Affiliation: Emory University
- Magnetic resonance imaging of activated proliferating rhesus macaque T cells labeled with superparamagnetic monocrystalline iron oxide nanoparticlesJ Bruce Sundstrom
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Woodruff Memorial Building, Room 2335A, 1639 Pierce Drive, Atlanta, GA, USA
J Acquir Immune Defic Syndr 35:9-21. 2004..These results indicate that intracellular labeling with MION can be a useful technique for noninvasively monitoring trafficking patterns of adoptively transferred leukocyte subsets in real-time by MRI in nonhuman primate models of AIDS...
- Diffusion tensor and functional magnetic resonance imaging of diffuse axonal injury and resulting language impairmentHui Mao
Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neuroimaging 17:292-4. 2007..The findings demonstrate the utility of DTI for identifying white matter changes secondary to traumatic brain injury (TBI)...
- Receptor-targeted nanoparticles for in vivo imaging of breast cancerLily Yang
Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, C 4088, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
Clin Cancer Res 15:4722-32. 2009..Cell-surface receptor-targeted magnetic iron oxide nanoparticles provide molecular magnetic resonance imaging contrast agents for improving specificity of the detection of human cancer...
- Changes of metabolite profile in kainic acid induced hippocampal injury in rats measured by HRMAS NMRHui Mao
Department of Radiology and Frederick Philips MR Research Center, Emory University School of Medicine, 1364 Clifton Road, Atlanta, Georgia 30322, USA
Exp Brain Res 183:477-85. 2007..This study demonstrates that ex vivo HRMAS NMR is a useful tool for analyzing and quantifying changes of neurochemistry and cerebral metabolism in the intact brain...
- Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imagingLily Yang
Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Small 5:235-43. 2009..Efficient internalization of ScFvEGFR nanoparticles into tumor cells after systemic delivery suggests that the EGFR-targeted nanoparticles can also be used for the targeted delivery of therapeutic agents...
- Casein-coated iron oxide nanoparticles for high MRI contrast enhancement and efficient cell targetingJing Huang
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States
ACS Appl Mater Interfaces 5:4632-9. 2013..These favorable properties suggest CNIOs as a class of biomarker targeted magnetic nanoparticles for MRI contrast enhancement and related biomedical applications...
- Biocompatible polysiloxane-containing diblock copolymer PEO-b-PgammaMPS for coating magnetic nanoparticlesHongwei Chen
Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, Atlanta, Georgia 30322, USA
ACS Appl Mater Interfaces 1:2134-40. 2009..Furthermore, a much lower level of intracellular uptake by macrophage cells was observed with polysiloxane containing diblock copolymers coated IONPs, suggesting the reduction of nonspecific cell uptakes and antibiofouling effect...
- T₁-weighted ultrashort echo time method for positive contrast imaging of magnetic nanoparticles and cancer cells bound with the targeted nanoparticlesLongjiang Zhang
Department of Radiology, Center for Systems Imaging, Emory University School of Medicine, Atlanta, Georgia, USA
J Magn Reson Imaging 33:194-202. 2011....
- EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastomaCostas G Hadjipanayis
Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 70:6303-12. 2010....
- PEGylation of protein-based MRI contrast agents improves relaxivities and biocompatibilitiesShunyi Li
Department of Chemistry and Biology, Georgia State University, Atlanta, GA 30303, USA
J Inorg Biochem 107:111-8. 2012..Such improvement can be important to the animal imaging and pre-clinical research at high or ultra-high field where there is an urgent need for molecular imaging probes and optimized contrast agent...
- Molecular imaging of pancreatic cancer in an animal model using targeted multifunctional nanoparticlesLily Yang
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Gastroenterology 136:1514-25.e2. 2009....
- Targeted magnetic iron oxide nanoparticles for tumor imaging and therapyXiang Hong Peng
Department of Medical Oncology Hematology, Emory University School of Medicine, Atlanta, GA 30322, USA
Int J Nanomedicine 3:311-21. 2008..We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy...
- Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancerGee Young Lee
Departments of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, United States
ACS Nano 7:2078-89. 2013....
- Blockade of glioma proliferation through allosteric inhibition of JAK2Kunyan He
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Sci Signal 6:ra55. 2013....
- Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinasesQi Qi
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 287:6113-27. 2012..Hence, combinatorial inhibition of EGFR and PKCs might provide proof of concept in developing therapeutic agents for treating malignant glioma and other human cancers...
- Targeted delivery of siRNA-generating DNA nanocassettes using multifunctional nanoparticlesYoung Seok Cho
Emory University School of Medicine, Atlanta, GA 30322, USA
Small 9:1964-73. 2013..The ability of expression of siRNAs from multiple nanocassettes conjugated to a single nanoparticle following receptor-mediated internalization should enhance the therapeutic effect of the siRNA-mediated cancer therapy...
- Group independent component analysis and functional MRI examination of changes in language areas associated with brain tumors at different locationsLiya Wang
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America
PLoS ONE 8:e59657. 2013..This study investigates the effect of tumor location on alterations of language network by brain tumors at different locations using blood oxygenation level dependent (BOLD) fMRI and group independent component analysis (ICA)...
- A dual-modal magnetic nanoparticle probe for preoperative and intraoperative mapping of sentinel lymph nodes by magnetic resonance and near infrared fluorescence imagingZhengyang Zhou
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA
J Biomater Appl 28:100-11. 2013....
