R H Lyles

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint A practical approach to computing power for generalized linear models with nominal, count, or ordinal responses
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Stat Med 26:1632-48. 2007
  2. pmc Likelihood-based methods for regression analysis with binary exposure status assessed by pooling
    Robert H Lyles
    Department of Biostatistics and Bioinformatics, The Rollins School of Public Health, Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Stat Med 31:2485-97. 2012
  3. pmc Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer
    Aki Morikawa
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Breast Cancer Res 7:R1051-7. 2005
  4. ncbi request reprint Design and analytic considerations for single-armed studies with misclassification of a repeated binary outcome
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
    J Biopharm Stat 14:229-47. 2004
  5. pmc Nonlinear model-based estimates of IC(50) for studies involving continuous therapeutic dose-response data
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
    Contemp Clin Trials 29:878-86. 2008
  6. ncbi request reprint Extending McNemar's test: estimation and inference when paired binary outcome data are misclassified
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Road N E, Atlanta, Georgia 30322, USA
    Biometrics 61:287-94. 2005
  7. ncbi request reprint Combining internal and external validation data to correct for exposure misclassification: a case study
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
    Epidemiology 18:321-8. 2007
  8. ncbi request reprint Inference for case-control studies when exposure status is both informatively missing and misclassified
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
    Stat Med 25:4065-80. 2006
  9. ncbi request reprint Improving point predictions of random effects for subjects at high risk
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Stat Med 26:1285-300. 2007
  10. ncbi request reprint Missing data in the 2 x 2 table: patterns and likelihood-based analysis for cross-sectional studies with supplemental sampling
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, U S A
    Stat Med 22:517-34. 2003

Detail Information

Publications40

  1. ncbi request reprint A practical approach to computing power for generalized linear models with nominal, count, or ordinal responses
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Stat Med 26:1632-48. 2007
    ..We illustrate the method for a variety of outcome types and covariate patterns, using simulations to demonstrate its accuracy for realistic sample sizes...
  2. pmc Likelihood-based methods for regression analysis with binary exposure status assessed by pooling
    Robert H Lyles
    Department of Biostatistics and Bioinformatics, The Rollins School of Public Health, Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Stat Med 31:2485-97. 2012
    ..We apply the methods to investigate gene-disease association in a population-based case-control study of colorectal cancer...
  3. pmc Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer
    Aki Morikawa
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Breast Cancer Res 7:R1051-7. 2005
    ..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors...
  4. ncbi request reprint Design and analytic considerations for single-armed studies with misclassification of a repeated binary outcome
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
    J Biopharm Stat 14:229-47. 2004
    ..The methods are illustrated numerically, and a real-life example motivating the proposed optimal design is provided...
  5. pmc Nonlinear model-based estimates of IC(50) for studies involving continuous therapeutic dose-response data
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
    Contemp Clin Trials 29:878-86. 2008
    ..Specific results for two cell lines are provided, along with a sample commercial software-based program for implementing a selection of the methods discussed...
  6. ncbi request reprint Extending McNemar's test: estimation and inference when paired binary outcome data are misclassified
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Road N E, Atlanta, Georgia 30322, USA
    Biometrics 61:287-94. 2005
    ..Two motivating examples are presented, using gold standard and surrogate bivariate binary diagnoses of bacterial vaginosis (BV) on women participating in the HIV Epidemiology Research Study (HERS)...
  7. ncbi request reprint Combining internal and external validation data to correct for exposure misclassification: a case study
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
    Epidemiology 18:321-8. 2007
    ..A case-control study of the association between maternal antibiotic use and sudden infant death syndrome provides a real-data example...
  8. ncbi request reprint Inference for case-control studies when exposure status is both informatively missing and misclassified
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
    Stat Med 25:4065-80. 2006
    ....
  9. ncbi request reprint Improving point predictions of random effects for subjects at high risk
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Stat Med 26:1285-300. 2007
    ..Straightforward extensions to incorporate covariates and additional random effects are briefly outlined...
  10. ncbi request reprint Missing data in the 2 x 2 table: patterns and likelihood-based analysis for cross-sectional studies with supplemental sampling
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, U S A
    Stat Med 22:517-34. 2003
    ..Adjustment for potential confounders via stratified analysis is also discussed...
  11. ncbi request reprint A note on estimating crude odds ratios in case-control studies with differentially misclassified exposure
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, 1518 Clifton Road N E, Atlanta, Georgia 30322, USA
    Biometrics 58:1034-6; discussion 1036-7. 2002
    ....
  12. ncbi request reprint Correlating two viral load assays with known detection limits
    R H Lyles
    Department of Biostatistics, The Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
    Biometrics 57:1238-44. 2001
    ..We apply the methods to HIV viral load data on women and infants from a trial in Bangkok, Thailand, and we discuss an extension of the original model to accommodate interval censoring arising due to the study design...
