Hinh Ly

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Functional characterization of telomerase RNA variants found in patients with hematologic disorders
    Hinh Ly
    Department of Pathology and Laboratory Medicine, Emory University, Whitehead Biomedical Research Bldg, 615 Michael St, Rm 175, Atlanta, GA 30322, USA
    Blood 105:2332-9. 2005
  2. pmc Identification of virulence determinants within the L genomic segment of the pichinde arenavirus
    Lisa McLay
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    J Virol 87:6635-43. 2013
  3. pmc Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers
    Yuying Liang
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1171:E65-74. 2009
  4. pmc NF-kappaB signaling differentially regulates influenza virus RNA synthesis
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
    J Virol 82:9880-9. 2008
  5. pmc Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers
    Shuiyun Lan
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Virol 83:6357-62. 2009
  6. ncbi request reprint Functional characterization of natural telomerase mutations found in patients with hematologic disorders
    Zhong Tao Xin
    Department of Pathology and Laboratory Medicine, Emory University, 105L Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Blood 109:524-32. 2007
  7. pmc Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 55:5553-9. 2011
  8. pmc Genome comparison of virulent and avirulent strains of the Pichinde arenavirus
    Shuiyun Lan
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, 105P Whitehead Bldg, Atlanta, GA 30322, USA
    Arch Virol 153:1241-50. 2008
  9. ncbi request reprint Functional characterization of yeast telomerase RNA dimerization
    Clay L Gipson
    Department of Pathology and Laboratory Medicine, Experimental Pathology Division, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:18857-63. 2007
  10. pmc Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever
    Lisa McLay
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, United States
    Antiviral Res 97:81-92. 2013

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Functional characterization of telomerase RNA variants found in patients with hematologic disorders
    Hinh Ly
    Department of Pathology and Laboratory Medicine, Emory University, Whitehead Biomedical Research Bldg, 615 Michael St, Rm 175, Atlanta, GA 30322, USA
    Blood 105:2332-9. 2005
    ..Therefore, loss of telomerase activity and of telomere maintenance resulting from inherited hTERC mutations may limit marrow stem cell renewal and predispose some patients to bone marrow failure...
  2. pmc Identification of virulence determinants within the L genomic segment of the pichinde arenavirus
    Lisa McLay
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    J Virol 87:6635-43. 2013
    ..Our laboratory findings serve to reinforce field observations that a high level of viremia often correlates with severe disease outcomes in LASV-infected patients...
  3. pmc Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers
    Yuying Liang
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1171:E65-74. 2009
    ..We have recently developed molecular clones for both the virulent and avirulent strains of PICV. Using the available reverse genetics tools, we are characterizing the molecular determinants of virulent arenavirus infections in vivo...
  4. pmc NF-kappaB signaling differentially regulates influenza virus RNA synthesis
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
    J Virol 82:9880-9. 2008
    ....
  5. pmc Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers
    Shuiyun Lan
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Virol 83:6357-62. 2009
    ..These novel infectious clones for the PICV provide essential tools to identify the virulence factors that are responsible for the severe VHF-like disease in infected animals...
  6. ncbi request reprint Functional characterization of natural telomerase mutations found in patients with hematologic disorders
    Zhong Tao Xin
    Department of Pathology and Laboratory Medicine, Emory University, 105L Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Blood 109:524-32. 2007
    ..Inherited telomerase gene mutations, therefore, operate by various mechanisms to shorten telomere lengths, leading to limited marrow stem cell reserve and renewal capacity in patients with hematologic disorders...
  7. pmc Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 55:5553-9. 2011
    ....
  8. pmc Genome comparison of virulent and avirulent strains of the Pichinde arenavirus
    Shuiyun Lan
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, 105P Whitehead Bldg, Atlanta, GA 30322, USA
    Arch Virol 153:1241-50. 2008
    ..Four out of the five amino acid changes in the L protein occur in a small region of the protein that may contribute to viral virulence by enhancing its function in viral genomic RNA synthesis...
