Research Topics
| I M LonginiSummaryAffiliation: Emory University Country: USA Publications
| Collaborators
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Detail Information
Publications
Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, ThailandMichael G Hudgens
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 98109, USA
Am J Epidemiol 155:159-68. 2002..Since many epidemiologic, virologic, and host factors can influence HIV transmission, it was difficult to conclude whether these differences in transmission probabilities were due to biologic properties associated with subtype...- Containing pandemic influenza with antiviral agentsIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
Am J Epidemiol 159:623-33. 2004..Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available... - Strategy for distribution of influenza vaccine to high-risk groups and childrenIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Am J Epidemiol 161:303-6. 2005..The effectiveness of the alternative plan could be assessed through nationwide community studies... - Containing pandemic influenza at the sourceIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
Science 309:1083-7. 2005..1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4... - Epidemic and endemic cholera trends over a 33-year period in BangladeshIra M Longini
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
J Infect Dis 186:246-51. 2002..Thus, epidemics of Inaba may selectively confer short-term population-level immunity for a longer period than those of Ogawa. These observations suggest that the Inaba antigen should be maximized in cholera vaccine designs... - Model-based estimation of vaccine effects from community vaccine trialsIra M Longini
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
Stat Med 21:481-95. 2002..Thus, it can be used as a public health policy tool for predicting the community level effects of vaccination. We demonstrate such use by predicting total vaccine effectiveness for the whole range of vaccination fractions... - Estimation of the efficacy of live, attenuated influenza vaccine from a two-year, multi-center vaccine trial: implications for influenza epidemic controlI M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
Vaccine 18:1902-9. 2000..The authors argue that mass vaccination of 70% of the children with the cold-adapted influenza vaccine could provide substantial protection to the community at large... - Semiparametric methods for multiple exposure mismeasurement and a bivariate outcome in HIV vaccine trialsG T Golm
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Biometrics 55:94-101. 1999..The pseudolikelihood method of Carroll and Wand (1991) and Pepe and Fleming (1991) was the more efficient of the two semiparametric methods... - Nonparametric maximum likelihood estimation for competing risks survival data subject to interval censoring and truncationM G Hudgens
Department of Biostatistics, Emory University, Atlanta, Georgia 30322, USA
Biometrics 57:74-80. 2001..The methods are then applied to data from a cohort of injecting drug users in Thailand susceptible to infection from HIV-1 subtypes B and E... - Measuring vaccine efficacy from epidemics of acute infectious agentsI M Longini
Division of Biostatistics, School of Public Health, Emory University, Atlanta, GA 30322
Stat Med 12:249-63. 1993..In addition, we apply the different vaccine efficacy estimators to data from a measles epidemic in Muyinga, Burundi... 
What is the best control strategy for multiple infectious disease outbreaks?Andreas Handel
Department of Biology, Emory University, Atlanta, GA 30322, USA
Proc Biol Sci 274:833-7. 2007..Here, we identify the best control strategy for such a situation. We further discuss ways in which such a strategy can be implemented to achieve additional public health objectives...
Neuraminidase inhibitor resistance in influenza: assessing the danger of its generation and spreadAndreas Handel
Department of Biology, Emory University, Atlanta, Georgia, United States of America
PLoS Comput Biol 3:e240. 2007..Better knowledge of the quantitative dynamics of the immune response during influenza infections will be crucial to further improve the results...- Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challengesRoland R Regoes
Department of Biology, Emory University, Atlanta, Georgia, USA
PLoS Med 2:e249. 2005..The belief that experiments involving realistically low challenge doses require large numbers of animals has so far prevented the development of alternatives to using high challenge doses... - Finding optimal vaccination strategies for pandemic influenza using genetic algorithmsRajan Patel
Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
J Theor Biol 234:201-12. 2005..GA is generalizable to the optimization of stochastic model parameters for other infectious diseases and population structures... - Antiviral resistance and the control of pandemic influenza: the roles of stochasticity, evolution and model detailsAndreas Handel
Department of Biology, Emory University, Atlanta, GA 30322, USA
J Theor Biol 256:117-25. 2009..If containment is not possible, mitigation works best at intermediate levels of antiviral control. Finally, we show that the results are not very sensitive to the way resistance generation is modeled... - Community interventions and the epidemic prevention potentialM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Vaccine 20:3254-62. 2002..The concepts are general and could be applied to other interventions, such as antivirals and quarantine... - The critical vaccination fraction for heterogeneous epidemic modelsAndrew N Hill
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Math Biosci 181:85-106. 2003..Separable or proportionate mixing is also treated. Conditions are conjectured for convexity of the threshold surface and the problem of minimizing the amount of vaccine used while remaining on the threshold surface is discussed... - Containing bioterrorist smallpoxM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Science 298:1428-32. 2002..It could also help targeted vaccination be more competitive with mass vaccination at both preventing and containing a deliberate introduction of smallpox... - Using validation sets for outcomes and exposure to infection in vaccine field studiesM E Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Am J Epidemiol 154:391-8. 2001.... - Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance culturesM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Am J Epidemiol 158:305-11. 2003..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies... - Controlling endemic cholera with oral vaccinesIra M Longini
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Med 4:e336. 2007..We used a large-scale stochastic simulation model to investigate the possibility of controlling endemic cholera with OCVs... 
