Research Topics
| Hinh LySummaryAffiliation: Emory University Country: USA Publications
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Publications
Functional characterization of telomerase RNA variants found in patients with hematologic disordersHinh Ly
Department of Pathology and Laboratory Medicine, Emory University, Whitehead Biomedical Research Bldg, 615 Michael St, Rm 175, Atlanta, GA 30322, USA
Blood 105:2332-9. 2005..Therefore, loss of telomerase activity and of telomere maintenance resulting from inherited hTERC mutations may limit marrow stem cell renewal and predispose some patients to bone marrow failure...
Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic feversYuying Liang
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Ann N Y Acad Sci 1171:E65-74. 2009..We have recently developed molecular clones for both the virulent and avirulent strains of PICV. Using the available reverse genetics tools, we are characterizing the molecular determinants of virulent arenavirus infections in vivo...- Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic feversShuiyun Lan
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
J Virol 83:6357-62. 2009..These novel infectious clones for the PICV provide essential tools to identify the virulence factors that are responsible for the severe VHF-like disease in infected animals... - NF-kappaB signaling differentially regulates influenza virus RNA synthesisNaveen Kumar
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
J Virol 82:9880-9. 2008.... - Functional characterization of natural telomerase mutations found in patients with hematologic disordersZhong Tao Xin
Department of Pathology and Laboratory Medicine, Emory University, 105L Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
Blood 109:524-32. 2007..Inherited telomerase gene mutations, therefore, operate by various mechanisms to shorten telomere lengths, leading to limited marrow stem cell reserve and renewal capacity in patients with hematologic disorders... - Receptor tyrosine kinase inhibitors that block replication of influenza a and other virusesNaveen Kumar
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Antimicrob Agents Chemother 55:5553-9. 2011.... - Genome comparison of virulent and avirulent strains of the Pichinde arenavirusShuiyun Lan
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, 105P Whitehead Bldg, Atlanta, GA 30322, USA
Arch Virol 153:1241-50. 2008..Four out of the five amino acid changes in the L protein occur in a small region of the protein that may contribute to viral virulence by enhancing its function in viral genomic RNA synthesis... - Functional characterization of yeast telomerase RNA dimerizationClay L Gipson
Department of Pathology and Laboratory Medicine, Experimental Pathology Division, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 282:18857-63. 2007..This study, therefore, highlights dimerization as a functionally conserved feature of the RNA templates utilized by reverse transcriptases of both viral and cellular origins... - Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenitaHinh Ly
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
Blood 106:1246-52. 2005.... - Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factorsZhong Tao Xin
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
PLoS ONE 6:e21333. 2011.... - Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segmentsYuhong Liang
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
J Virol 82:229-36. 2008..Interestingly, certain mutations showed strong tendencies to revert to wild-type sequences, which implies that these putative packaging signals are critical for the influenza life cycle... - Bipartite signal for genomic RNA dimerization in Moloney murine leukemia virusHinh Ly
Department of Pathology, University of California, San Francisco, California 94143-0511, USA
J Virol 76:3135-44. 2002..These findings support the view that in some retroviruses, dimer initiation and stability involve two or more closely linked DIS loci which together align the nascent dimer strands in parallel and in register... - Comprehensive structure-function analysis of the core domain of human telomerase RNAHinh Ly
Department of Pathology, University of California, San Francisco, California 94143, USA
Mol Cell Biol 23:6849-56. 2003..Additionally, we provide evidence that naturally occurring hTER sequence polymorphisms found in some patients with aplastic anemia can inhibit telomerase activity by disrupting critical structures within the hTER core domain... - Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemiaHiroki Yamaguchi
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
N Engl J Med 352:1413-24. 2005..We investigated whether mutations in genes for other components of telomerase also occur in aplastic anemia... - Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromesJunko Takeuchi
Division of Hematology, Department of Internal Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
Blood Cells Mol Dis 40:185-91. 2008..This study also highlights the rarity of genetic alterations in BMFS patients in Japan, which suggests that other factors may play a more prominent role in the disease pathogenesis in East Asia... - IL-12 RB1 genetic variants contribute to human susceptibility to severe acute respiratory syndrome infection among ChineseFang Tang
Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
PLoS ONE 3:e2183. 2008..Cytokines play important roles in antiviral action. We examined whether polymorphisms of interleukin (IL)-12 receptor B1 (IL-12RB1) affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS)... - A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase proteinJue Lin
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 101:14713-8. 2004..These results, combined with previous studies on telomerase RNAs from other budding yeasts, vertebrates, and ciliates, define a minimal universal core for telomerase RNAs... - A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomeraseHinh Ly
Departments of Pathology Microbiology, and Immunology, and Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
Genes Dev 17:1078-83. 2003..Such RNA-RNA interaction mirrors a known property of retroviral reverse transcriptases, which use homodimeric viral genomic RNA substrates... - Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexesMohammad A Khan
NIH, NIAID, 4/312, 4 Center Drive, MSC 0460, Bethesda, MD 20892-0460, USA
J Virol 79:5870-4. 2005..Our data suggest that packaging of APO3G into HIV-1 NPC is enhanced by viral RNA... - Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemiaSharon A Savage
Section of Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4605, USA
Exp Hematol 34:664-71. 2006..Abnormal telomere shortening has been observed in a subset of individuals with aplastic anemia (AA). We hypothesized that genetic variation in two genes critical in telomere biology, TERF1 and TERF2, could be a risk factor for AA...