  9. ncbi request reprint Functional characterization of yeast telomerase RNA dimerization
    Clay L Gipson
    Department of Pathology and Laboratory Medicine, Experimental Pathology Division, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:18857-63. 2007
    ..This study, therefore, highlights dimerization as a functionally conserved feature of the RNA templates utilized by reverse transcriptases of both viral and cellular origins...
  10. pmc Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever
    Lisa McLay
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, United States
    Antiviral Res 97:81-92. 2013
    ..This review summarizes current knowledge of the role of each viral protein and host factor in the pathogenesis of arenaviral HF. Insights from recent studies are being exploited for the development of novel therapies...
  11. pmc Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors
    Zhong Tao Xin
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 6:e21333. 2011
    ....
  12. pmc Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita
    Hinh Ly
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Blood 106:1246-52. 2005
    ....
  13. pmc Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments
    Yuhong Liang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
    J Virol 82:229-36. 2008
    ..Interestingly, certain mutations showed strong tendencies to revert to wild-type sequences, which implies that these putative packaging signals are critical for the influenza life cycle...
  14. ncbi request reprint Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromes
    Junko Takeuchi
    Division of Hematology, Department of Internal Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Blood Cells Mol Dis 40:185-91. 2008
    ..This study also highlights the rarity of genetic alterations in BMFS patients in Japan, which suggests that other factors may play a more prominent role in the disease pathogenesis in East Asia...
  15. ncbi request reprint Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia
    Hiroki Yamaguchi
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
    N Engl J Med 352:1413-24. 2005
    ..We investigated whether mutations in genes for other components of telomerase also occur in aplastic anemia...
  16. pmc Comprehensive structure-function analysis of the core domain of human telomerase RNA
    Hinh Ly
    Department of Pathology, University of California, San Francisco, California 94143, USA
    Mol Cell Biol 23:6849-56. 2003
    ..Additionally, we provide evidence that naturally occurring hTER sequence polymorphisms found in some patients with aplastic anemia can inhibit telomerase activity by disrupting critical structures within the hTER core domain...
  17. pmc Bipartite signal for genomic RNA dimerization in Moloney murine leukemia virus
    Hinh Ly
    Department of Pathology, University of California, San Francisco, California 94143 0511, USA
    J Virol 76:3135-44. 2002
    ..These findings support the view that in some retroviruses, dimer initiation and stability involve two or more closely linked DIS loci which together align the nascent dimer strands in parallel and in register...
  18. pmc IL-12 RB1 genetic variants contribute to human susceptibility to severe acute respiratory syndrome infection among Chinese
    Fang Tang
    Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
    PLoS ONE 3:e2183. 2008
    ..Cytokines play important roles in antiviral action. We examined whether polymorphisms of interleukin (IL)-12 receptor B1 (IL-12RB1) affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS)...
  19. ncbi request reprint Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia
    Sharon A Savage
    Section of Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4605, USA
    Exp Hematol 34:664-71. 2006
    ..Abnormal telomere shortening has been observed in a subset of individuals with aplastic anemia (AA). We hypothesized that genetic variation in two genes critical in telomere biology, TERF1 and TERF2, could be a risk factor for AA...
  20. pmc Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes
    Mohammad A Khan
    NIH, NIAID, 4 312, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
    J Virol 79:5870-4. 2005
    ..Our data suggest that packaging of APO3G into HIV-1 NPC is enhanced by viral RNA...
  21. pmc A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:14713-8. 2004
    ..These results, combined with previous studies on telomerase RNAs from other budding yeasts, vertebrates, and ciliates, define a minimal universal core for telomerase RNAs...
  22. pmc A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase
    Hinh Ly
    Departments of Pathology Microbiology, and Immunology, and Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Genes Dev 17:1078-83. 2003
    ..Such RNA-RNA interaction mirrors a known property of retroviral reverse transcriptases, which use homodimeric viral genomic RNA substrates...