No HIV stage is dominant in driving the HIV epidemic in sub-Saharan AfricaLaith J Abu-Raddad
Statistical Center for HIV AIDS Research and Prevention SCHARP, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, LE 400, P O Box 19024, Seattle, WA 98109, USA
AIDS 22:1055-61. 2008..To estimate the role of each of the HIV progression stages in fueling HIV transmission in sub-Saharan Africa by using the recent measurements of HIV transmission probability per coital per HIV stage in the Rakai study...- Analytic insights into the population level impact of imperfect prophylactic HIV vaccinesLaith J Abu-Raddad
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North LE 400, Seattle, WA 98109, USA
J Acquir Immune Defic Syndr 45:454-67. 2007.... - Containing a large bioterrorist smallpox attack: a computer simulation approachIra M Longini
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, LE 400, PO Box 19024, Seattle, WA 98109 1024, USA
Int J Infect Dis 11:98-108. 2007..A bioterrorist release of smallpox is a constant threat to the population of the USA and other countries... - Mitigation strategies for pandemic influenza in the United StatesTimothy C Germann
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Proc Natl Acad Sci U S A 103:5935-40. 2006..For higher R(0), we predict that multiple strategies in combination (involving both social and medical interventions) will be required to achieve similar limits on illness rates... - Safety of cold-adapted live influenza vaccineW Paul Glezen
Pediatr Infect Dis J 23:593-4; author reply 594. 2004 - Population-wide benefits of routine vaccination of children against influenzaDerek Weycker
Policy Analysis Inc, Four Davis Court, Brookline, MA 02445, USA
Vaccine 23:1284-93. 2005..Similar reductions were estimated to occur in influenza-related mortality and economic costs... - A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of BangladeshR Bradley Sack
Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Infect Dis 187:96-101. 2003..These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks... - Critical factors influencing the occurrence of Vibrio cholerae in the environment of BangladeshAnwar Huq
Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA
Appl Environ Microbiol 71:4645-54. 2005..g., plankton population blooms. The new information on the ecology of V. cholerae is proving useful in developing environmental models for the prediction of cholera epidemics... - Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy childrenManjusha J Gaglani
Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
Arch Pediatr Adolesc Med 158:65-73. 2004.... - Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004M Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Vaccine 25:4038-45. 2007..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza... - Public health. Community studies for vaccinating schoolchildren against influenzaM Elizabeth Halloran
Program of Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Science 311:615-6. 2006 - Detecting human-to-human transmission of avian influenza A (H5N1)Yang Yang
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Emerg Infect Dis 13:1348-53. 2007..The estimated lower limit on the local R0 was 1.14 (95% CI 0.61-2.14). Effective HPAI (H5N1) surveillance, containment response, and field evaluation are essential to monitor and contain potential pandemic strains... - Modeling targeted layered containment of an influenza pandemic in the United StatesM Elizabeth Halloran
Virginia Bioinformatics Institute, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA
Proc Natl Acad Sci U S A 105:4639-44. 2008.... - Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in AfricaLaith J Abu-Raddad
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 3:e2230. 2008..The potential impact of these interventions requires a quantitative assessment of the magnitude of the synergy between HIV and HSV-2 at the population level... - Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trialsM Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 165:212-21. 2007..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies...