Helen Mayberg

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi request reprint Neural stimulation successfully treats depression in patients with prior ablative cingulotomy
    Joseph S Neimat
    Toronto Western Hospital, 399 Bathurst St, WW4 425, Toronto, Ontario M5T 2S8, Canada
    Am J Psychiatry 165:687-93. 2008
  2. ncbi request reprint Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
  3. ncbi request reprint Posttraumatic stress disorder: a state-of-the-science review
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
    J Psychiatr Res 40:1-21. 2006
  4. ncbi request reprint Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with unipolar depression
    Michael C Gemar
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Depress Anxiety 24:597-601. 2007
  5. ncbi request reprint Defining the neural circuitry of depression: toward a new nosology with therapeutic implications
    Helen S Mayberg
    Biol Psychiatry 61:729-30. 2007
  6. pmc Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
    Trials 13:106. 2012
  7. pmc Targeted electrode-based modulation of neural circuits for depression
    Helen S Mayberg
    Department of Psychiatry and Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 119:717-25. 2009
  8. doi request reprint The subcallosal cingulate gyrus in the context of major depression
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
    Biol Psychiatry 69:301-8. 2011
  9. ncbi request reprint Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traits
    Philippe Fossati
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada M6A 2E1
    Neuroimage 22:1596-604. 2004
  10. pmc Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference
    Norman A S Farb
    Department of Psychology, University of Toronto, ON M5S 3G3, Canada
    Soc Cogn Affect Neurosci 2:313-22. 2007

