Research Topics
| R H LylesSummaryAffiliation: Emory University Country: USA Publications
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Publications
Likelihood-based methods for regression analysis with binary exposure status assessed by poolingRobert H Lyles
Department of Biostatistics and Bioinformatics, The Rollins School of Public Health, Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
Stat Med 31:2485-97. 2012..We apply the methods to investigate gene-disease association in a population-based case-control study of colorectal cancer...
Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancerAki Morikawa
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
Breast Cancer Res 7:R1051-7. 2005..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors...
Design and analytic considerations for single-armed studies with misclassification of a repeated binary outcomeRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
J Biopharm Stat 14:229-47. 2004..The methods are illustrated numerically, and a real-life example motivating the proposed optimal design is provided...- Inference for case-control studies when exposure status is both informatively missing and misclassifiedRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
Stat Med 25:4065-80. 2006.... - Improving point predictions of random effects for subjects at high riskRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
Stat Med 26:1285-300. 2007..Straightforward extensions to incorporate covariates and additional random effects are briefly outlined... - A practical approach to computing power for generalized linear models with nominal, count, or ordinal responsesRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
Stat Med 26:1632-48. 2007..We illustrate the method for a variety of outcome types and covariate patterns, using simulations to demonstrate its accuracy for realistic sample sizes... - Combining internal and external validation data to correct for exposure misclassification: a case studyRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
Epidemiology 18:321-8. 2007..A case-control study of the association between maternal antibiotic use and sudden infant death syndrome provides a real-data example... - Missing data in the 2 x 2 table: patterns and likelihood-based analysis for cross-sectional studies with supplemental samplingRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, U S A
Stat Med 22:517-34. 2003..Adjustment for potential confounders via stratified analysis is also discussed... - A note on estimating crude odds ratios in case-control studies with differentially misclassified exposureRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Road N E, Atlanta, Georgia 30322, USA
Biometrics 58:1034-6; discussion 1036-7. 2002.... - Extending McNemar's test: estimation and inference when paired binary outcome data are misclassifiedRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Road N E, Atlanta, Georgia 30322, USA
Biometrics 61:287-94. 2005..Two motivating examples are presented, using gold standard and surrogate bivariate binary diagnoses of bacterial vaginosis (BV) on women participating in the HIV Epidemiology Research Study (HERS)... - Effects of covariate measurement error in the initial level and rate of change of an exposure variableR H Lyles
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Biometrics 56:634-9. 2000..We illustrate the potential impact of such adjustments on the interpretation of an epidemiologic analysis... - Validation data-based adjustments for outcome misclassification in logistic regression: an illustrationRobert H Lyles
Department of Biostatistics and Bioinformatics, The Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
Epidemiology 22:589-97. 2011..These methods are readily applicable under random cross-sectional sampling, and we discuss the extent to which the main/internal analysis remains appropriate under outcome-dependent (case-control) sampling... - Correlation coefficient estimation involving a left censored laboratory assay variableR H Lyles
Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
Stat Med 20:2921-33. 2001.... - Correlating two viral load assays with known detection limitsR H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
Biometrics 57:1238-44. 2001..We apply the methods to HIV viral load data on women and infants from a trial in Bangkok, Thailand, and we discuss an extension of the original model to accommodate interval censoring arising due to the study design... - Estimating crude or common odds ratios in case-control studies with informatively missing exposure dataRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Am J Epidemiol 155:274-81. 2002..Simulations assess performance of the likelihood-based estimates and inferences, and they display the potential for bias in complete-case analyses. An example is presented to illustrate the approach... - Sensitivity analysis for misclassification in logistic regression via likelihood methods and predictive value weightingRobert H Lyles
Department of Biostatistics and Bioinformatics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
Stat Med 29:2297-309. 2010..Examples illustrate the flexibility of this unified strategy, and simulations suggest that it performs well relative to a maximum likelihood approach carried out via numerical optimization... - Nonlinear model-based estimates of IC(50) for studies involving continuous therapeutic dose-response dataRobert H Lyles
Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
Contemp Clin Trials 29:878-86. 2008..Specific results for two cell lines are provided, along with a sample commercial software-based program for implementing a selection of the methods discussed... - Barriers to diabetes education in urban patients: perceptions, patterns, and associated factorsMary K Rhee
Department of Medicine, Emory University, Atlanta, Georgia, USA
Diabetes Educ 31:410-7. 2005..Interventions at multiple levels that address the demographic and socioeconomic obstacles to diabetes education are needed to ensure successful self-management training... - Flexible modeling of longitudinal highly skewed outcomesHuichao Chen
Center for Biostatistics in AIDS Research, Department of Biostatistics, Harvard School of Public Health, Harvard University, 651 Huntington Avenue, FXB 502, Boston, MA 02115, USA
Stat Med 28:3811-28. 2009..Simulation studies are conducted to evaluate their performance. Finally, we apply the proposed method to exposure data collected from the Michigan polybrominated biphenyl (MIPBB) study... - Limited health care access impairs glycemic control in low income urban African Americans with type 2 diabetesMary K Rhee
Emory University School of Medicine, Atlanta, Georgia, USA
J Health Care Poor Underserved 16:734-46. 2005..08%; p=0.009). Policy decisions for improving diabetes outcomes should target barriers to health care access and focus on developing programs to help high-risk populations maintain a regular place of health care... 