  13. ncbi request reprint Effects of covariate measurement error in the initial level and rate of change of an exposure variable
    R H Lyles
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Biometrics 56:634-9. 2000
    ..We illustrate the potential impact of such adjustments on the interpretation of an epidemiologic analysis...
  14. pmc Sensitivity analysis for misclassification in logistic regression via likelihood methods and predictive value weighting
    Robert H Lyles
    Department of Biostatistics and Bioinformatics, The Rollins School of Public Health of Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Stat Med 29:2297-309. 2010
    ..Examples illustrate the flexibility of this unified strategy, and simulations suggest that it performs well relative to a maximum likelihood approach carried out via numerical optimization...
  15. ncbi request reprint Correlation coefficient estimation involving a left censored laboratory assay variable
    R H Lyles
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Stat Med 20:2921-33. 2001
    ....
  16. pmc Validation data-based adjustments for outcome misclassification in logistic regression: an illustration
    Robert H Lyles
    Department of Biostatistics and Bioinformatics, The Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
    Epidemiology 22:589-97. 2011
    ..These methods are readily applicable under random cross-sectional sampling, and we discuss the extent to which the main/internal analysis remains appropriate under outcome-dependent (case-control) sampling...
  17. ncbi request reprint Estimating crude or common odds ratios in case-control studies with informatively missing exposure data
    Robert H Lyles
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Am J Epidemiol 155:274-81. 2002
    ..Simulations assess performance of the likelihood-based estimates and inferences, and they display the potential for bias in complete-case analyses. An example is presented to illustrate the approach...
  18. ncbi request reprint Barriers to diabetes education in urban patients: perceptions, patterns, and associated factors
    Mary K Rhee
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Educ 31:410-7. 2005
    ..This study explored patients' perceptions of barriers to diabetes education among a mostly African American population of adults with diabetes...
  19. pmc Flexible modeling of longitudinal highly skewed outcomes
    Huichao Chen
    Center for Biostatistics in AIDS Research, Department of Biostatistics, Harvard School of Public Health, Harvard University, 651 Huntington Avenue, FXB 502, Boston, MA 02115, USA
    Stat Med 28:3811-28. 2009
    ..Simulation studies are conducted to evaluate their performance. Finally, we apply the proposed method to exposure data collected from the Michigan polybrominated biphenyl (MIPBB) study...
  20. ncbi request reprint Limited health care access impairs glycemic control in low income urban African Americans with type 2 diabetes
    Mary K Rhee
    Emory University School of Medicine, Atlanta, Georgia, USA
    J Health Care Poor Underserved 16:734-46. 2005
    ..08%; p=0.009). Policy decisions for improving diabetes outcomes should target barriers to health care access and focus on developing programs to help high-risk populations maintain a regular place of health care...
  21. ncbi request reprint A decay model for assessing polybrominated biphenyl exposure among women in the Michigan Long-Term PBB Study
    Metrecia L Terrell
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Expo Sci Environ Epidemiol 18:410-20. 2008
    ..The mixed-effects decay model predicted the observed serum PBB concentration levels significantly better than the OLS two-stage decay model (mixed-effects model, r=0.93; OLS two-stage model, r=0.86; P<0.0001)...
  22. ncbi request reprint Expression of e-cadherin in high-risk breast cancer
    Eugene M Howard
    Winship Cancer Institute, Emory University, 1365 C Clifton Road NE, Rm 3078, Atlanta, GA 30322, USA
    J Cancer Res Clin Oncol 131:14-8. 2005
    ....
  23. ncbi request reprint The Improving Primary Care of African Americans with Diabetes (IPCAAD) project: rationale and design
    Lawrence S Phillips
    Division of Endocrinology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Control Clin Trials 23:554-69. 2002
    ..We will compare two readily generalizable program interventions that should delineate approaches effective in a primary care setting as needed to improve care and prevent complications in urban African Americans with type 2 diabetes...
  24. ncbi request reprint The use of skin sparing mastectomy in the treatment of breast cancer: The Emory experience
    Grant W Carlson
    Winship Cancer Institute, Emory University School of Medicine, Emory University, 1365B, Clifton Road, Atlanta, GA 30322, USA
    Surg Oncol 12:265-9. 2003
    ..Long-term follow-up of the use of skin sparing mastectomy (SSM) in the treatment of breast cancer is presented to determine the impact of local recurrence (LR) on survival...
  25. ncbi request reprint Local recurrence after skin-sparing mastectomy: tumor biology or surgical conservatism?
    Grant W Carlson
    Winship Cancer Institute, Atlanta, Georgia 30322, USA
    Ann Surg Oncol 10:108-12. 2003
    ..Long-term follow-up of the use of skin-sparing mastectomy (SSM) in the treatment of breast cancer is presented to determine the impact of local recurrence (LR) on survival...
  26. ncbi request reprint Diabetes management by residents in training in a municipal hospital primary care site (IPCAAD 2)
    Christopher D Miller
    Divisions of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Ethn Dis 15:649-55. 2005
    ..Since diabetes is largely a primary care problem but we know little about management by residents in training--the primary care practitioners of the future--we examined surrogate outcomes reflective of their performance...