Research Grants

Detail Information

Publications41

  1. doi request reprint Neural stimulation successfully treats depression in patients with prior ablative cingulotomy
    Joseph S Neimat
    Toronto Western Hospital, 399 Bathurst St, WW4 425, Toronto, Ontario M5T 2S8, Canada
    Am J Psychiatry 165:687-93. 2008
  2. ncbi request reprint Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
    ....
  3. ncbi request reprint Posttraumatic stress disorder: a state-of-the-science review
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
    J Psychiatr Res 40:1-21. 2006
    ....
  4. ncbi request reprint Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with unipolar depression
    Michael C Gemar
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Depress Anxiety 24:597-601. 2007
    ..Previously reported mediofrontal changes in remitted patients are unlikely to be a consequence of maintenance medication and more likely are evidence of relapse vulnerability...
  5. ncbi request reprint Defining the neural circuitry of depression: toward a new nosology with therapeutic implications
    Helen S Mayberg
    Biol Psychiatry 61:729-30. 2007
  6. pmc Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
    Trials 13:106. 2012
    ..Consequently, we initiated a randomized clinical trial designed to identify factors that moderate response to three treatments for MDD among patients never treated previously for the condition...
  7. pmc Targeted electrode-based modulation of neural circuits for depression
    Helen S Mayberg
    Department of Psychiatry and Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 119:717-25. 2009
    ..Discussed here are converging imaging findings that established a rationale for testing a targeted neuromodulation strategy, deep brain stimulation, for treatment-resistant major depression...
  8. doi request reprint The subcallosal cingulate gyrus in the context of major depression
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
    Biol Psychiatry 69:301-8. 2011
    ..Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region...
  9. ncbi request reprint Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traits
    Philippe Fossati
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada M6A 2E1
    Neuroimage 22:1596-604. 2004
    ..Our results indicate that personally relevant words may signal important emotional clues and support the notion of a widely distributed set of brain regions involved in maintaining the concepts of self...
  10. pmc Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference
    Norman A S Farb
    Department of Psychology, University of Toronto, ON M5S 3G3, Canada
    Soc Cogn Affect Neurosci 2:313-22. 2007
    ..These results suggest a fundamental neural dissociation between two distinct forms of self-awareness that are habitually integrated but can be dissociated through attentional training: the self across time and in the present moment...
  11. pmc Exploratory structural equation modeling of resting-state fMRI: applicability of group models to individual subjects
    G Andrew James
    Biomedical Imaging Technology Center, Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA 30322 4600, USA
    Neuroimage 45:778-87. 2009
    ..These results suggest that exploratory SEM is a viable technique for neuroimaging connectivity analyses of individual subjects' resting-state fMRI data...
  12. doi request reprint Treatment resistant depression as a failure of brain homeostatic mechanisms: implications for deep brain stimulation
    Peter Giacobbe
    Department of Psychiatry, University Health Network, University of Toronto, Canada
    Exp Neurol 219:44-52. 2009
    ....
  13. ncbi request reprint Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Toronto, Canada
    Biol Psychiatry 64:461-7. 2008
    ..We now report the results of these and an additional 14 patients with extended follow-up...
  14. pmc Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, Georgia 30329, USA
    Nat Neurosci 10:1116-24. 2007
    ..Although many of these approaches are experimental, the rapidly developing understanding of emotional circuit regulation is likely to provide exciting and powerful future treatments for debilitating mood and anxiety disorders...
  15. pmc Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road NE, Building A, 3rd Floor, Atlanta, GA 30322, USA
    J Psychiatr Res 45:24-8. 2011
    ..However, a comprehensive analysis of the safety of this test in psychiatric patients has not previously been performed...
  16. pmc Disease state prediction from resting state functional connectivity
    R Cameron Craddock
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Magn Reson Med 62:1619-28. 2009
    ..The proposed framework for applying support vector classification to functional connectivity data is applicable to other disease states beyond major depression...
  17. pmc Stuck in a rut: rethinking depression and its treatment
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle NE, Suite 4000, Atlanta, GA 30322, USA
    Trends Neurosci 34:1-9. 2011
    ..We also discuss the implications of this revised definition for future clinical and basic research...
  18. doi request reprint A tractography analysis of two deep brain stimulation white matter targets for depression
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:276-82. 2009
    ..Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets...
  19. ncbi request reprint VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 31:1345-55. 2006
    ..Mechanisms that mediate the beneficial effects of VNS therapy for treatment-resistant depression remain obscure. Suggestions for future research directions are described...
  20. doi request reprint Minding one's emotions: mindfulness training alters the neural expression of sadness
    Norman A S Farb
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada
    Emotion 10:25-33. 2010
    ..Restoring balance between affective and sensory neural networks-supporting conceptual and body based representations of emotion-could be one path through which mindfulness reduces vulnerability to dysphoric reactivity...
  21. doi request reprint Neuropsychological impact of Cg25 deep brain stimulation for treatment-resistant depression: preliminary results over 12 months
    Heather E McNeely
    Schizophrenia Services, Neuropsychology Service, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Nerv Ment Dis 196:405-10. 2008
    ..Though the sample size is small, these results support cognitive safety of Cg25 DBS for TRD...
  22. ncbi request reprint Modulating limbic-cortical circuits in depression: targets of antidepressant treatments
    Helen S Mayberg
    Department of Psychiatry, University of Toronto, Ontario, Canada
    Semin Clin Neuropsychiatry 7:255-68. 2002
    ....
  23. pmc Dopaminergic activity in depressed smokers: a positron emission tomography study
    Usoa E Busto
    Clinical Neuroscience Section, Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 63:681-9. 2009
