I M Longini

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand
    Michael G Hudgens
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 98109, USA
    Am J Epidemiol 155:159-68. 2002
  2. ncbi request reprint Containing pandemic influenza with antiviral agents
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Epidemiol 159:623-33. 2004
  3. ncbi request reprint Strategy for distribution of influenza vaccine to high-risk groups and children
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Am J Epidemiol 161:303-6. 2005
  4. ncbi request reprint Containing pandemic influenza at the source
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Science 309:1083-7. 2005
  5. ncbi request reprint Epidemic and endemic cholera trends over a 33-year period in Bangladesh
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Infect Dis 186:246-51. 2002
  6. ncbi request reprint Model-based estimation of vaccine effects from community vaccine trials
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Stat Med 21:481-95. 2002
  7. ncbi request reprint Estimation of the efficacy of live, attenuated influenza vaccine from a two-year, multi-center vaccine trial: implications for influenza epidemic control
    I M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Vaccine 18:1902-9. 2000
  8. ncbi request reprint Semiparametric methods for multiple exposure mismeasurement and a bivariate outcome in HIV vaccine trials
    G T Golm
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Biometrics 55:94-101. 1999
  9. ncbi request reprint Nonparametric maximum likelihood estimation for competing risks survival data subject to interval censoring and truncation
    M G Hudgens
    Department of Biostatistics, Emory University, Atlanta, Georgia 30322, USA
    Biometrics 57:74-80. 2001
  10. ncbi request reprint Measuring vaccine efficacy from epidemics of acute infectious agents
    I M Longini
    Division of Biostatistics, School of Public Health, Emory University, Atlanta, GA 30322
    Stat Med 12:249-63. 1993

