Kenneth J Mandell

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint The JAM family of proteins
    Kenneth J Mandell
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Room 125, Atlanta, GA 30322, United States
    Adv Drug Deliv Rev 57:857-67. 2005
  2. ncbi request reprint Involvement of the junctional adhesion molecule-1 (JAM1) homodimer interface in regulation of epithelial barrier function
    Kenneth J Mandell
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 279:16254-62. 2004
  3. pmc Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function
    Kenneth J Mandell
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Invest Ophthalmol Vis Sci 48:3928-36. 2007
  4. ncbi request reprint Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on beta1 integrins and Rap1 activity
    Kenneth J Mandell
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:11665-74. 2005
  5. ncbi request reprint Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling
    Kenneth J Mandell
    Emory Eye Center, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Invest Ophthalmol Vis Sci 47:2408-16. 2006
  6. pmc Cis-dimerization mediates function of junctional adhesion molecule A
    Eric A Severson
    Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 19:1862-72. 2008
  7. pmc Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signaling
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 170:951-66. 2007
  8. ncbi request reprint The second loop of occludin is required for suppression of Raf1-induced tumor growth
    Zili Wang
    Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Oncogene 24:4412-20. 2005
  9. ncbi request reprint Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha
    Yuan Liu
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 172:2578-85. 2004
  10. ncbi request reprint Interaction of ICAM-1 with beta 2-integrin CD11c/CD18: characterization of a peptide ligand that mimics a putative binding site on domain D4 of ICAM-1
    Christoph Frick
    Department of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Berne, Switzerland
    Eur J Immunol 35:3610-21. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint The JAM family of proteins
    Kenneth J Mandell
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Room 125, Atlanta, GA 30322, United States
    Adv Drug Deliv Rev 57:857-67. 2005
    ..This review will highlight what is currently known about the structure, function, and mechanism of action of JAM proteins as well as comment on potential directions for future JAM-related research...
  2. ncbi request reprint Involvement of the junctional adhesion molecule-1 (JAM1) homodimer interface in regulation of epithelial barrier function
    Kenneth J Mandell
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 279:16254-62. 2004
    ..These findings suggest that homodimer formation may be important for localization of JAM1 at tight junctions and for regulation of epithelial barrier function...
  3. pmc Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function
    Kenneth J Mandell
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Invest Ophthalmol Vis Sci 48:3928-36. 2007
    ....
  4. ncbi request reprint Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on beta1 integrins and Rap1 activity
    Kenneth J Mandell
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:11665-74. 2005
    ..Together, these results suggest that JAM1 regulates epithelial cell morphology and beta1 integrin expression by modulating activity of the small GTPase Rap1...
  5. ncbi request reprint Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling
    Kenneth J Mandell
    Emory Eye Center, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Invest Ophthalmol Vis Sci 47:2408-16. 2006
    ..In this study, we sought to investigate the expression and function of JAM-A in the corneal endothelium...
  6. pmc Cis-dimerization mediates function of junctional adhesion molecule A
    Eric A Severson
    Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 19:1862-72. 2008
    ..These results suggest that dimerization of JAM-A regulates cell migration and adhesion through indirect mechanisms involving posttranscriptional control of beta1 integrin levels...
  7. pmc Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signaling
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 170:951-66. 2007
    ..These findings suggest that annexin 2 plays a role in targeting Rho to cellular membranes, thereby modulating Rho-related signaling events regulating cytoskeletal reorganization during epithelial cell migration...
  8. ncbi request reprint The second loop of occludin is required for suppression of Raf1-induced tumor growth
    Zili Wang
    Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Oncogene 24:4412-20. 2005
    ..These results demonstrate that the TJ protein occludin has a potent inhibitory effect on the Raf1-mediated tumorigenesis, and the second extracellular loop of occludin appears to be critical for this function...
  9. ncbi request reprint Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha
    Yuan Liu
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 172:2578-85. 2004
    ..Such peptide reagents may be useful for studies on experimental models of inflammation and provide a template for the design of anti-inflammatory agents...
  10. ncbi request reprint Interaction of ICAM-1 with beta 2-integrin CD11c/CD18: characterization of a peptide ligand that mimics a putative binding site on domain D4 of ICAM-1
    Christoph Frick
    Department of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Berne, Switzerland
    Eur J Immunol 35:3610-21. 2005
    ..Using ICAM-1 deletion constructs, we showed that domain D4 is required for interaction with CD11c/CD18, suggesting that C-GRWSGWPADL-C phage binds specifically to CD11c/CD18 by structurally mimicking the interaction site on D4 of ICAM-1...