A decay model for assessing polybrominated biphenyl exposure among women in the Michigan Long-Term PBB StudyMetrecia L Terrell
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
J Expo Sci Environ Epidemiol 18:410-20. 2008..The mixed-effects decay model predicted the observed serum PBB concentration levels significantly better than the OLS two-stage decay model (mixed-effects model, r=0.93; OLS two-stage model, r=0.86; P<0.0001)...- The Improving Primary Care of African Americans with Diabetes (IPCAAD) project: rationale and designLawrence S Phillips
Division of Endocrinology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Control Clin Trials 23:554-69. 2002..We will compare two readily generalizable program interventions that should delineate approaches effective in a primary care setting as needed to improve care and prevent complications in urban African Americans with type 2 diabetes... - Expression of e-cadherin in high-risk breast cancerEugene M Howard
Winship Cancer Institute, Emory University, 1365 C Clifton Road NE, Rm 3078, Atlanta, GA 30322, USA
J Cancer Res Clin Oncol 131:14-8. 2005..The ethnic and socio-economic risk stratification needs to be accounted for in studies correlating markers and prognosis... - The use of skin sparing mastectomy in the treatment of breast cancer: The Emory experienceGrant W Carlson
Winship Cancer Institute, Emory University School of Medicine, Emory University, 1365B, Clifton Road, Atlanta, GA 30322, USA
Surg Oncol 12:265-9. 2003..Long-term follow-up of the use of skin sparing mastectomy (SSM) in the treatment of breast cancer is presented to determine the impact of local recurrence (LR) on survival... - Local recurrence after skin-sparing mastectomy: tumor biology or surgical conservatism?Grant W Carlson
Winship Cancer Institute, Atlanta, Georgia 30322, USA
Ann Surg Oncol 10:108-12. 2003..Long-term follow-up of the use of skin-sparing mastectomy (SSM) in the treatment of breast cancer is presented to determine the impact of local recurrence (LR) on survival... - Diabetes management by residents in training in a municipal hospital primary care site (IPCAAD 2)Christopher D Miller
Divisions of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Ethn Dis 15:649-55. 2005.... - (F-18) fluorodeoxyglucose positron emission tomography as a predictor of pathologic grade and other prognostic variables in bone and soft tissue sarcomaA L Folpe
Department of Pathology, Emory University Medical Center, Atlanta, Georgia 30322, USA
Clin Cancer Res 6:1279-87. 2000..Further follow-up will be necessary to determine whether FDG-PET provides independent prognostic information... - Sentinel lymph node biopsy in the management of cutaneous head and neck melanomaGrant W Carlson
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
Plast Reconstr Surg 115:721-8. 2005..8 percent. Completion lymphadenectomy revealed residual disease in seven patients (33.3 percent). Sentinel lymph node mapping for head and neck melanoma can be performed with results comparable to those of other anatomical sites... - Surgical margin and Gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalanceWei Zhou
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, GA 30322, USA
Prostate 61:81-91. 2004..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors... - The amount of metastatic melanoma in a sentinel lymph node: does it have prognostic significance?Grant W Carlson
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
Ann Surg Oncol 10:575-81. 2003..The amount of metastatic disease in the sentinel lymph node (SLN) is examined as a prognostic factor in malignant melanoma... - Assay validation for left-censored dataHuiman X Barnhart
Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
Stat Med 24:3347-60. 2005..The concordance correlation coefficient is used as an agreement index. The methodology is illustrated using HIV RNA assay data collected as part of a long-term HIV cohort study... - Can we select which patients with small breast cancers should receive adjuvant chemotherapy?William C Wood
Surgical Oncology, Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Ann Surg 235:859-62. 2002..To identify the risk of systemic metastases from T1a and T1b N0 breast cancers in patients treated in an academic center, and to seek factors to identify the patients at greatest risk of such failure... - The potentially poor response to outpatient diabetes care in urban African-AmericansC B Cook
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
Diabetes Care 24:209-15. 2001..To search for reasons underlying differences in HbA1c outcome, we analyzed patients managed in an outpatient diabetes clinic... - Correlation and expression of p53, HER-2, vascular endothelial growth factor (VEGF), and e-cadherin in a high-risk breast-cancer populationEugene M Howard
Avon Pathogenomics Laboratory at Winship Cancer Institute and Emory University School of Medicine, P.O. Box 55440, Atlanta, GA 30308, USA
Int J Clin Oncol 9:154-60. 2004.... - Counting alleles in single lesions of prostate tumors from ethnically diverse patientsAki Morikawa
Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia 30322, USA
Prostate 68:231-40. 2008..Nevertheless, it is unclear whether such disparities are due to genetic alterations that are involved in prostate cancer initiation. Here, we evaluated chromosome 8p allelic loss in a racially diverse cohort... - Bias in a placebo-controlled study due to mismeasurement of disease status and the regression effectHung Mo Lin
Department of Health Evaluation Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
Control Clin Trials 23:497-501. 2002..Proper statistical analysis should include such data for an accurate portrayal of the effectiveness of the treatment... - Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infectionJanis V Giorgi
UCLA School of Medicine and Center for AIDS Research, Los Angeles, California 90095-1475, USA
J Acquir Immune Defic Syndr 29:346-55. 2002.... - Qualitative change in antibody responses of human immunodeficiency virus-infected individuals to pneumococcal capsular polysaccharide vaccination associated with highly active antiretroviral therapyKrishanthi S Subramaniam
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Room 709, Forchheimer Building, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Infect Dis 187:758-68. 2003..These findings suggest that HAART may influence qualitative aspects of the PPS response by restoring expression of certain V(H)3 genes used in the normal PPS response... - Estimation of the intervention effect in a non-randomized study with pre- and post-mismeasured binary responsesHung Mo Lin
Department of Health Evaluation Sciences, Penn State College of Medicine, A210, 600 Centerview Drive, Hershey, PA 17033, USA
Stat Med 24:419-35. 2005..We extend this approach to estimation of both the placebo and intervention effects in placebo-controlled studies designed with a misclassified binary outcome. Analyses of two biomedical studies are used for illustration...