  27. ncbi request reprint (F-18) fluorodeoxyglucose positron emission tomography as a predictor of pathologic grade and other prognostic variables in bone and soft tissue sarcoma
    A L Folpe
    Department of Pathology, Emory University Medical Center, Atlanta, Georgia 30322, USA
    Clin Cancer Res 6:1279-87. 2000
    ..Further follow-up will be necessary to determine whether FDG-PET provides independent prognostic information...
  28. ncbi request reprint Assay validation for left-censored data
    Huiman X Barnhart
    Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    Stat Med 24:3347-60. 2005
    ..The concordance correlation coefficient is used as an agreement index. The methodology is illustrated using HIV RNA assay data collected as part of a long-term HIV cohort study...
  29. ncbi request reprint Surgical margin and Gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance
    Wei Zhou
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, GA 30322, USA
    Prostate 61:81-91. 2004
    ..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors...
  30. pmc Can we select which patients with small breast cancers should receive adjuvant chemotherapy?
    William C Wood
    Surgical Oncology, Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann Surg 235:859-62. 2002
    ..To identify the risk of systemic metastases from T1a and T1b N0 breast cancers in patients treated in an academic center, and to seek factors to identify the patients at greatest risk of such failure...
  31. ncbi request reprint The amount of metastatic melanoma in a sentinel lymph node: does it have prognostic significance?
    Grant W Carlson
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Ann Surg Oncol 10:575-81. 2003
    ..The amount of metastatic disease in the sentinel lymph node (SLN) is examined as a prognostic factor in malignant melanoma...
  32. ncbi request reprint Sentinel lymph node biopsy in the management of cutaneous head and neck melanoma
    Grant W Carlson
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Plast Reconstr Surg 115:721-8. 2005
    ..8 percent. Completion lymphadenectomy revealed residual disease in seven patients (33.3 percent). Sentinel lymph node mapping for head and neck melanoma can be performed with results comparable to those of other anatomical sites...
  33. pmc Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation
    R E Grossmann
    Nutrition Health Sciences Program, Emory Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA
    Eur J Clin Nutr 66:1072-4. 2012
    ..This study supports the concept that vitamin D may help regulate inflammation in CF, and that further research is needed to elucidate the potential mechanisms involved and the impact on clinical outcomes...
  34. ncbi request reprint The potentially poor response to outpatient diabetes care in urban African-Americans
    C B Cook
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Diabetes Care 24:209-15. 2001
    ..To search for reasons underlying differences in HbA1c outcome, we analyzed patients managed in an outpatient diabetes clinic...
  35. ncbi request reprint Counting alleles in single lesions of prostate tumors from ethnically diverse patients
    Aki Morikawa
    Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia 30322, USA
    Prostate 68:231-40. 2008
    ..Nevertheless, it is unclear whether such disparities are due to genetic alterations that are involved in prostate cancer initiation. Here, we evaluated chromosome 8p allelic loss in a racially diverse cohort...
  36. ncbi request reprint Correlation and expression of p53, HER-2, vascular endothelial growth factor (VEGF), and e-cadherin in a high-risk breast-cancer population
    Eugene M Howard
    Avon Pathogenomics Laboratory at Winship Cancer Institute and Emory University School of Medicine, P O Box 55440, Atlanta, GA 30308, USA
    Int J Clin Oncol 9:154-60. 2004
    ....
  37. ncbi request reprint Bias in a placebo-controlled study due to mismeasurement of disease status and the regression effect
    Hung Mo Lin
    Department of Health Evaluation Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
    Control Clin Trials 23:497-501. 2002
    ..Proper statistical analysis should include such data for an accurate portrayal of the effectiveness of the treatment...
  38. ncbi request reprint Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection
    Janis V Giorgi
    UCLA School of Medicine and Center for AIDS Research, Los Angeles, California 90095 1475, USA
    J Acquir Immune Defic Syndr 29:346-55. 2002
    ....
  39. ncbi request reprint Qualitative change in antibody responses of human immunodeficiency virus-infected individuals to pneumococcal capsular polysaccharide vaccination associated with highly active antiretroviral therapy
    Krishanthi S Subramaniam
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Room 709, Forchheimer Building, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Infect Dis 187:758-68. 2003
    ..These findings suggest that HAART may influence qualitative aspects of the PPS response by restoring expression of certain V(H)3 genes used in the normal PPS response...
  40. ncbi request reprint Estimation of the intervention effect in a non-randomized study with pre- and post-mismeasured binary responses
    Hung Mo Lin
    Department of Health Evaluation Sciences, Penn State College of Medicine, A210, 600 Centerview Drive, Hershey, PA 17033, USA
    Stat Med 24:419-35. 2005
    ..We extend this approach to estimation of both the placebo and intervention effects in placebo-controlled studies designed with a misclassified binary outcome. Analyses of two biomedical studies are used for illustration...