Detail Information

Publications36

  1. ncbi request reprint Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand
    Michael G Hudgens
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 98109, USA
    Am J Epidemiol 155:159-68. 2002
    ..Since many epidemiologic, virologic, and host factors can influence HIV transmission, it was difficult to conclude whether these differences in transmission probabilities were due to biologic properties associated with subtype...
  2. ncbi request reprint Containing pandemic influenza with antiviral agents
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Epidemiol 159:623-33. 2004
    ..Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available...
  3. ncbi request reprint Strategy for distribution of influenza vaccine to high-risk groups and children
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Am J Epidemiol 161:303-6. 2005
    ..The effectiveness of the alternative plan could be assessed through nationwide community studies...
  4. ncbi request reprint Containing pandemic influenza at the source
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Science 309:1083-7. 2005
    ..1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4...
  5. ncbi request reprint Epidemic and endemic cholera trends over a 33-year period in Bangladesh
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Infect Dis 186:246-51. 2002
    ..Thus, epidemics of Inaba may selectively confer short-term population-level immunity for a longer period than those of Ogawa. These observations suggest that the Inaba antigen should be maximized in cholera vaccine designs...
  6. ncbi request reprint Model-based estimation of vaccine effects from community vaccine trials
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Stat Med 21:481-95. 2002
    ..Thus, it can be used as a public health policy tool for predicting the community level effects of vaccination. We demonstrate such use by predicting total vaccine effectiveness for the whole range of vaccination fractions...
  7. ncbi request reprint Estimation of the efficacy of live, attenuated influenza vaccine from a two-year, multi-center vaccine trial: implications for influenza epidemic control
    I M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Vaccine 18:1902-9. 2000
    ..The authors argue that mass vaccination of 70% of the children with the cold-adapted influenza vaccine could provide substantial protection to the community at large...
  8. ncbi request reprint Semiparametric methods for multiple exposure mismeasurement and a bivariate outcome in HIV vaccine trials
    G T Golm
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Biometrics 55:94-101. 1999
    ..The pseudolikelihood method of Carroll and Wand (1991) and Pepe and Fleming (1991) was the more efficient of the two semiparametric methods...
  9. ncbi request reprint Nonparametric maximum likelihood estimation for competing risks survival data subject to interval censoring and truncation
    M G Hudgens
    Department of Biostatistics, Emory University, Atlanta, Georgia 30322, USA
    Biometrics 57:74-80. 2001
    ..The methods are then applied to data from a cohort of injecting drug users in Thailand susceptible to infection from HIV-1 subtypes B and E...
  10. ncbi request reprint Measuring vaccine efficacy from epidemics of acute infectious agents
    I M Longini
    Division of Biostatistics, School of Public Health, Emory University, Atlanta, GA 30322
    Stat Med 12:249-63. 1993
    ..In addition, we apply the different vaccine efficacy estimators to data from a measles epidemic in Muyinga, Burundi...
  11. pmc What is the best control strategy for multiple infectious disease outbreaks?
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Biol Sci 274:833-7. 2007
    ..Here, we identify the best control strategy for such a situation. We further discuss ways in which such a strategy can be implemented to achieve additional public health objectives...
  12. pmc Neuraminidase inhibitor resistance in influenza: assessing the danger of its generation and spread
    Andreas Handel
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Comput Biol 3:e240. 2007
    ..Better knowledge of the quantitative dynamics of the immune response during influenza infections will be crucial to further improve the results...
  13. pmc Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challenges
    Roland R Regoes
    Department of Biology, Emory University, Atlanta, Georgia, USA
    PLoS Med 2:e249. 2005
    ..The belief that experiments involving realistically low challenge doses require large numbers of animals has so far prevented the development of alternatives to using high challenge doses...
  14. ncbi request reprint Finding optimal vaccination strategies for pandemic influenza using genetic algorithms
    Rajan Patel
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
    J Theor Biol 234:201-12. 2005
    ..GA is generalizable to the optimization of stochastic model parameters for other infectious diseases and population structures...
  15. pmc Antiviral resistance and the control of pandemic influenza: the roles of stochasticity, evolution and model details
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    J Theor Biol 256:117-25. 2009
    ..If containment is not possible, mitigation works best at intermediate levels of antiviral control. Finally, we show that the results are not very sensitive to the way resistance generation is modeled...
  16. ncbi request reprint Community interventions and the epidemic prevention potential
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Vaccine 20:3254-62. 2002
    ..The concepts are general and could be applied to other interventions, such as antivirals and quarantine...
  17. ncbi request reprint The critical vaccination fraction for heterogeneous epidemic models
    Andrew N Hill
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Math Biosci 181:85-106. 2003
    ..Separable or proportionate mixing is also treated. Conditions are conjectured for convexity of the threshold surface and the problem of minimizing the amount of vaccine used while remaining on the threshold surface is discussed...
  18. ncbi request reprint Containing bioterrorist smallpox
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Science 298:1428-32. 2002
    ..It could also help targeted vaccination be more competitive with mass vaccination at both preventing and containing a deliberate introduction of smallpox...
  19. ncbi request reprint Using validation sets for outcomes and exposure to infection in vaccine field studies
    M E Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 154:391-8. 2001
    ....
  20. ncbi request reprint Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 158:305-11. 2003
    ..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies...
  21. pmc Controlling endemic cholera with oral vaccines
    Ira M Longini
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e336. 2007
    ..We used a large-scale stochastic simulation model to investigate the possibility of controlling endemic cholera with OCVs...
  22. doi request reprint No HIV stage is dominant in driving the HIV epidemic in sub-Saharan Africa
    Laith J Abu-Raddad
    Statistical Center for HIV AIDS Research and Prevention SCHARP, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, LE 400, P O Box 19024, Seattle, WA 98109, USA
    AIDS 22:1055-61. 2008
    ..To estimate the role of each of the HIV progression stages in fueling HIV transmission in sub-Saharan Africa by using the recent measurements of HIV transmission probability per coital per HIV stage in the Rakai study...
  23. ncbi request reprint Analytic insights into the population level impact of imperfect prophylactic HIV vaccines
    Laith J Abu-Raddad
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North LE 400, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 45:454-67. 2007
    ....
  24. ncbi request reprint Containing a large bioterrorist smallpox attack: a computer simulation approach
    Ira M Longini
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, LE 400, PO Box 19024, Seattle, WA 98109 1024, USA
    Int J Infect Dis 11:98-108. 2007
    ..A bioterrorist release of smallpox is a constant threat to the population of the USA and other countries...
  25. pmc Mitigation strategies for pandemic influenza in the United States
    Timothy C Germann
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Proc Natl Acad Sci U S A 103:5935-40. 2006
    ..For higher R(0), we predict that multiple strategies in combination (involving both social and medical interventions) will be required to achieve similar limits on illness rates...
  26. ncbi request reprint Safety of cold-adapted live influenza vaccine
    W Paul Glezen
    Pediatr Infect Dis J 23:593-4; author reply 594. 2004
  27. ncbi request reprint Population-wide benefits of routine vaccination of children against influenza
    Derek Weycker
    Policy Analysis Inc, Four Davis Court, Brookline, MA 02445, USA
    Vaccine 23:1284-93. 2005
    ..Similar reductions were estimated to occur in influenza-related mortality and economic costs...
  28. ncbi request reprint A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh
    R Bradley Sack
    Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 187:96-101. 2003
    ..These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks...
  29. pmc Critical factors influencing the occurrence of Vibrio cholerae in the environment of Bangladesh
    Anwar Huq
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA
    Appl Environ Microbiol 71:4645-54. 2005
    ..g., plankton population blooms. The new information on the ecology of V. cholerae is proving useful in developing environmental models for the prediction of cholera epidemics...
  30. ncbi request reprint Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy children
    Manjusha J Gaglani
    Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
    Arch Pediatr Adolesc Med 158:65-73. 2004
    ....
  31. pmc Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Vaccine 25:4038-45. 2007
    ..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza...
  32. ncbi request reprint Public health. Community studies for vaccinating schoolchildren against influenza
    M Elizabeth Halloran
    Program of Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 311:615-6. 2006
  33. pmc Detecting human-to-human transmission of avian influenza A (H5N1)
    Yang Yang
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Emerg Infect Dis 13:1348-53. 2007
    ..The estimated lower limit on the local R0 was 1.14 (95% CI 0.61-2.14). Effective HPAI (H5N1) surveillance, containment response, and field evaluation are essential to monitor and contain potential pandemic strains...
  34. pmc Modeling targeted layered containment of an influenza pandemic in the United States
    M Elizabeth Halloran
    Virginia Bioinformatics Institute, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 105:4639-44. 2008
    ....
  35. pmc Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa
    Laith J Abu-Raddad
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 3:e2230. 2008
    ..The potential impact of these interventions requires a quantitative assessment of the magnitude of the synergy between HIV and HSV-2 at the population level...
  36. ncbi request reprint Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 165:212-21. 2007
    ..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies...