 2007..Although many of these approaches are experimental, the rapidly developing understanding of emotional circuit regulation is likely to provide exciting and powerful future treatments for debilitating mood and anxiety disorders... - Minding one's emotions: mindfulness training alters the neural expression of sadnessNorman A S Farb
Department of Psychology, University of Toronto, Toronto, Ontario, Canada
Emotion 10:25-33. 2010..Restoring balance between affective and sensory neural networks-supporting conceptual and body based representations of emotion-could be one path through which mindfulness reduces vulnerability to dysphoric reactivity... - Neuropsychological impact of Cg25 deep brain stimulation for treatment-resistant depression: preliminary results over 12 monthsHeather E McNeely
Schizophrenia Services, Neuropsychology Service, St Joseph s Healthcare, Hamilton, Ontario, Canada
J Nerv Ment Dis 196:405-10. 2008..Though the sample size is small, these results support cognitive safety of Cg25 DBS for TRD... - Modulating limbic-cortical circuits in depression: targets of antidepressant treatmentsHelen S Mayberg
Department of Psychiatry, University of Toronto, Ontario, Canada
Semin Clin Neuropsychiatry 7:255-68. 2002.... - Dopaminergic activity in depressed smokers: a positron emission tomography studyUsoa E Busto
Clinical Neuroscience Section, Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Synapse 63:681-9. 2009..Comorbid major depression and tobacco dependence exacerbates this effect, suggesting an altered dopamine system in comorbid patients... - Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapyKimberly Goldapple
Rotman Research Institute at Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Arch Gen Psychiatry 61:34-41. 2004..Unique directional changes in frontal cortex, cingulate, and hippocampus with CBT relative to paroxetine may reflect modality-specific effects with implications for understanding mechanisms underlying different treatment strategies... - Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblingsStephanie Krüger
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Am J Psychiatry 163:257-64. 2006..In this study, potential markers of bipolar risk and resilience were examined in a new cohort of lithium-responsive bipolar patients and their healthy siblings... - Positron emission tomography imaging in depression: a neural systems perspectiveHelen S Mayberg
Department of Psychiatry and Medicine Neurology, Rotman Research Institute, Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
Neuroimaging Clin N Am 13:805-15. 2003..An additional goal is the development of routine, brain-based clinical algorithms that optimize diagnosis and treatment of individual depressed patients... - Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trialSidney H Kennedy
University Health Network, Institute of Medical Science, University of Toronto, Department of Psychiatry, and Toronto General Hospital, 200 Elizabeth St, Eaton North Wing 8 222, Toronto, Ontario M5G 2C4, Canada
Am J Psychiatry 164:778-88. 2007..In this study, the authors report changes in fluorine-18-fluorodeoxyglucose PET in responders to CBT or venlafaxine during a randomized controlled trial... - Deep brain stimulation for Parkinson's disease dissociates mood and motor circuits: a functional MRI case studyTaresa Stefurak
Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada
Mov Disord 18:1508-16. 2003.... - Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatmentHelen S Mayberg
Department of Psychiatry and the Rotman Research Institute, University of Toronto, Ontario, Canada
Br Med Bull 65:193-207. 2003.... - Relationship between regional brain metabolism, illness severity and age in depressed subjectsJakub Z Konarski
Institute of Medical Science, University of Toronto, Toronto, ON, Canada
Psychiatry Res 155:203-10. 2007..The age-dependent changes documented herein may influence the distinct clinical presentation and treatment response described in older-age depression... - Personality influences limbic-cortical interactions during sad mood inductionMichelle L Keightley
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
Neuroimage 20:2031-9. 2003.... - Persistent auditory hallucinations that are unresponsive to antipsychotic drugsStephen E Nicolson
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
Am J Psychiatry 163:1153-9. 2006 - Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probeLescia K Tremblay
Neuropsychopharmacology Research Program, Sunnybrook and Women's College Health Sciences Centre, Sunnybrook Campus, University of Toronto, Toronto, Ontario, Canada
Arch Gen Psychiatry 62:1228-36. 2005..CONCLUSION: Dopamine-related neuroanatomical substrates are involved in altered reward processing in MDD, shedding light on the neurobiology of the anhedonic symptoms in MDD and suggesting these substrates as future therapeutic targets... - The role of imaging in United States courtroomsPurvak Patel
Department of Radiology, Emory University Hospital, D 112, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
Neuroimaging Clin N Am 17:557-67, x. 2007..This article reviews and discusses the current state of these issues... - Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depressionMario Liotti
Division of Psychiatry, Faculty of Medicine, University of Nottingham, A Floor, South Block, Queens Medical Centre, Nottingham NG7 2UH, UK
Am J Psychiatry 159:1830-40. 2002.... - An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuliMichelle L Keightley
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont, M6A 2E1 Canada
Neuropsychologia 41:585-96. 2003.... - Penfield revisited? Understanding and modifying behavior by deep brain stimulation for PDHelen S Mayberg
Neurology 59:1298-9. 2002 - State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challengeStephanie Krüger
Department of Psychiatry SK, University of Dresden, Dresden, Germany
Biol Psychiatry 54:1274-83. 2003..Imitating such stressors by the controlled transient exposure to an emotional stimulus may help to identify brain regions modulating this sensitivity... - Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depressionDarin D Dougherty
Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
J Neurosurg 99:1010-7. 2003..If confirmed, the availability of an index for noninvasively predicting a patient's response to cingulotomy for the treatment of major depression would be of great clinical value... - Neurobiological mechanisms of the placebo effectFabrizio Benedetti
Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
J Neurosci 25:10390-402. 2005 - The functional neuroanatomy of the placebo effectHelen S Mayberg
Department of Psychiatry, University of Texas at San Antonio, USA
Am J Psychiatry 159:728-37. 2002..Administration of placebo can result in a clinical response indistinguishable from that seen with active antidepressant treatment. Functional brain correlates of this phenomenon have not been fully characterized...
Research Grants
- Imaging Predictors of Treatment Response for DepressionHelen Mayberg; Fiscal Year: 2007..Identification of such biomarkers has additional implications for future testing of novel therapies in patients with distinct brain signatures, including development of evidence-based treatment algorithms for individual patients. ..
- Imaging Predictors of Treatment Response for DepressionHelen Mayberg; Fiscal Year: 2009..Identification of such biomarkers has additional implications for future testing of novel therapies in patients with distinct brain signatures, including development of evidence-based treatment algorithms for individual patients. ..