    ..Comorbid major depression and tobacco dependence exacerbates this effect, suggesting an altered dopamine system in comorbid patients...
  24. ncbi request reprint Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy
    Kimberly Goldapple
    Rotman Research Institute at Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Arch Gen Psychiatry 61:34-41. 2004
    ..Functional imaging studies of major depressive disorder demonstrate response-specific regional changes following various modes of antidepressant treatment...
  25. ncbi request reprint Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblings
    Stephanie Krüger
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Am J Psychiatry 163:257-64. 2006
    ..In this study, potential markers of bipolar risk and resilience were examined in a new cohort of lithium-responsive bipolar patients and their healthy siblings...
  26. ncbi request reprint Positron emission tomography imaging in depression: a neural systems perspective
    Helen S Mayberg
    Department of Psychiatry and Medicine Neurology, Rotman Research Institute, Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Neuroimaging Clin N Am 13:805-15. 2003
    ..An additional goal is the development of routine, brain-based clinical algorithms that optimize diagnosis and treatment of individual depressed patients...
  27. ncbi request reprint Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trial
    Sidney H Kennedy
    University Health Network, Institute of Medical Science, University of Toronto, Department of Psychiatry, and Toronto General Hospital, 200 Elizabeth St, Eaton North Wing 8 222, Toronto, Ontario M5G 2C4, Canada
    Am J Psychiatry 164:778-88. 2007
    ..In this study, the authors report changes in fluorine-18-fluorodeoxyglucose PET in responders to CBT or venlafaxine during a randomized controlled trial...
  28. ncbi request reprint Deep brain stimulation for Parkinson's disease dissociates mood and motor circuits: a functional MRI case study
    Taresa Stefurak
    Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 18:1508-16. 2003
    ....
  29. ncbi request reprint Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment
    Helen S Mayberg
    Department of Psychiatry and the Rotman Research Institute, University of Toronto, Ontario, Canada
    Br Med Bull 65:193-207. 2003
    ....
  30. ncbi request reprint Relationship between regional brain metabolism, illness severity and age in depressed subjects
    Jakub Z Konarski
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Psychiatry Res 155:203-10. 2007
    ..The age-dependent changes documented herein may influence the distinct clinical presentation and treatment response described in older-age depression...
  31. ncbi request reprint Personality influences limbic-cortical interactions during sad mood induction
    Michelle L Keightley
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Neuroimage 20:2031-9. 2003
    ....
  32. ncbi request reprint Persistent auditory hallucinations that are unresponsive to antipsychotic drugs
    Stephen E Nicolson
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Am J Psychiatry 163:1153-9. 2006
  33. ncbi request reprint Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe
    Lescia K Tremblay
    Neuropsychopharmacology Research Program, Sunnybrook and Women s College Health Sciences Centre, Sunnybrook Campus, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 62:1228-36. 2005
    ..The challenge is to elucidate the brain mechanisms of MDD behavioral symptoms, chiefly those of anhedonia...
  34. ncbi request reprint The role of imaging in United States courtrooms
    Purvak Patel
    Department of Radiology, Emory University Hospital, D 112, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
    Neuroimaging Clin N Am 17:557-67, x. 2007
    ..This article reviews and discusses the current state of these issues...
  35. ncbi request reprint Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression
    Mario Liotti
    Division of Psychiatry, Faculty of Medicine, University of Nottingham, A Floor, South Block, Queens Medical Centre, Nottingham NG7 2UH, UK
    Am J Psychiatry 159:1830-40. 2002
    ....
  36. ncbi request reprint Neurobiological mechanisms of the placebo effect
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
    J Neurosci 25:10390-402. 2005
  37. ncbi request reprint Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression
    Darin D Dougherty
    Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurosurg 99:1010-7. 2003
    ..The purpose of this study was to identify possible neuroimaging predictors of treatment response to anterior cingulotomy in patients with major depression...
  38. ncbi request reprint State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challenge
    Stephanie Krüger
    Department of Psychiatry SK, University of Dresden, Dresden, Germany
    Biol Psychiatry 54:1274-83. 2003
    ..Imitating such stressors by the controlled transient exposure to an emotional stimulus may help to identify brain regions modulating this sensitivity...
  39. ncbi request reprint An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuli
    Michelle L Keightley
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont, M6A 2E1 Canada
    Neuropsychologia 41:585-96. 2003
    ....
  40. ncbi request reprint Penfield revisited? Understanding and modifying behavior by deep brain stimulation for PD
    Helen S Mayberg
    Neurology 59:1298-9. 2002
  41. ncbi request reprint The functional neuroanatomy of the placebo effect
    Helen S Mayberg
    Department of Psychiatry, University of Texas at San Antonio, USA
    Am J Psychiatry 159:728-37. 2002
    ..Administration of placebo can result in a clinical response indistinguishable from that seen with active antidepressant treatment. Functional brain correlates of this phenomenon have not been fully characterized...

Research Grants4

  1. Imaging Predictors of Treatment Response for Depression
    Helen Mayberg; Fiscal Year: 2006
    ..Identification of such biomarkers has additional implications for future testing of novel therapies in patients with distinct brain signatures, including development of evidence-based treatment algorithms for individual patients. ..
  2. Imaging Predictors of Treatment Response for Depression
    Helen Mayberg; Fiscal Year: 2007
    ..Identification of such biomarkers has additional implications for future testing of novel therapies in patients with distinct brain signatures, including development of evidence-based treatment algorithms for individual patients. ..
  3. Imaging Predictors of Treatment Response for Depression
    Helen Mayberg; Fiscal Year: 2009
    ..Identification of such biomarkers has additional implications for future testing of novel therapies in patients with distinct brain signatures, including development of evidence-based treatment algorithms for individual patients. ..