- Protein-based MRI contrast agents for molecular imaging of prostate cancerLixia Wei
Department of Chemistry and Biology, Georgia State University, Atlanta, GA 30302, USA
Mol Imaging Biol 13:416-23. 2011....
- Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-PgammaMPS copolymer coatingHongwei Chen
Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322, USA
Biomaterials 31:5397-407. 2010....
- Detection of "oncometabolite" 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in gliomaJuliya Kalinina
Department of Neurosurgery, Emory University, Atlanta, GA 30329, USA
J Mol Med (Berl) 90:1161-71. 2012..It further opens up the possibility of developing analogous non-invasive MR-based imaging and spectroscopy studies directly in humans in the neuro-oncology clinic...
- Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effectHari Krishna Sajja
Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Room C 4088, 1365 C Clifton Road, Atlanta, GA 30322, USA
Curr Drug Discov Technol 6:43-51. 2009....
- Adaptor protein complex-4 (AP-4) deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disabilityAndres Moreno-De-Luca
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
J Med Genet 48:141-4. 2011..Hypoxic-ischaemic injury, long considered the most frequent causative factor, accounts for fewer than 10% of cases, whereas a growing body of evidence suggests that diverse genetic abnormalities likely play a major role...
- Re-examine tumor-induced alterations in hemodynamic responses of BOLD fMRI: implications in presurgical brain mappingLiya Wang
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
Acta Radiol 53:802-11. 2012..Blood oxygenation level dependent (BOLD) fMRI is used for presurgical functional mapping of brain tumor patients. Abnormal tumor blood supply may affect hemodynamic responses and BOLD fMRI signals...
- Targeted delivery of cisplatin to lung cancer using ScFvEGFR-heparin-cisplatin nanoparticlesXiang Hong Peng
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, United States
ACS Nano 5:9480-93. 2011..The new EHDDP nanoparticle delivery system significantly enhanced antitumor activity of DDP without weight loss or damage to the kidney and spleen in nude mice bearing H292 cell tumors...
- White matter hyperintensities and changes in white matter integrity in patients with Alzheimer's diseaseLiya Wang
Department of Radiology, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30329, USA
Neuroradiology 53:373-81. 2011..This study investigated the relationship between WMHs and white matter changes in AD using diffusion tensor imaging (DTI) and the sensitivity of each DTI index in distinguishing AD with WMHs...
- Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiationDan Yan
Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia, United States of America
PLoS ONE 5:e11397. 2010..In this study, we tested the new hypothesis: identifying the miRNAs to target DNA DSB repair genes could be a new way for sensitizing tumors to ionizing radiation...
- Improving the magnetic resonance imaging contrast and detection methods with engineered magnetic nanoparticlesJing Huang
1 Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Theranostics 2:86-102. 2012..Furthermore, MRI methods for imaging magnetic nanoparticles including several newly developed MRI approaches aiming at improving the detection and quantification of the engineered magnetic nanoparticles are described...
- Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imagingMatthew N Rhyner
Department of Biomedical Engineering, Chemistry, Hematology and Oncology, and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA
Nanomedicine (Lond) 1:209-17. 2006..g., anticancer) agents. In this review, recent advances in the development and applications of bioconjugated quantum dots and multifunctional nanoparticles for in vivo tumor imaging and targeting are discussed...
- Rational design of protein-based MRI contrast agentsJenny J Yang
Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA
J Am Chem Soc 130:9260-7. 2008..With good biocompatibility and potential functionalities, these protein contrast agents may be used as molecular imaging probes to target disease markers, thereby extending applications of MRI...
- Adiabatic pulse preparation for imaging iron oxide nanoparticlesSteven S Harris
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Magn Reson Med 67:1133-7. 2012..With its linearity with iron concentration and insensitivity to changes in the main magnetic field, the new method is well suited for quantitative iron oxide nanoparticle imaging...
- Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanismBalveen Kaur
Department of Neurosurgery, Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 69:1212-20. 2009..These results advance the understanding of brain-specific angiogenic regulation, and suggest that Vstat120 has therapeutic potential in the treatment of brain tumors and other intracerebral vasculopathies...
- Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporterJun Liu
Neuroscience Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA
Tissue Eng Part C Methods 15:739-47. 2009..The compatibility and functionality of ferritin as a reporter in mES cells opens up the possibility of using MRI for longitudinal noninvasive monitoring of ES cell-derived cell grafts at both molecular and cellular levels...
- Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor modelSeung Hee Kang
Department of Hematology Oncology, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 66:11991-7. 2006....
- Individual kidney blood flow measured with contrast-enhanced first-pass perfusion MR imagingDiego R Martin
Department of Radiology, Emory University School of Medicine, Building A, AT 622, 1365 Clifton Rd NE, Atlanta, GA 30322, USA
Radiology 246:241-8. 2008..This study demonstrates feasibility of the gadolinium chelate perfusion method for RBF measurement and discusses potential applications. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/246/1/241/DC1...
- Altered brain activation during cognitive control in patients with moderate to severe traumatic brain injuryRandall S Scheibel
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX 77030, USA
Neurorehabil Neural Repair 21:36-45. 2007..Persistent deficits in cognitive control have been documented following traumatic brain injury (TBI) but are inconsistently related to the presence and location of focal lesions...
- Detection of lactate in the human vitreous body using proton magnetic resonance spectroscopyJanet C Rucker
Arch Ophthalmol 121:909-11. 2003